检索结果-南通市图书馆

Comparison of QT Correction Methods in the Pediatric Population of a Community Hospital: A Retrospective Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Congenital Heart Disease 2024年第1期19卷 107-121页

作者： Koren Hyogene Kwag ibrahim Kak Ying Li Walid Khass Alec McKechnie oksana Nulman Brande Brown Manoj Chhabra Department of Pediatrics New York Presbyterian Brooklyn Methodist HospitalBrooklyn11215USA Department of Population Health Sciences Division of BiostatisticsWeill Cornell MedicineNew York10065USA

Objective:Accurate measurement of QT interval,the ventricular action potential from depolarization to repolarization,is important for the early detection of Long QT *** most effective QT correction(QTc)formula has yet to be determined in the pediatric population,although it has intrinsically greater extremes in heart rate(HR)and is more susceptible to errors in *** authors of this study compare six dif-ferent QTc methods(Bazett,Fridericia,Framingham,Hodges,Rautaharju,and a computer algorithm utilizing the Bazett formula)for consistency against variations in HR and RR ***:Descriptive Retrospective *** included participants from a pediatric cardiology practice of a community hospital who had an ECG performed in *** participants were healthy patients with no past medical history and no regular ***:ECGs from 95 participants from one month to 21 years of age(mean 9.7 years)were included with a mean HR of 91 beats per minute(bpm).The two-sample paired t-test or Wilcoxon signed-rank test assessed for any difference between QTc methods.A statistically signiﬁcant difference was observed between every combination of two QTc *** Spearman’s rank correlation analysis explored the QTc/HR and QTc/RR relationships for each *** method was most independent of HR and RR with the lowest absolute value of correlation coefﬁ*** and Computer had moderate correlations,while Framingham and Rautaharju exhibited strong *** were positive for Bazett and Computer,reﬂecting results from prior studies demonstrating an over-correction of Bazett at higher *** the linear QTc/HR regression analysis,Bazett had the slope closest to zero,although Computer,Hodges,and Fridericia had comparable ***,Fridericia had the linear QTc/RR regression coefﬁcient closest to *** Bland-Altman method assessed for bias and the limits of agreement between correction *** an

关键词： Corrected QT interval QT prolongation long QT syndrome electrocardiogram retrospective study bazett fridericia framingham hodges rautaharju computer algorithm

individual alcohol consumption by the population of Russia versus regional living conditions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Global Health Journal 2024年第1期8卷 24-31页

作者： Sergey A.Maksimov Svetlana A.Shalnova Galina A.Muromtseva Yuliya A.Balanova Svetlana E.Evstifeeva Anna V.Kapustina oksana M.Drapkina National Medical Research Center for Therapy and Preventive Medicine Moscow 101990Russia

Background:There are substantial regional differences in drinking alcohol in Russia,both at the population and individual ***,the causes of these differences have not been studied ***:The goal of our study was to examine the effect of regional living conditions on individual alcohol consumption by the population of ***:For the analysis,we used data from a cross-sectional epidemiological study conducted in *** final analytical sample included 18,130 people aged 25-64 *** conducted the interviews face to face,based on which any drinking in the last year,as well as alcohol abuse,were considered as a *** abuse was recorded when the respondent consumed 5.75 or more grams of pure ethanol per day(75th percentile of average daily alcohol consumption among alcohol drinkers).The assessment of the regional living conditions was accomplished via integral indexing,which was previously performed based on publicly available data for *** were assessed using generalized scoring equations with unchanging standard *** associations were expressed by odds ratios(OR)and 95%confidence intervals(C).Results:Deterioration of social conditions and increase in demographic depression in the region of residence increased the odds of any drinking(OR 1.51,95%Ci:1.33 to 1.72,Pi:1.05 to 1.41,P=***9,respectively).The odds of alcohol abuse increased with the deterioration of social living conditions and the growth of the industrial development in the region:OR 1.35,95%Ci:1.14 to 1.59,Pi:1.05 to 1.28,P=0.002,***:Our analysis allowed assessing the impact of the regional living conditions on individual drinking alcohol in the population of Russia.

关键词： Alcohol Living environment Regional features Russia

The hypoglycemic potential of phenolics from functional foods and their mechanisms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2023年第4期12卷 986-1007页

作者： oksana Golovinskaia Chin-Kun Wang Department of Nutrition Chung Shan Medical UniversityTaiwan 402China

Long-term postprandial hyperglycemia is a primary risk factor for developing chronic metabolic diseases such as obesity,type 2 diabetes,and cardiovascular *** hyperglycemia induces the glycation of proteins,oxidative stress,inflammation and increases plasma insulin and lipid *** resistance is the primary cause of postprandial excursions of blood glucose and *** can be treated by lowering dietary carbohydrates intake,digestion,and *** functional foods improve glucose metabolism by increasing insulin sensitivity and inhibitingα-glucosidase in the small *** phytochemicals,especially active phenolics are good antioxidants and show anti-inflammatory action and regulate blood *** review aimed to report on hypoglycemic properties of active phenolics from functional foods and their proposed anti-diabetic ***,further clinical trials are required to confirm the bioavailability,safety,and efficacy of phenolics,especially the dosage and duration of treatment,to avoid adverse effects and give better dietary recommendations.

关键词： Phenolics Functional foods Hypoglycemia insulin resistance insulin secretion

在线全文

学校读者我要写书评

暂无评论

巴黎蓬皮杜中心为何要“闭关修行”五年？

环球人文地理 2024年第3期 50-59页

作者： Rae 小盒饭子晋的时光碎片 nw7.eu Zhanpy Krists Luhaers Alex Vasey oksana Avramenko 摄图网

2019年，巴黎圣母院遭遇火灾，超过三分之二的塔尖烧毁，标志性尖顶坍塌。历经4年修复，2024巴黎奥运会前夕，它终于回到大众视野，即将重新开放。但惊喜之余，巴黎另一地标蓬皮杜中心宣布，它要迎来“闭关”期。和巴黎偏爱倾诉古典情...

2019年，巴黎圣母院遭遇火灾，超过三分之二的塔尖烧毁，标志性尖顶坍塌。历经4年修复，2024巴黎奥运会前夕，它终于回到大众视野，即将重新开放。但惊喜之余，巴黎另一地标蓬皮杜中心宣布，它要迎来“闭关”期。和巴黎偏爱倾诉古典情怀的卢浮宫、大教堂、歌剧院不同，乔治·蓬皮杜国家艺术和文化中心（下文简称蓬皮杜中心）是一场年轻人的艺术狂欢，巴黎城中的异类。它极尽叛逆张狂之事，

关键词：

Temperature dependence of LiNbO3 dislocation density in the near-surface layer

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Optics Letters 2022年第6期20卷 40-46页

作者： oksana Semenova Aleksei Sosunov Nikolai Prokhorov Roman Ponomarev Department of Nanotechnology and Microsystems Engineering Perm State UniversityPerm 614990Russia Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences Perm 614990Russia

Density of dislocations in the near-surface layer was investigated in X-cut LiNbO_(3) depending on thermal annealing in the temperature range of 400℃–600℃.A dynamic model of randomly distributed dislocations has been developed for LiNbO_(3) by using X-ray *** experimental results showed that the dislocation density of the near-surface layer reached the minimum at the thermal annealing temperature of 500℃,with the analysis being performed when wet selective etching and X-ray diffraction methods were *** concluded that homogenization annealing is an effective technique to improve the quality of photonic circuits based on LiNbO_(3).The results obtained are important for optical waveguides,LiNbO_(3)-on-insulator-based micro-photonic devices,electro-optical modulators,sensors,etc.

关键词： lithium niobate etching pits near-surface layer density of dislocations annealing X-ray diffraction

在线全文

学校读者我要写书评

暂无评论

作为策展人的爱森斯坦

当代电影 2024年第4期 149-157页

作者： [德]奥莎娜·布加科娃杨士博张超群叶晓娴不详中国电影艺术研究中心上海工程技术大学艺术设计学院

本文由爱森斯坦的代表作品《十月》入手,重点关注其对“物”的使用,以此将爱森斯坦与当时艺术展览的变革联系起来。作为一部在博物馆拍摄的影片,《十月》在各个段落中穿插了大量博物馆藏品的影像,是一部关于物品的电影。爱森斯坦通过对... 详细信息

本文由爱森斯坦的代表作品《十月》入手,重点关注其对“物”的使用,以此将爱森斯坦与当时艺术展览的变革联系起来。作为一部在博物馆拍摄的影片,《十月》在各个段落中穿插了大量博物馆藏品的影像,是一部关于物品的电影。爱森斯坦通过对物品影像的编排,构建了一种独特的体验方式,充分调动了观众的感知和联想。这些尝试既与他在那一时期的“理性电影”理论紧密相关,也能在20世纪艺术策展中找到相似的理念。

关键词：爱森斯坦理性电影蒙太奇艺术策展

Evolution of parthenogenetic reproduction in Caucasian rock lizards:A review

在线全文

学校读者我要写书评

暂无评论

Current Zoology 2023年第2期69卷 128-135页

作者： Marine Arakelyan Victor Spangenberg Varos Petrosyan Alexey Ryskov oksana Kolomiets Eduard Galoyan Department of Zoology Yerevan State UniversityYerevanArmenia Vavilov institute of General Genetics MoscowRussia Severtsov institute of Ecology and Evolution RAS MoscowRussia institute of Gene Biology RASMoscowRussia Zoological Museum of Moscow State University MoscowRussia

Despite numerous works devoted to hybrid origin of parthenogenesis in reptiles,the causes of hybridization between different species,resulting in the origin of parthenogenetic forms,remain *** studies demonstrate that sexual species considered parental to parthenogenetic rock lizards(Darevskia spp.)avoid interspecific mating in the secondary overlap areas.A specific combination of environmental factors during last glaciation period was critical for ectotherms,which led to a change in their distribution and sex *** population structure(e.g.,male bias)and limited available distributional range favored the deviation of reproductive behavior when species switched to interspecific *** date,at least 7 diploid parthenogenetic species of rock lizards(Darevskia,Lacertidae)originated through interspecific hybridization in the *** cytogenetic specifics of meiosis,in particular the weak checkpoints of prophase l,may have allowed the formation of hybrid karyotypes in rock *** and polyploidization are 2 important evolutionary forces in the genus *** present,throughout backcrossing between parthenogenetic and parental species,the triploid and tetraploid hybrid individuals appear annually,but no triploid species found among Darevskia *** current stage of *** speciation by hybridization with the long-term stage of diploid parthenogenetic species,non-distorted meiosis,together with the high ecological plasticity of Caucasian rock lizards provide us with a new model for considering the pathways and persistence of the evolution of parthenogenesis in vertebrates.

关键词： Caucasus glacial period hybridization reptiles reticulate evolution unisexual

Drug resistance in glioblastoma: from chemo- to immunotherapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Drug Resistance 2023年第4期6卷 688-708页

作者： Sachin Sharma oksana Chepurna Tao Sun Department of Neurosurgery Cedars-Sinai Medical CenterLos AngelesCA 90048USA

As the most common and aggressive type of primary brain tumor in adults,glioblastoma is estimated to end over 10,000 lives each year in the United States *** treatment for glioblastoma,including surgery followed by radiotherapy and chemotherapy(i.e.,Temozolomide),has been largely unchanged since early *** immunotherapy has significantly shifted the paradigm of cancer management in the past decade with various degrees of success in treating many hematopoietic cancers and some solid tumors,such as melanoma and non-small cell lung cancer(NSCLC).However,little progress has been made in the field of neuro-oncology,especially in the application of immunotherapy to glioblastoma *** this review,we attempted to summarize the common drug resistance mechanisms in glioblastoma from Temozolomide to *** intent is not to repeat the well-known difficulty in the area of neuro-oncology,such as the blood-brain barrier,but to provide some fresh insights into the molecular mechanisms responsible for resistance by summarizing some of the most recent *** this review,we also hope to share some new ideas for improving the immunotherapy outcome of glioblastoma treatment.

关键词： Glioblastoma immunotherapy drug resistance tumor microenvironment immunosuppression

Etiology and classification of acute pancreatitis in children admitted to iCU using the Pediatric Sequential Organ Failure Assessment (pSOFA) score

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases international 2023年第3期22卷 317-322页

作者： Vratislav Smolka Marie Rohanova Miroslav Seda Eva Karaskova oksana Tkachyk Martin Zapalka Jana Volejnikova Department of Pediatrics Faculty of Medicine and DentistryPalacky University and University Hospital OlomoucI.P.Pavlova 185/6Olomouc 77900Czech Republic

Background:Pediatric acute pancreatitis(AP)is rare but *** AP is associated with higher morbidity and ***,there are no universally accepted prognostic criteria for ***:This retrospective study included children with AP admitted to an intensive care unit(iCU)of our tertiary pediatric center between January 2009 and December *** severity of organ dysfunction in AP was assessed according to the modified Atlanta criteria using the Pediatric Sequential Organ Failure Assessment(p SOFA)and Computed Tomography Severity index(CTSi).Results:Seventy acute episodes of AP were evaluated in 55 children with primary *** addition,secondary AP was diagnosed in 15 patients originally admitted to iCU for different *** AP[no organ dysfunction,normal computed tomography(CT)finding]was the most prevalent(64/85 episodes in 49 children),followed by moderate AP(15 children;p SOFA 2-9 points,CTSi 3-4 points on admission).Severe AP(p SOFA 4-17 points,CTSi 6-10 points)was diagnosed in 6 children with traumatic or secondary *** most frequent etiologies of primary AP episodes were idiopathic(39%)and biliary(31%).Children with idiopathic AP had frequent relapses and *** AP was typically mild,but presented with high pancreatic enzyme levels and recurrence *** at iCU and an interval without enteral nutrition(EN)were relatively short in drug-induced AP and relatively long in secondary and traumatic *** retrograde cholangiopancreatography(ERCP)was performed in 13 patients with biliary AP and in 4 patients with traumatic *** AP-related death was ***:p SOFA score accurately reflects the severity and prognosis of AP in children.

关键词： Acute pancreatitis Children Organ dysfunction Prognosis pSOFA score