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Mesenchymal Bone Marrow-derived Stem Cells Transplantation in Patients with HCV Related Liver Cirrhosis

Journal of Clinical and Translational Hepatology 2014年第4期2卷 217-221页

作者： Sviatlana P. Lukashyk Vladimir M. Tsyrkunov yanina I. Isaykina oksana N. Romanova Artur T. Shymanskiy Olga V. Aleynikova Rimma I. Kravchuk Department of Infection Diseases The Belarusian State Medical University Minsk Republic of Belarus Department of Infection Diseases The Grodno State Medical University Grodno Republic of Belarus Cell biotechnology and cytotherapy laboratory The Republican Research and Practical Center of Pediatric Oncology and Hematology Minsk Republic of Belarus Central Scientific Research Laboratory The Grodno State Medical University Grodno Republic of Belarus

Background and Aims: To evaluate the effect of intrapar-enchymal transplantation of mesenchymal bone marrow-derived stem cells (BMSCs) in patients with hepatitis C virus (HCV)-related liver cirrhosis (LC). Methods: Mononuclear cells were isolated from patient bone marrow and were passaged several times in vitro in order to reach the required volume. Attributes of the BMSCs were evaluated by the presence of the surface markers CD105+, CD90+, and CD73+. Cells from each passage were evaluated for sterility, and they were transplanted intraparenchymally into liver tissue. Clinical and laboratory data were evaluated and morphological studies of liver biopsy were performed prior to and 6 months after transplantation. Results: On clinical evaluation, the general state of these patients was improved at 1 month following transplantation of BMSCs. At 1 and 6 months post-transplantation, jaundice was absent in four (67%) patients. After 6 months, functional hepatic indices were improved, i.e. decrease of ALT and AST activity and bilirubin level. However, these decreases were not statistically different (P>0.05). Expression of CD34 and α-SMA in liver biopsy samples were decreased at 6 months after transplanta-tion, consistent with structural improvements in mitochondria and nuclear compartments. Conclusions: Intraparenchymal transplantation of autologous BMSCs improved the functional condition of the liver, stimulated reparative processes in hepatocytes, and decreased extracellular matrix protein (EMP) count in hepatic tissues of patients with LC. It was well tolerated and was not associated with any complications both during and after BMSC transplantation.

关键词： Liver cirrhosis Mesenchymal bone marrow stem cells Trans-plantation therapy

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Correction to: Replication of LZTFL1 Gene Region as a Susceptibility Locus for COVID-19 in Latvian Population

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Virologica Sinica 2021年第6期36卷 1692-1692页

作者： Raimonds Rescenko Raitis Peculis Monta Briviba Laura Ansone Anna Terentjeva Helena Daiga Litvina Liga Birzniece Kaspars Megnis oksana Kolesova Baiba Rozentale Ludmila Viksna Vita Rovite Janis Klovins Latvian Biomedical Research and Study Centre Riga 1067Latvia Riga Stradins University Riga 1007Latvia

Correction to:Virologica Sinica https://***/10.1007/s12250-021-00448-x Due to our oversight,the author list of reference“Promchan *** *** M(2020)Leucine zipper transcription factor-like I binds adaptor protein comple... 详细信息

关键词： Replication LZTFL1 traffic

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中俄家庭观念的差异性研究

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课程教育研究 2015年第31期 12-12页

作者：陶慧 oksana IVANOVNA MIRONOVA 莫斯科国立社会大学

中俄两国虽然在家庭观念上有很多相似的地方,但是也存在不少独特的看法。因为两个民族在宗教信仰、历史文化和自然环境等方面的差异性,造成了他们在文化价值观念上必然会存在不同。本文将在儒家和宗教层面上对中俄两国家庭观念方面的差... 详细信息

中俄两国虽然在家庭观念上有很多相似的地方,但是也存在不少独特的看法。因为两个民族在宗教信仰、历史文化和自然环境等方面的差异性,造成了他们在文化价值观念上必然会存在不同。本文将在儒家和宗教层面上对中俄两国家庭观念方面的差别进行简要说明。

关键词：中国俄罗斯家庭观念差异性

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Prediction of the Melting Paths of Wollastonite-Containing Compositions

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China's Refractories 2020年第3期29卷 13-18页

作者： Sergey M.LOGVINKOV Ihor A.OSTAPENKO oksana N.BORISENKO Olga B.SKORODUMOVA Andriy A.IVASHURA Kharkiv National University of Economics named after Semen Kuznets KharkivUkraine PSC“Druzhkovka Refractory Plant” DruzhkovkaUkraine National University of Civil Defence of Ukraine KharkivUkraine

The article analyzed the main groups of thermal insulation(TIM)and slag-forming(SFM)mixtures produced by leading foreign companies:acidic ones based on the SiO2–Al2O3 system,basic ones based on the CaO–MgO–Al2O3 system and medium basic ones based on the CaO(MgO)system–Al2O3–*** is shown that achieving the necessary properties of the SFM and TIM requires strict observance of the mass content of the components of mixtures produced on the basis of synthetic materials in granular form with a given *** with a given composition and dispersion is associated with the need to provide a given melting temperature(for intermediate ladles 1250–1450℃,for molds 950–1150℃),neutrality to the cast metal,protection of the melt from secondary oxidation,minimization of heat loss from the melt mirror,absorption of non-metallic inclusions of various natures(Al2O3,CaO,SiO2,TiO2,less often MgO-containing)and sizes;as well as a number of specific requirements:compatibility with the working layer of the lining of the bucket,maintaining the work of the stoppers,minimizing harmful gaseous emissions,*** is known that Al2O3,TixOy,and CaO refractory inclusions in steel cause the majority of defects on the surface of a cold-rolled sheet,therefore,the aim of the work was to analyze the physicochemical regularities and melting paths of the wollastonite-containing compositions during the assimilation of nonmetallic inclusions by *** analyze the melting paths of the wollastonite-containing compositions in the CaO–Al2O3–SiO2 system,a diagram of the primary crystallization field of anorthite and the adjacent boundary curves is shown,indicating the directions of temperature drop and designating invariant *** presented scheme adequately reflects the topological regularities of the state diagram of the CaO–Al2O3–SiO2 *** analyze the melting paths of the wollastonite-containing SFM compositions during the assimilation of TiOx impurities from steel melts,a diagram of

关键词： wollastonite-containing compositions slag-forming mixtures heat-insulating mixtures solid-phase interaction

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区域经济的空间转换特征(英文)

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中南民族大学学报（自然科学版） 2014年第4期33卷 127-130页

作者：奥克萨娜.维克托罗夫娜塔季扬娜.安娜多丽耶夫娜俄罗斯坦波夫国立技术大学经济分析与质量系坦波夫392000

阐述了因生产及其他经济实体地理位置集中化的集聚过程,确定了区域面积集聚过程的主要目标.重点论述了在现代条件下聚集的关键标准,如人口超过10万人的"核心城市"的出现;分析了来自俄罗斯联邦从1989年到2012年的城市、城乡定居点的数据... 详细信息

阐述了因生产及其他经济实体地理位置集中化的集聚过程,确定了区域面积集聚过程的主要目标.重点论述了在现代条件下聚集的关键标准,如人口超过10万人的"核心城市"的出现;分析了来自俄罗斯联邦从1989年到2012年的城市、城乡定居点的数据,包括在这些区域的人口的数据;给出了区域经济的空间转换特征的定义.

关键词：区域经济空间转换集聚效应经济发展集聚核心城市定居核心城市中心城乡连接

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