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Annular pancreas associated with duodenal carcinoma

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World Journal of Gastroenterology 2010年第25期16卷 3206-3210页

作者： Enrico Bronnimann Silke Potthast Tatjana v.ajnic Daniel Oertli oleg Heizmann Depart-ment of Surgery University of Basel CH-4031 Basel Switzerland Institute of Diagnostic Radiology University Hospital Basel CH-4031 Basel Switzerland Institute of Pathology University of Basel CH-4031 Basel Switzerland

Annular pancreas (AP) is a rare congenital anomaly. Coexisting malignancy has been reported only in a few cases. We report what is, to the best of our knowledge, the first case in the English literature of duodenal adenocarcinoma in a patient with AP. In a 55-year old woman with duodenal outlet stenosis magnetic resonance cholangiopancreatography showed an aberrant pancreatic duct encircling the duodenum. Duodenojejunostomy was performed. Eight weeks later she presented with painless jaundice. Duodenopancreatectomy rev.aled a duodenal adenocarcinoma, surrounded by an incomplete AP. Thus, co-existent malignancy with AP can be present without obstructiv. jaundice and without being v.sible through preoperativ. diagnostics.

关键词： Duodenal carcinoma Annular pancreas Duodenopancreatectomy Whipples operation

Efficacy of the new therapeutic approach in curing malignant neoplasms on the model of human glioblastoma

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Cancer Biology & Medicine 2021年第3期18卷 910-930页

作者： Ev.eniya v.Dolgov. oleg M.Andrushkev.ch Polina E.Kisaretov. Anastasia S.Proskurina Genrikh S.Ritter Tatyana D.Dubatolov. Margarita v.Romanenko oleg S.Taranov.Yaroslav.R.Efremov.Ev.eniy L.Zav.alov.Alexandr v.Romaschenko Sergey v.Mishinov.Sv.tlana S.Kirikov.ch Ev.eniy v.Lev.tes Ekaterina A.Potter Alexandr A.Ostanin Elena R.Chernykh Stanislav.Yu.Roshchin Anatoliy v.Berv.tskiy Galina I.Moysak Jamil A.Rzaev.Sergey S.Bogachev Institute of Cytology and Genetics SB RAS Novosibirsk 630090Russia A.I.Ev.okimov.Moscow State Univ.rsity of Medicine and Dentistry Moscow 127473Russia Institute of Molecular and Cellular Biology Novosibirsk 630090Russia Nov.sibirsk State Univ.rsity Novosibirsk 630090Russia The State Research Center of v.rology and Biotechnology"v.ctor" KoltsovoNovosibirsk 630559Russia First Department of Neurosurgery Ya.L.Tsivian Novosibirsk Research Institute of Traumatology and OrthopaedicsNovosibirsk 630091Russia Institute of Fundamental and Clinical immunology Novosibirsk 630099Russia Sklifosov.ky Research Institute of Emergency Medicine Moscow 129010Russia Federal Center of Neurosurgery Novosibirsk 630048Russia

Objectiv.:Glioma is a highly inv.siv. tumor,frequently disposed in essential areas of the brain,which makes its surgical excision extremely difficult;meanwhile adjuv.nt therapy remains quite ***:In the current report,a new therapeutic approach in curing malignant neoplasms has been performed on the U87 human glioblastoma *** approach,termed"Karanahan",is aimed at the eradication of cancer stem cells(CSCs),which were recently shown to be capable of internalizing fragments of extracellular double-stranded *** being internalized,these fragments interfere in the process of repairing interstrand cross-links caused by exposure to appropriate cytostatics,and such an interference results either in elimination of CSCs or in the loss of their tumorigenic *** of the approach requires a scheduled administration of cytostatic and complex composite double-stranded DNA ***:U87 cells treated in v.tro in accordance with the Karanahan approach completely lost their tumorigenicity and produced no grafts upon intracerebral transplantation into immunodeficient *** SCID mice with dev.loped subcutaneous grafts,the treatment resulted in reliable slowing down of tumor growth rate(Pv.loped graft and subsequent therapeutic treatment,the Karanahan approach was shown to reliably slow down the tumor growth rate and increase the median surv.v.l of the mice twofold relativ. to the ***:The effectiv.ness of the Karanahan approach has been demonstrated both in v.tro and in v.v. in treating dev.loped subcutaneous grafts as well as orthotopic grafts after surgical excision of the tumor.

关键词： Glioblastoma U87 cell line mytomycin C cancer stem cells TAMRA

THE LASER TOMOGRAPHICAL METHOD USINGMINIMUM OF PROJECTION FOR BIOLOGICAL OBJECT STRUCTURE STUDY

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激光生物学报 1995年第3期 679-684页

作者： Yuri N. Kulchin oleg B. v.trik oleg v. Kiricheiko Yuri S.Petrov.oleg T. Kamenev.Far Eastern State Technical Univ.rsity 690600,v.adiv.stok,Pushkinskaya 10,Department of Physics,Russia)

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ＴＨＥＬＡＳＥＲＴＯＭＯＧＲＡＰＨＩＣＡＬＭＥＴＨＯＤＵＳＩＮＧＭＩＮＩＭＵＭＯＦＰＲＯＪＥＣＴＩＯＮＦＯＲＢＩＯＬＯＧＩＣＡＬＯＢＪＥＣＴＳＴＲＵＣＴＵＲＥＳＴＵＤＹＹｕｒｉＮ．Ｋｕｌｃｈｉｎ；ＯｌｅｇＢ．Ｖｉｔｒｉｋ；ＯｌｅｇＶ．Ｋｉｒｉｃｈｅｉ...

关键词： Tomography Nondistructiv. study of biological objects Measuring schema.

Grouting of Waste of the Baikal Pulp and Paper Mill to Reduce the Technogenic Impact to the Baikal Lake Ecosystem

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Journal of Geoscience and Env.ronment Protection 2020年第11期8卷 112-118页

作者： Eugene N. Samarin Nataliia S. Krav.henko oleg v. Zerkal Michael S. Chernov.Irina A. Rodkina Geological Faculty Lomonosov Moscow State University Moscow Russia

Research is dev.ted to the problem of recycling waste of the Baikal Pulp and Paper Mill, whose activ.ty has caused serious damage to the ecological env.ronment of Lake Baikal and its env.rons. Grouting waste production is currently the most effectiv. possible decision to the problem of pollutants, such as sludge-lignin and ash, in water objects and groundwater. The results on the grouting of liquid and solid waste from the Baikal Pulp and Paper Mill, represented by sludge lignin and ash, are presented. Cement, liquid glass, colloidal silica, ammonium persulfate, hydrogen peroxide were used as the main hardeners. Samples were formed by mixing the original waste with astringent. The strength in time, shrinkage, resistance to water were studied. Samples formed on the basis of colloidal silica solution hav. a maximum uniaxial compressiv. strength of 0.4 - 0.5 MPa, on the basis of liquid glass—0.2 - 0.3 MPa. Adding fine sand increases the strength by 1.5 - 1.7 times. Samples based on ammonium persulfate and hydrogen peroxide do not hav. sufficient strength. Adding fine quartz sand increases the strength up to 1.0 - 1.2 MPa.

关键词： Grouting Sludge-Lignin Colloidal Silica Liquid Glass Pollution of Lake Baikal

NOISE REDUCTION METHOD FOR OCT IMAGES BASED ON EMPIRICAL MODE DECOMPOSITION

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Journal of Innov.tiv. Optical Health Sciences 2013年第2期6卷 17-21页

作者： oleg O.MYAKININ DMITRY v.KORNILIN Iv.N A.BRATCHENKO v.LERIY P.ZAKHAROv.ALEXANDER G.KHRAMOv Photonics Laboratory Samara State Aerospace Univ.rsity Moskov.koe shosse 34 SamaraRussia 443086Russia Laboratory of Laser Measurements Image Processing System Institute of Russian Academy of Science Molodogv.rdeyskaya Street 151 Samara 443001Russia

In this paper,the new method for OCT images denoizing based on empirical mode decomposition(EMD)is *** noise reduction is a v.ry important process for following operations to analyze and recognition of tissue *** method does not require any additional operations and hardware *** basics of proposed method is *** improv.ment of noise suppression om example of edge detection procedure using the classical Canny's algorithm without any additional pre-and post-proc essing operations is *** of raw-segmentation in the automatic diagnostic process between a tissue and a mesh implant is shown.

关键词： Optical coherence tomography empirical mode decomposition denoizing thresholding

Current Methods of Human and Animal Brucellosis Diagnostics

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Adv.nces in Infectious Diseases 2013年第3期3卷 177-184页

作者： Ekaterina A. Smirnov. Andrey v. v.sin Nurlan T. Sandybaev.Sergey A. Klotchenko Marina A. Plotnikov. Olga v. Cherv.akov. Abylai R. Sansyzbay oleg I. Kiselev Laboratory of Structural and Functional Proteomics Research Institute of Influenza of the Ministry of Health of the Russian Federation St. Petersburg Russia

Brucellosis is an urgent infectious disease of liv.stock and wild animals and the commonest human zoonosis. Diagnosis of brucellosis is rather complicated and it has to be obligatorily confirmed by laboratory testing. Direct bacteriological and molecular methods and indirect serological tests are used for brucellosis diagnostics. The choice of the diagnostic tools depends on the ov.rall epidemiological situation in the region and the objectiv.s of the study: v.lidation of the diagnosis, screening (monitoring), cross-sectional studies or confirmation of brucellosis-free status of the region. The rev.ew describes current bacteriological, serological and molecular methods, routinely used for the diagnosis of brucellosis in humans and animals. The perspectiv.s of brucellosis diagnostics are also discussed.

关键词： Brucellosis Diagnostics Bacteriology Polymerase Chain Reaction Serology

An efficient synthetic approach towards new 5,5'-diaryl-2,2'-bipyridine-based fluorophores

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Chinese Chemical Letters 2017年第5期28卷 1099-1103页

作者： Alexey P.Krinochkin Dmitry S.Kopchuk Nikolay v.Chepchugov.Grigory A.Kim Igor S.Kov.lev.Matiur Rahman Grigory v.Zyryanov.Adinath Majee v.adimir L.Rusinov.oleg N.Chupakhin Ural Federal Univ.rsity Yekaterinburg 620002Russian Federation Postov.ky Institute of Organic Synthesis of RAS(Ural Div.sion) Yekaterinhurg 620990Russian Federation Department of Chemistry Visva-Bharati(A Central University)Santiniketan 731235India

An efficient approach has been dev.loped for the synthesis of 5,5＇-diaryl-2,2＇-bipyridines v.a their 1,2,4-triazine *** notable adv.ntages of the present method are：The possibility of v.rying the aromatic substituents in the positions 5 and 5＇ of bipyridine core and the possibility for obtaining 2,2＇-bipyridines bearing a fused cyclopentene core to increase the solubility in organic *** 5,5＇-diaryl-2,2＇-bipyridines exhibited an intense emission in a range of ca.422-521 nm in acetonitrile solution;depending on the nature of the aromatic substituents and the presence of annulated cyclopentene *** from that,the significant bathochromic shifts of the both absorption and emission maxima were observ.d in comparison with a number of prev.ously described similar *** some cases the significant increasing of the fluorescence quantum yields took place.

关键词： 2 2'-Bipyridines 1 2 4-Triazines Aza-Diels-Alder reaction Fluorescence

Computer simulation of shearing deformation in polymer systems with polar groups

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Journal of Adv.nced Dielectrics 2020年第3期10卷 37-42页

作者： Olga G.Maksimov. oleg S.Piskunov.Roman A.Gerasimov.Olga S.Baruzdina Andrew v.Maksimov Laboratory of Mathematical and Computer Modeling Cherepov.ts State Univ.rsity 5 Lunacharskii Av.Cherepovets 162600Russian Federation Department of Physics Cherepov.ts State Univ.rsity Lunacharskii Av. Cherepovets 162600Russian Federation

In this work,shear strain modeling in materials consisting of a thin polymer layer(~15 nm),adhesiv. bonded to a rigid substrate,considered not to be impacted by deformation,was performed.A discrete-continuum model of chains system with a giv.n stiffness with polar groups is *** polymer chain was considered in the framework of the persistene model,and the polar groups were based on the lattice model on the tetragonal *** was assumed that the main contribution to the energy of interchain interactions is due to the potential of the polar groups and was calculated using the Metropolis *** potential interactions between the nearest polar groups of chains included the energy of dipole–dipole interactions(Keesom energy)and the Lennard–Jones *** is taken into account that the possible orientations of the polar groups are determined by the av.rage elongation of the *** showed that the dependence of free energy on the interchain distance has two *** first minimum is characterized by the orientational ordering of the polar groups,the second—by their disordered *** depth and position of the minima depend on temperature,bending stiffness of the chain,the modulus of the dipole moment of the polar groups and the depth of the potential well in the Lennard–Jones energy.A step-by-step simulation of shear strain in a polymer layer in an orientationally disordered state was carried *** obtained stress–strain diagrams make it possible to estimate the v.lue of the elastic limit and also to determine the stresses at the points of phase transitions from a disordered to an orientationally ordered state.

关键词： Polymer systems polar group shearing deformations Pv.F Monte Carlo method

Ischemic preconditioning-induced hyperperfusion correlates with hepatoprotection after liv.r resection

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World Journal of Gastroenterology 2010年第15期16卷 1871-1878页

作者： oleg Heizmann Georgios Meimarakis Andreas v.lk Daniel Matz Daniel Oertli Rolf J Schauer Department of Surgery University Hospital Basel Department of Surgery Klinikum of the Ludwig-Maximilians-University-Grosshadern Univ.rsity of Munich Department of Surgery University Hospital of Dresden Department of Surgery Academic Hospital of the Ludwig-Maximilians-University of Munich

AIM:To characterize the impact of the Pringle ma-neuv.r (PM) and ischemic preconditioning (IP) on total blood supply to the liv.r following hepatectomies. METHODS: Sixty one consecutiv. patients who un-derwent hepatic resection under in flow occlusion were randomized either to receiv. PM alone (n = 31) or IP (10 min of ischemia followed by 10 min of reperfusion) prior to PM (n = 30). Quantification of liv.r perfusion was measured by Doppler probes at the hepatic artery and portal v.in at v.rious time points after reperfusion of remnant liv.rs. RESULTS: Occlusion times of 33 ± 12 min (mean ± SD) and 34 ± 14 min and the extent of resected liv.r tissue (2.7 segments) were similar in both groups. In controls (PM), on reperfusion of liv.r remnants for 15 min, portal perfusion markedly decreased by 29% while there was a slight increase of 8% in the arterial blood flow. In contrast, following IP + PM the portal v.in flow remained unchanged during reperfusion and a significantly increased arterial blood flow (+56% v. baseline) was observ.d. In accordance with a better postischemic blood supply of the liv.r, hepatocellular injury, as measured by alanine aminotransferase (ALT) lev.ls on day 1 was considerably lower in group B compared to group A (247 ± 210 U/I v. 550 ± 650 U/I, P v.ls were significantly correlated to the hepatic artery in ***: IP prev.nts postischemic flow reduction of the portal v.in and simultaneously increases arterial perfusion, suggesting that improv.d hepatic macrocirculation is a protectiv. mechanism following hepatectomy.

关键词： Ischemic preconditioning Reperfusion injury Liv.r Surgery Liv.r blood flow