检索结果-南通市图书馆

PE-UHMW/PE-HD/CNTs摩擦复合材料的制备及其摩擦学研究

在线全文

学校读者我要写书评

暂无评论

中国塑料 2006年第2期20卷 16-20页

作者：薛扬 olaf Jacobs 吴唯华东理工大学材料科学与工程学院上海200237 Lübeck University of Applied Sciences 华东理工大学石油化工学院上海201512

主要研究了超高相对分子质量聚乙烯和高密度聚乙烯以及纳米碳管复合材料的制备工艺及其抗磨损性能, 并系统地研究了复合材料中纳米碳管的质量份数、预处理方法以及摩擦对偶材料对复合材料摩擦性能的影响。结果表明,高密度聚乙烯的加入... 详细信息

主要研究了超高相对分子质量聚乙烯和高密度聚乙烯以及纳米碳管复合材料的制备工艺及其抗磨损性能, 并系统地研究了复合材料中纳米碳管的质量份数、预处理方法以及摩擦对偶材料对复合材料摩擦性能的影响。结果表明,高密度聚乙烯的加入可以提高复合材料的流动性能;纳米碳管可以显著提高复合材料的抗磨损性能,其比磨损率随纳米碳管质量份数的增加而减小;对偶材料100Cr6对复合材料的比磨损率大于X5CrNi18-10;纳米碳管可以分散在复合材料中,但团聚现象仍然存在。

关键词：超高相对分子质量聚乙烯纳米碳管高密度聚乙烯磨损

Supplementation of a lacto-fermented rapeseed-seaweed blend promotes gut microbial-and gut immune-modulation in weaner piglets

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2022年第1期13卷 138-151页

作者： Yan Hui Paulina Tamez-Hidalgo Tomasz Cieplak Gizaw Dabessa Satessa Witold Kot Søren Kjærulff Mette olaf Nielsen Dennis Sandris Nielsen Lukasz Krych Department of Food Science Faculty of ScienceUniversity of CopenhagenRolighedsvej 26DK-1958 Frederiksberg CDenmark Fermentationexperts A/S.Vorbassevej 12 DK-6622 BaekkeDenmark Department of Veterinary and Animal Sciences Faculty of Health and Medical SciencesUniversity of CopenhagenGrønnegårdsvej 3DK-1870 Frederiksberg CDenmark Department of Plant and Environmental Sciences Faculty of ScienceUniversity of CopenhagenRolighedsvej 26DK-1958 Frederiksberg CDenmark Department of Animal Science Faculty of Technical SciencesAarhus UniversityBlichers Alle 20DK-8830 TjeleDenmark

Background:The direct use of medical zinc oxide in feed will be abandoned after 2022 in Europe,leaving an urgent need for substitutes to prevent post-weaning ***:This study investigated the effect of using rapeseed-seaweed blend(rapeseed meal added two brown macroalgae species Ascophylum nodosum and Saccharina latissima)fermented by lactobacilli(FRS)as feed ingredients in piglet *** d 28 of life to d 85,the piglets were fed one of three different feeding regimens(n=230 each)with inclusion of 0%,2.5% and 5% *** this period,no significant difference of piglet performance was found among the three *** a subset of piglets(n=10 from each treatment),blood samples for hematology,biochemistry and immunoglobulin analysis,colon digesta for microbiome analysis,and jejunum and colon tissues for histopathological analyses were *** piglets fed with 2.5% FRS manifested alleviated intraepithelial and stromal lymphocytes infiltration in the gut,enhanced colon mucosa barrier relative to the 0% FRS *** colon microbiota composition was determined using V3 and V1-V8 region 16S rRNA gene amplicon sequencing by Illumina NextSeq and Oxford Nanopore MinION,*** two amplicon sequencing strategies showed high consistency between the detected *** sequencing strategies indicated that inclusion of FRS reshaped the colon microbiome of weaned piglets with increased Shannon *** stercorea was verified by both methods to be more abundant in the piglets supplied with FRS feed,and its abundance was positively correlated with colonic mucosa thickness but negatively correlated with blood concentrations of leucocytes and ***:FRS supplementation relieved the gut lymphocyte infiltration of the weaned piglets,improved the colon mucosa barrier with altered microbiota *** the dietary inclusion of FRS from 2.5% to 5% did not lead to further improvements.

关键词： Amplicon sequencing Colon microbiota Fermented feed Gut barrier

Insights into erlotinib action in pancreatic cancer cells using a combined experimental and mathematical approach

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第43期18卷 6226-6234页

作者： Falko Lange Katja Rateitschak Christina Kossow olaf Wolkenhauer Robert Jaster Department of Systems Biology and Bioinformatics University of Rostock 18057 Rostock Germany Department of Medicine Ⅱ Division of Gastroenterology University Medicine Rostock 18057 Rostock Germany Stellenbosch Institute for Advanced Study Wallenberg Research Centre at Stellenbosch University Stellenbosch 7600 South Africa

AIM:To gain insights into the molecular action of erlotinib in pancreatic cancer (PC) cells. METHODS:Two PC cell lines, BxPC-3 and Capan-1, were treated with various concentrations of erlotinib, the specific mitogen-activated protein kinase kinase (MEK) inhibitor U0126, and protein kinase B (AKT) inhibitor XIV. DNA synthesis was measured by 5-bromo-2'-deoxyuridine (BrdU) assays. Expression and phosphorylation of the epidermal growth factor receptor (EGFR) and downstream signaling molecules were quantified by Western blot analysis. The data were processed to calibrate a mathematical model, based on ordinary differential equations, describing the EGFRmediated signal transduction. RESULTS:Erlotinib significantly inhibited BrdU incorporation in BxPC-3 cells at a concentration of 1 mol/L, whereas Capan-1 cells were much more resistant. In both cell lines, MEK inhibitor U0126 and erlotinib attenuated DNA synthesis in a cumulative manner, whereas the AKT pathway-specific inhibitor did not enhance the effects of erlotinib. While basal phosphorylation of EGFR and extracellular signal-regulated kinase (ERK) did not differ much between the two cell lines, BxPC-3 cells displayed a more than five-times higher basal phospho-AKT level than Capan-1 cells. Epidermal growth factor (EGF) at 10 ng/mL induced the phosphorylation of EGFR, AKT and ERK in both cell lines with similar kinetics. In BxPC-3 cells, higher levels of phospho-AKT and phospho-ERK (normalized to the total protein levels) were observed. Independent of the cell line, erlotinib efficiently inhibited phosphorylation of EGFR, AKT and ERK. The mathematical model successfully simulated the experimental findings and provided predictions regarding phosphoprotein levels that could be verified experimentally. CONCLUSION:Our data suggest basal AKT phosphorylation and the degree of EGF-induced activation of AKT and ERK as molecular determinants of erlotinib efficiency in PC cells.

关键词： Erlotinib Pancreatic cancer Epidermal growth factor receptor Signal transduction Mathematical modeling

Effective Management of Own Funds in Polish Cooperative Banks

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Business Review 2014年第3期13卷 154-161页

作者： Rafal Balina olaf Kowalski Jerzy Rozynski Warsaw University of Life Sciences - SGGW Warsaw Poland

Today cooperative banks belong to the most significant financial institution in the world. Moreover, they can compete with commercial banks. The own funds of the cooperative bank are important in their activity. The main goal of this paper is to investigate how much the level of the own funds of the Polish cooperative banks influenced their efficiency. The research pertained to operating cooperative banks in Poland. The following measures of the efficiency were used in the research： return on Equity （ROE）, net profit, index C/I, and financial margin. The results of the study indicate that banks from the Quartile III （highest aggregate own funds）, had the highest net profits, the highest ROE, the lowest C/I value, the lowest ROE, and the lowest financial markups. On this basis, it remains to be recommended that banks of highest aggregate own funds continue expansion of own funds which will increase lending capacity and subsequently contribute to higher effectiveness.

关键词： cooperative bank own funds effectiveness

Does granulocyte-colony stimulating factor administration induce damage or repair response in schistosomiasis?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2010年第12期2卷 434-441页

作者： Lobna Y Ghanem Uta Dahmen olaf Dirsch Mona MF Nosseir Soheir S Mahmoud Wafaa AF Mansour Department of Electron Microscope Theodor Bilharz Research Institute Department of General Visceral and Transplantation SurgeryUniversity Hospital Essen Division of Pathology German Heart Institute Department of Pathology Theodor Bilharz Research Institute Department of Parasitology Theodor Bilharz Research Institute Department of Immunology Theodor Bilharz Research Institute

AIM:To introduce Granulocyte-colony stimulating factor (G-CSF) as a new therapeutic modality for schistosomiasis through stem cell mobilization,immunomodulation or fibrosis remodeling. METHODS:In this study,a 5 d course of human recombinant G-CSF (100 μg/kg sc) was applied to Schis-tosoma mansoni-infected mice at different stages of disease (5 d before infection as well as 3,5 and 7 wk post-infection). The animals were sacrificed at 10 d as well as 4,6 and 8 wk post infection. Mice were examined for:(1) Total leukocyte count which is an accepted surrogate marker for the stem cell mobilization into the circulation; (2) Egg count in intestine and liver tissue to assess the parasitic load; and (3) Histopathological changes in Hx/E and Masson trichrome stained sections as well as collagen content in Sirius redstained liver sections to determine the severity of liver fibrosis. RESULTS:Mice developed leukocytosis. The egg load and the number of granulomas were not affected by the G-CSF treatment but there was an obvious change in the composition of granulomas towards an increased cellularity. Moreover,fibrosis was significantly decreased in treated groups compared to untreated animals (collagen content either preinfection or at 3 and 5 wk post infection:5.8 ± 0.5,4.7 ± 0.5,4.0 ± 0.7 vs 8.2 ± 0.9; P ≤ 0.01). CONCLUSION:Although G-CSF did not cause direct elimination of the parasite,it enhanced granulomatous reaction and reduced the fibrosis. Further investigation of the underlying mechanisms of these two actions is warranted.

关键词： Schistosomiasis Granulocyte-colony stimulating factor Periovular granuloma Fibrosis Immunomodulation Stem cell mobilization

Reactions with Aminobenzoic Acids via Diazonium Salts Open New Routes to Bio-Derived Aromatics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Organic Chemistry 2016年第2期6卷 95-99页

作者： Anthony Farlow Jens olaf Krömer School of Chemical and Molecular Biosciences The University of Queensland Brisbane Australia Instituto de Biociências Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) Botucatu Brazil Centre for Microbial Electrochemical Systems The University of Queensland Brisbane Australia Advanced Water Management Centre The University of Queensland Brisbane Australia

Aromatics have a broad application in our everyday life ranging from plastics, coatings and fibres, to food and pharmaceuticals. To date the bulk of these aromatics is derived from naphtha-based pet-rochemistry. However, recent progress in the fermentative production of metabolites using renew-able resources and engineered microbes has enabled the production of bio-precursors, such as 4-amino benzoic acid (pABA) and 2-amino benzoic acid (oABA). In this work we explored the feasibility of Sandmeyer reactions for the conversion of pABA to terephthalic and oABA salicylic acid, providing two very important platform chemicals for the chemical and pharmaceutical industries. We could demonstrate that both acids can be obtained from the amino benzoic acids derived from the shikimate pathway in microbes and plants. Good conversions could be achieved using Sandmeyer reactions at mild conditions with biodegradable reagents and without organic solvents.

关键词： Aminobenzoic Acid Terephthalic Acid Salycilic Acid Sandmeyer Cyanations

Effect of toasting grain silages from field peas(Pisum sativum)and field beans(Vicia faba)on in vitro gas production,methane production,and post-ruminal crude protein content

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Nutrition 2020年第3期6卷 342-352页

作者： Martin Bachmann Christian Kuhnitzsch Sebastian Michel Annabel Thierbach Mandy Bochnia Jorg M.Greef Siriwan D.Martens olaf Steinhofel Annette Zeyner Institute of Agricultural and Nutritional Sciences Martin Luther University Halle-WittenbergHalle(Saale)06120Germany Saxon State Office for Environment Agriculture and GeologyKollitsch04886Germany Julius Kühn Institute Federal Research Centre for Cultivated PlantsInstitute for Crop and Soil ScienceBraunschweig38116Germany

Legume grains such as field peas and field beans can be produced on a local level,and may be reliable sources of dietary protein and energy apart from common soybean and rapeseed *** ruminants,protein,starch,and carbohydrates from peas and field beans are fermented in large part before reaching the small *** objective of this study was to evaluate the effects of a combination of ensiling and hydro-thermic treatment(i.e.,toasting at 160℃for 30 min)of grains of peas and field beans on the concentrations of post-ruminal crude protein(PRCP)and rumen-undegraded protein(RUP).Moreover,24-h gas production and methane production were *** this,an in vitro batch culture system with ruminal fluid from sheep was ***-undegraded protein was determined using the Streptomyces griseus protease *** electron micrographs were used to visualize morphological changes of starch granules and their joint matrices in peas and field beans after ensiling,toasting,or a combination of *** pea grains contained crude protein(CP)at 199 g/kg DM,PRCP at 155 g/kg DM at a ruminal passage rate of 0.08/h(Kp8),RUP at 33 g/kg DM at Kp8,and starch at 530 g/kg *** field beans contained CP at 296 g/kg DM,PRCP at 212 g/kg DM at Kp8,RUP at 54 g of/kg DM at Kp8,and starch at 450 g/kg *** PRCP did not considerably differ among native and treated peas or field *** in the peas,RUP at Kp8 increased after ensiling by 10 g/kg DM(i.e.,30%;P<0.05).Toasting increased RUP(Kp8)in ensiled peas by another 28%(P<0.05).Toasting had no effect on PRCP or RUP when the peas or field beans were not ensiled *** and methane production were not affected by any treatment,and scanning electron micrographs did not reveal structural changes on the starches doubtless of any *** seemed to be more affected by treatment with ensiled+toasted peas than with ensiled+toasted field beans,but starches and other carbohydrates from both legumes remained unaffec

关键词： Legume grain silage Toasting In vitro gas production Protein evaluation Streptomyces griseus protease test

在线全文

学校读者我要写书评

暂无评论

基于优化随机森林回归模型的土壤盐渍化反演

地球信息科学学报 2021年第9期23卷 1662-1674页

作者：杨练兵陈春波郑宏伟罗格平尚白军 olaf Hellwich 中国科学院新疆生态与地理研究所荒漠与绿洲生态国家重点实验室乌鲁木齐830011 新疆维吾尔自治区遥感与地理信息系统应用重点实验室乌鲁木齐830011 中国科学院大学北京100049 中国科学院中亚生态与环境研究中心乌鲁木齐830011 德国柏林工业大学计算机视觉和遥感研究所柏林10623

当前应用于土壤盐分含量(Soil Salinity Content,SSC)反演的随机森林回归(Random Forests Regression,RFR)较少关注对模型精度影响较大的反演参数子集和模型参数的同步优化。本研究选择渭-库绿洲和奇台绿洲为实验区,基于Landsat-5 TM、S... 详细信息

当前应用于土壤盐分含量(Soil Salinity Content,SSC)反演的随机森林回归(Random Forests Regression,RFR)较少关注对模型精度影响较大的反演参数子集和模型参数的同步优化。本研究选择渭-库绿洲和奇台绿洲为实验区,基于Landsat-5 TM、SRTM、MOD11A2.006遥感数据构建反演参数。首先,利用弹性网络(Elastic Net,EN)筛选出反演参数子集,然后利用遗传算法(Genetic Algorithm,GA)和贝叶斯优化算法(Bayesian Optimization Algorithm,BOA)分别优化随机森林回归(Random Forests Regression,RFR)参数,建立反演参数子集和模型参数分步优化的RFR模型(EN-GA-RFR、EN-BOA-RFR)。建立利用GA和BOA分别同步优化反演参数子集和模型参数的RFR模型(GA-RFR、BOA-RFR)。在每个实验区,对比EN-GARFR、EN-BOA-RFR、GA-RFR、BOA-RFR的预测精度。最后分析每个实验区各类盐渍土的空间分布,并对2个实验区的反演参数进行对比分析。结果表明:每个实验区模型预测精度由高到低的排序均为BOA-RFR>GA-RFR>EN-BOA-RFR=EN-GARFR,整体上BOA的优化性能均好于GA;渭-库绿洲和奇台绿洲面积占比最大的盐渍土类型分别为盐渍土和中度盐渍土;反演参数对SSC的表征能力存在空间分异性。

关键词：土壤盐分含量同步优化随机森林回归贝叶斯优化算法遗传算法弹性网络反演参数子集模型参数

Thorium/uranium mixed oxide nanocrystals： Synthesis, structural characterization and magnetic properties

在线全文

学校读者我要写书评

暂无评论

Nano Research 2014年第1期7卷 119-131页

作者： Damien Hudry Jean-Christophe Griveau Christos Apostolidis olaf Walter Eric Colineau Gert Rasmussen Di wang Venkata Sai Kiran Chakravadhaluna Eglantine Courtois Christian Kubel Daniel Meyer European Commission: Joint Research Centre Institute for Transuranium Elements P. O. Box 2340 76125 Karlsruhe Germany Karlsruhe Institute of Technology Institute ofNanotechnology Hermann-von-Helmholtz-Platz1 76344 Eggenstein-Leopoldshafen Germany Karlsruhe Institute of Technology Karlsruhe Nano Micro Facility Hermann-von-Helmholtz-Platz 1 76344 Eggenstein-Leopoldshafen Germany Helmholtz Institute UIm for Electrochemical Energy Storage Albert-Einstein-Allee 11 89069 UIm Germany Institut de Chimie Separative de Marcoule UMR 5257 BP 1717 1 30207 Bagnols sur Ceze Cedex France Karlsruhe Institute of Technology Institute for Catalysis Research and Technology Hermann-von-Helmholtz-Platz 1 76344 Eggenstein Leopoldshafen Germany

One of the primary aims of the actinide community within nanoscience is to develop a good understanding similar to what is currently the case for stable elements. As a consequence, efficient, reliable and versatile synthesis techniques dedicated to the formation of new actinide-based nano-objects （e.g., nanocrystals） are necessary. Hence, a ＂library＂ dedicated to the preparation of various actinidebased nanoscale building blocks is currently being developed. Nanoscale building blocks with tunable sizes, shapes and compositions are of prime importance. So far, the non-aqueous synthesis method in highly coordinating organic media is the only approach which has demonstrated the capability to provide size and shape control of actinide-based nanocrystals （both for thorium and uranium, and recently extended to neptunium and plutonium）. In this paper, we demonstrate that the non-aqueous approach is also well adapted to control the chemical composition of the nanocrystals obtained when mixing two different actinides. Indeed, the controlled hot co-injection of thorium acetylacetonate and uranyl acetate （together with additional capping agents） into benzyl ether can be used to synthesize thorium/uranium mixed oxide nanocrystals covering the full compositional spectrum. Additionally, we found that both size and shape are modified as a function of the thorium：uranium ratio. Finally, the magnetic properties of the different thorium/uranium mixed oxide nanocrystals were investigated. Contrary to several reports, we did not observe any ferromagnetic behavior. As a consequence, ferromagnetism cannot be described as a universal feature of nanocrystals of non-magnetic oxides as recently claimed in the literature.

关键词： thorium uranium mixed oxide non-aqueous synthesis nanoparticle nanocrystal magnetism