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Bioactive Steroid from the Root Bark of Psorospermum corymbiferum

中国天然药物 2011年第4期9卷 264-266页

作者： Zubair MF Oladosu IA olawore no Usman LA Fakunle CO Hamid AA Ali MS Department of Chemistry University of llorinNigeria Department of Chemistry University of IbadanNigeria Department of Chemistry Ladoke Akintola University of TechnologyOgbomoso Department of Chemistry Bowen UniversityIwoNigeria International Centre for Chemical and Biological Studies(ICCBS) Pakistan

AIM:To isolate,characterize and investigate the antifungal activity of the root bark of Psorospermum corymbiferum(Clusiaceae).METHODS:The finely ground root bark of Psorospermum corymbiferum was cold-extracted by percolation with 98% ethanol(5.0 L) for two *** ethanol extract was macerated with n-hexane,chloroform,ethylacetate and methanol successively to give the respective solvent *** of the extract was done using column chromatography on silica gel with cyclohexene:ethylacetate(1:1) as eluents,and the subfractions were purified by TLC using cyclohexane:ethylacetate(7:3).The structures were elucidated based on spectral analysis(IR,1H NMR and 13C NMR) in comparison with the data with those reported in the *** minimum inhibitory concentration(MIC) was determined on Candida alblican and Candida ***:Three known compounds,acetylvismione F,prenylated bianthrone and 1,8-dihydroxyanthraquinone and a steroid were isolated from the *** determined on Candida alblican and *** were 20 and 15 μ***-1,*** steroidal compound(diosgenin) was characterized for the first time from Psorospermum corymbiferum(Clusiaceae).CONCLUSION:The results suggested that the isolation has anticandidal properties,supporting the use of this plant in folk *** current drug of choice for disseminated Candidiasis is amphotericin B with MIC of 0.39 μ***-1,which could be a promising lead for a new antifungal drug especially if subjected to SAR in antifungal drug design.

关键词：生物活性化合物胆汁酸化学分析

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