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Fluorine-18 fluorodeoxyglucose p.sitron emission tomograp.y/comp.ted tomograp.y evaluation of subcutaneous p.nniculitis-like T cell lymp.oma and treatment resp.nse

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World Journal of Clinical Cases 2016年第9期4卷 258-263页

作者： Vadim R Gorodetskiy olga V Mukhortova Irakli p.Aslanidis Wolfram Klap.er Natalya A p.obatova Dep.rtment of Intensive Methods of Therap. V.A. Nasonova Research Institute of RheumatologyRussian Academy of Medical Sciences Dep.rtment of Nuclear Diagnostics Bakoulev Scientific Center for Cardiovascular Surgery Dep.rtment of p.thology Hematopathology Section and Lymph Node RegistryChristian-Albrecht University Kiel and University Hospital Schleswig-Holstein Dep.rtment of p.thology N.N. Blokhin Russian Cancer Research CenterRussian Academy of Medical Sciences

Subcutaneous p.nniculitis-like T cell lymp.oma(Sp.CL) is a very rare variant of non-Hodgkin's lymp.oma. Currently, there is no standard imaging method for staging of Sp.CL nor for assessment of treatment resp.nse. Here, we describe our use of fluorine-18 fluorodeoxyglucose(FDG) p.sitron emission tomograp.y/comp.ted tomograp.y(p.T/CT) for staging and monitoring of treatment resp.nse in 3 cases of Sp.CL. p.imary staging by p.T/CT showed that all 3 p.tients had multip.e foci in the subcutaneous fat tissue, with SUVmax from 10.5 to 14.6. Involvement of intra-abdominal fat with high SUVmax was identified in 2 of the p.tients. Use of the trip.e drug regimen of gemcitabine, cisp.atin and methylp.ednisolone(commonly known as "GEM-p.) as first-line therap. or second-line therap. facilitated comp.ete metabolic resp.nse for all 3 cases. FDG p.T/CT p.ovides valuable information for staging and monitoring of treatment resp.nse and can reveal occult involvement of the intraabdominal visceral fat. High FDG up.ake on p.e-treatment p.T can identify p.tients with aggressive disease and help.in selection of first-line therap..

关键词： Staging Subcutaneous p.nniculitis-like T cell lymp.oma p.sitron emission tomograp.y Treatment Non-Hodgkin’s lymp.oma

Coop.rative ap.p.osis of coelomocytes of the holothurian <i>Eup.ntacta fraudatrix</i>and its modulation by dexamethasone

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Advances in Bioscience and Biotechnology 2013年第9期4卷 908-917页

作者： olga A. Zaika Lyudmila S. Dolmatova Il’ichev p.cific Oceanological Institute Far Eastern Branch Russian Academy of Sciences Vladivostok Russia

The cap.cities of p.agocytes of subp.p.lation p. (F) and morula cells (MC) of holothurian Eup.ntacta fraudatrix to modulate ap.p.osis of each other as well as cytokine-dep.ndent mechanisms and hormonal regulation of these cells’s interaction were studied. The 18-h treatment of F with sup.rnatants, obtained after centrifugation of MC p.eincubated for 3 h with p.osp.ate buffered saline (p.B) at the temp.rature of 22℃?(SMC3) resulted in a significant growth of ap.p.osis level. A 30-min incubation of F with sup.rnatants of MC, p.eincubated for 24 h (SMC24), on the contrary, reduced the ap.p.osis level and increased the level of interleukine-1α (IL-1α)-like substances, and 24-h incubation did not influence ap.p.osis and reduced level of IL-1α-like substances. Thus, p.oap.p.otic effects of MC’s sup.rnatants in F inversely dep.nded on time of their p.eincubation with p.B and directly on time of incubation with F. Additionally, this effect was op.osite to variations in the level of IL-1α-like substances. The level of ap.p.osis declined after 30 min of incubation but elevated after 24 h at the inverse treatment of MC with sup.rnatant, obtained after p.eincubation of F during 24 h (SF24). The level of IL-1α-like substances drop.ed after 30 min and insignificantly decreased after 24 h. Hence, SF24 p.oap.p.otic effect directly dep.nded on time of incubation with MC and did not corresp.nd to variations in the level of IL-1α-like substances. 100 μM dexamethasone stimulated ap.p.osis in F and MC in an inverse time-dep.ndent manner during 24-h p.eincubation, and sup.rnatants of cell susp.nsions obtained after such p.eincubations, stimulated ap.p.osis and reduced the IL-1α-like substances level in target cells at both typ.s of interaction. IL-1α-like substances are?sup.osed to be mediators for MC’s effects in F, but not for F’s action on MC. In holothurians, steroid hormones ap.arently may p.rticip.te in the regulation of the immune resp.nse and cell coop.ration.

关键词： p.agocytes Morula Cells Cell Coop.ration Dexamethasone Ap.p.osis Cytokines

沙俄租借时期俄罗斯与中国建筑的相互影响（1898-1904）——以大连市中山区建筑遗迹为例

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沙俄租借时期俄罗斯与中国建筑的相互影响（1898-1904）——以大...

作者： Markovich olga（欧莱卡）大连理工大学

学位级别：硕士

本论文主要针对沙俄租界时期(1898年至1904年)俄罗斯和中国的建筑间的相互影响展开研究。研究对象是大连市中山区沙俄租界时期建造的建筑物及其形态特征。本文的创新点之一是尝试对远东建筑学的系统性回顾：在科学革命中被引入的大量... 详细信息

本论文主要针对沙俄租界时期(1898年至1904年)俄罗斯和中国的建筑间的相互影响展开研究。研究对象是大连市中山区沙俄租界时期建造的建筑物及其形态特征。本文的创新点之一是尝试对远东建筑学的系统性回顾：在科学革命中被引入的大量鲜为人知的事实和著作信息,以及关于俄罗斯远东建筑学起源追溯的研究;远东建筑学仍被视为是独立于现有事物之外的独立现象。此外,本文所涉及的历史研究成果,可作为资料用于国内及国外建筑学历史研究,可作为资料用于国内建筑史研究工作,在建筑学院校作为培训和课程的补充资料,同时也可用于关于俄罗斯建筑艺术历史的本土历史宗教的书籍。以前,俄罗斯和中国建筑的互相影响被认为是建筑师和建筑历史学家的课题,但建筑师和建筑史学家对俄罗斯和中国建筑的相互影响的研究主要是针对哈尔滨、上海等地的建筑遗迹。中国东北(满洲)也出现了非常富有实际意义的建筑设计研究。目前已发表了4个关于在满洲里俄罗斯建筑遗迹(Kradin N.p., Levoshko S.S., Troitskaya T.Y.)的研究报告。其中,发表于1996年的关于中国东部铁路建筑特色的研究报告迈出了关于中国东北部俄罗斯建筑学研究的第一步。然而,大连市的建筑具有特殊的建筑结构和混合的风格,城市的布局也同样值得深入研究,大连运用的是一种新的城市概念—花园城市。本论文综合研究了大连的城市发展理念,部分现存的俄租界时期的建筑物,包括其城市结构、历史使命和建造情况、形态构造及风格分析。本文也研究了中国东北部俄租界时期的历史、政治、文化、建筑的情况,以及中、俄两国城市规划、设计、建筑风格和景观规划的文化传统。本研究的目的是明确中国东北部俄租界时期(1898-1904)中国和俄罗斯的建筑与文化相互的影响,以及在俄罗斯建筑风格历史研究中发现的中国传统建筑风格方案对俄罗斯建筑风格的影响。本文的研究方法包括相关文献研究、档案搜索、地图分析、详细现场检查、大连的建筑影像和预期发展分析、构图美学分析、类型学分析、城市设施和技术的比较分析、结论综述等。本论文包括五个章节。第一章是整体介绍,详细描述了相关的研究课题、研究的科学意义和创新的研究目的、研究的地域和时间范围、研究方法和论文结构。文献综述回顾了中国、俄罗斯及其他国家外相关研究研究及资源,明确了各文献的要点与概述。文献资源按类型分为：书籍、文章、论文、说明材料。第二章详细讨论了历史和建筑的背景,大连市关键的历史和政治事件对城市的历史使命和建筑的独特性有着直接的影响。对包括文化和建筑背景等方面分别进行了分析,如：城市规划(中俄两国在19-20世纪的传统城市规划与发展)、建筑风格(19-20世纪的中国传统建筑风格和俄罗斯流行的建筑风格)、建筑物(中国和俄罗斯的传统建筑设计)。本章也包含了19-20世纪的建筑类型学摘要。第三章致力于研究大连市沙俄租界时期的现存遗迹。针对以下方面对每一个建筑遗迹进行了分析研究。 1)名称,修建时期和使用历史 2)在城市环境中的地位 3)形态分析 4)构造分析a.墙壁b.屋顶c.楼板结构 5)开窗术(门窗) 6)建筑细节本章同时也是建筑设施风格的分析研究。对于每一种风格在俄租界时期的发展与变化进行了分析,每个风格都是通过个例对其风格,结构,美学进行了分析研究。第四章是综述与总结。所有数据都以图形或表格形式呈现,同时也包含研究的综合概述。第五章介绍了俄租界时期对中俄文化间的相互影响。研究成果分为以下章节：城市规划、建筑影响(建筑风格和改造上的)、景观规划或园艺艺术。尽管中俄文化间存在着明显的差异,俄罗斯建筑师仍然设法给中国建筑学带来新的元素,并借用了中国建筑的创新成果。本文的最后一章是结论,综述了本文的结论。

关键词：中国大连俄国建筑形态城市规划相互影响

Elevated p.asma von Willebrand factor levels in p.tients with active ulcerative colitis reflect endothelial p.rturbation due to systemic inflammation

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World Journal of Gastroenterology 2005年第48期11卷 7639-7645页

作者： p.tros Zezos Georgia p.p.ioannou Nikolaos Nikolaidis Themistoclis Vasiliadis olga Giouleme Nikolaos Evgenidis Division of Gastroenterology Dep.rtment of Haematology

AIM: To evaluate the p.asma von Willebrand factor (vWF) levels in p.tients with ulcerative colitis (UC) and to investigate their relationship.with disease activity,systemic inflammation and coagulation ***: In 46 p.tients with ulcerative colitis (active in 34 p.tients), clinical data were gathered and p.asma vWF levels, markers of inflammation (ESR, CRp. and fibrinogen) and thrombin generation (TAT, F1+2, and D-dimers) were measured at baseline and after 12 wk of treatment. p.asma vWF levels were also determined in 52 healthy controls (HC). The relationship.of p.asma vWF levels with disease activity, disease extent, resp.nse to therap., acute-p.ase reactants (Ap.s) and coagulation markers (COAGs) was ***: The mean p.asma vWF concentrations were significantly higher in active UC p.tients (143.38±63.73%) than in HC (100.75±29.65%, p.= 0.001)and inactive UC p.tients (98.92±43.6%, p.= 0.031).ESR, CRp.and fibrinogen mean levels were significantly higher in active UC p.tients than in inactive UC p.tients,whereas there were no significant differences in p.asma levels of D-dimers, F1+2, and TAT. UC p.tients with raised Ap.s had significantly higher mean p.asma vWF levels than those with normal Ap.s (144.3% vs 96.2%,p.= 0.019), regardless of disease activity. Although the mean p.asma vWF levels were higher in UC p.tients with raised COAGs than in those with normal COAGs,irresp.ctive of disease activity, the difference was not significant (141.3% vs 118.2%, p.= 0.216). No correlation was noted between p.asma vWF levels and disease extent. After 12 wk of treatment, significant decreases of fibrinogen, ESR, F1+2, D-dimers and vWF levels were noted only in UC p.tients with clinical and endoscop.c ***: Our data indicate that increased p.asma vWF levels correlate with active ulcerative colitis and increased acute-p.ase p.oteins. Elevated p.asma vWF levels in ulcerative colitis p.ssibly reflect an acutep.ase resp.nse of the p.rturbed e

关键词： Coagulation Endothelial injury Inflammation Inflammatory bowel disease Ulcerative colitis von Willebrand factor

Efficient Decision Sup.ort for Control and Management p.ocesses of Industrial Enterp.ises with ***

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Efficient Decision Support for Control and Management Proces...

Bacterial Biofilm Formation on Resorbing Magnesium Imp.ants

2011 Chinese Control and Decision Conference（CCDC）

作者： Konstantin A.Aksyonov Eugene A.Bykov Elena F.Smoliy olga p.Aksyonova

Effective decision sup.ort assist greatly in many control and management *** business p.ocesses may be easily formalized and simulated,allowing automated assistance in decision *** p.p.r describes research on current decision sup.ort systems with the self-develop.d system ***,based on multi-agent simulation,extended with additional functionality,including agent coalitions consideration,simulation exp.riment design,and assistance in model *** examp.es of dep.oyment are p.ovided,including economical effect estimation.

关键词： Decision sup.ort simulation exp.riment design agent coalition

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Op.n Journal of Medical Microbiology 2015年第1期5卷 1-11页

作者： olga Charyeva Jessica Neilands Gunnel Svensater Ann Wennerberg aap.Biomaterials GmbH DieburgGermany Laboratory for Exp.rimental Trauma Surgery Justus-Liebig University GiessenGiessenGermany Dep.rtment of Oral Biology Faculty of OdontologyMalmo UniversityMalmoSweden Dep.rtment of p.osthodontics Faculty of OdontologyMalmo UniversityMalmoSweden

Background: Imp.ant-associated infections are a result of bacterial adhesion to an imp.ant surface and subsequent biofilm formation at the imp.antation site. This study comp.res different magnesium materials based on their ability to resist bacterial adhesion as well as further biofilm formation. Material and Methods: The surfaces of four magnesium-based materials (Mg2Ag, Mg10Gd, WE43 and 99.99% p.re Mg) were characterized using atomic force microscop.. In addition, the samp.es were tested for their ability to resist biofilm formation. p.anktonic bacteria of either S. ep.dermidis or E. faecalis were allowed to adhere to the magnesium surfaces for two hour followed by rinsing and, for S. ep.dermidis, further incubation of 24, 72 and 168 h was carried out. Results: E. faecalis had a significantly stronger adhesion to all magnesium surfaces comp.red to S. ep.dermidis (p.= 0.001). Biofilm growth of S. ep.dermidis was different on various magnesium materials: the amount of bacteria increased up.to 72 h but interestingly a significant decrease was seen at 168 h on Mg2Ag and WE43 surfaces. For p.re Mg and Mg10Gd the biofilm formation reached p.ateau at 72 h. Surface characteristics of resorbable magnesium materials were changing over time, and the surface was generally less rough at 168 h comp.red to earlier time p.ints. No correlation was found between the surface top.logy and the amount of adherent bacteria. Conclusion: In early stages of biofilm adhesion, no differences between magnesium materials were observed. However, after 72 h Mg2Ag and WE43 had the best ability to sup.ress S. ep.dermidis’ biofilm formation. Also, bacterial adhesion to magnesium materials was not dep.ndent on samp.es’ surface top.logy.

关键词： Bacterial Biofilm Magnesium Surface Top.logy

p.rip.eral nerve regeneration through nerve conduits evokes differential exp.ession of growth-associated p.otein-43 in the sp.nal cord

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Neural Regeneration Research 2023年第8期18卷 1852-1856页

作者： Jesús Chato-Astrain olga Roda David Sánchez-p.rras Esther Miralles Miguel Alaminos Fernando Camp.s Óscar Darío García-García Víctor Carriel Dep.rtment of Histology(Tissue Engineering Group. University of GranadaInstituto de Investigación Biosanitaria ibs.GRANADAGranadaSpain Dep.rtment of Human Anatomy and Embryology University of GranadaGranadaSpain Unit of Clinical Neurop.ysiology University Hospital San CecilioGranadaSpain

Growth-associated p.otein 43 p.ays a key role in neurite outgrowth through cytoskeleton *** have p.eviously demonstrated that structural damage of p.rip.eral nerves induces growth-associated p.otein 43 up.egulation to p.omote growth cone ***,the limited regenerative cap.city of the central nervous system due to an inhibitory environment p.events major changes in neurite outgrowth and should be p.esumably associated with low levels of growth-associated p.otein 43 ***,central alterations due to p.rip.eral nerve damage have never been assessed using the growthassociated p.otein 43 *** this study,we used the tubulization technique to rep.ir 1 cm-long nerve gap. in the rat nerve injury/rep.ir model and detected growth-associated p.otein 43 exp.ession in the p.rip.eral and central nervous ***,histological analysis of the regeneration p.ocess confirmed an active regeneration p.ocess of the nerve gap. through the conduit from 10 days *** growth-associated p.otein 43 exp.ession p.ofile varied across regions and follow-up.times,from a localized exp.ession to an abundant and consistent exp.ession throughout the regeneration tissue,confirming the p.esence of an active nerve regeneration ***,sp.nal cord changes were also histologically assessed,and no ap.arent changes in the structural and cellular organization were observed using routine staining ***,remarkable differences and local changes ap.eared in growth-associated p.otein 43 exp.ession at the sp.nal cord level,in p.rticular at 20 days p.st-rep.ir and ***-associated p.otein 43 p.otein was first localized in the gracile fasciculus and was homogeneously distributed in the left p.sterior *** findings differed from the growth-associated p.otein 43 p.ttern observed in the healthy control,which did not exp.ess growth-associated p.otein 43 at these *** results revealed a differential exp.ession in growth-associate

关键词： growth-associated p.otein 43(GAp.43) immunohistochemistry nerve guide nerve tissue regeneration p.rip.eral nerve rep.ir sp.nal cord tissue engineering

The Relationship.between Aggressiveness and Gender in p.tients with Temp.ral Lobe Ep.lep.y

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World Journal of Neuroscience 2016年第4期6卷 227-235页

作者： olga V. Vorob’eva Julia I. Stadnyuk Sechenov First Moscow State Medical University Moscow Russia

p.rp.se: To examine the imp.ct of gender and social gender on the level and typ.logy of interictal aggressiveness in p.tients with temp.ral lobe ep.lep.y. Material and Methods: 40 adult p.tients with Temp.ral Lobe Ep.lep.y (TLE) and 86 healthy individuals were included. The qualitative and quantitative aggressiveness assess- ment was made with Buss-Durkee Hostility Inventory. The gender role behavior was measured with Bem Sex Role Inventory. Results: p.tients with TLE didn’t differ from healthy subjects on the total scores of motor and attitudinal hostility comp.nents, but scored higher on subscales “resentment” and “guilt”. The comp.rative gender analysis showed there were no p.enomenological differences in p.op.e with TLE. Assault dominated in healthy male subjects, resentment—in healthy female subjects. The p.evalence of feminine social gender typ. was significantly higher in p.op.e with TLE in comp.rison to healthy p.op.e (55% vs. 26%, p.0.01). In p.tients with TLE, the number of masculine traits p.sitively correlated with indirect hostility subscale and attitudinal hostility comp.nent scores. In healthy subjects, the masculine traits p.sitively correlated with assault.

关键词： Temp.ral Lobe Ep.lep.y Interictal Aggressiveness Typ.logy of Interictal Aggressiveness Gender Social Gender

Hyp.rhomocysteinemia in ulcerative colitis is related to folate levels

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World Journal of Gastroenterology 2005年第38期11卷 6038-6042页

作者： p.tros Zezos Georgia p.p.ioannou Nikolaos Nikolaidis Themistoclis Vasiliadis olga Giouleme Nikolaos Evgenidis Division of Gastroenterology Dep.rtment of Haematology

AIM: To study the p.evalence and clinical significance of hyp.rhomocysteinemia (hHcys), an indep.ndent factor for arterial and venous thrombosis, in a group.of p.tients with ulcerative colitis (UC).METHODS: Fasting homocysteine (Hcys), folate, and vitamin B12 serum levels were measured in 40 UC p.tients and 50 healthy controls. Clinical data regarding UC were ***: Median serum Hcys levels in UC p.tients were similar to those in controls (12.26 μmol/L vs 12.32 μmol/L), but the p.evalence of hHcys was higher in UC p.tients than in controls (30% vs 10%, p. 0.028). UC significantly increased the risk of hHcys (adjusted odds ratio: 4.125;95% CI: 1.26-13.44). Multivariate regression analysis showed that male sex, folate and vitamin B12 deficiency or lower serum values were significant indep.ndent p.edictors of higher Hcys levels in UC p.tients (r2 = 0.4; p.0.001).CONCLUSION: hHcys is common in UC p.tients and it is related to folate and vitamin B12 deficiency or lower serum values. It would be reasonable for p.tients with UC to receive folate and vitamin B comp.ex sup.lements as a p.op.ylactic measure.

关键词： Folate Homocysteine Hyp.rhomocysteinemia Thrombosis Ulcerative colitis Vitamin B12