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P53 rs1042522 and CD95 rs1800682 genetic variations in HCV-4a response to antiviral therapy

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genes & Diseases 2015年第2期2卷 197-210页

作者： Ahmed A.Abd-Rabou Emad F.Eskander Mervat S.Mohamed Shaymaa M.M.Yahya Ashraf El Sherbini olfat g.shaker Hormones Department Medical Research DivisionNational Research CentreCairo 12622Egypt Chemistry Department Biochemistry SpecialtyFaculty of ScienceCairo UniversityEgypt Internal Medicine Department Medical Research DivisionNational Research CentreCairoEgypt Medical Biochemistry and Molecular Biology Department Faculty of MedicineCairo UniversityEgypt

Current estimates indicate that the hepatitis C(HCV)is the leading cause of mortality around the world,with infection rates steadily increasing in *** dual therapy for this silent epidemic with pegylated-interferon-a2b/ribavirin has markedly improved the success rates in genotype-4 *** was reported that apoptosis plays a vital mechanistic role in limiting viral replication.P53,a key regulator of apoptosis,induces CD95 gene expression and subsequently initiates apoptotic cascade to be *** current study examined the impact of P53 rs1042522 and CD95 rs1800682 polymorphisms on the treatment *** groups of 240 volunteers were enrolled in this study;86 in sustained virological responders group,74 in non-responders group,and 80 in control *** patients had HCV genotype-4a and were interferon treatment naı¨*** of HCV-RNA by qRT-PCR and histological scores were performed for all *** addition,genotyping of HCV-RNA,P53 rs1042522 Arg/Pro and CD95 rs1800682 A/g polymorphisms were investigated in all *** was resulted that P53 Pro/Pro homozygous genotype has high significant increase,while CD95 A/A homozygous genotype has high significant decrease when comparing non-responders with ***,it was concluded that Pro variant of P53 rs1042522 may be used as a genetic predictor for non-responsiveness,while A/A variant of CD95 rs1800682 may be used as a sensitive biomarker for responsiveness to antiviral therapy of HCV genotype-4a *** addition,low prolactin,high total testosterone,and high gH levels may provide promising biomarkers for early prediction of the response when associated with these genetic polymorphisms.

关键词： CD95 rs1800682 HCV gentotype-4a P53 rs1042522 Response SNPs

Swift XRT Analysis of Type II-P Supernova SN 2008ij

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International Journal of Astronomy and Astrophysics 2024年第3期14卷 220-229页

作者： SH. M. Shehata Ahmed M. Fouad R. M. Samir A. A. shaker National Research Institute of Astronomy and geophysics (NRIAg) Helwan Egypt

This study investigates the X-ray properties and evolution of Type II supernovae (SNe II) observed by Swift, examining variations among supernovae and exploring their X-ray characteristics over time. We present the first X-ray study of the Type IIp supernova SN 2008ij using data from the Swift X-ray mission. This investigation focuses on its spectral properties, identifying an X-ray flux of 1.20 (+0.11, −0.10) × 10−13 erg/cm2/s and a plasma temperature of 4.76 (+1.22, −0.83) keV. Our study marks an advancement in understanding SN 2008ij, providing crucial results into its X-ray emission characteristics. These results lay the groundwork for future studies of Type IIp supernovae, offering a foundation for exploring their evolutionary and physical processes.

关键词： X-Ray Core Collapse Supernova Swift (XRT) Observations

Targeting Transforming growth Factor-<i>β</i>(TgF-<i>β</i>) in Cancer and Non-Neoplastic Diseases

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Journal of Cancer Therapy 2014年第7期5卷 735-747页

作者： Michael Nacif olfat shaker Department of Biochemistry and Molecular Biology Faculty of Medicine Cairo University Giza Egypt Department of Molecular Diagnostics Genetic Engineering and Biotechnology Research Institute (GEBRI) Sadat City University Sadat City Egypt

Transforming growth factor-β?(TgF-β) superfamily is a key player in the regulation of a wide variety of physiological processes from development to pathogenesis. Since the discovery of the prototypic member, TgF-β, almost three decades ago, there have been tremendous advances in our understanding of its complex biology. TgF-β?misregulation has been implicated in the pathogenesis of a variety of diseases, including cancer with a direct role in facilitating metastasis, fibrosis and inflammation. Consequently, TgF-β?is currently explored as a prognostic candidate biomarker of tumor invasiveness and metastasis;and it offers an attractive target for cancer therapy. Several anti-TgF-β?approaches, such as TgF-β?antibodies, antisense oligonucleotides and small molecules inhibitors of TgF-β?type 1 receptor kinase, have shown great promise in the preclinical studies. Here, we consider why the TgF-βsignaling pathway is a drug target, the potential clinical applications of TgF-β?inhibition, the issues arising with anti-TgF-β?therapy and how these might be adopted using personalized approaches with a special care for patient selection and timing of therapy so that we may bring forward all the potentials of targeting this pathway for therapeutic uses in both cancer, preferentially in combination therapy, and non-neoplastic diseases.

关键词： Transforming growth Factor-β (TgF-β) Monoclonal Antibodies (MoAbs) Antisense Oligonucleotides (ASO) Small Molecule Receptor Kinase Inhibitors (SMIs)

Prevalence of Mastitis and Associated Risk Factors in Lactating Camels (Camelus Dromedarius) on Dairy Farms in Benadir Region, Somalia

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Open Journal of Veterinary Medicine 2024年第6期14卷 111-123页

作者： Shafii Abdullahi Mohamed Mahad Mohamud Abdi Abdiaziz Idiris Mohamud Yonis Abukar Mohamed Ahmed Ali Omar Abdirahman Barre Chandra shaker Chouhan Md. Amimul Ehsan Faculty of Veterinary Science Benadir University Mogadishu Somalia Faculty of Veterinary Medicine and Animal Husbandry Somali National University Mogadishu Somalia Somali Animal Welfare Society (SAWS) Mogadishu Somalia Camel Research Center Mogadishu Somalia Department of Medicine Faculty of Veterinary Science Bangladesh Agricultural University Mymensingh Bangladesh

The study took a comprehensive approach to understanding mastitis in lactating camels, a disease that significantly impacts milk quantity and quality. This complex and multifactorial disease poses a significant challenge to dairy camel farming, particularly in Somalia. The studys objective was to determine the prevalence of mastitis and the risk factors associated with it among lactating camels on dairy farms in Benadir, Somalia. To achieve this, a cross-sectional study was conducted from May to September 2022 in the Benadir region of Somalia. A total of 96 lactating camels underwent examination using the California Mastitis Test (CMT) to identify clinical and subclinical mastitis cases. Additionally, a questionnaire survey was conducted among 20 farm employees/owners to gather information on hygiene practices, parity, lactation stage, tick infestation, and the presence of udder/teat lesions. Data regarding parity and lactation stage were obtained through owner interviews. The data collected on specifically designed forms were recorded and entered into a Microsoft Excel spreadsheet for analysis using SPSS version 20 statistical software, ensuring a comprehensive and reliable analysis of the data. The studys findings revealed a significant prevalence of camel mastitis, with 34.4% (33/96) of lactating camels affected and clinical and subclinical cases constituting 5.2% and 29.2%, respectively. Quarter-level prevalence was 46.3%, with clinical and subclinical mastitis at 4.7% and 41.6%, respectively. The study also identified significant associations (P g risk factors such as stage of lactation, parity, and age, indicating a higher susceptibility to mastitis in older camels during early lactation compared to those in late lactation and younger camels. These findings underscore the crucial role of inadequate hygienic conditions on camel farms and udder tick infestations in driving the elevated prevalence of mastitis, highlighting the need for improved manage

关键词： Mastitis Camel Prevalence Risk Factors Somalia

Radiometric normalization of overlapping LiDAR intensity data for reduction of striping noise

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International Journal of Digital Earth 2016年第7期9卷 649-661页

作者： Wai Yeung Ahmed shaker Department of Civil Engineering Ryerson UniversityTorontoOntarioCanada

Airborne LiDAR data are usually collected with partially overlapping strips in order to serve a seamless and fine resolution mapping *** of the factors limiting the use of intensity data is the presence of striping noise found in the overlapping *** recent researches have proposed physical and empirical approaches for intensity data correction,the effect of striping noise has not yet been *** paper presents a radiometric normalization technique to normalize the intensity data from one data strip to another one with partial *** normalization technique is built based on a second-order polynomial function fitted on the joint histogram plot,which is generated with a set of pairwise closest data points identified within the overlapping *** proposed method was tested with two individual LiDAR datasets collected by Teledyne Optech’s gemini(1064 nm)and Orion(1550 nm)*** experimental results showed that radiometric correction and normalization can significantly reduce the striping noise found in the overlapping LiDAR intensity data and improve its capability in land cover *** coefficient of variation of five selected land cover features was reduced by 19–65%,where a 9–18%accuracy improvement was achieved in different classification *** the proven capability of the proposed method,both radiometric correction and normalization should be applied as a pre-processing step before performing any surface classification and object recognition.

关键词： LiDAR intensity striping noise radiometric correction radiometric normalization joint histogram land cover classification

Frequency-domain generelaized singular peruturbation method for relative error model order reduction

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控制理论与应用（英文版） 2009年第1期7卷 57-62页

作者： Hamid Reza shaker Section for Automation and Control Institute for Electronic SystemsAalborg University

A new mixed method for relative error model order reduction is proposed. In the proposed method the frequency domain balanced stochastic truncation method is improved by applying the generalized singular perturbation method to the frequency domain balanced system in the reduction procedure. The frequency domain balanced stochastic truncation method, which was proposed in [15] and [17] by the author, is based on two recently developed methods, namely frequency domain balanced truncation within a desired frequency bound and inner-outer factorization techniques. The proposed method in ttiis paper is a carry over of the frequency-domain balanced stochastic truncation and is of interest for practical model order reduction because in this context it shows to keep the accuracy of the approximation as high as possible without sacrificing the computational efficiency and important system properties. It is shown that some important properties of the frequency domain stochastic balanced reduction technique are extended to the proposed reduction method by using the concept and properties of the reciprocal systems. Numerical results show the accuracy, simplicity and flexibility enhancement of the method.

关键词： Large-scale systems Model reduction Balanced realization Frequency-domain grammian

Extending the Lifetime of Copper-beryllium Alloys as Plastic Injection High-end Needle Valve Mold Nozzle Tips Through a Heat-treatment-based Microstructure Optimization Approach

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Journal of Wuhan University of Technology(Materials Science) 2023年第3期38卷 665-668页

作者：孟晓敏 ZHAO Dong MAJID shaker Chongqing 2D Materials Institute Chongqing 400701China Chengdu Lianyu Precision Machinery Co. Ltd.Chengdu 611730China Lehrstuhl Für Physikalische Chemie II Universitat Erlangen-NürnbergEgerlandstraBe 391058ErlangenGermany

The relationship between the microstructure and the practical performance of two different copper-beryllium alloys including their lifetime has been ***,two valves made of two different alloys with very similar compositions and the same heat treatment methods were investigated by various standard techniques including metallography,X-ray diffraction,chemical composition,microhardness,and thermal conductivity *** both alloys experienced the same heat-treatment processes,they revealed different thermal and mechanical properties due to the minor difference in their chemical *** alloy providing a longer lifetime (40%more) as the tip had a higher thermal conductivity of 280.3 W(m·K)^(-1) (about two times that of the other alloy).Regarding the metallography images and the measured thermal conductivity values of the alloys,the extended lifetime of the nozzle with the optimum performance is ascribed to its biphasic microstructure and the minor grain boundaries and interfacial thermal *** important difference in the chemical composition was investigated in this study.

关键词： crystal structure grain boundaries metals and alloys thermal properties needle valve

μPMU-based smart adaptive protection scheme for microgrids

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Journal of Modern Power Systems and Clean Energy 2019年第4期7卷 887-898页

作者： Mohamed Salah ELBANA Nabil ABBASY Ashraf MEgHED Nahil shaker Electrical Engineering Department Faculty of EngineeringAlexandria UniversityLotfy El-Sied St.P.O.ElhadaraAlexandria 21544Egypt

The concepts of microgrids(Mgs)and smart grid represent the recent targeted revolution towards fully smart electrical network integrated with high penetration of renewable energy sources(RESs).The protection system of Mgs becomes a challenge due to variable characteristics of its currents,bidirectional power flow and output power fluctuations of RES,causing selectivity and sensitivity issues for conventional protective devices(PDs)with fixed *** this paper,a smart protection scheme(SPS)is proposed using micro-phasor measurement units(μPMUs)to obtain the continuous rapid synchronized phasor measurement *** it is communicated with a microgrid central controller(MgCC)through highly reliable communication architecture to carry out online smart adaptive protection *** index coefficients and abnormality coefficients are calculated for each feeder to detect the fault location and the abnormality *** modeling of an Mg including 10-bus connected distribution system with integrated distributed generation(Dg)is simulated using ETAP *** proposed protection algorithm is modeled and evaluated using MATLAB *** proposed fault detector and abnormality detector can enable quick and accurate fault identification and isolation.

关键词： Fault index coefficients Microgrid(Mg) Micro-phasor measurement unit(μPMU) Renewable energy source(RES) Smart protection scheme(SPS)

Repositioning of dipeptidyl peptidase-4 inhibitors and glucagon like peptide-1 agonists as potential neuroprotective agents

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Neural Regeneration Research 2019年第5期14卷 745-748页

作者： shaker A.Mousa Bassam M.Ayoub Pharmaceutical Research Institute Albany College of Pharmacy and Health Sciences The Center for Drug Research and Development (CDRD) Pharmaceutical Chemistry Department Faculty of Pharmacy The British University in Egypt

Repositioning of dipeptidyl peptidase-4 inhibitors and glucagon like peptide-1 receptor agonists is a breakthrough in the field of neural regeneration research increasing glucagon like peptide-1 bioavailability, hence its neuroprotective activities. In this article, the authors suggest not only crossing blood-brain barrier and neurodegenerative disease as off target for dipeptidyl peptidase-4 inhibitors and glucagon like peptide-1 receptor agonists, but also for ophthalmic preparations for diabetic retinopathy, which may be the latest breakthrough in the field if prepared and used in an appropriate nano-formulation to target the retinal nerves. The relation of neurodegenerative diseases' different mechanisms to the dipeptidyl peptidase-4 inhibitors and glucagon like peptide-1 receptor agonists should be further examined in preclinical and clinical settings. The repositioning of already marketed antidiabetic drugs for neurodegenerative diseases should save the high cost of the time-consuming normal drug development process. Drug repositioning is a hot topic as an alternative to molecular target based drug discovery or therapeutic switching. It is a relatively inexpensive pathway due to availability of previous pharmacological and safety data. The glucagon like peptide-1 produced in brain has been linked to enhanced learning and memory functions as a physiologic regulator in central nervous system by restoring insulin signaling. Intranasal administration of all marketed gliptins(or glucagon like peptide-1 receptor agonists) may show enhanced blood-brain barrier crossing and increased glucagon like peptide-1 levels in the brain after direct crossing of the drug for the olfactory region, targeting the cerebrospinal fluid. Further blood-brain barrier crossing tests may extend dipeptidyl peptidase-4 inhibitors' effects beyond the anti-hyperglycemic control to intranasal spray, intranasal powder, or drops targeting the blood-brain barrier and neurodegenerative diseases wit

关键词： repositioning DPP-4 inhibitors gLP-1RA neural regeneration blood-brain barrier Parkinson’s disease Alzheimer’s disease diabetic retinopathy