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Population dynamics of Amur tigers(Panthera tigris altaica)in Sikhote-Alin Biosphere Zapovednik:1966–2012

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Integrative Zoology 2015年第4期10卷 315-328页

作者： Dale G.MIQUELLE Evgeny N.SMIRNOv olga Yu.ZAUMYSLOvA Svetlana v.SOUTYRINA Douglas H.JOHNSON Wildlife Conservation Society BronxNew YorkUSA Sikhote-Alin Biosphere Zapovednik TerneiPrimorskii KraiRussia USGS Northern Prairie Wildlife Research Center Saint PaulMinnesotaUSA

In 2010,the world’s tiger(Panthera tigris)range countries agreed to the goal of doubling tiger numbers over 12 years,but whether such an increase is biologically feasible has not been ***-term monitoring of tigers in Sikhote-Alin Biosphere Zapovednik(SABZ),Russia provided an opportunity to determine growth rates of a recovering population.A 41-year growth phase was followed by a rapid decline in tiger *** growth rates during the growth phase averaged 4.6%,beginning near 10%in the earliest years but quickly dropping below 5%.Sex ratio(females per male)mirrored growth rates,declining as population size *** rapid decline from 2009 to 2012 appeared to be tied to multiple factors,including poaching,severe winters and *** indicators of this population are similar to those of Bengal tiger populations,suggesting that growth rates may be *** results suggest that,first,tiger populations likely in general grow slowly:3–5%yearly increases are realistic and larger growth rates are likely only when populations are highly depressed,mortality rates are low and prey populations are high relative to numbers of adult ***,while more research is needed,it should not be assumed that tiger populations with high prey densities will necessarily grow more quickly than populations with low prey ***,while growth is slow,decline can be ***,because declines can happen so quickly,there is a constant need to monitor populations and be ready to respond with appropriate and timely conservation interventions if tiger populations are to remain ***,an average annual growth rate across all tiger populations of 6%,required to reach the Global Tiger Initiative’s goal of doubling tiger numbers in 12 years,is a noble but unlikely scenario.

关键词： Amur tiger growth rates population dynamics

Selective footprints and genes relevant to cold adaptation and other phenotypic traits are unscrambled in the genomes of divergently selected chicken breeds

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Journal of Animal Science and Biotechnology 2023年第3期14卷 887-907页

作者： Michael N.Romanov Alexandra S.Abdelmanova vladimir I.Fisinin Elena A.Gladyr Natalia A.volkova olga A.Koshkina Andrey N.Rodionov Anastasia N.vetokh Igor v.Gusev Dmitry v.Anshakov olga I.Stanishevskaya Arsen v.Dotsev Darren K.Griffin Natalia A.Zinovieva L.K.Ernst Federal Research Centre for Animal Husbandry DubrovitsyPodolskMoscow RegionRussia School of Biosciences University of KentCanterburyUK Federal State Budget Scientific Institution Federal Research Centre“All-Russian Poultry Research and Technological Institute”of the Russian Academy of Sciences Sergiev PosadMoscow RegionRussia Breeding and Genetic Centre“Zagorsk Experimental Breeding Farm”–Branch of the Federal Research Centre“All-Russian Poultry Research and Technological Institute”of the Russian Academy of Sciences Sergiev PosadMoscow RegionRussia Russian Research Institute of Farm Animal Genetics and Breeding–Branch of the L.K.Ernst Federal Research Centre for Animal Husbandry St.PetersburgRussia

Background The genomes of worldwide poultry breeds divergently selected for performance and other phenotypic traits may also be affected by,and formed due to,past and current admixture *** to diverse environments,including acclimation to harsh climatic conditions,has also left selection footprints in breed *** Using the Chicken 50K_CobbCons SNP chip,we genotyped four divergently selected breeds:two aboriginal,cold tolerant Ushanka and Orloff Mille Fleur,one egg-type Russian White subjected to artificial selection for cold tolerance,and one meat-type White *** of selective sweeps were determined in the studied breeds using three methods:(1)assessment of runs of homozygosity islands,(2)F_(ST) based population differential analysis,and(3)haplotype differentiation *** regions of true selection signatures were identified by two or more methods or in two or more *** these regions,we detected 540 prioritized candidate genes supplemented them with those that occurred in one breed using one statistic and were suggested in other *** them,SOX5,ME3,ZNF536,WWP1,RIPK2,OSGIN2,DECR1,TPO,PPARGC1A,BDNF,MSTN,and beta-keratin genes can be especially mentioned as candidates for cold *** factors may be involved in regulating some of these important genes(e.g.,TPO and BDNF).Conclusion Based on a genome-wide scan,our findings can help dissect the genetic architecture underlying various phenotypic traits in chicken *** include genes representing the sine qua non for adaptation to harsh *** tolerance in acclimated chicken breeds may be developed following one of few specific gene expression mechanisms or more than one overlapping response known in cold-exposed individuals,and this warrants further investigation.

关键词： Acclimation Adaptation Chicken breeds Cold tolerance Divergent selection Genetic diversity Genomewide scan Phenotypic traits Selective sweeps

Contribution of functional KIR3DL1 to ankylosing spondylitis

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Cellular & Molecular Immunology 2010年第6期7卷 471-476页

作者： Ivan v Zvyagin Ilgar Z Mamedov olga v Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna v Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis v Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry RASMoscowRussia Institute of Rheumatology RAMSMoscowRussia DNA-Technology JSC MoscowRussia vavilov Institute of General Genetics MoscowRussia

Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune *** particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several ***,none of the studies analyzed these associations in the context of functionality of polymorphic *** better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)*** genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 *** the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low ***3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1**** finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating ***,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1**** activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective ***,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS.

关键词： ankylosing spondylitis autoimmune disease HLA-B27 KIR KIR3DL1 KIR3DS1 KIR3DL1*004 NK cell T cell

Identification of genes involved in the formation of soluble dietary fiber in winter rye grain and their expression in cultivars with different viscosities of wholemeal water extract

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The Crop Journal 2022年第2期10卷 532-549页

作者： Liudmila v.Kozlova Alsu R.Nazipova Oleg v.Gorshkov Liliya F.Gilmullina olga v.Sautkina Natalia v.Petrova Oksana I.Trofimova Sergey N.Ponomarev Mira L Ponomareva Tatyana A.Gorshkova Kazan Institute of Biochemistry and Biophysics Federal Research CenterKazan Scientific Center of the Russian Academy of Sciences420111 KazanRussia Tatar Scientific Research Institute of Agriculture Federal Research CenterKazan Scientific Center of the Russian Academy of Sciences420059 KazanRussia

The grain of rye(Secale cereale L.) used for baking contains a large amount of non-starch polysaccharides,making it an excellent component of functional foods. But rye grain intended for alcohol production and forage use should have a reduced content of these polysaccharides. A comprehensive parameter that can predict the best field of application for winter rye grain is the viscosity of its wholemeal water ***, our understanding of the genetic background underlying this key trait and associated features of rye grain is poor. By analyzing six Russian winter rye cultivars, we identified the most contrasting forms and characterized the peculiarities of their water-soluble carbohydrates capable of influencing the viscosity of water extracts. Then, using phylogenetic and transcriptomic analyses, we identified in the rye genome many genes encoding putative glycosyltransferases and glycosylhydrolases responsible for the synthesis and degradation of arabinoxylans, mixed-linkage glucans, cellulose, and some other polysaccharides. We determined the dynamics of m RNA abundance for these genes at three stages of kernel development. Comparisons of gene expression levels in two contrasting cultivars revealed specific members of multigene families that may serve as promising targets for manipulating non-starch polysaccharide content in rye grain. High-viscosity cultivars were characterized by up-regulation of many glycosyltransferases involved in the biosynthesis of arabinoxylans and other cell-wall polysaccharides,whereas low-viscosity cultivars showed up-regulation of several genes encoding polysaccharidedegrading enzymes.

关键词： Rye(Secale cereale) Kernel development Arabinoxylan Mixed-linkage glucan viscosity

Novel screening test for celiac disease using peptide functionalised gold nanoparticles

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World Journal of Gastroenterology 2018年第47期24卷 5379-5390页

作者： Anantdeep Kaur olga Shimoni Michael Wallach Institute for Biomedical Materials and Devices Faculty of Science University of Tech-nology Sydney School of Life Sciences Faculty of Science University of Technology Sydney

AIM To develop a screening test for celiac disease based on the coating of gold nanoparticles with a peptide sequence derived from gliadin, the protein that triggers celiac ***20 nm gold nanoparticles were first coated with NeutrAvidin. A long chain Polyethylene glycol(PEG) linker containing Maleimide at the Ω-end and Biotin group at the α-end was used to ensure peptide coating to the gold nanoparticles. The maleimide group with the thiol(-SH) side chain reacted with the cysteine amino acid in the peptide sequence and the biotinylated and PEGylated peptide was added to the NeutrAvidin coated gold nanoparticles. The peptide coated gold nanoparticles were then converted into a serological assay. We used the peptide functionalised gold nanoparticle-based assay on thirty patient serum samples in a blinded assessment and compared our results with the previously run serologicaland pathological tests on these *** A stable colloidal suspension of peptide coated gold nanoparticles was obtained without any aggregation. An absorbance peak shift as well as color change was caused by the aggregation of gold nanoparticles following the addition of anti-gliadin antibody to peptide coated nanoparticles at levels associated with celiac disease. The developed assay has been shown to detect anti-gliadin antibody not only in quantitatively spiked samples but also in a small-scale study on real non-hemolytic celiac disease patient's *** The study demonstrates the potential of gold nanoparticlepeptide based approach to be adapted for developing a screening assay for celiac disease diagnosis. The assay could be a part of an exclusion based diagnostic strategy and prove particularly useful for testing high celiac disease risk populations.

关键词： Celiac disease Serological point-of-care Gold nanoparticles Diagnostic test Autoantibodies

Comparison of the performance and dynamics of the asymmetric single-sided and symmetric double-sided vibro-impact nonlinear energy sinks with optimized designs

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International Journal of Mechanical System Dynamics 2024年第3期4卷 303-316页

作者： Petro Lizunov olga Pogorelova Tetyana Postnikova Department of Constructive Mechanics Kyiv National University of Construction and ArchitectureKyivUkraine Research Institute of Structural Mechanics Kyiv National University of Construction and ArchitectureKyivUkraine

The operation of symmetric double-sided and asymmetric single-sided vibro-impact nonlinear energy sinks(DSvI NES and SSvI NES)is considered in this *** methodology of optimization procedures is *** is emphasized that the execution of optimization procedures is ambiguous,allows for a great deal of arbitrariness,and requires experience and intuition on the part of the *** are a lot of damper parameter sets providing similar attenuation of the primary structure(PS)*** is shown that the efficiency of such mitigation for both vI NES types with optimized parameters is ***,their dynamic behavior differs *** system with the attached DSvI NES exhibits calm dynamics with periodic motion and symmetrical bilateral impacts on both *** system with attached SSvI NES exhibits rich complex dynamics when the exciting force frequency is *** modes of different periodicity with different numbers of asymmetric impacts per cycle on the PS directly and on the obstacle alternate with various irregular regimes,namely,chaotic mode,intermittency,and crisis-induced *** regions of bilateral impacts are narrow and located near resonance;they are narrower for a system with an attached DSvI *** a system with an attached SSvI NES,there are wider areas of asymmetric unilateral impacts.

关键词： vibro-impact damper nonlinear energy sink single-sided double-sided vibrations mitigation optimization

Mitochondrial translocator protein(TSPO),astrocytes and neuroinflammation

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Neural Regeneration Research 2016年第7期11卷 1056-1057页

作者： olga v.Chechneva Wenbin Deng Department of Biochemistry and Molecular Medicine University of California Institute for Pediatric Regenerative Medicine Shriners Hospitals for Children

Mitochondrial translocator protein（TSPO）has been a somewhat mysterious player in searching for its true biological *** is involved in mitochondrial cholesterol transport and steroids biosynthesis and predominantly e... 详细信息

关键词： steroids predominantly somewhat synthesizing mitochondrial searching biosynthesis severity macrophages astrocyte

Kinetic Model Heterogeneous Reaction Self-assembly on Nanocomposit Sorbent and Their Peculiarity

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Journal of Chemistry and Chemical Engineering 2018年第3期12卷 124-128页

作者： Kibalnikova olga v. Saratov State University named after N.G. Chernyshevsky 83 Astrakhanskaya St. Saratov 410012 Russia

Kinetic modeling of self-assembly reactions occurring on a nanocomposite with the formation of dimers in a solvent cell and molecular complexes in micelles is *** this self-organization occurs due to the synergistic effect,due to a combination of nonvalent *** approach opens up new possibilities in the field of chromatographic and separation technologies related to the analysis of complex *** coefficientαof the self-assembling processes at the *** is shown thatαcan have different values,for example,for pyridine dimer in cage solvent this coefficient is2.5~*** chemical calculations show that the surface of the nanocomposite is doped with alkaline metal,which restores hydrogen atoms,turning them into H-.This is used in a chromate-mass spectrometer in identify environmental toxicants,the technique of determining metaphase in food products.

关键词： Self-assembly reaction,nanocomposit equation N.I.Brensted intercaljacia,chromate-mass-spectrometrija metaphos,helium

A comparative life cycle assessment of phytosterol and meadowsweet (Filipendula ulmaria) oncoprotective functional food ingredients

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Food Bioscience 2022年第6期50卷 1204-1216页

作者： Aigul v.Miniakhmetova olga I.Sergienko victoria S.Ilina Artem I.Lepeshkin Denis A.Baranenko Faculty of Ecotechnology ITMO UniversitySt.Petersburg191002Russia International Research Centre “Biotechnologies of the Third Millennium” Faculty of Biotechnologies (BioTech)ITMO UniversitySt.Petersburg191002Russia

The urgent and relevant goals of providing a healthier diet and sustainable food systems taken together require a systematic approach that considers a broader environment for food choice. The paper compares three technologies to produce functional ingredients for preventing oncological diseases - each of them involving different sources of raw materials - a by-product of soybean processing, wild meadowsweet extract and planted meadowsweet extract. Life cycle assessment (LCA) has been selected to justify the choice of raw ingredients and the best technology for the stakeholders. Life cycle inventory analysis (LCIA) of technologies was carried out based on the SimaPro 9.***.1.1. To confirm the results of the LCIA of technologies to produce biologically active substances (BAS) from by-products of soybean oil processing, the following models of the SimaPro 9.***.1.1 software were used: EPD (2018) v1.01, ReCiPe 2016 (Midpoint (H) v1.04 / World (2010) H) and IPCC 2013 (GWP 500a v1.01). The validation of the results and the assessment of the impact of uncertainties in the initial data on the LCA calculations of the technologies were carried out using Monte Carlo method. The results showed that production of BAS from a by-product of soybean oil processing is the most environmentally friendly technology, and the data obtained could add to the life cycle database for the category of “Functional food ingredients” or serve as an example for further research and comparison with other targeted functional ingredients.

关键词： Prevention of non-communicable diseases Biologically active substances Encapsulation LCA Environmental product declaration