检索结果-南通市图书馆

Frequency of Monthly Ejaculation at Sexual Intercourse, DNA Fragmentation Index and Fertilization Rate among Sperm Donors and Fertility-Challenged Men in Sub-Saharan Africa: Paper 2

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Urology 2020年第3期10卷 60-78页

作者： Abayomi B. Ajayi Bamgboye M. Afolabi Victor D. Ajayi Ifeoluwa O. Oyetunji Adedamilola Atiba Seun Saanu Ayodeji T. adeoye Joy I. Ehichioya Ibukun I. Ayelehin Nordica Fertility Center Lagos Nigeria Health Environment and Development Foundation Lagos Nigeria

Introduction: Heterogenous sexual intercourse often produces a powerful orgasm that stimulates the pituitary function. Studies have suggested ejaculation frequency based on age. Materials and Methods: Semi-structured questionnaires were used to collect information from subjects. Semen samples were collected from sperm donors and sub-fertile men who presented for infertility challenges. Processing and analysis of semen samples were done according to World Health Organization (WHO) guidelines. Sperm deoxyribonucleic acid (DNA) fragmentation was evaluated using the Halosperm kit. Results: Among sperm donors, those aged χ2 = 0.09, P-value = 0.81, OR = 3.2, 95% CI: 0.23, 45.19) while among sub-fertile men those aged ≥40 years were approximately 2.3 times more likely to have very low frequency of MESI compared to aged χ2 = 2.11, P-value = 0.51, OR = 2.27, 95% CI: 0.74, 9.92). The frequency of all categories of MESI was highest among sub-fertile men aged χ2 = 0.03, P-value = 0.57, OR = 2.42, 95% CI: 0.41, 14.46). Sub-fertile men aged ≥40 with diastolic hypertension (≥90 mmHg) were approximately 6 times more likely to have a low (6 - 10) frequency of MESI compared to those aged χ2 = 1.97, P-value = 0.16, OR = 6.22, 95% CI: 0.69, 55.77). Overall mean fertilization rate was significantly higher (t-test = 2.44, P-value = 0.01) among sub-fertile men aged Conclusion: Cigarette smoking, more than alcohol consumption, appears to be a major factor that significantly affects the frequency of MESI among sub-fertile men in all age groups. Frequency of MESI negatively but insignificantly correlated with systolic blood pressure.

关键词： Monthly Ejaculation at Sexual Intercourse Systolic and Diastolic Blood Pressures DNA Fragmentation Index Fertilization Rates Social Habits Sub-Fertile Males Sub-Sahara Black Africans

Evaluation of Sperm DNA Fragmentation amongst Infertile Black Africans. A Nigerian Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Urology 2018年第11期8卷 297-316页

作者： Abayomi B. Ajayi Bamgboye M. Afolabi Victor D. Ajayi Ifeoluwa O. Oyetunji Adedamilola Atiba Seun Saanu Ayodeji T. adeoye Temilade E. Adeshida Joy Ehichioya Ibukun I. Ayelehin Nordica Fertility Center Lagos Nigeria Health Environment and Development Foundation Lagos Nigeria

Background: Male infertility is approaching an epidemic proportion. Almost 50% of all cases of infertility may be associated with a male factor. The diagnostic usefulness of sperm DNA integrity is now accessible as an additional tool to Seminal Fluid Analysis. Objective: To assess sperm DNA fragmentation index (SDFI) in male infertility and its relationship with obesity, alcohol consumption and cigarette smoking among infertile Nigerians. Patients and Methods: Patients who presented for infertility at three health facilities of Nordica Fertility Center in Lagos, Asaba and Abuja cities in Nigeria. STATA 13 was used for student’s t-test to compare the means of continuous variables among smokers and non-smokers and among alcohol consumers and non-consumers. Linear regression analysis was employed to assess the correlation between SDFI as dependent variable and some independent variables. Results: There was no significant difference in the SDFI of men aged −1.80, P-value = 0.04) than that of obese men (30.2%). Obese men were 2.12 times as likely to have SDFI ≥25% compared to normal weight men (χ2-2.16, P-value = 0.14, OR = 2.12, 95% CI: 0.77, 5.80). Mean SDFI of men who consume alcohol (37.1%) was significantly higher (t = −1.97, P-value = 0.03) than that of those who did not consume alcohol. Although Pearson’s correlation matrix (r) indicated that sperm DNA fragmentation index was positively correlated with history of infertility (r = 0.01), groin surgery (r = 0.04), mumps (r = 0.04) and sexually transmitted illness (r = 0.04), however the degree of correlation was not significant (P-value ≥ 0.5) in each case. Conclusion: This is the first report in Black Africa that describes a correlation between sperm DNA integrity, as measured by the halo test and age, BMI and alcohol consumption. Men with normal BMI were more likely to have excellent to good SDFI and hence good fertility potential. Data from this study indicate that the infertile men had significan

关键词： Sperm Fragmentation Index Obesity Alcohol Consumption Male Infertility Assisted Reproduction Technology Black Africans

Predicting Mortality and Functional Outcomes after Ischemic Stroke: External Validation of a Prognostic Model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Behavioral and Brain Science 2018年第10期8卷 587-597页

作者： Achala Vagal Heidi Sucharewv Christopher Lindsell Dawn Kleindorfer Kathleen Alwell Charles J. Moomaw Daniel Woo Matthew Flaherty Pooja Khatri Opeolu adeoye Simona Ferioli Jason Mackey Sharyl Martini Felipe De Los Rios La Rosa F. Brett Kissela Departments of Radiology University of Cincinnati Medical Center Cincinnati OH USA Department of Biostatistics and Epidemiology Cincinnati Children’s Hospital Cincinnati OH USA Department of Emergency Medicine University of Cincinnati Medical Center Department of Neurology Cincinnati OH USA University of Cincinnati Medical Center Cincinnati OH USA Department of Neurology Indiana University School of Medicine Indianapolis Indiana USA Baylor College of Medicine Baptist Health Neuroscience Center Miami Florida USA

Background: We previously developed predictive models for 3-month mortality and modified Rankin Score (mRS) after ischemic stroke. Aim: The aim was to test model validity for 3-month mortality and mRS after ischemic stroke in two independent data sets. Methods: Our derivation models used data from 451 subjects with ischemic stroke in 1999 enrolled in the Greater Cincinnati/Northern Kentucky Stroke Study (GCKNSS). We utilized two separate cohorts of ischemic strokes through GCKNSS (460 in 2005 and 504 in 2010) to assess external validity by utilizing measures of agreement between predicted and observed values, calibration, and discrimination using Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis. Results: The 3-month mortality model performed well in the validation datasets with an average prediction error (Brier score) of 0.045 for 2005 and 0.053 for 2010 and excellent discrimination with an area under the curve of 0.86 (95% CI: 0.79, 0.93) for 2005 and 0.84 (0.76, 0.92) for 2010. Predicted 3-month mRS also performed well in the validation datasets with R2 of 0.57 for 2005 and 0.50 for 2010 and a root mean square error of 0.85 for 2005 and 1.05 for 2010. Predicted mRS tended to be higher than actual in both validation datasets. Re-estimation of the model parameters for age and severe white matter hyperintensity in both 2005 and 2010, and for diabetes in 2005, improved predictive accuracy. Conclusions: Our previously developed stroke models performed well in two study periods, suggesting validity of the model predictions.

关键词： Ischaemic Stroke Epidemiology Stroke Leukoaraiosis African American Stroke Prevalence

Malaria Retinopathy among Under-Five Children with Severe and Uncomplicated Malaria in a Tertiary Health Institution in Southwest Nigeria: A Comparative Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Infectious Diseases 2023年第3期13卷 355-374页

作者： Olusoji Omotayo Olayinka Philip Olayele Abiodun Tolulope Opeoluwa Jegede Ifedayo Olabisi Fasoranti Qasim Olakunle Salau Abiodun John Kareem Juliet Nnenda Olayinka Evbenaye Stanley Obasohan Babatunde David Babalola adeoye Adeleke Ademuyiwa Foluwakemi Tope Ekogiawe Ikechukwu Sunday Abazu Emmanuel Olasunkanmi Babalola Department of Paediatrics Federal Medical Centre Owo Nigeria Department of Pharmacology Afe Babalola University Ado-Ekiti Nigeria

Introduction: Malaria retinopathy refers to retinal abnormalities unique to malaria resulting from prolonged parasitization by Plasmodium falciparum. Identifying these features and treating them promptly could prevent lethal complications of malaria. Therefore, this study was conducted to identify and compare retinal findings in severe and uncomplicated malaria. Methods: A cross-sectional study of 260 subjects was equally divided into two groups of severe and uncomplicated malaria. Direct ophthalmoscopy was done at recruitment for all subjects. Information on sociodemographics, physical examination, nutritional status, and retinal abnormalities were recorded. A p-value Results: There were 141 (54.2%) males and 70 (26.9%) aged between 13 - 24 months. Severe anaemia, multiple convulsions, prostration, and cerebral malaria were the predominant forms of severe malaria. Twenty-three (17.7%) subjects with severe malaria and none with uncomplicated malaria had retinopathy. Retinal whitening (17.7%), vessel changes (16.2%), and retinal haemorrhages (5.4%) were the major forms of retinopathy. Retinopathy occurred in 43.8% of those with cerebral malaria. Retinal whitening and vessel changes were significantly associated with multiple convulsions, cerebral malaria, and metabolic acidosis;retinal haemorrhage was associated with cerebral malaria and haemoglobinuria (p = 0.022) and vessel changes with hypoglycaemia (p = 0.037). Cerebral malaria was an independent predictor of retinal whitening (p = 0.004) and vessel changes (p = 0.008) while haemoglobinuria was an independent predictor of retinal haemorrhages (p = 0.007). Conclusion: Ophthalmoscopy is an important examination in children with severe malaria which could assist in early detection and with prompt treatment, reduce morbidities and mortalities.

关键词： Children Malaria Nigeria Ophthalmoscopy Retinopathy

Prostate Specific Antigen Screening among Men in Abakaliki, South East Nigeria

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Urology 2017年第5期7卷 79-85页

作者： E. N. Afogu I. Sunday-adeoye K. C. Ekwedigwe M. E. Isikhuemen S. C. Okenwa S. A. Popoola M. O. Eliboh I. C. Amamilo Urology Unit Department of Surgery Federal Teaching Hospital Abakaliki Nigeria National Obstetric Fistula Centre Abakaliki Nigeria

Background: Prostate cancer is the most common type of cancer among Nigerian men. Prostate specific antigen (PSA) is produced by the prostate gland and it is an important tumor marker in the screening and diagnosis of prostate cancer because the latter is often associated with elevated PSA levels. The aim of this study was to evaluate the profile and PSA levels of men presenting for prostate cancer screening at the National Obstetric Fistula Centre, Abakaliki, Nigeria. Methods: This was a retrospective study of 103 patients who were seen between January 2014 and December 2015 and screened for prostate cancer using PSA assay. Data was extracted from folders of patients using a proforma and analysed using the Statistical Package for Social Sciences (SPSS), version 21. Result: Out of the 103 clients studied, 67 (65%) were between the ages of 40 and 59 years. The mean age was 54.38 ± 12.5 years. Eighty-one (78.6%) of the study population had PSA levels 4 ng/ml and below, 5 (4.9%) had PSA levels of 4.1 - 10 ng/ml, while 17 (16.5%) had PSA levels > 10 ng/ml. The mean PSA was 4.75 ± 8.2 ng/ml. None of the patients with family history of cancer had PSA levels of >4 ng/ml. Those who were positive for HIV also had normal PSA results. Conclusion: The findings from this study showed that the prevalence of men with raised PSA (>4 ng/ml) was high (21.4%) especially in the 60 - 69 years age group. There is need to increase prostate cancer screening using PSA in our setting. The use of other parameters such as digital rectal examination, PSA density, PSA velocity and free PSA will be helpful to determine the need for histological diagnosis in these patients.

关键词： Prostate Cancer PSA Screening

Enterovesical Fistula Complicating Myomectomy: A Case Report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Urology 2017年第4期7卷 75-78页

作者： K. C. Ekwedigwe I. Sunday-adeoye S. Lengman M. E. Isikhuemen A. B. C. Daniyan E. N. Yakubu M. O. Eliboh I. E. A. Uguru National Obstetric Fistula Centre Abakaliki Nigeria

Background: Enterovesical fistula is an abnormal communication between the bladder and the gastrointestinal tract. It is an uncommon type of genital fistula, occasionally complicating pelvic surgeries. However, it is the most common type of fistula associated with diverticular disease of the colon. Other causes include cancer, trauma and iatrogenic injuries. Pneumaturia and fecaluria usually implies enterovesical fistula. Enterovesical fistula complicating myomectomy is an uncommon finding. Our aim is to report a case of enterovesical fistula following myomectomy. Case presentation: She is a 33-year-old nullipara who presented at the National Obstetric Fistula Centre, Abakaliki, Ebonyi State, South-Eastern Nigeria with a history of fecaluria, pneumaturia and haematochezia which started after myomectomy. Feculent fluid was obtained on urethral catheterization. Cystography was suggestive of enterovesical fistula. Conclusion: Enterovesical fistula is a possible complication of myomectomy. A high index of suspicion for this rare but potentially devastating condition is important for early diagnosis and appropriate management.

关键词： Enterovesical Fistula Myomectomy Uterine Fibroid

Vesicocutaneous Fistula: A Rare Complication of Pelvic Trauma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Obstetrics and Gynecology 2017年第2期7卷 245-249页

作者： I. Sunday-adeoye K. C. Ekwedigwe K. Waaldijk A. B. C. Daniyan M. E. Isikhuemen M. O. Eliboh S. M. Uguru S. C. Okenwa National Obstetric Fistula Centre Abakaliki Nigeria

Background: Vesicocutaneous fistula is a rare type of urinary fistula. It is often distressing and may negatively impact on the quality of life of an affected person. Our aim in this case report is to document a case of vesicocutaneous fistula following pelvic trauma from road traffic accident and share our experience in the management of this condition. Case Report: We report the case of a 30 year-old primipara who had urinary incontinence following pelvic trauma sustained from road traffic accident. Examination findings were in keeping with vesicocutaneous fistula. She subsequently had surgical repair of vesicocutaneous fistula which was successful. Conclusion: This case report highlights pelvic trauma as one of the causes of urinary fistula and the key role of surgery in its management.

关键词： Vesicocutaneous Fistula Pelvic Trauma Road Traffic Accident Bladder

急性脑卒中患者静脉内对比剂使用与急性肾脏疾病的关联:基于人群的研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华高血压杂志 2017年第3期25卷 231-231页

作者：刘莉叶鹏 Demel SL Grossman AW Khoury JC Moomaw CJ Alwell K Kissela BM Woo D Flaherty ML Ferioli S Mackey J De Los Riosla Rosa F Martini S adeoye O Kleindorfer DO

计算机断层血管造影和常规血管造影为脑卒中患者提供即时的血管解剖学信息。然而，碘化对比剂可能引起急性肾损伤（acutekidneyinjury，AKI）。在一个大型、包括两个族裔的人群中，研究人员检查了脑卒中患者住院期间新发或恶化的肾脏病... 详细信息

计算机断层血管造影和常规血管造影为脑卒中患者提供即时的血管解剖学信息。然而，碘化对比剂可能引起急性肾损伤（acutekidneyinjury，AKI）。在一个大型、包括两个族裔的人群中，研究人员检查了脑卒中患者住院期间新发或恶化的肾脏病的发病率，及其与静脉内给对比剂的相关性。方法：纳入大辛辛那提／北肯塔基州2010年急诊住院的急性缺血性脑卒中或脑出血的所有成年居民。在确定接受或未接受静脉注射对比剂的两组患者中，确定急诊问诊时未察觉到的肾脏疾病的发生率及人院后AKI发生率。

关键词：静脉内对比剂脑卒中患者急性肾损伤肾脏疾病人群计算机断层血管造影急性缺血性脑卒中常规血管造影

2018年急性缺血性卒中患者早期管理指南美国心脏协会／美国卒中协会为医疗专业人员制定的指南

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

国际脑血管病杂志 2018年第2期26卷 81-113页

作者： William J. Powers Alejandro A. Rabinstein Teri Ackerson Opeolu M. adeoye Nicholas C. Bambakidis Kyra Becker José Biller Michael Brown Bart M. Demaerschalk Brian Hoh Edward C. Jauch Chelsea S. Kidwell Thabele M. Leslie-Mazwi Bruce Ovbiagele Phillip A. Scott Kevin N. Sheth Andrew M. Southerland Deborah V. Summers David L. Tirschwell 徐加平刘慧慧张霞石际俊黄志超尤寿江郭志良肖国栋杜万良曹勇军美国心脏协会卒中委员会苏州大学附属第二医院 215004 首都医科大学附属北京天坛医院北京100050

背景和目的本指南旨在在单个文件中为治疗成年急性动脉性缺血性卒中患者的临床医生提供最新全面的系列推荐意见。目标读者为院前急救人员、医生、综合医疗保健人员和医院管理人员。本指南将取代2013年版指南及其后续更新。方法写作组成... 详细信息

背景和目的本指南旨在在单个文件中为治疗成年急性动脉性缺血性卒中患者的临床医生提供最新全面的系列推荐意见。目标读者为院前急救人员、医生、综合医疗保健人员和医院管理人员。本指南将取代2013年版指南及其后续更新。方法写作组成员由美国心脏协会卒中委员会的科学声明监督委员任命，代表各领域的医学专家。严格遵循美国心脏协会的利益冲突原则。不允许写作组成员对存在企业利益关系的相关议题进行讨论或投票。所有推荐意见必须得到写作组成员的一致通过，除非企业利益关系妨碍了成员投票。由4名同行评议专家以及卒中委员会的科学声明监督委员会和领导委员会成员对指南草案进行发布前评审。本指南采用了美国心脏病学学会／美国心脏协会2015年推荐意见分类和证据级别标准以及新版美国心脏协会指南格式。结果本指南详细介绍了院前医疗、紧急和急诊评估、静脉和血管内治疗以及院内管理，包括在发病后最初2周内启用的二级预防措施。本指南支持院前和院内卒中医疗系统的一体化概念。结论本指南基于目前可获得的最佳证据。然而，许多情况资料有限，迫切需要对急性缺血性卒中的治疗进行持续研究。

关键词： AHA科学声明二级预防卒中治疗