检索结果-南通市图书馆

Methionine sources and genotype affect embryonic intestinal development, antioxidants, tight junctions, and growth-related gene expression in chickens

引用

Animal Nutrition 2024年第1期16卷 218-230页

作者： James K.lugata Sawadi F.Ndunguru Gebrehaweria K.Reda Xénia E.Ozsváth Eszter Angyal levente Czeglédi Gabriella Gulyás Renáta Knop János oláh Zoltán Mészár Rita Varga Brigitta Csernus Csaba Szabó Department of Animal Nutrition and Physiology Faculty of Agriculture and Food Sciences and Environmental Management University of Debrecen Faculty of Agriculture and Food Sciences and Environmental Management Doctoral School of Animal Science University of Debrecen Department of Animal Husbandry Faculty of Agriculture and Food Sciences and Environmental Management University of Debrecen Department of Evolutionary Zoology and Human Biology Faculty of Science and Technology University of Debrecen Institutes for Agricultural Research and Educational Farm University of Debrecen Department of Anatomy Histology and Embryology Faculty of Medicine University of Debrecen

Methionine(Met) is an essential and first limiting amino acid in the poultry diet that plays a significant role in chicken embryonic development and growth. The present study examined the effect of in ovo injection of Dl-Met and l-Met sources and genotypes on chicken embryonic-intestinal development and health. Fertilized eggs of the two genotypes, TETRA-Sl layer hybrid(TSl)—commercial layer hybrid and Hungarian Partridge colored hen breed(HPC)—a native genotype, were randomly distributed into four treatments for each genotype. The treatment groups include the following: 1) control non-injected eggs(NoIn); 2) saline-injected(SaIn); 3) Dl-Met injected(DlM); and 4) l-Met injected(lM). The in ovo injection was carried out on 17.5 d of embryonic development; after hatching, eight chicks per group were sacrificed, and the jejunum was extracted for analysis. The results showed that both DlM and lM groups had enhanced intestinal development as evidenced by increased villus width, villus height, and villus area(P ol. The DlM group had significantly reduced crypt depth, glutathione(GSH) content, glutathione S-transferase 3 alpha(GST3), occludin(OClN) gene expression and increased villus height to crypt depth ratio in the TSl genotype than the lM group(P lin-like growth factor 1(IGF1) gene, tricellulin(MD2), occludin(OClN),superoxide dismutase 1(SOD1), and GST3 genes than the TSl genotype(P lusion, these findings showed that in ovo injection of Met enhanced intestinal development, and function, with genotypes responding differently under normal conditions. Genotypes also influenced the expression of intestinal antioxidants, tight junction, and growth-related genes.

关键词： Dl-Methionine l-Methionine In ovo injection Intestinal development Poultry

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

oligodendroctyes:the forgotten players of diabetes pathophysiology

引用

Neural Regeneration Research 2024年第11期19卷 2349-2350页

作者： Juan Antonio lópez-Villodres Beatriz García-Díaz Departamento Fisiología Humana Histología HumanaAnatomía Patológica y Educación Física y DeportivaFacultad de MedicinaUniversidad de MálagaMálagaSpain UGC Neurociencia.Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina(IBIMA Plataforma Bionand) MálagaSpain

oligodendrocytes(ols),glial cells that provide myelin sheaths to axons in the central nervous system(CNS),have a dual ***,this myelin fatty cover around the axons protects the nerves and is crucial for the saltatory propagation of action *** and not less important,ols provide trophic support to neurons and ***,ol metabolism is important for ol well-being and the proper accomplishment of their functions,and ol metabolism energetics directly affect the energy metabolism of neighboring neurons.

关键词： metabolism nerves myelin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

C-reactive protein may be a prognostic factor for the whole gastroenteropancreatic neuroendocrine tumor group

引用

World Journal of Gastrointestinal Oncology 2019年第2期11卷 139-152页

作者： ?mer Koma? G?ksel Bengi ?zgül Sa?ol Mesut Akarsu Department of Internal Medicine Dokuz Eylul University Faculty of Medicine Department of Gastroenterology Dokuz Eylul University Faculty of Medicine Department of Pathology Dokuz Eylul University Faculty of Medicine

BACKGROUND long non-coding RNAs(lncRNAs) are a kind of single-stranded RNA of more than 200 nucleotides in length and have no protein-coding function. Amounting studies have indicated that lncRNAs could play a vital role in the initiation and development of cancers, including gastric cancer(GC). Considering the crucial functions of lncRNAs, the identification and exploration of novel lncRNAs in GC is *** To identify independent prognostic markers for the whole gastroenteropancreatic neuroendocrine tumor(GEP-NET) *** Ninety-three patients diagnosed with GEP-NETs within a specified period were included in this study. Patient data were retrospectively analyzed. The relationships between all independent variables and 5-year survival status calculated during the follow-up period(months) were assessed. In addition, the relationships between the independent variables were *** When 5-year survival rate was compared, a statistically significant relationship between the age at diagnosis, male gender, tumor size, tumor stage, liver and/or distant metastasis, and tumor grade determined by the Ki-67 level and mitotic count, and the level of C-reactive protein(CRP), was observed. The meansurvival(overall survival) of the study group was 102.5 ± 6.3(SD) mo. The percentages of 1, 3 and 5-year survival were 90%, 72%, and 61%, respectively. In63 of 93 patients, Ki-67 and the mitotic count determined the same grade. The Ki-67 levels in 29 patients and the mitotic count in only 1 patient were in the higher grade. The risk of death increased by 4% for every 1 year increase at the diagnosis age and was 2.0-fold higher for male patients, 3.0-fold higher for G3 according to the mitotic count, 3.7-fold higher for G3 according to the Ki-67 level, 12.7-fold higher for cases with tumor stage 3 or 4 by a 1 cm increase in the ratio of 9% in tumor size, and 6.1-fold higher for patients with liver metastasis for every 1 mg/dl increase in the ratio of 1.5% in CR

关键词： Gastroenteropancreatic neuroendocrine tumors C-reactive protein Prognostic factor Neuroendocrine tumors Gastrointestinal system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Estimating Risk-aware Flexibility Areas for Electric Vehicle Charging Pools via AC Stochastic Optimal Power Flow

引用

Journal of Modern Power Systems and Clean Energy 2023年第4期11卷 1247-1256页

作者： Juan S.Giraldo Nataly Bañol Arias Pedro P.Vergara Maria Vlasiou Gerwin Hoogsteen Johann l.Hurink Energy Transition Studies Group Netherlands Organisation for Applied Scientific Research(TNO)Amsterdam1043 NTThe Netherlands Department of Electrical Engineering Mathematics and Computer ScienceUniversity of TwenteEnschede7522 NBThe Netherlands Intelligent Electrical Power Grids Group Electrical EngineeringMathematics and Computer ScienceDelft University of TechnologyDelft2628 CDThe Netherlands

This paper introduces an AC stochastic optimal power flow(SOPF)for the flexibility management of electric vehicle(EV)charging pools in distribution networks under *** AC SOPF considers discrete utility functions from charging pools as a compensation mechanism for eventual energy not served to their charging *** application of the AC SOPF is described where a distribution system operator(DSO)requires flexibility to each charging pool in a day-ahead time frame,minimizing the cost for flexibility while guaranteeing technical *** areas are defined for each charging pool and calculated as a function of a risk parameter involving the uncertainty of the *** show that all players can benefit from this approach,i.e.,the DSO obtains a riskaware solution,while charging pools/tasks perceive a reduction in the total energy payment due to flexibility services.

关键词： Electric vehicle flexibility management stochastic optimal power flow(SOPF) risk awareness compensation mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Discrepancies between clinical and autopsy findings in patients who had an acute stroke

引用

Stroke & Vascular Neurology 2022年第3期7卷 215-221页

作者： lilla Hudák Attila Csaba Nagy Sarolta Molnár Gábor Méhes Katalin Erzsébet Nagy lászlóoláh lászlóCsiba Department of Neurology University of Debrecen Faculty of MedicineDebrecenHungary Department of Preventive Medicine University of Debrecen Faculty of Public HealthDebrecenHungary Department of Pathology University of Debrecen Clinical CenterDebrecenHungary Doctoral School of Neuroscience University of Debrecen Faculty of MedicineDebrecenHungary

Objectives According to international observations,the incidence of clinical autopsies is declining worldwide,plummeting below 5%in the USA and many European *** is an unfavourable trend as,in 7%-12%of cases,recent clinicopathological studies found discrepancies that might have changed the therapy or the outcome if known *** previous large-scale observations have examined varied patient populations,we aimed to focus on the differences between the clinical and pathological diagnostic findings in only patients who had a *** and methods We assessed the postmortem non-neuropathological and neuropathological findings of 534 consecutive patients who had a stroke who passed *** neoplasms,pneumonias,thromboembolisms and haemorrhagic transformations revealed only by autopsy were considered severe abnormalities;in addition,benign abnormalities important from an educational or scientific point of view were also *** In 26 of the 534 cases(4.9%),the presence of systemic neoplasms had already been confirmed in the clinical stage;however,8(1.5%)malignant tumours were only detected during ***,80(15%)thromboembolic events,73(13.6%)pneumonias and 66(18%)haemorrhagic transformations were only diagnosed at *** hospital stay(from admission to death)resulted in fewer discrepancies between clinical and autopsy diagnosis of thromboembolic events and pneumonias(ple the type of acute stroke is reliably diagnosed with imaging techniques,postmortem autopsies are also important in patients who had a stroke as autopsies may reveal clinically silent diseases(eg,tumour),and contribute to knowing the actual incidence of stroke-related thromboembolic and pneumonia complications.

关键词： neoplasms clinical finding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rilmenidine prevents blood pressure increase in rats with compromised nitric oxide production

引用

Acta Pharmacologica Sinica 2004年第12期25卷 74-80页

作者： Mria GEROV,Jozef TRK,ol’ga PECHV,Jana MATUKOV Institute ofNormal and Pathological Physiology SlovakAcademy of Sciences 813 71 Bratislava Slovak Republic Institute ofNormal and Pathological Physiology SlovakAcademy of Sciences 813 71 Bratislava Slovak Republic Institute ofNormal and Pathological Physiology SlovakAcademy of Sciences 813 71 Bratislava Slovak Republic Institute of Pathophysiology Medical School Comenius University Bratislava Slovak Republic Now in Center for Blood Research and Department of Pathology Harvard MedicalSchool Boston USA.

AIM: To search tools of high blood pressure in the model of nitric oxide (NO)-defective hypertension, and the study focused on the effect of rilmenidine, agonist of imidazoline receptors, which was suggested to modulate central sympathetic outflow. METHODS: Three experimental groups, each consisting of 7 rats, were used: (I) rats with inhibition of NO synthase (NOS) by NG-nitro-l-arginine methyl ester (l-NAME) 40 mg·kg-1·d-1 for 4 weeks in drinking water, (II) rats with inhibited NOS as in group I , plus agonist of imidazoline receptors rilmenidine 3 mg·kg-1·d-1 for 4weeks by gavage, and(III) control rats. Systolic blood pressure wasmeasured weekly noninvasively. At the end of experiment aortic ring isometric tension was followed, NOS expression (aorta, left ventricle), and NOS activity (left ventricle and brain) were determined. RESUlTS: In the group I systolic blood pressure in- creased significantly, aortic ring relaxation to acetylcholine was significantly attenuated. Rilmenidine administered simultaneously with l-NAME (group II) prevented the increase of blood pressure which did not differ significantly from control values; aortic ring relaxation to acetylcholine did not differ from control. No change in NOS expres- sion (aorta and left ventricle) was found in groups I and II. Significant decline in NOS activity (left ventricle and brain) wasfound in groups I and II. CONClUSION: Rilmenidinehas aremarkable role inNO-defective hypertension, possibly by inhibiting central sympathetic outflow and by affecting receptors in vascular smooth muscle also. The prime cause of hypertension in this experimental model - the compromised production of NO due to inhibition of NOS - was not affected by rilmenidine.

关键词： NO deficiency hypertension imidazoline receptor nitric-oxide synthase sympathetic activity

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Microbiomics and metabolomics insights into the microbial regulation on the formation of flavor components in the traditional fermentation process of Chinese Hongqu aged vinegar

引用

Food Science and Human Wellness 2024年第5期13卷 2765-2778页

作者： Shangong Tong Wenlong li Yuandong Rao Yanqin Xiao Yingyin Yan Weiling Guo Xucong lü Jinyuan Sun lianzhong Ai li Ni Institute of Food Science and Technology College of Biological Science and EngineeringFuzhou UniversityFuzhou 350108China Food Nutrition and Health Research Center School of Advanced ManufacturingFuzhou UniversityJinjiang 362200China School of Food Science and Technology Jiangnan UniversityWuxi 214122China Beijing laboratory for Food Quality and Safety Beijing Technology and Business UniversityBeijing 100048China School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China

This study aimed to investigate microbial succession and metabolic dynamics during the traditional fermentation of Hongqu aged vinegar,and explore the core functional microbes closely related to the formation of flavor *** analysis demonstrated that lactobacillus,Acetobacter,Bacillus,Enterobacter,lactococcus,leuconostoc and Weissella were the predominant bacterial genera,while Aspergillus piperis,Aspergillus oryzae,Monascus purpureus,Candida athensensis,***,Penicillium ochrosalmoneum and Simplicillium aogashimaense were the predominant fungal *** analysis revealed that Acetobacter was positively correlated with the production of tetramethylpyrazine,acetoin and acetic acid,lactococcus showed positive correlation with the production of 2-nonanone,2-heptanone,ethyl caprylate,ethyl caprate,1-hexanol,1-octanol and 1-octen-3-ol,*** and *** were positively associated with the production of diethyl malonate,2,3-butanediyl diacetate,acetoin,benzaldehyde and ***,non-volatile metabolites were also detected through ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.A variety of amino acids and functional dipeptides were identified during the traditional brewing of Hongqu aged *** analysis revealed that lactobacillus was significantly associated with Dl-lactate,indolelactic acid,D-(+)-3-phenyllactic acid,pimelic acid,pregabalin and 3-aminobutanoic *** study is useful for understanding flavor formation mechanism and developing effective strategies for the suitable strains selection to improve the flavor quality of Hongqu aged vinegar.

关键词： Hongqu aged vinegar Traditional fermentation Microbial dynamics Flavor components Bidirectional orthogonal partial least squares

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of coating on the triamcinolone release of alginate chitosan beads for colonic drug delivery

引用

Natural Science 2011年第11期3卷 955-962页

作者： Nadir Veiga vier Ruth Meri lucinda-Silva 不详

The aim of this study was to evaluate the effect of coating of alginate-chitosan (Al:CS) beads on the colonic drug delivery. The Al:CS systems containing triamcinolone (TC) were coated with the HPMCP and Eudragit? l100 by immersion and by spraying methods. The drug release profile in simulated colonic medium was determined using 5% human fecal content suspension in 0.01 N buffer solution, pH 6.8. The systems coated with HPMCP showed a lower rate of drug delivery in simulated enteric medium. The delivery profile in simulated colonic medium followed zero-order kinetic. The coated systems provided a promising drug-delivery profile for application in colonic drug delivery.

关键词： Alginate Beads Chitosan Colon-Specific Drug Delivery Triamcinolone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development of a multiprimer metabarcoding approach to understanding trophic interactions in agroecosystems

引用

Insect Science 2022年第4期29卷 1195-1210页

作者： Ivan Batuecas Oscar Alomar Cristina Castañe Josep Piñol Stéphane Boyer lorena Gallardo-Montoya Nuria Agustí IRTA Sustainable Plant ProtectionCabrilsBarcelonaSpain Universitat Autònoma Barcelona Cerdanyola del VallèsSpain CREAF Cerdanyola del VallèsSpain Institut de Recherche sur la Biologie de l'Insecte(IRBI) Tours UniversityToursFrance

To understand trophic interactions and the precise ecological role of each predatory species,it is important to know which arthropod and plant resources are used by generalist predators in *** approaches,such as the use of high-throughput sequencing(HTS),play a key role in identifying these *** study develops a multiprimer metabarcoding approach for screening the most common trophic interactions of two predatory arthropods with contrasting morphologies,Rhagonycha fulva(Coleoptera:Cantharidae)and Anthocoris nemoralis(Hemiptera:Anthocoridae)collected from a peach *** reduce the time and cost of this metabarcoding approach,we first evaluated the effect of using two different predator-pools of different size(10 and 23 individuals of the same species).We also used our system to analyze the performance of one and two primer pairs in the same *** results show that the analysis of 23 individuals together with the use of two primer pairs in the same library optimize the HTS *** these best-performing conditions,we then analyzed the entire bodies of field-collected predators as well as the washing solutions used to clean the insect *** were able to identify both gut content(i.e.,diet)and external pollen load(i.e.,on the insects’bodies).This study also demonstrates the importance of washing predatory insects’bodies prior to HTS analysis when the target species have a considerable size(>10 mm)and hairy *** metabarcoding approach has significant potential for the study of trophic links in agriculture,revealing expected and unexpected trophic relationships.

关键词： high-throug hput sequencing metabarcoding molecular diet analysis multiprimer approach predatory arthropods trophic interactions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anti-inflammatory and antinociceptive activities of Rhipicephalus microplus saliva

引用

Asian Pacific Journal of Tropical Biomedicine 2018年第4期8卷 194-200页

作者： DF.Buccini AA.Nunes GGO.Silva ON.Silva ol.Franco SE.Moreno Programa de Pos-Graduacao em Biotecnologia e Biodiversidade Universidade Federal do Mato Grosso do Sul S-Inova Biotech Programa de Pos-Graduacao em Biotecnologia Universidade Catolica Dom Bosco Programa de Pos-Graduacao em Patologia Molecular Universidade de Brasilia Centro de Analises Proteomicas e Bioquimicas Programa de Pos-Graduacao em Ciencias Genomicas e Biotecnologia Universidade Catolica de Brasilia

To evaluate the antinociceptive and anti-inflammatory activities and the toxic effects of Rlhipicephalus microplus saliva for elucidating the modulation mechanism between arthropod saliva and ***:For saliva collection,engorged ticks were obtained from a controlled bovine infestation and collected by natural *** ticks were fixed and injected pilocarpine 0.2%for induction of *** was collected,lyophilized and stored at-80℃.Cytotoxic activity was assessed by the hemolysis method(25,50,100,200 and 300μg/ml)and MTT cell viability assay(2.5,5,10,20 and 40μg/ml)for 24,48 and 72 ***-inflammatory activity was evaluated using the method of neutrophil migration to the peritoneal cavity of mice at doses of l0,15 and 20 mg/kg;antinociceptive activity was assessed using the acetic acid-induced writhing test,and formalin-induced paw-licking in mice at dose of 15 mg/***:Saliva did not cause erythrocytes hemolysis at any concentration tested,as well as did not decrease cell viability in the MTT *** inhibited neutrophil migration by 87%and 73%at doses of l5 and 20 mg/kg,*** the nociceptive tests,saliva presented analgesic activity of69.96%in the abdominal writhing test,and of 84.41%in the formalin *** study proves that Rlhipiceplhalus microplus saliva has significant in vivo anti-inflammatory and antinociceptive *** data presented herein support the development of further studies to elucidate the active principles of Rhipicephalus microplus saliva and its mechanism of action and,in future,to develop novel anti-inflammatory and analgesic drugs.

关键词： Rhipicephalus microplus Saliva Tick Antinociceptive Anti-inflammatory

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：