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Ionotropic receptors mediate olfactory learning and memory in Drosophila

Insect Science 2024年第4期31卷 1249-1269页

作者： Md Zeeshan Ali Anushree Aarif Ahsan Mohammad Shamsul ola Rizwanul Haque Jawaid Ahsan Department of Biotechnology Central University of South BiharGayaBiharIndia Department of Radiation Oncology University of MichiganAnn ArborMichiganUSA Department of Biochemistry College of ScienceKing Saud UniversityRiyadhSaudi Arabia

Phenylacetaldehyde(PAH),an aromatic compound,is present in a diverse range of fruits including overripe bananas and prickly pear cactus,the two major host fruits for Drosophila *** acts as a potent ligand for the ionotropic receptor 84a(IR84a)in the adult fruit fly and it is detected by the IR84a/IR8a heterotetrameric *** role in the male courtship behavior through IR84a as an environmental aphrodisiac is of additional *** ***,two distinct kinds of olfactory receptors,that is,odorant receptors(ORs)and ionotropic receptors(IRs),perceive the odorant *** display unique structural,molecular,and functional characteristics in addition to having different evolutionary ***,olfactory cues detected by the ORs such as ethyl acetate,1-butanol,isoamyl acetate,1-octanol,4-methylcyclohexanol,*** as aliphatic esters and alcohols have been employed in olfactory classical conditioning using fruit *** underlines the participation of OR-activated olfactory pathways in learning and memory *** study elucidates that likewise ethyl acetate(EA)(an OR-responsive odorant),PAH(an IR-responsive aromatic compound)too can form learning and memory when associated with an appetitive gustatory *** association of PAH with sucrose(PAH/SUC)led to learning and formation of the long-term memory(LTM).Additionally,the Orco^(1),Ir84a^(MI00501),and Ir8a^(1)mutant flies were used to confirm the exclusive participation of the IR84a/IR8a complex in PAH/SUC olfactory associative *** results highlight the involvement of IRs via an IR-activated pathway in facilitating robust olfactory behavior.

关键词： appetitive conditioning Drosophila melanogaster ethyl acetate ionotropic receptors learning and memory phenylacetaldehyde

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Astragalus kahiricus根提取物对乙醇诱导的大鼠肝细胞凋亡的肝保护作用(英文)

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中国天然药物 2013年第4期11卷 354-361页

作者： Rasha M.Allam Dina A.Selim Asser I.Ghoneim Mohamed M.Radwan Salwa M.Nofal Amani E.Khalifa ola a.sharaf Soad M.Toaima Aya M.Asaad Nadia A.El-Sebakhy Pharmacology Department Medical DivisionNational Research CenterGizaEgypt Department of Pharmacognosy Faculty of PharmacyThe University of AlexandriaAlexandria 21521Egypt Department of Pharmacology and Toxicology Faculty of PharmacyDamanhour UniversityDamanhourEgypt Department of Pharmacology & Therapeutics Faculty of PharmacyBeirut Arab UniversityBeirutLebanon National Center for Natural Products Research School of PharmacyThe University of MississippiUniversity 38677 MSUSA Department of Pharmacology and Toxicology Faculty of PharmacyAin Shams UniversityCairoEgypt

The hepatoprotective activity of the ethanol extract of Astragalus kahiricus(Fabaceae) roots against ethanol-induced liver apoptosis was evaluated and it showed very promising hepatoprotective actions through different *** extract counteracted the ethanol-induced liver enzymes leakage and glutathione *** addition,it demonstrated anti-apoptotic effects against caspase-3 activation and DNA fragmentation that were confirmed by liver histopathological ***,the phytochemical study of this extract led to the isolation of four cycloartane-type triterpenes identified as astrasieversianin II(1),astramembrannin II(2),astrasieversianin XIV(3),and cycloastragenol(4).The structures of these isolates were established by HRESI-MS and 1D and 2D NMR *** antimicrobial,antimalarial,and cytotoxic activities of the isolates were further evaluated,but none of them showed any activity.

关键词：实验药理学药理病理作用天然药物

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Cardiac differentiation is modulated by anti-apoptotic signals in murine embryonic stem cells

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World Journal of Stem Cells 2024年第5期16卷 551-559页

作者： Amani Yehya Joseph Azar Mohamad Al-Fares Helene Boeuf Wassim Abou-Kheir Dana Zeineddine ola Hadadeh Department of Anatomy Cell Biology and Physiological SciencesAmerican University of BeirutBeirut 1107-2020Lebanon Inserm BiotisU1026University BordeauxBordeaux F-33000France Rammal Rammal Lab Physio-Toxicity Environmental TeamFaculty of SciencesLebanese UniversityNabatieh 0000Lebanon

BACKGROUND Embryonic stem cells(ESCs)serve as a crucial ex vivo model,representing epiblast cells derived from the inner cell mass of blastocyst-stage *** exhibit a unique combination of self-renewal potency,unlimited proliferation,and *** latter is evident by the ability of the isolated cells to differ-entiate spontaneously into multiple cell lineages,representing the three primary embryonic germ *** regulatory networks guide ESCs,directing their self-renewal and lineage-specific ***,or programmed cell death,emerges as a key event involved in sculpting and forming various organs and structures ensuring proper embryonic ***-ever,the molecular mechanisms underlying the dynamic interplay between diffe-rentiation and apoptosis remain poorly *** To investigate the regulatory impact of apoptosis on the early differentiation of ESCs into cardiac cells,using mouse ESC(mESC)models-mESC-B-cell lym-phoma 2(BCL-2),mESC-PIM-2,and mESC-metallothionein-1(MET-1)-which overexpress the anti-apoptotic genes Bcl-2,Pim-2,and Met-1,*** mESC-T2(wild-type),mESC-BCL-2,mESC-PIM-2,and mESC-MET-1 have been used to assess the effect of potentiated apoptotic signals on cardiac *** hanging drop method was adopted to generate embryoid bodies(EBs)and induce terminal differentiation of *** size of the generated EBs was measured in each condition compared to the wild *** the functional level,the percentage of cardiac differentiation was measured by calculating the number of beating cardiomyocytes in the manipulated mESCs compared to the *** the molecular level,quantitative reverse transcription-polymerase chain reaction was used to assess the mRNA expression of three cardiac markers:Troponin T,GATA4,and ***,troponin T protein expression was evaluated through immunofluorescence and western blot *** Our findings showed that the upregulation of Bcl-

关键词： Mouse embryonic stem cells Self-renewal Apoptosis Cardiac differentiation B-cell lymphoma 2 PIM-2 Metallothionein-1

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Nonlinear Analysis of Organic Polymer Solar Cells Using Differential Quadrature Technique with Distinct and Unique Shape Function

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Computer Modeling in Engineering & Sciences 2023年第12期137卷 2193-2217页

作者： ola Ragb Mokhtar Mohamed Mohamed S.Matbuly Omer Civalek Department of Engineering Mathematics and Physics Faculty of EngineeringZagazig UniversityZagazig44519Egypt Basic Science Department Faculty of EngineeringDelta University for Science and TechnologyGamasa11152Egypt Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung404327TaiwanChina

Four numerical schemes are introduced for the analysis of photocurrent transients in organic photovoltaic *** for organic polymer solar cells contains a nonlinear diffusion-reaction partial differential equation system with electrostatic convection attached to a kinetic ordinary differential *** solve the problem,Polynomial-based differential quadrature,Sinc,and Discrete singular convolution are combined with block marching *** schemes are employed to reduce the problem to a nonlinear algebraic *** iterative quadrature technique is used to solve the reduced *** obtained results agreed with the previous exact one and the finite element ***,the effects of different times,different mobilities,different densities,different geminate pair distances,different geminate recombination rate constants,different generation efficiencies,and supporting conditions on photocurrent have been *** novelty of this paper is that these schemes for photocurrent transients in organic polymer solar cells have never been presented before,so the results may be useful for improving the performance of solar cells.

关键词： Sinc differential quadrature block marching organic solar cells discrete singular convolution

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Population increase impacts the climate,using the sensitive Arctic as an example

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Atmospheric and Oceanic Science Letters 2022年第2期15卷 71-74页

作者： ola M.Johannessen Elena V.Shalina Nansen Scientific Society BergenNorway Nansen International Environmental and Remote Sensing Centre St.PetersburgRussia Institute of Earth Sciences St.Petersburg State UniversityRussia

The global population during the last 100 years has increased from 2 to 7.7 billion,causing an increase in greenhouse gases in the *** order to see how population increase is directly related to physical variables of the climate,this Perspective article places observations and scenarios of climate change into context and puts forth a statistical modeling study on how the sensitive Arctic climate responds to the increasing *** relationships between population,Arctic sea-ice extent(SIE),and surface air temperature(SAT)are very strong,with the increasing population explaining 96%of the decreasing SIE and about 80%of the increasing SAT in the *** projection for the SIE using the population as a“proxy predictor”for a projected population of 10 billion people on the Earth in 2100,yields a SIE of 9.30 and 8.21 million km 2 for a linear and squared relationship,respectively,indicating no“tipping point”for the annual ice extent in this *** adds another dimension to climate understanding for the public at large using population as a proxy variable,instead of the more abstract CO_(2)*** also indicates that it is important to attempt to limit the ongoing increase in population,which is the main cause of the greenhouse gas emissions,in addition to reducing per capita emissions by an exponential increase in implementing renewable energy,a formidable challenge in this century.

关键词： Population Climate Sea ice Arctic

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Will the summer sea ice in the Arctic reach a tipping point?

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Atmospheric and Oceanic Science Letters 2023年第3期16卷 58-62页

作者： ola M.Johannessen Elena V.Shalina Nansen Scientific Society BergenNorway Nansen International Environmental and Remote Sensing Centre St PetersburgRussia

The Arctic sea-ice cover has decreased in extent,area,and thickness over the last six *** global climate models project that the summer sea-ice extent(SIE)will decline to less than 1 million(mill.)km^(2) in this century,ranging from 2030 to the end of the century,indicating large ***,some models,using the same emission scenarios as required by the Paris Agreement to keep the global temperature below 2°C,indicate that the SIE could be about 2 ***^(2) in 2100 but with a large uncertainty of±1.5 ***^(2).Here,the authors take another approach by exploring the direct relationship between the SIE and atmospheric CO_(2) concentration for the summer-fall *** authors correlate the SIE and In(CO_(2)/CO_(2)r)during the period 1979-2022,where CO_(2)r is the reference value in *** these transient regression equations with an R2 between 0.78 and 0.87,the authors calculate the value that the CO_(2) concentration needs to reach for zero *** results are that,for July,the CO_(2) concentration needs to reach 691±16.5 ppm,for August 604±16.5 ppm,for September 563±17.5 ppm,and for October 620±21 *** values of CO_(2)for an ice-free Arctic are much higher than the targets of the Paris Agreement,which are 450 ppm in 2060 and 425 ppm in 2100,under the IPCC SSP1-2.6 *** these targets can be reached or even almost reached,the "no tipping point"hypothesis for the summer SIE may be valid.

关键词： Sea ice Arctic Climate change Tipping point

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Determinants of mortality among seniors acutely readmitted for heart failure: racial disparities and clinical correlations

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Journal of Geriatric Cardiology 2022年第9期19卷 719-724页

作者： Tuoyo O Mene-Afejuku Gini P Jeyashanmugaraja Mahfuz Hoq olatunde ola Amit J Shah Department of Cardiology Tower Health SystemReading HospitalPAUSA Yale New Haven Health System Bridgeport hospitalCTUSA Mayo Clinic Health System La CrosseWIUSA Department of Cardiology Emory UniversityAtlantaGAUSA

Heart failure(HF)is a devastating condi-tion characterized by a high rate of mor-tality.[1]About 6.2 million individuals are grappling with the burden of HF in the United States(U.S).[2]Of this over 6 million individuals af-fected with HF,a higher proportion is made up of people older than 65 years.[3,4]More than 50%of pa-tients hospitalized due HF are older than 75 years.[5]Seniors do not just account for the greater propor-tion of individuals affected by HF but also have a worse outcome compared to younger individuals with HF.[6−14]In the light of the above,we aim to address racial disparities as they affect seniors with HF in terms of mortality in addition to other potential prognostic indices.

关键词： admitted mortality clinical

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Solriamfetol impurities:Synthesis,characterization,and analytical method(UPLC-UV)validation

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Journal of Pharmaceutical Analysis 2023年第4期13卷 403-411页

作者： Nafisah Al-Rifai Anas Alshishani Fouad Darras ola Taha Shereen Abu-Jalloud Lena Shaghlil Yousef Al-Ebini Pharmaceutical and Chemical Engineering Department School of Medical SciencesGerman Jordanian UniversityAmmanJordan Faculty of Pharmacy Zarqa UniversityZarqaJordan Research and Development Department Resonance Research LabAmmanJordan Department of Pharmaceutics College of PharmacyKing Khalid UniversityAbhaSaudi Arabia

Given that impurities may affect the quality and safety of drug products,impurity identification and profiling is an integral part of drug quality control and is particularly important for newly developed medications such as solriamfetol,which is used to treat excessive daytime *** the highperformance liquid chromatography analysis of commercial solriamfetol has revealed the presence of several impurities,their synthesis,structure elucidation,and chromatographic determination have not been reported *** bridge this gap,we herein identified,synthesized,and isolated eight processrelated solriamfetol impurities,characterized them using spectroscopic and chromatographic techniques,and proposed plausible mechanisms of their ***,we developed and validated a prompt impurity analysis method based on ultrahigh-performance liquid chromatography with UV detection,revealing that its selectivity,linearity,accuracy,precision,and quantitation limit meet the acceptance criteria of method validation stipulated by the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human ***,the developed method was concluded to be suitable for the routine analysis of solriamfetol substances.

关键词： Solriamfetol Impurity analysis Impurity synthesis UPLC Method validation

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Quantization of Time Independent Damping Systems Using WKB Approximation

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Journal of Applied Mathematics and Physics 2023年第9期11卷 2615-2620页

作者： ola A. Jarab’ah Department of Applied Physics Tafila Technical University Tafila Jordan

In this work time independent damping systems are studied using Lagrangian and Hamiltonian for time independent damping, which are present through the factor eλq. The Hamilton Jacobi equation is formulated to find the Hamilton Jacobi function S using separation of variables technique. We can form this function in compact form of two parts the first part as a function of coordinate q, and the second part as a function of time t. Finally, we find the ability of these systems to quantize through an illustrative example.

关键词： Quantization Hamilton Jacobi Equation Hamilton Jacobi Function Momentum

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Lagrangian Formulation of Fractional Nonholonomic Constrained Damping Systems

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Advances in Pure Mathematics 2023年第9期13卷 552-558页

作者： ola A. Jarab’ah Department of Applied Physics Tafila Technical University Tafila Jordan

Fractional Euler Lagrange equations for fractional nonholonomic constrained damping systems have been presented. The equations of motion are obtained using fractional Euler Lagrange equations in a similar manner to the usual technique. The results of fractional method reduce to those obtained from classical method when μ →0 and α,β →1 are equal unity only. This work is discussed using illustrative example.

关键词： Euler-Lagrange Equations Nonholonomic Constraints Generalized Momenta

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