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Personalized medicine:Clinical oncology on molecular view of treatment

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World Journal of Clinical Oncology 2024年第8期15卷 992-1001页

作者： Rafick Costa Dos Santos Da Silva Nathalia de Andrade Simon AndréAlves Dos Santos Gabriel De Melo olegário Jayne Ferreira Da Silva Naide Oliveira Sousa Manuel Alvarez Troncoso Corbacho Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória Da Conquista 45029-094BahiaBrazil

Cancer,the second leading global cause of death,impacts both physically and *** treatments such as surgeries,chemotherapy,and radiotherapy have adverse effects,driving the need for more precise *** medicine enables more targeted *** mapping,alongside other molecular biology approaches,identifies specific genes,contributing to accurate *** review addresses,in clinical use,a molecular perspective on *** like alpha-fetoprotein,beta-human chorionic gonadotropin,5-hydroxyindoleacetic acid,programmed death-1,and cytotoxic T lymphocyte-associated protein 4 are explored,providing valuable ***,with an emphasis on artificial intelligence,revolutionizes the analysis of biological data,offering more accurate *** like liquid biopsy are emphasized for early *** medicine guides therapeutic strategies based on the molecular characteristics of the tumor,as evidenced in the molecular subtypes of breast *** allow personalized treatments,highlighting the role of trastuzumab and endocrine *** the benefits,challenges persist,including high costs,tumor heterogeneity,and ethical *** obstacles requires collaboration,ensuring that advances in molecular biology translate into accessible benefits for all.

关键词： Oncology Neoplasia Molecular biology Personalized medicine Molecular Markers Cancer

Mathematical modeling of nanodispersed hardening of FCC materials

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Acta Metallurgica Sinica(English Letters) 2018年第12期31卷 1297-1304页

作者： oleg Matvienko Olga Daneyko Tatyana Kovalevskaya National Research Tomsk State University TomskRussia 634050 Tomsk State University of Architecture and Building TomskRussia 634003

The plastic deformation of the pipe made of Cu-based alloy hardened by incoherent nanoparticles and subjected to theuniform internal pressure was investigated. The limits of elastic and plastic resistance are determined. The insignificantexcess in the limit of the elastic resistance enables the plastic deformation in the most part of the pipe wall. The densities ofshear-forming dislocations and prismatic dislocation loops are higher in alloys strengthened with coarse particles than inalloys strengthened with fine particles. At small distances between the strengthening particles, this effect is the mostpronounced.

关键词： Deformation Dislocation Dispersion-strengthening - Nanoparticles Hardening Stress Strain Elastic-plastic deformation Pipe

Structure,strength and superplasticity of ultrafine-grained 1570C aluminum alloy subjected to different thermomechanical processing routes based on severe plastic deformation

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Transactions of Nonferrous Metals Society of China 2021年第4期31卷 887-900页

作者： oleg SITDIKOV Elena AVTOKRATOVA Oksana LATYPOVA Michael MARKUSHEV Institute for Metals Superplasticity Problems Russian Academy of Science39 Khalturin str.Ufa 450001Russia

A comparative study of the structure and mechanical behavior of an Al-5 Mg-0.18 Mn-0.2 Sc-0.08 Zr-0.01 Fe-0.01 Si(wt.%)alloy ingot subjected to multidirectional isothermal forging(MIF)to a strain of 12 or equal-channel angular pressing(ECAP)to a strain of 10 at 325℃,and subsequent warm and cold rolling(WR and CR)at 325 and 20℃,was *** results showed that the MIF process of ultrafine-grained structure with a(sub)grain size dUFG=2μm resulted in enhanced room-temperature ductility and superplastic elongation up to 2800%.Further grain refinement under WR as well as development of a heavily-deformed microstructure with high dislocation density by subsequent CR resulted in a yield/ultimate tensile strength increase from 235/360 MPa after MIF to 315/460 and 400/515 MPa after WR and CR,***,WR led to improved superplastic elongation up to 4000%,while after CR the elongation remained sufficiently high(up to 1500%).Compared with MIF,ECAP resulted in more profound grain refinement(dUFG=1μm),which promoted higher strength and superplastic ***,this effect smoothed down upon WR,ensuring equal properties of the processed *** of the ECAPed alloy,in contrast,led to higher strengthening and slightly better superplastic behavior than those after CR following MIF.

关键词： aluminum alloy severe plastic deformation rolling grain refinement mechanical properties

2024 aluminum alloy ultrahigh-strength sheet due to two-level nanostructuring under cryorolling and heat treatment

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Transactions of Nonferrous Metals Society of China 2020年第1期30卷 14-26页

作者： Stanislav KRYMSKIY oleg SITDIKOV Elena AVTOKRATOVA Michael MARKUSHEV Institute for Metals Superplasticity Problems Russian Academy of Sciences39 Khalturin str.Ufa 450001Russia

The effect of rolling to a total effective strain of 2 at the liquid nitrogen temperature and subsequent natural and artificial aging on the structure and service properties of the pre-quenched hot-pressed 2024 aluminum alloy was *** optical and electron microscopy,and X-ray analysis,it was found that the cryorolling did not qualitatively change the type of the initial coarse-fibered microstructure,but produced a well-developed nanocell substructure inside *** aging led to decomposition of the preliminary supersaturated and work-hardened aluminum solid solution and precipitation of strengthening phases in the statically recovered and/or recrystallized *** a result,the rolled and naturally aged alloy demonstrated the yield and ultimate tensile strengths(YS=590 MPa,UTS=640 MPа)much higher than those in the pressed andТ6-heat treated alloy at equal elongation to failure(El^6%).Artificial aging at a temperature less than conventional T6 route could provide the extra alloy strengthening and the unique balance of mechanical properties,involving enhanced strength(YS=610 MPa,UTS=665 MPа)and ductility(El^10%),and good static crack resistance(the specific works for crack formation and growth were 42 and 18 k J/m^2,respectively)and corrosion resistance(the intensity and depth of intercrystalline corrosion were 23%and 50μm,respectively).

关键词： aluminum alloy cryogenic rolling heat treatment nanostructure mechanical behavior intergranular corrosion

Development and prospects of the fire space monitoring system in Kazakhstan

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Frontiers of Earth Science 2012年第3期6卷 276-282页

作者： Lev SPIVAK oleg ARKHIPKIN Gulshat SAGATDINOVA Space Research Institute National Center of Space Research and Technology Shevchenko Almaty 050010 Kazakhstan

This article provides a brief description of the fire space monitoring system in Kazakhstan, including the GIS-technology incorporated in its structure. The system performs operative space monitoring of fire areas and burnt areas, mapping of large fire areas, analysis of seasonal and long-term dynamics of burnt areas, and estimation of fire risk zones. Examples of output information obtained from space monitoring of fires are given. Possible directions of development of fire space monitoring in Kazakhstan are specified.

关键词： space images remote sensing fire space monitoring fire areas burnt areas operating mapping,zones of high fire risk

Variable binaries and variables in binaries in the Binary star DataBase

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Research in Astronomy and Astrophysics 2019年第3期19卷 7-12页

作者： Dana Kovaleva oleg Malkov Pavel Kaygorodov Institute of Astronomy Russian Academy of Sciences

The Binary star DataBase(BDB, http://***) combines data from catalogs of binary and multiple stars of all observational types. There is a number of ways for variable stars to form or to be a part of binary or multiple... 详细信息

关键词： astronomical data bases-stars binaries general-stars variables general

STABILIZED BARZILAI-BORWEIN METHOD

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Journal of Computational Mathematics 2019年第6期37卷 916-936页

作者： oleg Burdakov Yuhong Dai Na Huang Department of Mathematics Linkoping UniversityLinkopingSweden LSEC ICMSECAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China Department of Applied Mathematics College of ScienceChina Agricultural UniversityBeijing 100083China

The Barzilai-Borwein(BB)method is a popular and efficient tool for solving large-scale unconstrained optimization *** search direction is the same as for the steepest descent(Cauchy)method,but its stepsize rule is *** to this,it converges much faster than the Cauchy method.A feature of the BB method is that it may generate too long steps,which throw the iterates too far away from the ***,it may not converge,even when the objective function is strongly *** this paper,a stabilization technique is *** consists in bounding the distance between each pair of successive iterates,which often allows for decreasing the number of BB *** the BB met hod does not converge,our simple modification of this method makes it *** strongly convex functions with Lipsch计s gradients,we prove its global convergence,despite the fact that no line search is involved,and only gradient values are *** the number of stabilization steps is proved to be finite,the stabilized version inherits the fast local convergence of the BB met *** presented results of extensive numerical experiments show that our stabilization technique often allows the BB method to solve problems in a fewer计erations,or even to solve problems where the latter fails.

关键词： Unconstrained optimization Spectral algorithms Stabilization Convergence analysis.

Forecast of the key parameters of the 24-th solar cycle

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Research in Astronomy and Astrophysics 2010年第9期10卷 935-942页

作者： oleg Vasilievich Chumak Tatiana Viktorovna Matveychuk Sternberg Astronomical Institute Moscow State University

To predict the key parameters of the solar cycle, a new method is proposed based on the empirical law describing the correlation between the maximum height of the preceding solar cycle and the entropy of the forthcoming one. The entropy of the forthcoming cycle may be estimated using this empirical law, if the maximum height of the current cycle is known. The cycle entropy is shown to correlate well with the cycle＇s maximum height and, as a consequence, the height of the forthcoming maximum can be estimated. In turn, the correlation found between the height of the maximum and the duration of the ascending branch （the Waldmeier rule） allows the epoch of the maximum, Tmax, to be estimated, if the date of the minimum is known. Moreover, using the law discovered, one can find out the analogous cycles which are similar to the cycle being forecasted, and hence, obtain the synoptic forecast of all main features of the forthcoming cycle. The estimates have shown the accuracy level of this technique to be 86%. The new regularities discovered are also interesting because they are fundamental in the theory of solar cycles and may provide new empirical data. The main parameters of the future solar cycle 24 are as follows： the height of the maximum is Wmax = 95±20, the duration of the ascending branch is Ta = 4.5±0.5 yr, the total cycle duration according to the synoptic forecast is 11.3 yr.

关键词： Sun solar activity -- Sun forecasts

Microstructure and thermoelectric properties of Bi1.9Lu0.1Te3 compound

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Rare Metals 2018年第8期37卷 642-649页

作者： Maxim Yaprintsev Roman Lyubushkin Oxana Soklakova oleg Ivanov Joint Research Centre Belgorod State University BelgorodRussian Federation 308015 Voronezh State Technical University VoronezhRussian Federation 394026

Effect of fabrication conditions on microstructure and thermoelectric properties of the ***3 compound was studied. Starting nanopowder with mean nanoparticle size of -37 nm was synthesized by a microwave-solvothermal method. In order to prepare samples with various micro-grained structures, the synthesized nanopowder was compacted by two methods. The first method is cold isostatic pressing with further high- temperature annealing, while the second method is spark plasma sintering at various temperatures of process （653 and 683 K）. It is found that mean grain size is equal to -290,-730 and -1160 nm for cold isostatically pressed and spark plasma sintered at 653 and 683 K samples, respectively. The micro-grained sample with maximum mean grain size shows the best thermoelectric properties. This sample is structurally inhomogeneous and has the lowest thermal conductivity and the specific electrical resistivity. Maximum dimensionless figure of merit for this sample is equal to -0.9 for temperature range of 450-500 K.

关键词： Bi1.9Lu0.1Te3 compound Spark plasmasintering Cold isostatic pressing Grain structure Thermoelectric properties