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Efficacy of the new therapeutic approach in curing malignant neoplasms on the model of human glioblastoma

Cancer Biology & Medicine 2021年第3期18卷 910-930页

作者： Evgeniya V.Dolgova oleg M.Andrushkevich Polina E.Kisaretova Anastasia s.Proskurina Genrikh s.Ritter Tatyana D.Dubatolova Margarita V.Romanenko oleg s.taranov Yaroslav R.Efremov Evgeniy L.Zavyalov Alexandr V.Romaschenko sergey V.Mishinov svetlana s.Kirikovich Evgeniy V.Levites Ekaterina A.Potter Alexandr A.Ostanin Elena R.Chernykh stanislav Yu.Roshchin Anatoliy V.Bervitskiy Galina I.Moysak Jamil A.Rzaev sergey s.Bogachev Institute of Cytology and Genetics sB RAs Novosibirsk 630090Russia A.I.Evdokimov Moscow state University of Medicine and Dentistry Moscow 127473Russia Institute of Molecular and Cellular Biology Novosibirsk 630090Russia Novosibirsk state University Novosibirsk 630090Russia The state Research Center of Virology and Biotechnology"Vector" KoltsovoNovosibirsk 630559Russia First Department of Neurosurgery Ya.L.Tsivian Novosibirsk Research Institute of Traumatology and OrthopaedicsNovosibirsk 630091Russia Institute of Fundamental and Clinical immunology Novosibirsk 630099Russia sklifosovsky Research Institute of Emergency Medicine Moscow 129010Russia Federal Center of Neurosurgery Novosibirsk 630048Russia

Objective:Glioma is a highly invasive tumor,frequently disposed in essential areas of the brain,which makes its surgical excision extremely difficult;meanwhile adjuvant therapy remains quite ***:In the current report,a new therapeutic approach in curing malignant neoplasms has been performed on the U87 human glioblastoma *** approach,termed"Karanahan",is aimed at the eradication of cancer stem cells(CsCs),which were recently shown to be capable of internalizing fragments of extracellular double-stranded *** being internalized,these fragments interfere in the process of repairing interstrand cross-links caused by exposure to appropriate cytostatics,and such an interference results either in elimination of CsCs or in the loss of their tumorigenic *** of the approach requires a scheduled administration of cytostatic and complex composite double-stranded DNA ***:U87 cells treated in vitro in accordance with the Karanahan approach completely lost their tumorigenicity and produced no grafts upon intracerebral transplantation into immunodeficient *** sCID mice with developed subcutaneous grafts,the treatment resulted in reliable slowing down of tumor growth rate(Psplantation of U87 cells followed by surgical excision of the developed graft and subsequent therapeutic treatment,the Karanahan approach was shown to reliably slow down the tumor growth rate and increase the median survival of the mice twofold relative to the ***:The effectiveness of the Karanahan approach has been demonstrated both in vitro and in vivo in treating developed subcutaneous grafts as well as orthotopic grafts after surgical excision of the tumor.

关键词： Glioblastoma U87 cell line mytomycin C cancer stem cells TAMRA

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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

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Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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Co-controlling CO2 and NOx emission in China's cement industry:An optimal development pathway study

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Advances in Climate Change Research 2018年第1期9卷 34-42页

作者： FENG Xiang-Zhao oleg LUGOVOY QIN Hu Policy Research Centre for Environment and Economy of the Ministry of Environmental Protection Beijing 100029China Environmental Defense Fund Washington DC 20009USA Environmental Defense Fund Beijing 100007China

It is of important practical significance to reduce NOx emission and CO2 emission in China's cement *** paper firstly identifies key factors that influence China's future cement demand,and then uses the Gompertz model to project China's future cement demand and ***,the multi-pollutant abatement planning model(MAP)was developed based on the TIMEs model to analyze the co-benefits of CO2 and NOx control in China's cement *** modeling analysis,three scenarios such as basic as usual scenario(BAU),moderately low carbon scenario(MLC),and radically low carbon scenario(RLC),were built according to different policy constraints and emission control ***,the benefits of co-controlling NOx and CO2 emission in China's cement industry have been ***,this paper proposes a cost-efficient,green,and low carbon development roadmap for the Chinese cement sector,and puts forwards countermeasures as follows:first,different ministries should enhance communication and coordination about how to promote the co-control of NOx and CO2 in cement ***,co-control technology list should be issued timely for cement industry,and the R&D investment on new technologies and demonstration projects should be ***,the phase-out of old cement capacity needs to be continued at policy ***,it is important to scientifically evaluate the relevant environmental impact and adverse motivation of ammonia production by NOx removal requirement in cement industry.

关键词： Cement industry CO2 abatement NOx reduction Co-benefit analysis

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A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

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Carbon emission scenarios of China's power sector:Impact of controlling measures and carbon pricing mechanism

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Advances in Climate Change Research 2018年第1期9卷 27-33页

作者： LIU Qiang ZHENG Xiao-Qi ZHAO Xu-Chen CHEN Yi oleg LUGOVOY National Center for Climate Change strategy and International Cooperation Beijing 100038China school of Environment&Natural Resources of Renmin University of China Beijing 100872China Environmental Defense Fund China Program Beijing 100007China

The study constructs a low-carbon path analysis model of China's power sector based on TIMEs model and presents a comparative analysis of carbon emissions under Reference,Low-Carbon and Enhanced Low-Carbon scenarios,and the main difference of the three scenarios is manifested by policy selection and policy *** conclusions are drawn as follows:(1)The peak of carbon emission in China's power sector will range from 4.0 GtCO2 to 4.8 GtCO2,which implies an increment of 0.5e1.3 billion or 14%e35%from the 2015 levels.(2)Introducing carbon price is an effective way to inhibit coal power and promote non-fossil fuels and Carbon Capture,Utilization and storage applications(CCUs).The carbon emission reduction effects will gradually increase with carbon *** the carbon price attains to CN￥150 t1CO2,the CO2 emission can decrease by 36%than that without carbon price.(3)CCUs is one of important contributing factor to reduce CO2 emission in power *** speaking,the development of non-fossil fuels and energy efficiency improvement are two main drivers for carbon mitigation,but once the carbon price reaches up to CN￥106 t 1CO2,the CCUs will be required to equip with thermal power units and its contribution on carbon emission reduction will remarkably *** carbon price increases to CN￥150 t1CO2 in 2050,the application of CCUs will account for 44%of total emission reduction.(4)In the scenario with carbon price of CN￥150 t1CO2,power sector would be decarbonized significantly,and the CO2 intensity will be 0.22 kgCO2(kW h)1,but power sector is far from the goal that achieving net zero *** order to realize the long-term low greenhouse gas emission development goal that proposed by the Paris Agreement,more efforts are needed to be put to further reduce the carbon emission reduction of power *** on the above scenario analysis,the study proposes four recommendations on the low-carbon development of China's power sector:(1)improve the ene

关键词： Power sector TIMEs model scenario analysis Carbon peak Carbon pricing Policy recommendations

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The concept of sUAs/DL-based system for detecting and classifying abandoned small firearms

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Defence Technology（防务技术） 2023年第12期30卷 23-31页

作者： Jungmok Ma oleg A.Yakimenko Department of Defense science Korea National Defense University(KNDU)Republic of Korea Department of systems Engineering Naval Postgraduate School(NPS)USA

Military object detection and identification is a key capability in surveillance and *** is a major factor in warfare effectiveness and warfighter ***,portable,and rapidly deployable small unmanned aerial systems(s UAs)in conjunction with powerful deep learning(DL)based object detection models are expected to play an important role for this *** prove overall feasibility of this approach,this paper discusses some aspects of designing and testing of an automated detection system to locate and identify small firearms left at the training range or at the *** a system is envisioned to involve an s UAs equipped with a modern electro-optical(EO)sensor and relying on a trained convolutional neural network(CNN).Previous study by the authors devoted to finding projectiles on the ground revealed certain challenges such as small object size,changes in aspect ratio and image scale,motion blur,occlusion,and *** study attempts to deal with these challenges in a realistic operational scenario and go further by not only detecting different types of firearms but also classifying them into different *** study used a YOLOv2CNN(Res Net-50 backbone network)to train the model with ground truth data and demonstrated a high mean average precision(m AP)of 0.97 to detect and identify not only small pistols but also partially occluded rifles.

关键词： small firearms Object detection Deep learning small unmanned aerial systems

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Understanding activity of butyrate at a cellular level

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Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber

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