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A longitudinal assessment of retinal function and structure in the APP/PS1 transgenic mouse model of Alzheimer’s disease

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Translational Neurodegeneration 2019年第1期8卷 372-381页

作者： Dana Georgevsky Stephanie Retsas Newsha Raoufi olga Shimoni S.Mojtaba Golzan Vision Science group Graduate School of Health(Orthoptics Discipline)University of Technology Sydney15 BroadwayUltimoSydneyNSW 2007Australia Institute of biomedical Materials&Devices(IbMD) Faculty of ScienceUniversity of Technology Sydney15 BroadwayUltimoSydneyNSW 2007Australia

background:A great body of evidence suggests that there are retinal functional and structural changes that occur in Alzheimer’s disease(AD).However,whether such changes are primary or secondary remains to be *** studied a range of retinal functional and structural parameters in association with AD-specific pathophysiological markers in the double transgenic APP/PS1 and control mice across ***:Electroretinogram(ERG)and optical coherence tomography(OCT)was performed in APP/PS1 and wild type(WT)control mice every 3 months from 3 to 12 months of *** functional assessment,the a-and b-wave of the ERG,amplitude of oscillatory potentials(OP)and the positive scotopic threshold response(pSTR)were quantified at each time *** structural assessment,the inner and outer retinal thickness was segmented and measured from OCT *** memory was evaluated at 6,9 and 12 months of age using the novel object recognition *** beta(Aβ)distribution in the hippocampus and the retina were visualised at 3,6 and 12 months of *** intra-group analysis was performed to study rate of change for each parameter between the two ***:Inter-group analysis revealed a significant difference in b-wave and OPs of APP/PS1 compared to WT controls starting from 3 months(pbetween the two groups starting from 6 months(pbetween the two groups,was observed starting from 9 months(pbserved an age-related decline in retinal functional and structural parameters in both APP/PS1 and WT controls,however,inter-group analysis revealed that inner retinal functional and structural decline is exacerbated in APP/PS1 mice,and that retinal functional changes precede structural changes in this *** studies are required to confirm whether such phenomenon occurs in humans and if studying ret

关键词： Retinal function Retinal structure Retinal imaging biomarkers Alzheimer’s disease Early assessment

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In vitro and in vivo studies on pure Mg, Mg-1Ca and Mg-2Sr alloys processed by equal channel angular pressing

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Nano Materials Science 2020年第1期2卷 96-108页

作者： Wenting Li Yunong Shen Jie Shen Danni Shen Xiao Liu Yufeng Zheng Kelvin W.K.Yeung Shaokang Guan olga b.Kulyasova R.Z.Valiev Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China College of Materials Science and Engineering University of Science and Technology BeijingBeijing100083China Department of Orthopaedics and Traumatology The University of Hong KongPokfulamHong KongChina School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450001China Ufa State Aviation Technical University 12 Karl Marx StreetUfa450008Russia

In the present work,the biomedical as-cast pure Mg,Mg–1 Ca and Mg–2 Sr alloys were processed with equal channel angular pressing(ECAP)technique to develop ultrafine microstructure within the materials,and their microstructures,mechanical properties,degradation behavior,cytocompatibility in vitro and biocompatibility in vivo were studied ***-gained microstructures and improved mechanical properties of these three materials after ECAP were confirmed compared to their as-cast ***,after ECAP the degradation rate of pure Mg was increased while that of Mg–1 Ca or Mg–2 Sr alloys decreased compared to the ascast ***,good in vitro cytocompatibility and in vivo biocompatibility of these three materials were revealed by cell cultural tests using osteoblastic MC3 T3-E1 and human mesenchymal stem cells(h MSC)and in vivo animal tests at the lateral epicondyle of SD-rats’*** study offers an alternative powerful avenue to achieve good comprehensive properties of magnesium-based biodegradable *** might also help to extend the applied range of magnesium-based biodegradable metals in orthopedic field.

关键词： Magnesium alloys Equal channel angular pressing Mechanical property Degradation behavior biocompatibility

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Thermal Conditions in Córdoba City, Argentina, during 1960-2010 Period

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American Journal of Climate Change 2014年第2期3卷 193-204页

作者： Antonio C. de la Casa olga b. Nasello Facultad de Ciencias Agropecuarias Universidad Nacional de Córdoba Córdoba Argentina Facultad de Matemática Astronomía y Física Universidad Nacional de Córdoba and IFEG-CONICET Medina Allende s/n Ciudad Universitaria (5000) Córdoba Argentina

The present work analyzes daily minimum (Tmin) and maximum (Tmax) temperature series from Córdoba Observatory weather station, which is located near the center of the city of Córdoba, Argentina, and from the Pajas blancas and Pilar observatories, in order to have a reference counterpart of regional climate. The air temperature in Córdoba city during 1960-2010 period shows lower/higher frequency of Tmin categories lower/higher than 15°C, with respect to rural thermal conditions. Tmax categories higher/lower than 30°C, in turn, presented higher/lower frequency in the city. While the mean annual Tmin showed a significant positive trend in the entire region in the study period, Tmax presented no significant changes over time. The difference between urban and rural thermal regimes remained uniform throughout the study period, so the process of urbanization does not seem to have changed the Urban heat island status measure from Córdoba Observatory, even though the population of the metropolis has doubled. Although nocturnal thermal conditions have changed over the period, particularly in urban areas, there has been no change in the regime of extreme daytime temperatures across the region. The annual mean Tmin increase is not monotonic, but presents a significant positive partial trend until a breakpoint around 1990, and then becomes neutral or negative and loses significance. For the annual mean Tmax, the partial trend slopes are not significant in any case, so the variation of annual mean thermal amplitude is due mainly to the increase of the Tmin, probably associated with increased rainfall in the region.

关键词： Maximum and Minimum Daily Temperature Partial Trends Urban Heat Island Climate Change

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Geomaterials on the basis of Analcime-bearing Rocks

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Geomaterials 2011年第2期1卷 33-40页

作者： Dmitry A. Shushkov olga b. Kotova boris A. Goldin Establishment of Russian Academy of Sciences Institute of Geology of Komi SC Ub RAS Syktyvkar

Analcime-bearing rocks (Komi Republic, Russia) are perspective raw for geological materials. The article represents possibilities of their application for water purification, as raw for ceramic industry and poor ore f... 详细信息

关键词： Analcime-bearing Rocks Water Purification Ion Exchange Ceramics Aluminum Extraction

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Campanian Climatic Change:Isotopic Evidence from Far East,North America,North Atlantic and Western Europe

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Acta Geologica Sinica(English Edition) 2007年第6期81卷 1049-1069页

作者： Yuri D. ZAKHAROV Yasunari SHIGETA Kazushige TANAbE Yasuhiro IbA olga P. SMYSHLYAEVA Ekaterina A. SOKOLOVA Alexander M. POPOV Tatiana A. VELIVETSKAYA Tamara b. AFANASYEVA Far Eastern Geological Institute FEB RAS Stoletiya Prospect 159 Vladivostok 690022 Russia Department of Geology National Science Museum 3-23-1 Hyakunincho Shinjuku-ku Tokyo 169-0073 Japan University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan Institute of Oceanology RAS Nakhimovskij Prospect 36 Moscow 117997 Russia

Paleoclimatic settings have been reconstructed for the Campanian using original oxygenisotopic analyses of well-preserved molluskan and foraminifera shells from Russian Far East, Hokkaido, USA, belgium and some DSDP holes （95, 98, 102, 390A, and 392A） in North Atlantic. Early Early Campanian climatic optimum has been recognized from data on high bottom shelf water paleotemperatures in middle latitudes of both the western circum-Pacific （to 24.2℃） and the eastern circum-Pacific （to 26.4℃） areas and high bottom shallow water paleotemperatures in high latitudes of the Koryak Upland （22.4-25.5℃）, which agrees with the data on the Campanian barykovskaya flora in high latitudes （Golovneva and Herman, 1998） and Jonker flora and its equivalents in middle latitudes. Judging from the data on comparatively high bottom shallow water paleotemperature values in high latitudes, South Alaska （19.4℃） and the Koryak Upland （22.4-25.5℃）, we also expect Latest Campauian temperature maximum, which has not been confirmed, however, for low and middle latitudes by neither of isotopic nor paleobotanic data now. Main dimatic tendency during the Campanian （with the exception of Latest Campanian） has been learned from isotopic composition of Campanian aragonitic ammonoid shells from the Hokkaido-South Sakhalin （Krilyon） marine basin. In contrary to Huber＇s et al. （2002） assumption, we expect warm greenhouse conditions during the most part of the Campanian.

关键词： isotopic data cephalopod bivalve and gastropod mollusks paleotemperatures,Campanian Sakhalin Hokkaido Koryak Upland North America Netherlands Atlantic

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Development and characterization of whey protein films incorporated with tarbush polyphenols and candelilla wax

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Food bioscience 2022年第1期45卷 1-7页

作者： olga b.Alvarez-Perez Janeth M.Ventura-Sobrevilla Cristian Torres-Leon Romeo Rojas-Molina Raúl Rodríguez-Herrera Miguel A.Aguilar-Gonzalez Cristobal N.Aguilar bioprocesses and bioproducts Research Group Food Research DepartmentSchool of ChemistryUniversidad Autonoma de Coahuila25280SaltilloCoahuilaMexico School of Health Sciences Universidad Autonoma de Coahuila26090Piedras NegrasCoahuilaMexico School of Agronomy Research Center and Development for Food IndustryUniversidad Autonoma de Nuevo Leon6050General EscobedoNuevo LeonMexico Center for Research and Advanced Studies of the National Polytechnique Institute Parque Industrial Saltillo-Ramos ArizpeCoahuilaMexico

Edible films were prepared with whey protein incorporating candelilla wax,and glycerol in aqueous *** polyphenols were added as bioactive *** optimization based on the water vapor permeability(WVP)of the formulation was performed using a box-behnken *** films were characterized by the determination of WVP,moisture,solubility,color,antioxidant and antifungal *** electron microscopy(SEM)was also performed to observe the surface and cross-section *** lowest permeability values were found with concentrations of 1.27,0.3 and 0.5% of protein,wax and glycerol *** was proved that the addition of polyphenols into films causes a significant effect only on solubility and transparency *** films have suitable properties as a barrier for the goods they could be applied *** is proposed for use in foods such as fresh or minimally processed fruits and vegetables.

关键词： Edible films Whey protein Shelf life Candelilla wax Euphorbia antisyphilitica Fluorensia cernua polyphenols

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Females choose gentle, but not healthy or macho males in Campbell dwarf hamsters （Phodopus campbelli Thomas 1905）

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Current Zoology 2017年第5期63卷 545-554页

作者： Konstantin A. ROGOVIN Anastasiya M. KHRUSHCHOVA olga N. SHEKAROVA Nina A. VASlLIEVA Nina Yu VASILIEVA A.N. Severtsov Institute of Ecology and EvoLution RAS Leninskii prospect 33 Moscow 119071 Russia

Androgen-dependent male sexual traits （STs） as well as immunocompetence are theoreticallyassumed to be key indicators of a male＇s quality for the mate-choosing female. We studied matechoice by sexually motivated （SM） females of Campbell＇s dwarf hamsters. Females chose between2 tethered male siblings that differed in expression of STs. Males were unrelated to the female andable to contact and copulate with her. In both males, we measured sex-related morphology ofbody mass, mid-ventral specific skin gland, ano-genital distance, and external testicular *** also estimated levels of blood testosterone and cortisol, specific T- and b-cell immune re-sponses to antigens, as well as aggressive and sexual dominance in sibling males through add-itional encounter experiments with another SM female （male sibs could freely compete for thefemale）. We found that SM females chose a partner among 2 male sibs and spent over 80% of theirtime on average with the preferred male compared with the non-preferred one. Her choice was notassociated with the first visit of the chosen male, with a higher expression of sex-related traits,higher levels of blood testosterone, or with aggressive dominance. The choice was not associatedwith the intensity of T-cell immune response to phitohemagglutinin （PHA）. Instead there was a ten-dency for a negative relationship with the expression of STs and b-cell response to the antigenchallenge. The only character that unambiguously influenced female choice was the non-aggressive male to female grooming during sexual contact. There was no difference in breedingsuccess between preferred and non-preferred males paired with virgin females.

关键词： Campbell's dwarf hamsters, female mate choice, immunocompetence handicap, male-male aggression, sexual traits,testosterone.

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Expression of anti-Mullerian hormone receptor on the appendix testis in connection with urological disorders

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Asian Journal of Andrology 2013年第3期15卷 400-403页

作者： Kornel Kistamas olga Ruzsnavszky Andrea Telek Livia Kosztka Ilona Kovacs beatrix Dienes Laszlo Csernoch Tamas Jozsa Department of Physiology Medical and Health Science Center University of Debrecen Debrecen 4032 Hungary Department of Pathology Kenezy Gyula Hospital Debrecen 4032 Hungary Department of Pediatrics Medical and Health Science Center University of Debrecen Debrecen 4032 Hungary Department of Pediatric Surgery Division of Urology Astrid Lindgren Children's Hospital Karolinska University Hospital Stockholm SE-171 76 Sweden

The female internal sex organs develop from the paramesonephric （Mullerian） duct. In male embryos, the regression of the Mullerian duct is caused by the anti-Mullerian hormone （AMH）, which plays an important role in the process of testicular descent. The physiological remnant of the Mullerian duct in males is the appendix testis （AT）. In our previous study, we presented evidence for the decreased incidence of AT in cryptorchidism with intraoperative surgery. In this report, the expression of the anti-Mullerian hormone receptor type 2 （AMHR2）, the specific receptor of AMH, on the AT was investigated in connection with different urological disorders, such as hernia inguinalis, torsion of AT, cysta epididymis, varicocele, hydrocele testis and various forms of undescended testis. The correlation between the age of the patients and the expression of the AMHR2 was also examined. Reverse transcriptase-polymerase chain reaction （RT-PCR） and immunohistochemistry were used to detect the receptor＇s mRNA and protein levels, respectively. We demonstrate that AMHR2 is expressed in the ATs. Additionally, the presence of this receptor was proven at the mRNA and protein levels. The expression pattern of the receptor correlated with neither the examined urological disorders nor the age of the patients; therefore, the function of the AT remains obscure.

关键词： anti-Mullerian hormone receptor (AMHR) appendixtestis (AT) hernia inguinal is retention testis testicular descent testisretractile

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Effect of erythromycin on image quality and transit time of capsule endoscopy: A two-center study

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World Journal of Gastroenterology 2008年第16期14卷 2561-2565页

作者： Eva Niv Ido bogner olga barkey Zamir Halpern Elisabeth Mahajna Roman Depsames Yael Kopelman Zvi Fireman Department of Gastroenterology Hillel Yaffe Medical Center Department of Gastroenterology Tel Aviv Sourasky Medical Center

AIM: To compare the effect of oral erythromycin vs no preparation with prokinetics on the transit time and the image quality of capsule endoscopy (CE) in evaluating small bowel (Sb) pathology. METHODS: We conducted a retrospective, blinded (to the type of preparation) review of 100 CE studies, 50 with no preparation with prokinetics from one medical center (Group A) and 50 from another center with administration of a single dose of 200 mg oral erythromycin 1 h prior to CE (Group b). Gastric, Sb and total transit times were calculated, the presence of bile in the duodenum was scored, as was cleanliness within the proximal, middle and distal intestine. RESULTS: The erythromycin group had a slightly shorter gastric transit time (21 min vs 28 min, with no statistical significance). Sb transit time was similar for both groups (all P > 0.05). Total transit time was almost identical in both groups. The rate of incomplete examination was 16% for Group A and 10% for Group b (P = 0.37). bile and cleanliness scores in different parts of the intestine were similar for the two groups (P > 0.05). CONCLUSION: Preparation for capsule endoscopy with erythromycin does not affect Sb or total transit time. It tends to reduce gastric transit time, but it does not increase the cecum-reaching rate. Erythromycin does not adversely affect image quality. We consider the routine use of oral erythromycin preparation as being unjustified, although it might be considered in patients with known prolonged gastric emptying time.

关键词： Capsule endoscopy Gastric transit time Small bowel transit time Erythromycin Image quality

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Pole to Equator Temperature Gradient for Coniacian Time,Late Cretaceous:Oxygen and Carbon Isotopic Data on the Koryak Upland and Hokkaido

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Journal of Earth Science 2012年第1期23卷 19-32页

作者： Yuri D Zakharov olga P Smyshlyaeva Alexander M Popov Tatiana A Velivetskaya Tamara b Afanasyeva Kazushige Tanabe Yasunari Shigeta Haruyoshi Maeda Far Eastern Geological Institute Russian Academy of Sciences Far Eastern Branch Geological Institute University of Tokyo Department of Geology National Museum of Nature and Science Department of Earth and Planetary Sciences Graduate School of Science

The purpose of this study was to estimate the Coniacian latitudinal thermal gradient in the Northern Hemisphere. both hemipelagic （ammonoids） and benthic （brachiopods and bivalves） δ18O and δ^13C records were used. They originated from Coniacian shallow-water sequences across a wide range of paleolatitudes, from the Koryak upland （northern Kamchatka, Russian Far East） in the north, to Hokkaido （Japan） in the south. Among Coniacian ammonoids, both migrants from Hokkaido living in high latitudes （Kamchatka） and endemic forms dwelling in middle-low latitudes （Hokkaido） indicate seemingly close optimal growth temperatures. Nevertheless, certain differences in climatic conditions, prevailing during high-latitude coldest seasons, undoubtedly provoked growth cessation in some groups of ammonites. Our isotopic study suggests latitudinal temperature changes of only 0.12 ℃ per degree of latitude for the Northern Hemisphere in Coniacian times, while the average annual temperature in North Kamchatka seems about 3.3 ℃ lower than that in Hokkaido.

关键词： Coniacian oxygen and carbonisotope paleotemperature Kamchatka Hok-kaido.

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