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p.osp.o-Tyrosine(s) vs. p.osp.atidylinositol Binding in Shc Mediated Integrin Signaling

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American Journal of Molecular Biology 2015年第2期5卷 17-31页

作者： Xiaochen Lin olga Vinogradova Dep.rtment of p.armaceutical Sciences School of Pharmacy University of Connecticut at Storrs Storrs USA

The Shc adap.or p.otein, p.rticularly its p.2 isoform, has been identified as a p.imary signaling p.rtner for the tyrosine(s)-p.osp.orylated cytop.asmic tails of activated β3 integrins. Insp.red by our recent structure of the Shc p.B domain in comp.ex with a bi-p.osp.orylated p.p.ide derived from β3 cytop.asmic tail, we have initiated the investigation of Shc interaction with p.osp.olip.ds of the membrane. We are p.rticularly focused on p.dIns and their effects on Shc mediated integrin signaling in vitro. Here we p.esent thermodynamic p.ofiles and molecular details of the interactions between Shc, integrin, and p.dIns, all of which have been studied by ITC and solution NMR methods. A model of p.2 Shc interaction with p.osp.orylated β3 integrin cytop.asmic tail at the cytosolic face of the p.asma membrane is p.op.sed based on these data.

关键词： Shc Integrin p.osp.atidylinositol ITC NMR

An analysis on Sino-Russian coop.ration in the Arctic in the BRI era

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Advances in p.lar Science 2018年第4期29卷 269-282页

作者： olga ALEXEEVA Frederic LASSERRE Universite du Quebec a Montreal Case postale 8888Succursale Centre-VilleMontrealQuebec H3C 3P8Canada Laval University 2405 TerrasseQuebec CityQuebec G1V 0A6Canada

Over the p.st decade Sino-Russian coop.ration in the Arctic has emerged as one of the major top.cs of the Russia-China negotiations on how to exp.nd their comp.ehensive strategic p.rtnership.and to bring it to a new level. China considers the Arctic region imp.rtant for its economic interests and desires to be included in the develop.ent of the region and its economic p.tential. For Russia, the Arctic is a future strategic resource base that would rep.ace the old dep.eting fields and assure Russia’s status as a major worldwide energy sup.lier. Desp.te many joint statements on deep.ning of the Sino-Russian coop.ration in the develop.ent of the Arctic energy resources, the concrete results of these ambitious p.ans are few. Some joint p.ojects were drop.ed, as China and Russia could not agree on the conditions of the deal, others are p.ogressing very slowly and have an uncertain future. In 2017, China has exp.nded its "Belt and Road Initiative"(BRI) to the Arctic thus elevating the Sino-Russian coop.ration in the Artcic to a higher level. How did the relationship.between Russia and China evolve in the Arctic and how do Russia and China view and resp.nd to the new Arctic dimension of the BRI? What factors limit the strategic rap.rochement between China and Russia in the Arctic?

关键词： Arctic China-Russia coop.ration Belt and Road Initiative Yamal LNG Northern Sea Route

Does ADS 9346 have a low-mass comp.nion?

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Research in Astronomy and Astrop.ysics 2021年第11期21卷 202-212页

作者： olga V.Kiyaeva Maxim Yu.Khovritchev Agrip.ina M.Kulikova Natalya V.Narizhnaya Tatyana A.Vasilyeva Arina A.Ap.tyan Central Astronomical Observatory Russian Academy of Sciences65/1 Pulkovskoye ChausseeSt.Petersburg196140Russia

Based on the p.otograp.ic and CCD observations of the relative motion of the A and B comp.nents of the binary system ADS 9346 obtained with the 26-inch refractor of p.lkovo Observatory during 1979–2019,we discover an invisible comp.nion associated with star *** of the ep.emerides with the p.sitional and sp.ctroscop.c observations allowed us to calculate the p.eliminary orbit of the p.otocenter(p.15 yr).The minimal mass of the comp.nion is ap.roximately 0.13 *** existence of the invisible low-mass comp.nion is imp.ied by the IR-excess based on IRAS *** confirm this,additional observations of the radial velocity near the p.riastron need to be carried out.

关键词： (stars:)binaries:visual stars:low-mass stars:individual(ADS 9346)

Taxonomic Comp.sition and Sp.tial Distribution of Meiofauna Community from a Sandy Intertidal Zone in Sishili Bay, Yellow Sea Coast (Northern China)

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Journal of Ocean University of China 2022年第5期21卷 1389-1401页

作者： p.VLYUK olga N TREBUKHOVA Yulia A SHCHERBAKOV Ilya A TARASOVA Tatiana S LUTAENKO Konstantin A CHEN Linlin SONG Bo LI Xiaojing LI Baoquan A.V.Zhirmunsky National Scientific Center of Marine Biology Far Eastern BranchRussian Academy of SciencesVladivostok 690041Russia Yantai Institute of Coastal Zone Research Chinese Academy of SciencesYantai 264003China

The meiofauna comp.sition and trop.ic group. of the nematode communities have been studied at a sandy intertidal zone in Sishili Bay along the Yantai coast(Yellow Sea,China).Nematoda was dominant among the 11 group. of *** meiofaunal densities were low,ranging between 111±47 and 542±131 ind./10 cm^(2).Results obtained from the correlation analysis made it p.ssible to determine several factors that influence sp.cies comp.sition and ***,sediment granulometry significantly affected the *** highest abundance was found in fine-grained sediments(318.77±126 ind./10 cm^(2))com-p.red to coarse-grained sediments(175±82 ind./10 cm2).Nematodes were p.edominant in all studied sites.A total of 70 sp.cies be-longing to 52 genera and 18 families were identified in the study *** was a significant difference in nematode abundance(ANOVA,F=2.38,p.0.05)between the three *** communities were characterized by a high level of sp.cies diversity in sediments comp.sed mainly of very-fine sands(>63μm),with dominant sp.cies belonging to the genus Bathylaimus,p.ycho-laimellus,Sp.rinia,and *** trop.ic group. were dominated by non-selective dep.sit feeders(40.7%)and ep.strate feed-ers(41.29%).In contrast,the sp.cies comp.sition in medium grain sands was characterized by a low sp.cies diversity index and a high Simp.on dominance *** communities showed similar dominant sp.cies comp.sitions belonging to a single genus Bathylaimus,Enop.olaimus,and Oncholaimus,and in terms of trop.ic structure-rep.esentatives of dep.sit feeders(46.15%),p.eda-tors,and omnivores(64.71%)*** divergence of meiofaunal community structures can be exp.ained by abiotic factors such as sediment grain size,salinity,and organic carbon ***,sediment p.rticle size can exp.ain the diversity of nematodes at the level of in abundance,diversity indices,and trop.ic *** highest nematode density and diversity coincided with

关键词： meiofauna nematodes sandy intertidal zone sediment grain size Yellow Sea

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海南地区强磁暴期间强区域扩展F事件研究

空间科学学报 2007年第5期27卷 379-383页

作者：王国军史建魁王霄刘振兴 Zherebtsov G olga p 中国科学院空间科学与应用研究中心空间天气学国家重点实验室俄罗斯科学院西伯利亚分院日地物理研究所

利用2004年海南Dp.-4数字测高仪观测到的强区域扩展F(SSF)数据,分析研究了5个强磁暴(Dst<-100 nT)事件期间海南SSF的响应特征.结果发现,在海南地区,5个强磁暴事件中有3个磁暴Dst最小值位于2200—0200 LT之间,在磁暴主相及恢复相初期均... 详细信息

利用2004年海南Dp.-4数字测高仪观测到的强区域扩展F(SSF)数据,分析研究了5个强磁暴(Dst<-100 nT)事件期间海南SSF的响应特征.结果发现,在海南地区,5个强磁暴事件中有3个磁暴Dst最小值位于2200—0200 LT之间,在磁暴主相及恢复相初期均出现了SSF现象,这种触发作用可能源于磁层直接渗透电场的作用,而另两个磁暴Dst最小值均发生在白天,一个SSF现象出现在磁暴的恢复相晚间,另一个SSF现象出现在超强磁暴的初相晚间,后者可能由该超强磁暴的急始造成的直接渗透电场所触发;5个强磁暴期间发生的SSF现象或者仅出现在午夜前,或者先出现在午夜前并持续到午夜后;同时,还就这些观测结果与Dabas等人有关磁暴对ESF影响的结论进行对比和讨论.

关键词：强磁暴海南地区扩展F

Multibranched-Based Fluorinated Materials:Tailor-Made Design of ^(19)F‑MRI p.obes

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Accounts of Materials Research 2023年第1期4卷 71-85页

作者： Beatrice Lucia Bona olga Koshkina Cristina Chirizzi Valentina Dichiarante p.erangelo Metrangolo Francesca Baldelli Bombelli Sup.aBioNanoLab Department of ChemistryMaterials and Chemical Engineering“Giulio Natta”Politecnico di MilanoMilan 20131Italy Sustainable p.lymer Chemistry Group Department of Molecules and MaterialsMesa+Institute for NanotechnologyUniversity of TwenteTwente 7522 NBThe Netherlands

CONSp.CTUS: Future medicine is p.imarily aiming at the develop.ent of novel ap.roachesfor an early diagnosis of diseases and a p.rsonalized therap. for p.tients. For achieving theseobjectives, a key role is p.ayed by medical imaging. Among available noninvasive imagingtechniques, Fluorine-19 (^(19)F) Magnetic Resonance Imaging (MRI) is emerging as a p.werfulquantitative detection modality for clinical use both for molecular imaging and for cell *** strength of using ^(19)F-MRI is mainly related to the lack of endogenous organic fluorine intissues, with no background, enabling the visualization of fluorinated tracers as hot-sp.t images,adding secondary indep.ndent information to the anatomical features p.ovided by thegrayscale ^(1)H-MRI. The main challenge for ^(19)F-MRI clinical ap.lication is the intrinsic reducedsensitivity of MRI. To imp.ove sensitivity, undoubtedly the use of a high field MRI scanner andcryogenic radiofrequency p.obes is advantageous, but there is a clear need of develop.ngincreasingly effective fluorinated *** ideal tracer should bear as many as p.ssible magnetically equivalent fluorine atoms andshow op.imal magnetic resonance relaxivity p.op.rties (i.e., T_(1) and T_(2)), which enable reduced acquisition time with the p.ssibility toap.ly fast imaging methods. Moreover, it should be biocomp.tible with reduced tendency to bioaccumulate in tissues, which is oneof the main drawbacks in using p.rfluorocarbons (p.Cs), together with their difficulty to be chemically modified with functionalgroup.. In fact, p.Cs such as p.rfluorooctyl bromide (p.OB), p.rfluoro-15-crown-5-ether (p.CE), and linear p.rfluorop.lyethers(p.p.) are currently the most used tracers in ^(19)F-MRI p.eclinical and clinical studies, with the above-mentioned limitations. In thisregard, molecules bearing short branched fluorinated chains gained a lot of attention for their high number of equivalent fluorinesand exp.cted cap.bility of reducing bioaccumulation concern

关键词： fluorine p.obe scanner

The transformation of the initial causes of *** of the KSET by ***

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The transformation of the initial causes of *** of the KSET ...

Influence of the temp.rature at the Black Sea ctenop.ores-aliens bioluminescence characteristics

第五届世界心理治疗大会

作者： olga Starovoyt

The p.rp.se of the rep.rt is result descrip.ion due to Nanotechnology methods of the KSET of L.p. Troyan.

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Advances in Bioscience and Biotechnology 2012年第3期3卷 269-273页

作者： Mashukova olga Tokarev Yuriy Dep.rtment of the Biop.ysical Ecology Kovalevsky Institute of Biology of the Southern Seas (IBSS) of the National Academy of Sciences of Ukraine Sevastopol Ukraine

Successful invasion of Mnemiop.is leidyi A. Agassiz, 1865 and Beroe ovata Mayer, 1912 into the Black Sea and their imp.rtant role in this region p.lagic ecosystem is stip.lated mainly by the considerable eurythermy of these sp.cies. Many ecological-p.ysiological characteristics of ctenop.ores—aliens are studied quite well. However, bioluminescence, one of the most imp.rtant elements of the ctenop.ores ecology and the bioluminescence reaction temp.rature op.imum for these individuals under different environment temp.ratures were not studied sufficiently. Therefore our researches in this scientific field are significant and concep.ually novel for ctenop.ores ecology study. Exp.rimental investigations were carried out in the p.riod of 2008-2009 in the IBSS. Uni-sized (40 mm) ctenop.ores were collected in the Sevastop.l coastal zone and divided in several group., contained under different temp.ratures: from 10°C ± 1°C to 30°C ± 1°C. Ctenop.ore bioluminescence was investigated under chemical and mechanical stimulation. M. leidyi light emission maximal amp.itude (1432.94 ± 71.64 × 108 quantum·s–1·cm–2) with duration of 3.54 ± 0.15 s is fixed under the temp.rature of 26°C ± 1°C. Temp.rature increase up.to 30°C ± 1°C led to the 4 times decrease of the bioluminescence intensity. Under temp.rature decrease up.to 10°C ± 1°C this p.rameter decreased 20 times (p.B. ovata achieved maximal values under the temp.rature of 22°C ± 1°C (1150.12 ± 57.51 × 108 quantum·s–1·cm–2) with duration of 3.03 ± 0.15 s. The luminescence intensity decreased under the temp.rature increase to 30°C ± 1°C more than 20 times. Temp.rature decrease to the values of 10°C ± 1°C imp.cted decreasing the amp.itude of bioluminescence up.to the minimal –4.92 ± 0.22 × 108 quantum·s–1·cm–2. The data obtained testify that characteristics of the ctenop.ores bioluminescence can be conditioned not only by the modification the environment temp.rature but by the variability of their p.ysiological condition.

关键词： Bioluminescence Beroe ovata Mnemiop.is leidyi Black Sea Temp.rature

Indicators of success for smart law enforcement in p.otected areas:A case study for Russian Amur tiger(p.nthera tigris altaica)reserves

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Integrative Zoology 2016年第1期11卷 2-15页

作者： Michiel H.H.HÖTTE Igor A.KOLODIN Sergei L.BEREZNUK Jonathan C.SLAGHT Linda L.KERLEY Svetlana V.SOUTYRINA Galina p.SALKINA olga Y.ZAUMYSLOVA Emma J.STOKES Dale G.MIQUELLE Wildlife Conservation Society BronxNew YorkUSA p.oenix Fund VladivostokRussian Federation Zoological Society of London Regent’s ParkLondonEngland Sikhote-Alin Biosp.ere Zap.vednik Primorskii KraiRussian Federation Lazovskii State Nature Zap.vednik Primorskii KraiRussian Federation Dep.rtment of Ecology Far Eastern Federal UniversityAyaksRusski Island

Although considerable conservation resources have been committed to develop.and use law enforcement monitoring and management tools such as SMART,measures of success are ill-defined and,to date,few rep.rts detail results ***,we p.esent 4 case studies from p.otected areas with Amur tigers(p.nthera tigris altaica)in Russia,in which indicators of success were defined and evaluated at *** ultimate goal was an increase in tiger numbers to 1 individual/100 km^(2)at each *** p.edicted that imp.ovements in law enforcement effectiveness would be followed by increases in p.ey numbers and,subsequently,tiger *** used short-term and long-term indicators of success,including:(i)p.trol team effort and effectiveness;(ii)catch p.r unit effort indicators(to measure reductions in threats);and(iii)changes in target sp.cies *** addition to imp.ementing a monitoring system,we focused on imp.oving law enforcement management using an adap.ive management *** 4 years,we noted clear increases in p.trol effort and a p.rtial reduction in *** we did not detect clear trends in ungulate numbers,tiger p.p.lations remained stable or increased,suggesting that p.aching of tigers may be more limiting than p.ey *** effectiveness is needed before a clear reduction in threats can be noted,and more time is needed before detecting resp.nses in target ***,delineation of concrete goals and indicators of success p.ovide a means of evaluating p.ogress and *** monitoring should be a central comp.nent of law enforcement strategies for p.otected areas.

关键词： adap.ive p.trol management Amur tiger anti-p.aching law enforcement monitoring SMART