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Large-scale genome-wide SNP analysis reveals the rugged(and ragged)landscape of global ancestry,phylogeny,and demographic history in chicken breeds

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 324-340页

作者： Natalia v.DEMENTIEvA Yuri S.SHCHERBAKOv ol.a I.STANISHEvSKAYA Anatoly B.vAKHRAMEEv Tatiana A.LARKINA Artem P.DYSIN ol.a A.NIKolAEvA Anna E.RYABOvA Anastasiia I.AZOvTSEvA ol.a v.mitrofanova Grigoriy K.PEGLIvANYAN Natalia R.REINBACH Darren K.GRIFFIN Michael N.ROMANOv Russian Research Institute of Farm Animal Genetics and Breeding-Branch of the L.K.Ernst Federal Research Centre for Animal Husbandry.Pushkin St.Petersburg196601Russia School of Biosciences University of KentCanterburyCT27NJUK L.K.Ernst Federal Research Center for Animal Husbandry DubrovitsyPodolskMoscow Oblast142132Russia

The worldwide chicken gene pool encompasses a remarkable,but shrinking,number of divergently selected breeds of diverse *** study was a large-scale genome-wide analysis of the landscape of the complex molecular architecture,genetic variability,and detailed structure among 49 *** populations represent a significant sample of the world's chicken breeds from Europe(Russia,Czech Republic,France,Spain,UK,etc.),Asia(China),North America(USA),and Oceania(Australia).Based on the results of breed genotyping using the Illumina 60K single nucleotide polymorphism(SNP)chip,a bioinformatic analysis was carried *** included the calculation of heterozygosity/homozygosity statistics,inbreeding coefficients,and effective population *** also included assessment of linkage disequilibrium and construction of phylogenetic *** multidimensional scaling,principal component analysis,and ADMIXTURE-assisted global ancestry analysis,we explored the genetic structure of populations and subpopulations in each *** overall 49-population phylogeny analysis was also performed,and a refined evolutionary model of chicken breed formation was proposed,which included egg,meat,dual-purpose types,and ambiguous *** a large-scale survey of genetic resources in poultry farming using modern genomic methods is of great interest both from the viewpoint of a general understanding of the genetics of the domestic chicken and for the further development of genomic technologies and approaches in poultry *** general,whole genome SNP genotyping of promising chicken breeds from the worldwide gene pool will promote the further development of modern genomic science as applied to poultry.

关键词： Chicken genome diversity Single nucleotide polymorphism(SNP)analysis Gene pool Global ancestry Phylogeny Demographic history

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Numerical 3D-modeling of spall and shear fractures in shells of austenitic 12Kh18N10T steel and 30KhGSA steel under their spherical and quasi-spherical explosive loading

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International Journal of Modeling, Simulation, and Scientific Computing 2015年第1期6卷 173-211页

作者： Evgeny A.Kozlov oleg v.ol’khov Ekaterina v.Shuvalova Russian Federal Nuclear Center–Zababakhin Research Institute of Technical Physics Snezhinsk Russia Russian Federal Nuclear Center–Research Institute of Experimental Physics Sarov Russia

To pursue vNIIEF–vNIITF joint investigations,this paper briefly describes the experimental setup and provides numerical 3D-computation results(LEGAK-3D technique)on special features in the convergence dynamics of steel shells under their quasi-spherical explosive loading in the system with the 40-mm outer radius of the explosive *** computation results were compared with the data experimentally registered for shells of the 30KhGSA steel,both as-received and quenched to HRC 35...40,and the austenitic 12Kh18N10T stainless *** comparison was also made with laserinterferometry results obtained directly under explosive loading,as well as with gammatomography and scanning electron microscopy investigations of the recovered shells.

关键词： Convergence dynamics of shell spall and shear damages explosive loading

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Rilmenidine prevents blood pressure increase in rats with compromised nitric oxide production

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Acta Pharmacologica Sinica 2004年第12期25卷 74-80页

作者： Mria GEROv,Jozef TRK,ol’ga PECHv,Jana MATUKOv Institute ofNormal and Pathological Physiology SlovakAcademy of Sciences 813 71 Bratislava Slovak Republic Institute ofNormal and Pathological Physiology SlovakAcademy of Sciences 813 71 Bratislava Slovak Republic Institute ofNormal and Pathological Physiology SlovakAcademy of Sciences 813 71 Bratislava Slovak Republic Institute of Pathophysiology Medical School Comenius University Bratislava Slovak Republic Now in Center for Blood Research and Department of Pathology Harvard MedicalSchool Boston USA.

AIM: To search tools of high blood pressure in the model of nitric oxide (NO)-defective hypertension, and the study focused on the effect of rilmenidine, agonist of imidazoline receptors, which was suggested to modulate central sympathetic outflow. METHODS: Three experimental groups, each consisting of 7 rats, were used: (I) rats with inhibition of NO synthase (NOS) by NG-nitro-L-arginine methyl ester (L-NAME) 40 mg·kg-1·d-1 for 4 weeks in drinking water, (II) rats with inhibited NOS as in group I , plus agonist of imidazoline receptors rilmenidine 3 mg·kg-1·d-1 for 4weeks by gavage, and(III) control rats. Systolic blood pressure wasmeasured weekly noninvasively. At the end of experiment aortic ring isometric tension was followed, NOS expression (aorta, left ventricle), and NOS activity (left ventricle and brain) were determined. RESULTS: In the group I systolic blood pressure in- creased significantly, aortic ring relaxation to acetylcholine was significantly attenuated. Rilmenidine administered simultaneously with L-NAME (group II) prevented the increase of blood pressure which did not differ significantly from control values; aortic ring relaxation to acetylcholine did not differ from control. No change in NOS expres- sion (aorta and left ventricle) was found in groups I and II. Significant decline in NOS activity (left ventricle and brain) wasfound in groups I and II. CONCLUSION: Rilmenidinehas aremarkable role inNO-defective hypertension, possibly by inhibiting central sympathetic outflow and by affecting receptors in vascular smooth muscle also. The prime cause of hypertension in this experimental model - the compromised production of NO due to inhibition of NOS - was not affected by rilmenidine.

关键词： NO deficiency hypertension imidazoline receptor nitric-oxide synthase sympathetic activity

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The determination of white dwarf parameters in dwarf novae by optical spectral modeling

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Research in Astronomy and Astrophysics 2021年第7期21卷 37-40页

作者： Anastasiya Andreevna Dudnik Arina Alekseevna mitrofanova vladislav vladimirovich Shimansky Nikolay vladimirovich Borisov Nail Abdullovich Sakhibullin Kazan(vol.a Region)Federal University KazanRepublic of TatarstanRussia Special Astrophysical Observatory Russian Academy of ScienceNizhnii ArkhysKarachai-Cherkessian RepublicRussia

This paper presents the results of a model analysis of optical spectra and determination of the parameters of three individual SU UMa and WZ Sge type dwarf *** moderate resolution spectra of TY Psc,FL Psc and v455 And were obtained at the 6-m BTA of the SAO RAS in the low state of these systems with the determination of white dwarf *** theoretical spectra were calculated using the grid models of hydrogen dwarf atmospheres of white dwarfs by varying the parameters(T_(eff) and log g) to reach the best agreement with the observed *** highlight different effects of the parameters on the shape and intensity of the HI ***,it is possible to unambiguously determine T_(eff) and log g from the analysis of *** fundamental parameters of white dwarfs(M and R) were found by comparing the parameters of atmospheres with theoretical models of the internal *** obtained parameters of the primaries of TY Psc,FL Psc and v455 And are consistent with the average values for SU UMa and WZ Sge *** a result,we demonstrate the efficiency of the method for determining the parameters of such systems based on the analysis of a limited set of observed optical spectra.

关键词： techniques:spectroscopic stars:variables:dwarf novae stars:individual:TY Psc stars:individual:FL Psc stars:individual:v455 And

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Highly Heat-Resistant Materials for Microelectronics:Hydrodynamic,Optical,and Conformational Properties of Fluorine Containing Poly(Amido-ortho-Hydroxy Amide)

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Journal of Wuhan University of Technology(Materials Science) 2020年第1期35卷 223-230页

作者： Irina A Strelina Liudmila I Rudaya ol’ga v Okatova Maxim N Bol’shakov Aleksey YuMarfichev Galina K Lebedeva Yuliya v Shagayko Stanislav M Ramsh Institute of Macromolecular Compounds Russian Academy of SciencesBolshoi pr.VO 31St Petersburg199004 Russia Saint-Petersburg State Institute of Technology(Technical University) Moskovskii pr.26St Petersburg190013 Russia

The polycondensation of the mixture of diamines 5,5-methylene bis(2-aminophenol) and 4,4-(hexafluoroisopropylidene)dianiline(molar ratio 0.8:0.2) with isophthaloyl dichloride was used to synthesize poly(amido-o-hydroxy amide)(POA-F)-new heat resistant binder of the composites for microelectronics. The copolymer was fractionated, its hydrodynamic, optical, and conformational properties were researched, and molecular masses(ММ) of the fractions were defined. The polydispersity index was estimated. Based on experimental data, calculation of the size of a segment of Kuhn characterizing degree of an intramolecular orientation order and value of coefficients of the equation of Mark-Kuhn-Hauvink for viscometric and diffusion data were performed. It was demonstrated that introducing 20 mol % of the monomer with-CF3-groups does not lead to any changes in conformational properties of the macromolecules and does not change the degree of intramolecular orientational order(the Kuhn segment length). Optical characteristics of POA-F solutions are virtually similar to the corresponding values for POA prepared with the use of single amine-containing component-5,5-methylene bis(2-aminophenol). The received MM distribution for POA-F(prepolymer) provided the solubility of its films in alkaline solutions. The heat resistance(τ5 and τ10-temperatures corresponding to 5% and of 10% PBO-F mass loss of a polymer) of the powders and the films of PBO, PBO-F were determined. The electrophysical parameters-dielectric permittivity(ε) and dielectric loss tangent(tan δ) of the PBO-F films decreased down to 3.30 and 0.017, in comparison 3.40 and 0.025 for PBO respectively.

关键词： poly(o-hydroxy amide) 4,4-(hexafluoroisopropylidene) dianiline Kuhn segment Mark-Kuhn-Houwink equations translational diffusion intrinsic viscosity flow birefringence

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Elafibranor治疗原发性胆汁性胆管炎患者的临床研究

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中国临床药理学杂志 2024年第1期40卷 106-106页

作者： KOWDLEY K v 戴荣源

引自:KOWDLEY K v,et *** and safety of elafibranor in primary biliary cholangitis[J/ol].N Engl J Med,2023.2023-11-13[2023-12-05].https://***/37962077/.美国西雅图西北肝脏研究所KOWDLEY团队研究了Elafibranor治疗原发性胆汁性胆管炎的疗效和安全性。在这项跨国、3期、双盲、安慰剂对照试验中,研究人员将对熊去氧胆酸反应不足或药物不良反应不可耐受的原发性胆汁性胆管炎患者(按2∶1的比例)进行随机分组,每天接受1次Elafibranor 80 mg或安慰剂。主要终点是第52周的生化缓解(定义为碱性磷酸酶水平<正常范围上限的1.67倍,比基线降低≥15%,总胆红素水平正常)。关键次要终点是第52周碱性磷酸酶水平正常化,以及从基线到第24、52周瘙痒强度的变化[根据最严重瘙痒数值评定量表(the Worst Itch Numeric Rating Scale,WI-NRS)评定]。

关键词：原发性胆汁性胆管炎安慰剂对照疗效和安全性熊去氧胆酸碱性磷酸酶药物不良反应团队研究 DLE

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Nicotinic receptors modulate antitumor therapy response in triple negative breast cancer cells

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World Journal of Clinical Oncology 2022年第6期13卷 505-519页

作者： Alejandro Español Yamila Sanchez Agustina Salem Jaqueline Obregon Maria Elena Sales Laboratory of Immunopharmacology and Tumor Biology CEFYBO CONICET University of Buenos AiresBuenos Aires C1121ABGArgentina

BACKGROUND Triple negative breast cancer is more aggressive than other breast cancer subtypes and constitutes a public health problem worldwide since it has high morbidity and mortality due to the lack of defined therapeutic *** to chemotherapy complicates the course of patients’*** authors have highlighted the participation of nicotinic acetylcholine receptors(nAChR)in the modulation of conventional chemotherapy treatment in cancers of the ***,in breast cancer,less is known about the effect of nAChR activation by nicotine on chemotherapy treatment in smoking *** To investigate the effect of nicotine on paclitaxel treatment and the signaling pathways involved in human breast MDA-MB-231 tumor *** Cells were treated with paclitaxel alone or in combination with nicotine,administered for one or three 48-h *** effect of the addition of nicotine(at a concentration similar to that found in passive smokers’blood)on the treatment with paclitaxel(at a therapeutic concentration)was determined using the 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** signaling mediators involved in this effect were determined using selective *** also investigated nAChR expression,and ATP“binding cassette”G2 drug transporter(ABCG2)expression and its modulation by the different treatments with Western *** effect of the treatments on apoptosis induction was determined by flow cytometry using annexin-v and 7AAD *** Our results confirmed that treatment with paclitaxel reduced MDA-MB-231 cell viability in a concentration-dependent manner and that the presence of nicotine reversed the cytotoxic effect induced by paclitaxel by involving the expression of functionalα7 andα9 nAChRs in these *** action of nicotine on paclitaxel treatment was linked to modulation of the protein kinase C,mitogen-activated protein kinase,extracellular signal-regulated kinase,and NF-κB signaling pathways,

关键词： Breast cancer Paclitaxel Nicotinic acetylcholine receptors Drug therapy Signal transduction Drug transporter

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Effect of pineapple peel extract on total phospholipids and lipid peroxidation in brain tissues of rats

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Asian Pacific Journal of Tropical Medicine 2011年第3期4卷 182-184页

作者： Erukainure ol.ajiboye JA Adejobi RO Okafor OY Kosoko SB Owolabi FO Food Technology Division Federal Institute of Industrial ResearchOshodiNigeria College of Natural and Applied Sciences Bells University of TechnologyOtaNigeria

Objective:To investigate the ability of the methanolic extract of pineapple peel to attenuate alcohol-induced changes in total phospholipids and lipid peroxidation in brain tissues. Methods:Oxidative stress was induced by oral administration of ethanol(20%w/v) at a dosage of 5 mL/kg bw in *** 28 days of treatment,the rats were fasted overnight and sacrificed by cervical *** tissues were assayed for total phospholipid(TP) content and malondialdehyde(MDA).Results:Administration of alcohol significantly caused a reduction in TP *** with pineapple peel extract significantly increased the TP content. Significant high levels of MDA was observed in alcohol-fed rats,treatment with pineapple peel extract significantly reduced the MDA ***:Results obtained from this study indicates that pineapple peel extract protects against alcohol-induced changes in total phospholipids and lipid peroxidation in brain tissues.

关键词： Brain Malondialdehyde Total phospholipids Alcohol

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Modulatory effect of pineapple peel extract on lipid peroxidation,catalase activity and hepatic biomarker levels in blood plasma of alcoholinduced oxidative stressed rats

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Asian Pacific Journal of Tropical Biomedicine 2011年第1期1卷 12-14页

作者： Okafor OY Erukainure ol.ajiboye JA Adejobi RO Owolabi FO Kosoko SB Food Technology Division Federal Institute of Industrial Research College of Natural and Applied Sciences Bells University of Technology

Objective:To investigate the ability of the methanolic extract of pineapple peel to modulate alcohol-induced lipid peroxidation,changes in catalase activities and hepatic biochemical marker levels in blood ***:Oxidative stress was induced by oral administration of ethanol(20%w/v) at a dosage of 5 niL/kg bw in *** 28 days of treatment,the rats were fasted overnight and sacrificed by cervical *** was collected with a 2 mL syringe by cardiac puncture and was centrifuged at 3000 rpm for 10 *** plasma was analyzed to evaluate malondialdehyde(MDA),catalase activity,aspartate aminotransferase(AST),alkaline phosphatase(ALP) and alanine aminotransferase(ALT) ***:Administration of alcohol caused a drastic increase(87.74%) in MDA level compared with the *** peel extract significantly reduced the MDA level by 60.16%at 2.S mL/kg *** fed alcohol only had the highest catalase activity,treatment with pineapple peel extract at 2.5 mL/kg bw however, reduced the *** AST,ALP and ALT activities were observed in rats fed alcohol only respectively,treatment with pineapple peel extract drastically reduced their activities. Conclusions:The positive modulation of lipid peroxidation,catalase activities as well as hepatic biomarker levels of blood plasma by the methanolic extract of pineapple peels under alcoholinduced oxidative stress is an indication of its protective ability in the management of alcoholinduced toxicity.

关键词： Blood plasma Catalase Lipid peroxide Aspartate aminotransferase Alkaline phosphatase Alanine aminotransferase Hepatic biomarker Pineapple peel extract Oxidative stress Lipid peroxidation

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Mechanical Properties of Living Adherent Cells :Relationship with Structure and Function

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生物医学工程学杂志 2005年第S1期22卷 9-10页

作者： R. FODIL S. Féréol E. PLANUS v.M. LAURENT B. LOUIS D. ISABEY Inserm UMR 651 Fonctions Cellulaire et Moléculaire de l'Appareil Respiratoire et des Vaisseaux Equipe Biomécanique Cellulaire et Respiratoire Faculté de Médecine Créteil 94 010 FranceInserm UMR 651 Fonctions Cellulaire et Moléculaire de l'Appareil Respiratoire et des Vaisseaux Equipe Biomécanique Cellulaire et Respiratoire Faculté de Médecine Créteil 94 010 FranceInserm UMR 651 Fonctions Cellulaire et Moléculaire de l'Appareil Respiratoire et des Vaisseaux Equipe Biomécanique Cellulaire et Respiratoire Faculté de Médecine Créteil 94 010 FranceInserm UMR 651 Fonctions Cellulaire et Moléculaire de l'Appareil Respiratoire et des Vaisseaux Equipe Biomécanique Cellulaire et Respiratoire Faculté de Médecine Créteil 94 010 FranceInserm UMR 651 Fonctions Cellulaire et Moléculaire de l'Appareil Respiratoire et des Vaisseaux Equipe Biomécanique Cellulaire et Respiratoire Faculté de Médecine Créteil 94 010 FranceInserm UMR 651 Fonctions Cellulaire et Moléculaire de l'Appareil Respiratoire et des Vaisseaux Equipe Biomécanique Cellulaire et Respiratoire Faculté de Médecine Créteil 94 010 France

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