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Place of Bone Scintigraphy in the Assessment of Extension and Follow-Up of Breast Cancer in Senegal: Study of 165 Cases in the Nuclear Medicine Department of Idrissa Pouye General Hospital (Dakar)

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Open Journal of Medical Imaging 2024年第1期14卷 10-30页

作者： El Hadji Amadou Lamine Bathily Mamoudou Salif Djigo Djimby Ba Gora Thiaw Ousseynou Diop Kalidou Gueye olatounde herbert fachinan Boucar Ndong Omar Ndoye Mamadou Mbodj Nuclear Medicine Department Idrissa Pouye General Hospital (HOGIP) Dakar Senegal Biophysics Laboratory FMPO UCAD Dakar Senegal Nuclear Medicine Department Hospital Dalal Jamm Dakar Senegal Nursing and Obstetrics Training Institute Parakou University Parakou Benin

Introduction: Breast cancer is the most common cancer in women worldwide, accounting for an estimated 22% of all female cancers. It is the leading cause of cancer mortality in women, almost all of which is due to metastases, with 73% of metastases occurring in the bone. In oncology, metastable technetium 99-labelled methylene bisphosphonate bone scintigraphy (BS) remains the standard examination for detecting and assessing the extent of bone metastases. The aim of this study was to assess the role of BS in the evaluation and follow-up of breast cancer in Senegal. Methodology: This was a retrospective study of breast cancer patients who underwent bone scintigraphy with 99mTc-HMDP in the nuclear medicine department of Idrissa Pouye General Hospital (IPGHO), from July 2009 to June 2022. Results: We enrolled 165 patients, mean age 46.79 years (27 - 87 years). BS was performed in 94.37% of cases for post-therapeutic monitoring and in 5.63% for pre-therapeutic assessment. Results were contributory in 131 patients (92.25%), of whom 72 cases (50.70%) were normal and 59 cases (41.55%) positive or presenting bone metastases;and non-contributory or doubtful in 11 cases (7.75%). Secondary bone locations were multiple in 57 cases (96.61%) and single or solitary in 2 cases (3.39%). The scintigraphic appearance of bone metastases was hyper-fixative in 58 cases (98.31%) and mixed in 1 case (1.69%). Bone lesions were quantified using the Soloway’s grading classification. Conclusion: BS with 99mTc-labelled bisphosphonates remains the examination of choice for skeletal exploration, in the detection and extension of bone metastases in breast cancer. Performance has been enhanced by the development of SPECT coupled with CT (SPECT-CT).

关键词： Breast Cancer Bone Scintigraphy 99mTc-HMDP Bone Metastases

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Contribution of Bone Scintigraphy in the Metastatic Extension Assessment of Prostate Cancer: A Study of 288 Cases in the Nuclear Medicine Department of Idrissa Pouye General Hospital, Dakar

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Open Journal of Biophysics 2024年第2期14卷 79-98页

作者： El Hadji Amadou Lamine Bathily Ousseynou Diop Mamoudou Salif Djigo Gora Thiaw Kalidou Gueye Mohamed Chekhma olatounde herbert fachinan Boucar Ndong Omar Ndoye Mamadou Mbodj Department of Nuclear Medicine Idrissa Pouye General Hospital (HOGIP) Dakar Senegal Biophysical Laboratory FMPO Cheikh Anta Diop University (UCAD) Dakar Senegal Department of Nuclear Medicine Hospital Dalal Jamm Dakar Senegal

Introduction: Prostate cancer is the most frequently diagnosed male malignancy and the fifth leading cause of cancer death in men worldwide. Since the advent of screening methods such as Prostate Specific Antigen (PSA) assay, digital rectal examination (DRE) and prostate biopsy, its incidence has increased significantly. The aim of our study was to analyse aspects of bone scintigraphy (BS) as part of the metastatic extension assessment of prostate cancer in Senegal. Patients and Methods: This was a retrospective descriptive and analytical study, running from January 1er 2022 to August 31 2023. Patients with histologically confirmed prostate cancer were included. Whole-body scans (WBS) were performed using a dual-head SPECT gamma camera (Mediso Nucline TM Spirit DH-V type), 3 hours after intravenous injection of 8 MBq/kg (555 to 740 MBq) of 99mTc-HMDP. Results: A total of 288 patients with a mean age of 68.37 ± 7.79 years were included. The median total PSA level was 97.6 ng/ml, with 144 patients having a level greater than or equal to 20 ng/ml. All patients had adenocarcinoma, and the Gleason score was available in 202 (70.13%) patients, 75.75% of whom had a score greater than or equal to 7. BS was contributory in 70.48% of cases, with 30.90% positive and 39.58% negative. The result was inconclusive in 85 patients (29.51%). The mean PSA for patients with a positive scan was 190.2 ng/ml and 40.6 ng/ml for those with a negative scan. Multiple metastatic lesions predominated (87.35% of cases). Metastatic lesions occurred preferentially in the axial skeleton, with a proportion of 68% versus 32% in the appendicular skeleton. Classification of bone metastases according to the SOLOWAY score revealed grade I (62.07%), grade II (35.63%) and grade IV (2.30%). Conclusion: In Senegal, prostate cancer is generally diagnosed in men of advanced age. The presence of bone metastases is frequent in its evolution, transforming a curable localized disease into a g

关键词： Prostate Cancer Bone Metastasis Bone Scintigraphy Senegal

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Contribution of Bone Scintigraphy in the Diagnosis of a Case of SAPHO in the Nuclear Medicine Department of Idrissa Pouye General Hospital (Dakar, Senegal)

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Open Journal of Medical Imaging 2024年第1期14卷 1-9页

作者： El Hadji Amadou Lamine Bathily Kalidou Gueye Serigne Moussa Badiane Mamoudou Salif Djigo Gora Thiaw Ousseynou Diop olatounde herbert fachinan Papa Mady Sy Alfonse Rodrigue Djiboune Kokou Fofo Toussaint Adambounou Louis Augustin Diaga Diouf Boucar Ndong Gora Mbaye Omar Ndoye Mounibé Diarra Mamadou Mbodj Nuclear Medicine Department Idrissa Pouye General Hospital (HOGIP) Dakar Senegal Biophysical Laboratory FMPO Cheikh Anta Diop University (UCAD) Dakar Senegal Biophysical Laboratory UFR2S Gaston Berger University (UGB) Saint-Louis Senegal Nuclear Medicine Department Hospital Dalal Jamm Dakar Senegal Laboratory of Physical and Pharmaceutical Biophysics FMPO Cheikh Anta Diop University Dakar Senegal Biophysical Laboratory University of Lome Lome Togo

Introduction: The acronym SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) is a syndrome combining osteoarticular and cutaneous manifestations. It occurs mainly between the ages of 30 and 50. Sternocostoclavicular hyperostosis is one of the main distinguishing features. We report a case of SAPHO in Dakar diagnosed by bone scintigraphy. Observation: 28-year-old Senegalese women presented with left shoulder pain and relative functional impotence for over 2 years. Examination revealed right sternoclavicular hyperostosis and left shoulder pain on palpation. Questioning revealed a history of acne and hyperostosis of the right first toe. Bone scintigraphy, performed after injection of 630 MBq of 99mTc-HMDP, revealed: hyperfixation of the bilateral (right++) manubrio-sternal and sternoclavicular junction, producing the classic bull’s horn image;hyperfixation of the left shoulder with an inflammatory appearance;hyperfixation of the sacroiliac joints suggestive of bilateral sacroiliitis;hyperfixation of the right first toe;two mandibular hyper fixations probably related to dental damage. This scintigraphic appearance in one was strongly suggestive of SAPHO syndrome. Conclusion: SAPHO syndrome, related to spondyloarthropathy, associates cutaneous and osteoarticular signs. It is characterized by frequent delays in diagnosis due to poor recognition. Soy is an invaluable diagnostic tool, enabling us to assess the extent of the disease and its evolution.

关键词： SAPHO Bone Scintigraphy Young Woman Senegalese

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Contribution of Bone Scintigraphy in the Metastatic Extension Assessment of Prostate Cancer: A Study of 288 Cases in the Nuclear Medicine Department of Idrissa Pouye General Hospital, Dakar

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Open Journal of Biophysics（生物物理学期刊） 2024年第2期 79页

作者： El Hadji Amadou Lamine Bathily Ousseynou Diop Mamoudou Salif Djigo Gora Thiaw Kalidou Gueye Mohamed Chekhma olatounde herbert fachinan Boucar Ndong Omar Ndoye Mamadou Mbodj

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Open Journal of Medical Imaging（医学影像期刊） 2024年第1期 10页

作者： El Hadji Amadou Lamine Bathily Mamoudou Salif Djigo Djimby Ba Gora Thiaw Ousseynou Diop Kalidou Gueye olatounde herbert fachinan Boucar Ndong Omar Ndoye Mamadou Mbodj

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Contribution of Bone Scintigraphy in the Diagnosis of a Case of SAPHO in the Nuclear Medicine Department of Idrissa Pouye General Hospital (Dakar, Senegal)

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Open Journal of Medical Imaging（医学影像期刊） 2024年第1期 1页

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Contribution of Scintigraphy in the Assessment of Extension of Osteophilic Cancers in Senegal from 2018 to 2021

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Open Journal of Biophysics 2023年第1期13卷 1-13页

作者： Olatoundé herbert fachinan El Hadji Lamine Bathily Mamadou Salif Djigo Gilles David Houndétoungan Djibrillou Moussa Issoufou Boucar Ndong Kuassi Marcellin Amoussou-Guénou Mamadou Mbodj Institut de Formation en Soins Infirmiers et Obstétricaux Université de Parakou Parakou Bénin Service de Médecine Nucléaire H&ocirc pital Général Idrissa Pouye Dakar Sénégal Laboratoire de Biophysique Médecine Nucléaire Université Cheikh Anta Diop Dakar Sénegal Unité D’Enseignement et de Recherche de Biophysique et Médecine Nucléaire Faculté des Sciences de Santé Université d’Abomey-Calavi Cotonou Bénin Département de Médecine Nucléaire Institut des Radio-Isotopes Niamey Niger

The aim of this study was to highlight the contribution of bone scintigraphy in the assessment of extension of osteophilic cancers in Senegal. This was a retrospective study, with a descriptive and analytical purpose, carried out over a period of four (04) years between January 01, 2018 and December 31, 2021. It focused on the files of patients who underwent bone scintigraphy for extension assessment of an osteophilic cancer during the study period. According to the study, prostate cancer was by far the most representative primary cancer (86.9%). Scintigraphy contributed in 75% of cases (362 cases) with 35% positive scintigraphy and 40% negative scintigraphy. The result was doubtful in 25% of cases (120 cases). The metastatic lesions were located preferentially at the level of the axial skeleton and only one case was of an exclusive appendicular site. More than half of patients with metastases (70%) had a poor prognosis with the SOLOWAY score greater than or equal to II. With the improvement of the nuclear imaging technical platform in Senegal (performance of SPECT/CT examinations), doubtful cases in our sample could be better explored with the advantage of adequate patient care.

关键词： Bone Scintigraphy Osteophilic Cancers Bone Metastases

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Inventory of Radiation Protection in Hospitals of Level III in Senegal

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Open Journal of Biophysics 2021年第4期11卷 397-406页

作者： Boucar Ndong Sidi Ahmed Dia Mamadou Salif Djigo herbert fachinan El Hadji Lamine Bathily Ousseynou Diop Kanta Ka Gérard Léra Kelvin Akpo El Hadji Fallou Diouf Louis Auguinstin Diaga Diouf Pape Mady Sy Alphonse Djiboune Gora Mbaye Maguette Diagne Omar Ndoye Mamadou Mbodji Laboratoire de Biophysique Médecine Nucléaire Universite Cheikh Anta Diop Dakar Senegal Service de Médecine du Travail Universite Cheikh Anta Diop Dakar Senegal Faculté de Médecine Université de Parakou Parakou Benin Service de Radiothérapie de Dalal Jamm Dakar Senegal Service de Radiologie de l’Hô pital Aristide Le Dantec Dakar Senegal Laboratoire de Physique Pharmaceutique Universite Cheikh Anta Diop Dakar Senegal Service de Radiothérapie de l’Hô pital Aristide Le Dantec Dakar Senegal

The aim of this study was to evaluate the level of protection of employees who are exposed to radiation in a level III hospital establishment. It was a descriptive cross-sectional survey of six months’ duration, involving eight level III Hospitals (Aristide Le Dantec, Fann, Hoggy, Hear, Abass Ndao, Pikine, Touba, and Thiès) in Senegal. Sixty-one of the one hundred questionnaires were recovered (overall response rate of 61%). The population of the study was mainly female (54.1%). The average age was 38.57 with extremes ranging from 23 to 65 years old. In the places where ionizing radiation sources are handled, only at the Aristide Le Dantec Hospital did we find a “competent person in radiation protection”. This explained the lack of a classification of employees and work areas. Forty out of sixty-one (73.77%) had no knowledge of the basic principles of radiation protection (justification, optimisation, dose limitation) and had not ever taken radiation holidays. For radiovigilance, exposure time limits to ionizing radiation concerned only 29/61 or 47.54% of the study population. The inverse square law of distance was known by only 40 workers, of whom 15 had no compliance. We found the presence of dosifilms in only 7/61 or 11.47% of the workers. On the other hand, the use of lead aprons was well established and concerned 57/61 workers, i.e., 93.44%. In sum, ionizing radiation causes adverse health effects. The absence of a good radiation protection culture in Senegal requires the presence of at least 4 to 5 competent persons in radiation protection for quality training of workers in radiobiology, radiopathology and radiation protection.

关键词： Ionizing Radiation Radiation Protection Workers Senegal

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Contribution of Scintigraphy in the Assessment of Extension of Osteophilic Cancers in Senegal from 2018 to 2021

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Open Journal of Biophysics（生物物理学期刊） 2023年第1期

作者： Olatoundé herbert fachinan El Hadji Lamine Bathily Mamadou Salif Djigo Gilles David Houndétoungan Djibrillou Moussa Issoufou Boucar Ndong Kuassi Marcellin Amoussou-Guénou Mamadou Mbodj

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Inventory of Radiation Protection in Hospitals of Level III in Senegal

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Open Journal of Biophysics（生物物理学期刊） 2021年第4期

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