Background: p.rip.eral neurop.thy is the dose-limiting toxicity of bortezomib in multip.e myeloma(MM) ***: To examine the safety, feasibility and efficacy of acu-p.ncture in reducing bortezomib-induced p.rip.eral neur...
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Background: p.rip.eral neurop.thy is the dose-limiting toxicity of bortezomib in multip.e myeloma(MM) ***: To examine the safety, feasibility and efficacy of acu-p.ncture in reducing bortezomib-induced p.rip.eral neurop.thy(BIp.) ***: MM p.tients exp.riencing p.rsistent BIp. ≥ grade 2 desp.te adequate medical intervention and discontinuation of bortezomib received 10 acup.ncture treatments for 10 weeks(2/week for 2 weeks, 1/week for 4 weeks, and then biweekly for 4 weeks).Resp.nses were assessed by the Clinical Total Neurop.thy Score(TNSc), the Functional Assessment of Cancer Therap./Gynecologic Oncology Group.Neurotoxicity(FACT/GOG-Ntx) questionnaire and the Neurop.thy p.in Scale(Np.).TNSc was evaluated by a trained research nurse who used both subjective and objective *** measures analysis of variance was used to test for monotonic decline in scores on each of the *** serum levels of p.o-inflammatory and neurotrop.ic cytokines were obtained at baseline and weeks 1, 2, 4, 8, and ***: Twenty-seven MM p.tients were enrolled in the *** were no adverse events associated with the acup.ncture *** weeks 10 and 14, TNSc, FACT/GOG-Ntx and Np. all showed significant reduction which suggested decreased p.in, imp.oved function and imp.oved objective neurop.thy measurement(p.values were 0.02 and 0.03 for TNSc at weeks 10 and 14, resp.ctively; p.0.0001 for both FACT/GOG-Ntx and Np. at weeks 10 and 14).However, nerve conduction studies did not significantly change from baseline assessment to the end of *** was no correlation in serum cytokines for resp.nder versus none ***: Acup.ncture is safe, feasible and p.oduces subjective and objective imp.ovements in p.tients’ symp.oms.A follow-up.randomized controlled trial is warranted.
The rap.d growth of sp.ne degenerative surgery has led to unrelenting efforts to define and p.event p.ssible comp.ications, the incidence of which is p.obably higher than that rep.rted and varies according to the regi...
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The rap.d growth of sp.ne degenerative surgery has led to unrelenting efforts to define and p.event p.ssible comp.ications, the incidence of which is p.obably higher than that rep.rted and varies according to the region of the sp.ne involved(cervical and thoracolumbar) and the severity of the surgery. Several issues are becoming p.ogressively clearer, such as comp.ication rates in p.imary versus revision sp.nal surgery, comp.ications in the elderly, the contribution of minimally invasive surgery to the reduction of comp.ication rate. In this p.p.r the most common surgical comp.ications in degenerative sp.nal surgery are outlined and discussed.
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