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Using of spectral analysis of heart rate variability for increasing reliability of bicycle ergometry results

Health 2011年第8期3卷 477-481页

作者： Vladimir Ivanovich Gridnev Anton Robertovich Kiselev olga mikhailovna posnenkova Vladimir Alexandrovich Shvartz 不详

The aim was to study the suitability of the heart rate variability (HRV) spectral parameters for evaluations of bicycle ergometry results in coronary heart disease (CHD) patients. Methods. Our study included 243 male CHD patients aged 49±8 years. The coronary atherosclerosis was assessed by coronary angiography. The results of bicycle ergometry, Doppler echocardio-graphy and HRV spectral analysis were also analyzed. The duration of each stage of bicycle ergometry was 3 min, the initial load value was 25 W. Dynamic load continued until the patient had reached 75% of heart rate from his maximal age level. The maximal level of load achieved (i.e. load tolerance) was taken into consideration. We calculated sensitivity (Se), specificity (Sp), likelihood ratios of positive (LR+) and negative (LR-) bicycle ergometry results. Results. All patients had similar clinical characteristics. LR+ become maximal under the moderate load tolerance. LR- are maximal in the CHD patients with high load tolerance. Thus, the excessiveness of false-negative results of bicycle ergometry is in CHD patients with high load tolerance. Reliability of results of bicycle ergometry increased under using assessments of low-frequency (LF) range power of HRV spectrum. Conclusions. Thus,the using of LF range power of HRV spectrum increases reliability of bicycle ergometry (or other load tests) results in CHD patients.

关键词： Heart Rate Variability Bicycle Ergometry Coronary Heart Disease

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A New Glance on Energy Metabolism Investigation in Cultured Cells

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Journal of Biosciences and Medicines 2020年第8期8卷 45-55页

作者： Larisa mikhailovna Obukhova Marina Vadimovna Shirmanova olga Nikolaevna Nikiforova Maria Maksimovna Lukina Elena Ivanovna Erlykina Federal State Budgetary Educational Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation Nizhny Novgorod Russia

The aim of the study was to analyze the input of cytosolic and oxidative pathways of energy metabolism in ATP production of cultured cells by using FLIM and routine biochemical techniques. Fluorescent imaging of endogenous cofactors NADH and FAD demonstrated a more pronounced oxidative redox status of fibroblasts compared to tumor cells and significant differences in metabolic processes in which FAD is involved. Analysis of glucose and lactate content and absorption showed that tumor cells not only absorb glucose more intensively from the environment, but also use it more intensively during anaerobic glycolysis. Lower energy efficiency of glycolysis and FAD oxidative path and greater energy consumption is the reason for the lower concentration of ATP in tumor cells. Presumably, the prevalence of glycolytic metabolism in tumor cells could be largely determined by their hypoxic reprogramming through the PI3K/AKT/mTOR signal pathway. The results of the study suggest that correlation between intracellular consumption of glucose and cytosolic concentration of NADH may contribute to the characteristic of energy metabolism state of cultured cells and serve as the biosensor of malignant cell transformation.

关键词： Metabolic Imaging Glycolysis ATP Tumor Cells of HeLa Kyoto

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