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Antimalarial potential of kolaviron,a biflavonoid from Garcinia kola seeds,against Plasmodium berghei infection in Swiss albino mice

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Asian Pacific Journal of Tropical Medicine 2014年第2期7卷 97-104页

作者： Adaramoyc Oluwatosin Akinpelu Tolulope Kosoko Ayokulchin okoric patricia Kehinde Aderemi Falade Catherine Ademowo Olusegun Biochemistry Department University of IbadanUniversity wayOyo-OjooRoadIbadanIbadan.Oyo/South-West 20005Nigeria Pharmacology Department University of IbadanUniversity way.Oyo-OjooRoadIbadanIbadanOyo/South-West 20005Nigeria Medical Microbiology Department.University of Ibadan University wayOyo-OjooRoadIbadanIbadanOyo/South-West 20005Nigeria Pharmacology and IAMRAT Department.University of Ibadan University wayOyo-OjooRoad.IbadanIbadanOyo/South-West 20005.Nigeria

Objective:To investigate the antimalarial potential of kolaviron(KV),a biflavonoid fraction from Garcinia kola seeds,against Plasmodium berghei(***)infection in Swiss albino ***:The study consists of seven groups of ten mice *** I,II and III were normal mice that received com ***1 and chloroquine(CQ),*** IV,V,ⅥandⅦwere infected mice that received corn ***,KYI and ***1 and KV2were given at 10-,100-and 200-mg/kg daily,respectively for three consecutive ***:Administration of KV1 and KV2 significantly(P<0.05)suppressed ***-infection in the mice by 85%and 90%.respectively,while CQ produced 87%suppression relative to untreated infected group after the fifth day of ***,KV2 significantly(P<0.05)increased the mean survival time of the infected mice by 175%.The biflavonoid prevented a drastic reduction in HCV from day4 of treatment,indicating its efficacy in ameliorating ***(P<0.05)oxidative stress assessed by the elevation of serum and hepatic malondialdehydewere observed in unlrealed ***-infected ***,senum and hepatic malondialdehyde levels increased by93%and 78%,resjiectively in the unlrealed infecled ***,antioxidant indices,viz;superoxide ***,*** peroxidase and reduced gluathione decreased significantly(P<0.05)in the tissues of untreated ***-infected *** significantly(P<0.05)ameliorated the ***-induced decrease in antioxidant status of the infected ***:This study shows that kolaviron,especially at 200 mg/kg,has high antimalarial activities in ***-infected mice,in addition to its known antioxidant properties.

关键词： Antimalaria Antioxidant Biflavonoid Kolaviron Plasmodium berghei

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