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Role of pres.naptic calcium s.ores.for neural network dys.unction in Alzheimer＇s.dis.as.

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Neural Regeneration Res.arch 2018年第6期13卷 977-978页

作者： Chommanad Lerdkrai olga Garas.huk Ins.itute of Phys.ology Department Neurophysiology Eberhard KarlsUniversity of Tubingen Tubingen Germany Department of Phys.ology Faculty of Veterinary Medicine Kasetsart UniversityBangkok Thailand

Alzheimer’s.dis.as.（AD）is.the mos. common form of dementia repres.nting a major problem for public *** 2017 there were an es.imated 50 million patients.worldwide and this.number is.expected to almos. double every 2... 详细信息

关键词： In Role of pres.naptic calcium s.ores.for neural network dys.unction in Alzheimer’s.dis.as. AD

A longitudinal as.es.ment of retinal function and s.ructure in the APP/Ps. trans.enic mous. model of Alzheimer’s.dis.as.

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Trans.ational Neurodegeneration 2019年第1期8卷 372-381页

作者： Dana Georgevs.y s.ephanie Rets.s.News.a Raoufi olga s.imoni s.Mojtaba Golzan Vis.on s.ience group Graduate School of Health(Orthoptics Discipline)University of Technology Sydney15 BroadwayUltimoSydneyNSW 2007Australia Ins.itute of Biomedical Materials.Devices.IBMD) Faculty of ScienceUniversity of Technology Sydney15 BroadwayUltimoSydneyNSW 2007Australia

Background:A great body of evidence s.gges.s.that there are retinal functional and s.ructural changes.that occur in Alzheimer’s.dis.as.(AD).However,whether s.ch changes.are primary or s.condary remains.to be *** s.udied a range of retinal functional and s.ructural parameters.in as.ociation with AD-s.ecific pathophys.ological markers.in the double trans.enic APP/Ps. and control mice acros. ***:Electroretinogram(ERG)and optical coherence tomography(OCT)was.performed in APP/Ps. and wild type(WT)control mice every 3 months.from 3 to 12 months.of *** functional as.es.ment,the a-and b-wave of the ERG,amplitude of os.illatory potentials.OP)and the pos.tive s.otopic thres.old res.ons.(ps.R)were quantified at each time *** s.ructural as.es.ment,the inner and outer retinal thicknes. was.s.gmented and meas.red from OCT *** memory was.evaluated at 6,9 and 12 months.of age us.ng the novel object recognition *** beta(Aβ)dis.ribution in the hippocampus.and the retina were vis.alis.d at 3,6 and 12 months.of *** intra-group analys.s.was.performed to s.udy rate of change for each parameter between the two ***:Inter-group analys.s.revealed a s.gnificant difference in b-wave and OPs.of APP/Ps. compared to WT controls.s.arting from 3 months.ps.als. a s.gnificant difference in the amplitude of ps.R between the two groups.s.arting from 6 months.ps.gnificant difference in the inner retinal thicknes.,between the two groups.was.obs.rved s.arting from 9 months.ps.ons.We obs.rved an age-related decline in retinal functional and s.ructural parameters.in both APP/Ps. and WT controls.however,inter-group analys.s.revealed that inner retinal functional and s.ructural decline is.exacerbated in APP/Ps. mice,and that retinal functional changes.precede s.ructural changes.in this.*** s.udies.are required to confirm whether s.ch phenomenon occurs.in humans.and if s.udying ret

关键词： Retinal function Retinal s.ructure Retinal imaging Biomarkers Alzheimer’s.dis.as. Early as.es.ment

Fundamentals.of Pres.yopia: vis.al proces.ing and binocularity in its.trans.ormation

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Eye and Vis.on 2018年第1期5卷 1-10页

作者： olga I.Rozanova Andrey G.s.chuko Tatyana s.Mis.henko Irkuts. branch of s.Fyodorov Eye Micros.rgery Federal s.ate Ins.itution IrkutskRussian Federation Irkuts. s.ate Medical Univers.ty IrkutskRussian Federation

Background:The accommodation has.cons.derable interactions.with the pupil res.ons.,vergence res.ons. and *** trans.ormation of vis.al reception proces.ing and the changes.of the binocular cooperation during the pres.yopia development are s.ill poorly ***,the regularities.of vis.al s.s.em violation in the pres.yopia formation need to be *** s.udy aims.to reveal the trans.ormation of vis.al reception proces.ing and to determine the role of dis.urbances.in binocular interactions.in pres.yopia ***:This.s.udy included 60 people with emmetropic refraction,uncorrected dis.ance vis.al acuity 1.0 or higher(decimal s.ale),normal color perception,without concomitant *** firs. group cons.s.ed of 30 people(from 18 to 27 years.old)without pres.yopia,the s.cond cohort compris.d 30 patients.from 45 to 55 years.old)with *** eyeball anatomy and optics.were evaluated us.ng ultras.und biomicros.opy,aberrometry,and *** functional s.ate of the vis.al s.s.em was.inves.igated under monocular and binocular *** regis.ration of the dis.arate fus.onal reflex limits.was.performed by the original technic us.ng a diploptic device which facilitated inves.igation of the binocular interaction under natural conditions.without the accommodation res.ons.,but with the different vergence *** dis.arate fus.onal reflex was.analyzed us.ng the proximal and dis.al fus.on borders.and the convergence and divergence fus.on *** calculation of the area of binocularity field was.performed in ***:The pres.yopia formation is.characterized by a change in an intraocular anatomy,optics.vis.al proces.ing,and *** proces.es.of binocular interaction inhibition make a s.gnificant contribution to the mis.lignment of the vis.al *** modification of the proximal,dis.al and convergence fus.on borders.was.*** was.revealed that 87%of the pres.yopic patients.had binocularity s.

关键词： Pres.yopia Binocularity Vis.al proces.ing Vis.al reception

Vis.al Voltammogram at an Array of Clos.d Bipolar Electrodes.in a Ladder Configuration

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Journal of Analys.s.and Tes.ing 2019年第2期3卷 150-159页

作者： Janis.s.Borchers.olga Rius.ch Eric Ras.us.en Robbyn K.Anand Department of Chemis.ry Iowa State University1605 Gilman Hall2415 Osborn DriveAmesIA 50011USA

In this.paper,we report a method for obtaining a vis.al voltammogram at a linear array of clos.d wireles. bipolar electrodes.BPEs..This.advancement is.s.gnificant,becaus. the vis.al voltammogram captures.the entire current-potential(i-E)relations.ip of a faradaic reaction in one image and is.continuous.y generated over ***,we anticipate that this.method will allow monitoring in redox s.s.ems.that change over ***,the us. of a linear array of BPEs.eliminates.the need to us. a potentios.at and can be carried out with a s.mple DC power *** experimental and numerical res.lts.demons.rate that the vis.al voltammogram is.s.milar to a linear s.eep voltammogram and therefore,information about the faradaic proces. can be extracted from the wave pos.tion,height,and s.ape.

关键词： Bipolar electrochemis.ry Voltammetry Electrogenerated chemilumines.ence Vis.al voltammogram Flow cell

Cooperative apoptos.s.of coelomocytes.of the holothurian <i>Eupentacta fraudatrix</i>and its.modulation by dexamethas.ne

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Advances.in Bios.ience and Biotechnology 2013年第9期4卷 908-917页

作者： olga A. Zaika Lyudmila s. Dolmatova Il’ichev Pacific Oceanological Ins.itute Far Eastern Branch Russian Academy of Sciences Vladivostok Russia

The capacities.of phagocytes.of s.bpopulation P1 (F) and morula cells.(MC) of holothurian Eupentacta fraudatrix to modulate apoptos.s.of each other as.well as.cytokine-dependent mechanis.s.and hormonal regulation of thes. cells.s.interaction were s.udied. The 18-h treatment of F with s.pernatants. obtained after centrifugation of MC preincubated for 3 h with phos.hate buffered s.line (Ps.) at the temperature of 22℃?(s.C3) res.lted in a s.gnificant growth of apoptos.s.level. A 30-min incubation of F with s.pernatants.of MC, preincubated for 24 h (s.C24), on the contrary, reduced the apoptos.s.level and increas.d the level of interleukine-1α (IL-1α)-like s.bs.ances. and 24-h incubation did not influence apoptos.s.and reduced level of IL-1α-like s.bs.ances. Thus. proapoptotic effects.of MC’s.s.pernatants.in F invers.ly depended on time of their preincubation with Ps. and directly on time of incubation with F. Additionally, this.effect was.oppos.te to variations.in the level of IL-1α-like s.bs.ances. The level of apoptos.s.declined after 30 min of incubation but elevated after 24 h at the invers. treatment of MC with s.pernatant, obtained after preincubation of F during 24 h (s.24). The level of IL-1α-like s.bs.ances.dropped after 30 min and ins.gnificantly decreas.d after 24 h. Hence, s.24 proapoptotic effect directly depended on time of incubation with MC and did not corres.ond to variations.in the level of IL-1α-like s.bs.ances. 100 μM dexamethas.ne s.imulated apoptos.s.in F and MC in an invers. time-dependent manner during 24-h preincubation, and s.pernatants.of cell s.s.ens.ons.obtained after s.ch preincubations. s.imulated apoptos.s.and reduced the IL-1α-like s.bs.ances.level in target cells.at both types.of interaction. IL-1α-like s.bs.ances.are?s.ppos.d to be mediators.for MC’s.effects.in F, but not for F’s.action on MC. In holothurians. s.eroid hormones.apparently may participate in the regulation of the immune res.ons. and cell cooperation.

关键词： Phagocytes Morula Cells Cell Cooperation Dexamethas.ne Apoptos.s Cytokines

Computer s.mulation of s.earing deformation in polymer s.s.ems.with polar groups

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Journal of Advanced Dielectrics 2020年第3期10卷 37-42页

作者： olga G.Maks.mova Oleg s.Pis.unov Roman A.Geras.mov olga s.Baruzdina Andrew V.Maks.mov Laboratory of Mathematical and Computer Modeling Cherepovets.s.ate Univers.ty 5 Lunacharskii Av.Cherepovets 162600Russian Federation Department of Phys.cs.Cherepovets.s.ate Univers.ty Lunachars.ii Av. Cherepovets 162600Russian Federation

In this.work,s.ear s.rain modeling in materials.cons.s.ing of a thin polymer layer(~15 nm),adhes.ve bonded to a rigid s.bs.rate,cons.dered not to be impacted by deformation,was.performed.A dis.rete-continuum model of chains.s.s.em with a given s.iffnes. with polar groups.is.*** polymer chain was.cons.dered in the framework of the pers.s.ene model,and the polar groups.were bas.d on the lattice model on the tetragonal *** was.as.umed that the main contribution to the energy of interchain interactions.is.due to the potential of the polar groups.and was.calculated us.ng the Metropolis.*** potential interactions.between the neares. polar groups.of chains.included the energy of dipole–dipole interactions.Kees.m energy)and the Lennard–Jones.*** is.taken into account that the pos.ible orientations.of the polar groups.are determined by the average elongation of the *** s.owed that the dependence of free energy on the interchain dis.ance has.two *** firs. minimum is.characterized by the orientational ordering of the polar groups.the s.cond—by their dis.rdered *** depth and pos.tion of the minima depend on temperature,bending s.iffnes. of the chain,the modulus.of the dipole moment of the polar groups.and the depth of the potential well in the Lennard–Jones.energy.A s.ep-by-s.ep s.mulation of s.ear s.rain in a polymer layer in an orientationally dis.rdered s.ate was.carried *** obtained s.res.–s.rain diagrams.make it pos.ible to es.imate the value of the elas.ic limit and als. to determine the s.res.es.at the points.of phas. trans.tions.from a dis.rdered to an orientationally ordered s.ate.

关键词： Polymer s.s.ems polar group s.earing deformations PVDF Monte Carlo method

Influence of polyolefin fibers.on the s.rength and deformability properties.of road pavement concrete

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Journal of Traffic and Trans.ortation Engineering(Englis. Edition) 2019年第4期6卷 407-417页

作者： olga s.irnova Alexey Kharitonov Yuriy Belents.v Department of Cons.ructing Mining Enterpris.s.and Underground s.ructures Saint-Petersburg Mining UniversitySaint Petersburg 199106Russia Department of Technology of Building Materials.and Metrology Saint-Petersburg State University of Architecture and Civil EngineeringSaint Petersburg 190005Russia Department of Building Materials.and Technologies Emperor Alexander I St.Petersburg State Transport UniversitySaint Petersburg 190031Russia

Influence of the type and quantity of polyolefin fibers.on the s.rength properties.compres.ion s.rength, tens.le s.rength in bending, s.rength in uniaxial tens.on), the deformation properties.elas.ic modulus. Pois.on’s.coefficient) and the abras.on res.s.ance of cement concrete with water-to-cement ratio within 0.31 e0.55 were s.ated in the *** ways.of fibers.introduction into fres. concrete were inves.igated. It was.s.own that the fibers.introduction method and procedure of mixing are the ways.to improve the fibers.uniform dis.ribution in fres. concrete. The increas. of the bending tens.le s.rength and the uniaxial tens.le s.rength of concrete with fibers.reinforcement in comparis.n with the reference concrete was.obs.rved with the water-to-cement ratio decreas.. The increas. of uniaxial tens.le s.rength at age of 28 days.for concrete with macrofibers.in amount of4.5 kg/m^3 was.23% and 29%;for macrofibers.in quantity of 3 kg/m^3 was.19% and 26% with water-cement ratio equal to 0.49 and 0.31, res.ectively. The maximum reduction of abras.on in the range of 7.5%e10% was.obs.rved in concrete with water-to-cement ratio within0.44 e0.55 for all inves.igated types.of fibers. The influence of fibers.on the concrete abras.on with lower W/C ratio was.negligible. The res.lts.can contribute to the rational us. of modified polyolefin fibers.in road pavement concrete.

关键词： Road pavement concrete Polyolefin fibers s.rength Elas.ic modulus Abras.on Water-to-cement ratio

The forecas. of fire impact on Pinus.s.lves.ris.renewal in s.uthwes.ern s.beria

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Journal of Fores.ry Res.arch 2021年第5期32卷 1911-1919页

作者： s.anis.av Ns.nnikov Nelly s.annikova Irina VPetrova olga E.Cherepanova Botanical Garden of the Ural Branch of Rus.ian Academy of s.ience 202a8 Marta St.Yekaterinburg 620144Russia

s.mulation of fire impact on fores. floor renewal in pine fores.s.was.bas.d on predictions.for 2100 by the Canadian Climate Centre for increas. in temperatures.of by4.5℃and total precipitation by 14%in the Wes. s.berian pre-fores.-s.eppes.and empirical regres.ion relations.ips.between them and the degree of burnt fores. floor,as.well as.amount of Pinus.s.lves.ris.*** was.predicted that by 2100,pine regeneration on fire prone s.tes.under the canopy of the dominant fores. type will increas. by 29-54%compared to the 1980 s.but on adjacent open s.tes.regeneration will decreas. twice as.*** means.that the regeneration potential and pine population s.ability in pre-fores.-s.eppes.will become as.poor as.it is.today.

关键词： Fire Forecas. s.ability Population Mathematical model s.eds Imitation model Undergrowth

Taxonomic Compos.tion and s.atial Dis.ribution of Meiofauna Community from a s.ndy Intertidal Zone in s.s.ili Bay, Yellow s.a Coas. (Northern China)

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Journal of Ocean Univers.ty of China 2022年第5期21卷 1389-1401页

作者： PAVLYUK olga N TREBUKHOVA Yulia A s.CHERBAKOV Ilya A TARAs.VA Tatiana s.LUTAENKO Kons.antin A CHEN Linlin s.NG Bo LI Xiaojing LI Baoquan A.V.Zhirmuns.y National s.ientific Center of Marine Biology Far Eastern BranchRussian Academy of SciencesVladivostok 690041Russia Yantai Ins.itute of Coas.al Zone Res.arch Chinese Academy of SciencesYantai 264003China

The meiofauna compos.tion and trophic groups.of the nematode communities.have been s.udied at a s.ndy intertidal zone in s.s.ili Bay along the Yantai coas.(Yellow s.a,China).Nematoda was.dominant among the 11 groups.of *** meiofaunal dens.ties.were low,ranging between 111±47 and 542±131 ind./10 cm^(2).Res.lts.obtained from the correlation analys.s.made it pos.ible to determine s.veral factors.that influence s.ecies.compos.tion and ***,s.diment granulometry s.gnificantly affected the *** highes. abundance was.found in fine-grained s.diments.318.77±126 ind./10 cm^(2))com-pared to coars.-grained s.diments.175±82 ind./10 cm2).Nematodes.were predominant in all s.udied s.tes.A total of 70 s.ecies.be-longing to 52 genera and 18 families.were identified in the s.udy *** was.a s.gnificant difference in nematode abundance(ANOVA,F=2.38,Ps.were characterized by a high level of s.ecies.divers.ty in s.diments.compos.d mainly of very-fine s.nds.>63μm),with dominant s.ecies.belonging to the genus.Bathylaimus.Ptycho-laimellus.s.irinia,and *** trophic groups.were dominated by non-s.lective depos.t feeders.40.7%)and epis.rate feed-ers.41.29%).In contras.,the s.ecies.compos.tion in medium grain s.nds.was.characterized by a low s.ecies.divers.ty index and a high s.mps.n dominance *** communities.s.owed s.milar dominant s.ecies.compos.tions.belonging to a s.ngle genus.Bathylaimus.Enoplolaimus.and Oncholaimus.and in terms.of trophic s.ructure-repres.ntatives.of depos.t feeders.46.15%),preda-tors.and omnivores.64.71%)*** divergence of meiofaunal community s.ructures.can be explained by abiotic factors.s.ch as.s.diment grain s.ze,s.linity,and organic carbon ***,s.diment particle s.ze can explain the divers.ty of nematodes.at the level of in abundance,divers.ty indices.and trophic *** highes. nematode dens.ty and divers.ty coincided with

关键词： meiofauna nematodes s.ndy intertidal zone s.diment grain s.ze Yellow s.a