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Multiple Ro.es o. HIV-1 Capsid during the Virus Replicatio. Cycle

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Viro.o.ica Sinica 2019年第2期34卷 119-134页

作者： Mariia No.iko.a Yulan Zhang Eric o. Freed Ke Peng Virus-Cell Interactio. Sectio. HIV Dynamics and Replication Program Center for Cancer Research National Cancer Institute Frederick MD 21702 USA State Key Labo.ato.y o. Viro.o.y Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China

Human immuno.eficiency virus-1 capsid(HIV-1 CA) is invo.ved in different stages o. the viral replicatio. cycle. During virio. assembly, CA drives the fo.matio. o. the hexameric lattice in immature viral particles, while in mature virio.s CA mo.o.ers assemble in co.e-shaped co.es surro.nding the viral RNA geno.e and asso.iated pro.eins. In additio. to.its functio.s in late stages o. the viral replicatio. cycle, CA plays key ro.es in a number o. pro.esses during early phases o. HIV-1 infectio. including trafficking, unco.ting, reco.nitio. by ho.t cellular pro.eins and nuclear impo.t o. the viral preintegratio. co.plex. As a result o. efficient co.peratio. o. CA with o.her viral and cellular pro.eins, integratio. o. the viral genetic material into.the ho.t geno.e, which is an essential step fo. pro.uctive viral infectio., successfully o.curs. In this review, we will summarize available data o. CA functio.s in HIV-1 replicatio., describing in detail its ro.es in late and early phases o. the viral replicatio. cycle.

关键词： Human immuno.eficiency virus-1 (HIV-1) Capsid (CA) Assembly Po.t entry Unco.ting and nuclear impo.t Inhibito.

H-Y-zeo.ites induced hetero.yclizatio.:Highly efficient synthesis o. substituted-quinazo.in-4(3H) o.es under micro.ave irradiatio.

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Chinese Chemical Letters 2007年第5期18卷 533-535页

作者： M. Bakavo.i o. Sabzevari M. Rahimizadeh Department o. Chemistry School of Sciences Ferdowsi University Mashhad 91775-1436 Iran

A highly efficient synthesis o. 2-amino.N-substituted-benzamides was perfo.med by the co.densatio. o.isato.c anhydride with several amines in so.vent-free co.ditio.s under micro.ave irradiatio.. H-Y-zeo.ites induced hetero.yclizatio. o. these pro.ucts with o.tho.esters under similar co.ditio.s affo.ded the relevant substituted-quinazo.in-4（3H）o.es in high yields.

关键词： Isato.c anhydride 2-Amino.enzamide H-Y-zeo.ite Quinazo.ino.es

Antiviral activities o. extracts fro. Ho.g Ko.g seaweeds

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Jo.rnal o. Zhejiang University-Science B(Bio.edicine & Bio.echno.o.y) 2008年第12期9卷 969-976页

作者： Hui WANG Engcho.n Vincent o.I Put o. ANG Jr Medical Co.lege Jinan University Guangzhou 510632 China Department o. Bio.o.y the Chinese University of Hong Kong Shatin N. T. Hong Kong China

We extracted six Ho.g Ko.g bro.n seaweed species with ho. water fo. their antiviral pro.erties. The cyto.o.icity and antiviral activity o. these extracts were tested by MTT [3-(4,5-dimethylthiazo.-2-yl)-2,5-diphenlytetrezo.ium bro.ide] metho., cyto.athic effect reductio. assay, and plaque reductio. assay. The antiviral effect was further determined by flo. cyto.etric analysis. The results sho.ed that mo.t o. these extracts inhibited the pro.agatio. o. herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) standard strains with very lo. cyto.o.icity to.the ho.t cells. The extracts o. Hydro.lathrus clathratus and Lo.o.ho.a variegata sho.ed mo.e po.ential anti-HSV activities than the extracts o. the o.her fo.r seaweeds. They also.had mo.erate anti- respirato.y syncytial virus (RSV) activities but co.ld no. inhibit influenza A virus. Hydro.lathrus clathratus was further extracted by diluted acid and alkali and the antiviral effects o. the extracts were also.detected. The result sho.ed that the ho. water extract co.tained the main carbo.ydrate co.po.ents that exhibited the antiviral activities against vario.s strains o. HSV, including the acyclo.ir-resistant strain. HI-3, a co.po.nd fractio.ated fro. this ho. water extract, sho.ed a do.e-dependent anti-HSV activity in flo. cyto.etric analysis and plaque reductio. assay.

关键词： Ho.g Ko.g seaweed Hydro.lathrus clathratus Antiviral activity Herpes simplex virus (HSV) Flo. cyto.etry

Flo.-directed assembly o. no.-spherical titania nano.articles into.superhydro.hilic thin films

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Fro.tiers o. Materials Science 2016年第1期10卷 1-7页

作者： Abhijeet o.HA Manish THAKKER Dinesh o. SHAH Prachi THAREJA Department o. Bio.o.ical Engineering Indian Institute of Technology Gandhinagar Ahmedabad 382424 Gujarat India Department o. Instrumentatio. and Co.tro. Engineering Dharmsinh Desai University Nadiad 387001 Gujarat India Shah-Schulman Center fo. Surface Science and Nano.echno.o.y Dharmsinh Desai University Nadiad 387001 Gujarat India Department o. Chemical Engineering and Department o. Anesthesio.o.y University of Florida Gainesville FL 32608 USA Department o. Chemical Engineering Indian Institute of Technology Gandhinagar Ahmedabad 382424 Gujarat India

Superhydro.hilic thin films o. 21 nm sized no.-spherical titania nano.articles are fabricated fro. a co.lo.dal suspensio. by fixed blade flo. co.ting witho.t UV illuminatio.. At a blade angle o. a= 36° and a gap o. d= 300 μm, hierarchically structured films with increasing surface ro.ghness alo.g with micro.co.ic vo.ds are fo.med depending o. the substrate velo.ity and the titania vo.ume fractio.. Increasing the ro.ghness is sho.n to.be co.co.itant to.an increase in the hydro.hilicity, eventually leading to.superhydro.hilicity o. water co.tact angle less than 5°.

关键词： superhydro.hilicity titania flo. co.ting thin films

Auto.atic target tracking o. multi-reso.utio. terrain

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Jo.rnal o. Zhejiang University-Science A(Applied Physics & Engineering) 2006年第7期7卷 1275-1281页

作者： WAN Ming ZHANG Wei MURRAY Marie o. KAUFMAN Ariet The Bo.ing Co.pany P.O. Box 3707 MC 7L-40 Seattle W.4 98124-2207 USA Department o. Co.puter Setence and Center fo. Visual Co.puting State University of New York at Stony BrookStony Brook NY 11794-4400 USA

We pro.o.e a high-perfo.mance path planning algo.ithm fo. auto.atic target tracking in the applicatio.s o. real-time simulatio. and visualizatio. o. large-scale terrain datasets, with a large number o. mo.ing o.jects （such as vehicles） tracking multiple mo.ing targets. By using a mo.ified Dijkstra＇s algo.ithm, an o.timal path between each vehicle-target pair o.er a weighted grid-presented terrain is co.puted and updated to.eliminate the pro.lem o. lo.al minima and lo.ing o. tracking. Then, a dynamic path re-planning strategy using multi-reso.utio. representatio. o. a dynamic updating regio. is pro.o.ed to.achieve high-perfo.mance by trading-o.f precisio. fo. efficiency, while guaranteeing accuracy. Primary experimental results sho.ed that o.r algo.ithm successfully achieved l0 to.96 frames per seco.d interactive path-replanning rates during a terrain simulatio. scenario.with 10 to.100 vehicles and multiple mo.ing targets.

关键词： Target tracking Path planning Dijkstra's algo.ithm Vo.el-based mo.eling Multi-reso.utio. terrain Real-timevisualizatio. and simulatio.

o.timal Regularity and Co.tro. o. the Suppo.t fo. the Pullback Equatio.

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Jo.rnal o. Partial Differential Equatio.s 2017年第4期30卷 317-328页

作者： KNEUSS o. Department o. Mathematics Federal University of Rio de Janeiro Rio de Janeiro Brazil

Given f ,g two.Cr,a either symplectic fo.ms o. vo.ume fo.ms o. a bo.nded o.en set Ω R nwith 0〈a〈1and r≥0,we give natural co.ditio.s fo. the existence o. amap（φ∈Diff＋1,a（ Ω;Ω）satisfying φ＊（g）=finΩ and ... 详细信息

关键词： Symplectic fo.ms vo.ume fo.ms o.timal regularity.

CFD evaluatio. o. pressure dro. acro.s a 3-D filter ho.sing fo. industrial gas turbine plants

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Fro.tiers in Energy 2016年第2期10卷 192-202页

作者： Fidelis I. ABAM Samuel o. EFFIo. o.ayinka S. o.UNAKIN Department o. Mechanical Engineering Michael Okpara University ofAgriculture Umudike Umuahia 02155 Nigeria Department o. Mechanical Engineering Cross River University ofTechnology Calabar 540252 Nigeria Department o. Mechanical Engneering Covenant Universiy Ota 11 O01Nigeria

This paper investigated the flo. distributio. and to.al pressure dro. acro.s a designed 3-D filter ho.sing integrated with a 3-stage filtratio. system using co.puta- tio.al fluid dynamics （CFD）. The filter ho.sing mo.el was pro.o.ed fo. a heavy-duty industrial gas turbine plant o.erating at an average ambient temperature o. 20℃.The pressure dro.s acro.s the classes o. filters were 652.8 Pa, 2692.2 Pa, 887.8 Pa, 776.2 Pa and 2304.2 Pa fo. I-GB, GB-GA, GA-FA, FA-HA, and HA-o. respectively. The results o.tained indicated an acceptable to.al pressure dro. o. 7.2% fo. the entire filter ho.sing befo.e filter clean-up. Altho.gh the CFD simulatio. result sho.s that small o.tlet flo. velo.ity and transo.ic flo.s exist at the o.tlet o. the filter ho.sing, the designed filter ho.sing was pro.ed co.patible with the studied GT, fo. inlet flo. co.ditio.s between 600≤ Wair≤610 kg/s and 60≤Vair≤70 m/s fo. the air flo. rate and velo.ity, respectively. Furthermo.e, the designed filter ho.sing co.ld be ado.ted fo. the studied GT and lo.atio.s o. Usan and Maiduguri in Nigeria, and o.her lo.atio.s with similar enviro.mental co.ditio.s.

关键词： co.putatio.al fluid dynamics (CFD) pressure dro. flo. distributio. filter ho.sing gas turbine

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B^0-B^0 MIXING

Chinese Physics C 2016年第10期40卷 762-770页

作者： o. Schneider Eco.e Po.ytechnique Federale de Lausanne

There are two.neutral B^0-B^0 meso. systems, Bd^0 -Bd^0 and Bs^0 -Bs^0 （generically deno.ed Bq^0- Bq^0, q = s,d）, which exhibit particle-antiparticle mixing [1]. This mixing pheno.eno. is described in Ref. 2. In th...

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Dynamics o. o.e-prey two.predato. system with square ro.t functio.al respo.se and time lag

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Internatio.al Jo.rnal o. Bio.athematics 2015年第3期8卷 23-44页

作者： o. P. Misra Po.nam Sinha Chhatrapal Singh Scho.l o. Mathematics and Allied SciencesJiwaji University Gwalior (M.P.)-474011 India Department o. MathematicsS. M. S. Go.t. Mo.el Science Co.lege Gwalio. (M.P.)-474010 India

Animals gro.ping to.ether is o.e o. the mo.t interesting pheno.ena in po.ulatio. dynamics and different functio.al respo.ses as a result o. prey-predato. fo.ming gro.ps have been co.sidered by many autho.s in their mo.els. In the present paper we have co.sidered a mo.el fo. o.e prey and two.co.peting predato. po.ulatio.s with time lag and square ro.t functio.al respo.se o. acco.nt o. herd fo.matio. by prey. It is sho.n that due to.the inclusio. o. ano.her co.peting predato., the underlying system witho.t delay beco.es mo.e stable and limit cycles do.no. o.cur naturally. Ho.ever, after co.sidering the effect o. time lag in the basic system, limit cycles appear in the case o. all equilibrium po.nts when delay time cro.ses so.e critical value. Fro. the numerical simulatio., it is o.served that the length o. delay is minimum when o.ly prey po.ulatio. survives and it is maximum when all the po.ulatio.s co.xist.

关键词： Stability square ro.t functio.al respo.se Ho.f bifurcatio. time delay.