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Aphrodisiac potentials of the aqueous extract of Fadogia agrestis(*** Hiern) stem in male albino rats

Asian Journal of Andrology 2005年第4期7卷 399-404,页

作者： M.T.Yakubu M.A.Akanji A.T.oladiji Medicinal Plants Research Laboratory Department of BiochemistryUniversity of IlorinPMB 1515IlorinNigeria

Aim： To evaluate the phytochemical constituents and the agrestis （Rubiaceae） stem in male albino rats. Methods： aphrodisiac potential of the aqueous extract of Fadogia The aqueous stem extract of the plant was screened for phytochemical constituents. Male rats were orally dosed with 18 mg/kg, 50 mg/kg and 100 mg/kg body weight, respectively, of the extract at 24 h intervals and their sexual behavior parameters and serum testosterone concentration were evaluated at days 1, 3 and 5. Results： Phytochemical screening revealed the presence of alkaloids and saponins while anthraquinones and flavonoids are weakly present. All the doses resulted in significant increase in mount frequency, intromission frequency and significantly prolonged the ejaculatory latency （P 〈 0.05） and reduced mount and intromission latency （P 〈 0.05）. There was also a significant increase in serum testosterone concentrations in all the groups in a manner suggestive of dose-dependence （P 〈 0.05）. Conclusion： The aqueous extract of Fadogia agrestis stem increased the blood testosterone concentrations and this may be the mechanism responsible for its aphrodisiac effects and various masculine behaviors. It may be used to modify impaired sexual functions in animals, especially those arising from hypotestosteronemia.

关键词： Fadogia agrestis aphrodisiacs sexual behavior testosterone erectile dysfunction

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Abortifacient Potential of Aqueous Extract of Senna alata Leaves in Rats

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Journal of Reproduction and Contraception 2010年第3期21卷 163-177页

作者： Yakubu MT Adeshina AO oladiji at Akanji MA Oloyede OB Jimoh GA Olatinwo AWO Afolayan AJ Phytomedicine ToxicologyReproductive and Developmental Biochemistry Research LaboratoryDepartment of BiochemistryUniversity of Ilorin Department of Obstetrics and Gynaecology University of Ilorin Centre for Phytomedicine Research Department of BotanyUniversity of Fort Hare

Objective To study the abortifacient activity of aqueous extract of Senna alata leaves in female Wistar *** Pregnant rats weighing 143.65 ± 13.11 g were completely randomized into 5 groups（A-E）.Rats in group A（negative control） were orally administered,once daily with 0.5 ml of distilled water on days 10-18 post-coitum while those in groups B,C,D,and E were treated exactly like the negative control except they received the same volume containing 2.85 mg/kg body weight of mifepristone（group B,reference drug）,250,500 and 1 000 mg/kg body weight of the extract respectively（groups C-E）.Results Phytochemical screening of the extract showed positive results for saponins（1.22%）,flavonoids（1.06%）,cardiac glycosides（0.20%）,cardenolides and dienolides（0.18%）,phenolics（0.44%） and alkaloids（0.52%）.Respiratory distress,salivation,diarrhoea,changes in the appearance of hair as well as maternal mortality were not observed at any time during the exposure period except in the mifepristone-treated animals where there was episode of diarrhoea and *** extract significantly reduced（P〈0.05） the number of life foetus,weight and survival ratio of the foetus,numbers of implantations and Corpora lutea,implantation index,progesterone,prolactin,estradiol,follicle stimulating and luteinizing hormones whereas the number of dead foetus,number and percentage of rats that aborted,percentage vaginal opening,resorption index,pre-and post-implantation losses increased *** addition,mifepristone-treated animals produced resorption index that compared well with the distilled water *** was also no dead or life foetus and serum progesterone concentration was increased in the animals treated with *** cases of abortion were accompanied with vaginal ***,the final weight of the rats increased significantly,the feed and water intake were not significantly altered in all the treatment *** weight of the uterus,uterine-body weight ratio,le

关键词： abortifacient estrogenicity implantation site leguminosae mifepristone pregnancy reproductive hormones Senna alata uterogenicity uterus

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