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Lecanemab Unveiled:Exploring Alzheimer’s Treatment Advancements,Assessing Strengths,Limitations,and Its Therapeutic Landscape Position

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Biomedical and Environmental Sciences 2024年第4期37卷 428-431页

作者： VICTOR Abiola Adepoju okechukwu Innocent Onyezue SAFAYET Jamil OLALEKAN John Okesanya DON Eliseo Lucero-Prisno Ⅲ Department of HIV and Infectious Diseases Jhpiegoan affiliate of John Hopkins UniversityAbujaNigeria Department of Prevention and Community Directorate APIN Public Health InitiativesAbujaNigeria Department of Public Health Daffodil International UniversityDhaka-1216Bangladesh Department of Public Health and Maritime Transport University of ThessalyVolosGreece Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUnited Kingdom

In the ever-evolving landscape of Alzheimer’s treatment,lecanemab(Leqembi)has emerged as a promising *** conventional therapies that merely alleviate symptoms,lecanemab is a humanized monoclonal antibody with a distinct *** targets protofibrils,insoluble fibrils,amyloid oligomers,and soluble amyloid-beta protofibrils,which are known to be especially damaging to neurons,with high accuracy.

关键词： Alzheimer amyloid Therapeutic

Retrospective Evaluation of Intussusception in Under-Five Children in Nigeria

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World Journal of Vaccines 2014年第3期4卷 123-132页

作者： Beckie Nnenna Tagbo Jason Mwenda Christopher Eke Tagbo Oguonu Sebastin Ekemze Uchechukwu Obiora Ezomike Benedict Edelu Ogechukwu Amadi Ifeyinwa Okeke okechukwu ani Roservelt okechukwu Nnani Vina Okafor Henrietta Uche Okafor Egbuna Obidike Emmanuel Abanida Chris Elemuwa Toyin Odetunde Department of Paediatric Surgery Enugu State University Teaching Hospital Enugu Nigeria Department of Paediatric Surgery University of Nigeria Teaching Hospital Enugu Nigeria Department of Paediatrics Enugu State University Teaching Hospital Enugu Nigeria Department of Paediatrics University of Nigeria Teaching Hospital Enugu Nigeria Institte of Child Health University of Nigeria Teaching Hospital Enugu Nigeria Institute of Child Health and Department of Paediatrics University of Nigeria Teaching Hospital Enugu Nigeria National Primary Health Care Development Agency Federal Ministry of Health Abuja Nigeria World Health Organization Regional Office for Africa (WHO/AFRO) Brazzaville Republic of Congo

Background: Assessment of the safety profile of the new rotavirus vaccines in Africa requires base-line epidemiological data on intussusception. Hence, this study was aimed at describing the prevalence and associated factors of intussusception in under-five children in Enugu, Southeast, Nigeria. Methods: This was a retrospective descriptive study involving the sixty reported cases of intussusception in under-five children admitted in a hospital in Enugu between 2007 and 2012. Cases of intussusception were selected using the Brighton collaboration intussusception working group level I diagnostic criteria. Information sought from the patients’ folders included demographic characteristics and clinical manifestations including history of previous rotavirus vaccination, duration of illness prior to presentation, diarrhoea, vomiting, passage of red currant jelly-like stool, abdominal mass and distension, method of diagnosis, treatment option(s) employed and their outcomes. The data was analyzed using SPSS version 17.0. Results: The majority of the cases were aged less than one year (53;88.3%) while the average incidence of intussusception was 0.1 per 1000. None of the cases had received rotavirus vaccinations. The common clinical presentations were vomiting, 55 (17.2%), passage of red currant stool 50 (15.6%), fever 50 (15.6%) and abnormal/absent bowel sound 43 (15.9%). Diagnosis was essentially with the aid of abdominal ultrasonography, 38 (63.3%) while surgery (laparotomy) was the treatment of choice in most cases 48 (80.0%). The case fatality rate was 3 (5.0%). Conclusion: None of the cases studied could be directly linked to rotavirus vaccinations. But seasonal peak incidence coincided with rotavirus diarrhea peak incidence. Efforts should be made to institute post-rotavirus vaccine licensure prospective surveillance study in order to fully determine any relationship between rotavirus vaccination and intussusception in Enugu, South east, Nigeria.

关键词： Intussusception Children Rotavirus Surgery Bloody Stool Nigeria

Monkeypox: A Viral Zoonotic Disease of Rising Global Concern

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Infectious Diseases & Immunity 2024年第3期4卷 121-131页

作者： Sukumaran ani Betsy Joseph Mary Thomas Vishnupriya K.Sweety Nandita Suresh Tumos Waltimo Department of Dentistry Oral Health InstituteHamad Medical CorporationPost Box 3050DohaQatar College of Dental Medicine Qatar UniversityPost Box 2713DohaQatar Department of Periodontology Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennai 600077India Department of Oral and Maxillofacial Diseases Helsinki University and University HospitalHelsinki 00014Finland Pushpagiri Institute of Medical Sciences and Research Centre MedicityPerumthuruthyTiruvallaKerala 689101India Clinic for Oral Health and Medicine University Center for Dental Medicine Basel UZBUniversity of Basel4058 BaselSwitzerland.

Monkeypox(mpox)is a rare viral zoonotic disease,endemic to Central and West Africa,caused by the monkeypox virus,an orthopoxvirus similar to the variola virus(smallpox).Although sporadic travel-associated cases have historically occurred outside Africa,in May 2022,mpox began spreading globally in multiple nonendemic countries across several *** 2024,there has been an increase in globally reported confirmed cases of mpox and deaths from mpox,making it a public health emergency of international *** reasons for the unusual global spread are under investigation but likely relate to increased travel and waning population immunity to *** now appears to be mainly through close,intimate contact,especially among men who have sex with *** is usually a self-limited *** limited approved antiviral treatments are available,such as tecovirimat,which the European Medicines Agency approved in January 2022 for the treatment of mpox,their widespread availability and effectiveness in the current outbreak remain to be *** health control measures include surveillance,case identification/isolation,contact tracing,and targeted vaccination of contacts at high risk of ***,challenges remain in curtailing the current unprecedented *** knowledge gaps include animal reservoir(s)responsible for initial spillover events,viral mutations that may enhance transmissibility,optimal diagnostics for noninvasive specimens,effective antiviral therapies,next-generation vaccines providing longer-term immunity,and building global capacity for outbreak *** review summarizes the current literature on mpox virology,epidemiology,pathogenesis,clinical manifestations,diagnostics,treatment,prevention,and public health control *** investigation and research are needed to better understand mpox’s evolving epidemiology,pathogenicity,transmissibility,and ecology to guide strategies for containin

关键词： Antiviral agents Disease outbreaks Epidemiology Mpox Smallpox vaccine Zoonoses

Comparative Study of the Socioeconomic Characteristics and Digital Literacy Level of Agricultural Extension Personnel in Imo and Ebonyi States, South-East, Nigeria

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Agricultural Sciences 2024年第2期15卷 230-245页

作者： Ogbonnaya Okoro Aja Cyril Chigozie Asiabaka Anthony Okorie ani Edna Chioma Matthews-Njoku Department of Agricultural Extension Federal University of Technology Owerri Nigeria

The study comparatively analysed the socioeconomic characteristics and digital literacy level of Agricultural Extension personnel (AEP) in Ebonyi and Imo States, South-East, Nigeria. The specific objectives were to describe the socioeconomic characteristics of agricultural extension personnel in Ebonyi and Imo States, and to ascertain the digital literacy level of AEP in the studied states. Purposive sampling technique was used to select 312 Agricultural Extension personnel (132 from Ebonyi State Agricultural Development Program and 180 from Imo State Agricultural Development Program) for the study. Data were collected through the use of validated and structured questionnaire, and administered through the help of well-trained enumerators. Data were analysed using simple descriptive statistical tools such as percentages mean score, standard deviation and weighted mean. Findings indicated that they were more male in the both States (55.3% and 57.8%) for Ebonyi and Imo State respectively and that the average age of AEP in Ebonyi and Imo States were 44.7 years and 49.2 years respectively. It was further revealed that the majority (77.3% and 82.8%) had ***./HND as their highest academic qualifications, belonged to professional organisations (62.1% and 75%), and were earning an average monthly income of N58,798 and N62,648 for Ebonyi and Imo State respectively. Also, it was revealed that their mean years of service were 12.4 years and 13.4 years for Ebonyi and Imo State respectively. Almost all of them (87.9% and 95.0%) own a smartphone, had access to the internet (80.3% and 90.0%), but do not own a laptop/ipad (82.6% and 72.8%) for Ebon-yi and Imo State respectively. Results further revealed that Agricultural extension personnel in both Ebonyi and Imo State respectively had low digital literacy level ( = 2.41 and 2.32). The study concluded that AEP in Ebonyi and Imo State respectively had similar socioeconomic characteristics and low level of digital literacy. The study

关键词： Agricultural Extension Personnel Digital Literacy Ebonyi State Imo State Socioeconomic Characteristics

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基于奇异值分解张拉整体结构找形方法

哈尔滨工程大学学报 2024年第5期45卷 957-963页

作者：罗阿妮曹紫莺刘贺平哈尔滨工程大学机电工程学院黑龙江哈尔滨150001

张拉整体结构是由一组不连续的受压单元包含于连续受拉单元组成的稳定自平衡结构,为了寻找自平衡状态下的构型,引入奇异值分解的方法,将寻找张拉整体结构的自平衡构型问题转化为最小奇异值的判定。通过广义节点坐标和构件之间的连接关... 详细信息

张拉整体结构是由一组不连续的受压单元包含于连续受拉单元组成的稳定自平衡结构,为了寻找自平衡状态下的构型,引入奇异值分解的方法,将寻找张拉整体结构的自平衡构型问题转化为最小奇异值的判定。通过广义节点坐标和构件之间的连接关系建立结构的数学模型;引入力密度的概念,对张拉整体结构进行受力分析,列写包含平衡矩阵的平衡方程;对平衡矩阵进行奇异值分解,利用分解获得的最小奇异值判断平衡方程是否有解,对张拉整体结构是否存在自平衡构型进行初步判定,再依据获得的力密度的均匀性(同组构件力密度大小相等)和正负属性(杆的力密度小于0,索的力密度大于0)对结构自平衡状态进一步判断;通过实例分析对该找形方法的可行性进行了验证,结果表明:该方法可以找到张拉整体结构自平衡构型。本文为寻找自平衡张拉整体结构提供了一种思路。

关键词：张拉整体结构找形方法节点坐标连接矩阵平衡矩阵平衡方程奇异值分解力密度

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满约束轴向拼接张拉整体结构的自稳定性分析

哈尔滨工程大学学报 2024年第3期45卷 552-560页

作者：刘贺平王艳蒙曹紫莺罗阿妮王焰新哈尔滨工程大学机电工程学院黑龙江哈尔滨150001 上汽通用汽车汽车有限公司武汉分公司湖北武汉430208

为获得更多张拉整体构型和拓扑结构,本文基于平衡方程,研究张拉整体拼接结构自稳定条件下的结构参数关系的求取方法。基于三杆张拉整体单元轴向拼接形成的臂状张拉整体结构,以减少结构节点约束数为目的去除索构件,获得一种新型满约束轴... 详细信息

为获得更多张拉整体构型和拓扑结构,本文基于平衡方程,研究张拉整体拼接结构自稳定条件下的结构参数关系的求取方法。基于三杆张拉整体单元轴向拼接形成的臂状张拉整体结构,以减少结构节点约束数为目的去除索构件,获得一种新型满约束轴向拼接张拉整体结构;分析此结构的节点坐标、构件向量的求取方法,推导结构的平衡方程;依据节点和构件之间的连接关系,以获得方阵形式的平衡矩阵为目标,提出了平衡方程缩减原则;根据平衡方程有非零解,平衡矩阵行列式为零的原则,获得保证张拉整体结构自稳定的结构参数关系。通过具体实例分析,证明此方法正确,获得的结构参数关系能够保证确定的满约束轴向拼接张拉整体结构的自稳定性。

关键词：张拉整体基本单元找形稳定构型节点矩阵连接矩阵节点力平衡平衡方程

2-苯基-5-氯甲基-7-对甲苯胺基吡唑并[1,5-a]嘧啶的合成研究

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辽宁化工 2024年第6期53卷 938-942页

作者：刘杨包安丽四川化工职业技术学院四川泸州646300 成都新恒创药业有限公司四川成都611137

吡唑并[1,5-a]嘧啶类化合物是一类具有良好生物活性的含氮杂环化合物,其分子中同时存在吡唑和嘧啶两类重要的活性单元,因而此类化合物常表现出良好的生物活性,被广泛应用于医药、农药和化工等相关领域,用以开发新型的抗肿瘤药物、酶抑... 详细信息

吡唑并[1,5-a]嘧啶类化合物是一类具有良好生物活性的含氮杂环化合物,其分子中同时存在吡唑和嘧啶两类重要的活性单元,因而此类化合物常表现出良好的生物活性,被广泛应用于医药、农药和化工等相关领域,用以开发新型的抗肿瘤药物、酶抑制、杀菌剂及除草剂等。本文主要合成2-苯基-5-氯甲基-7-对甲苯胺基吡唑并[1,5-a]嘧啶。并就实验过程中遇到的问题及解决方案做出详细说明,探索筛选合成路线,优化合成方法。

关键词：吡唑并[1,5-a]嘧啶含氮杂环化合物合成方法路线优化

大型飞机多支柱交联式起落架一体化载荷校准及建模研究

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空军工程大学学报 2024年第1期25卷 25-30页

作者：汤阿妮郭正旺胡小敏张海涛中国飞行试验研究院飞机所西安710089

针对某大型飞机多支柱交联式起落架结构受力及传力特点,首次采用一体校准、独立建模的载荷试验方法,三支柱起落架侧挂正向一体安装、一体加载,解决了多支柱之间的载荷影响问题。根据交联式多支柱结构受力及传力特点,进行应变电桥及载荷... 详细信息

针对某大型飞机多支柱交联式起落架结构受力及传力特点,首次采用一体校准、独立建模的载荷试验方法,三支柱起落架侧挂正向一体安装、一体加载,解决了多支柱之间的载荷影响问题。根据交联式多支柱结构受力及传力特点,进行应变电桥及载荷工况设计,载荷工况既包括常规的单支柱加载,还包括满足多支柱影响的两支柱及三支柱组合加载工况。提出了多支柱广义响应系数概念,并通过广义响应系数对支柱之间的影响效果进行分析,显示支柱载荷向前单向传递,后支柱影响紧邻前支柱,前支柱不影响后支柱。据此提出了支柱独立建模、载荷逐次迭代、基于广义响应系数的支柱消扰载荷建模方法,获得了满足精度要求的载荷模型。

关键词：多支柱交联式起落架一体化载荷校准载荷工况响应系数载荷模型

Erratum to “Retrospective Evaluation of Intussusception in Under-Five Children in Nigeria” [World Journal of Vaccines Vol.4 No.3 (August 2014) 123-132]

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World Journal of Vaccines 2015年第3期5卷 147-147页

作者： Beckie Nnenna Tagbo Jason Mwenda Christopher Eke Tagbo Oguonu Sebastian Ekenze Uchechukwu Obiora Ezomike Benedict Edelu Ogechukwu Amadi Ifeyinwa Okeke okechukwu ani Roservelt okechukwu Nnani Vina Okafor Henrietta Uche Okafor Egbuna Obidike Emmanuel Abanida Chris Elemuwa Toyin Odetunde Institute of Child Health and Department of Paediatrics University of Nigeria Teaching Hospital Enugu Nigeria World Health Organization Regional Office for Africa (WHO/AFRO) Brazzaville Republic of Congo Department of Paediatrics University of Nigeria Teaching Hospital Enugu Nigeria Department of Paediatric Surgery University of Nigeria Teaching Hospital Enugu Nigeria Department of Paediatrics Enugu State University Teaching Hospital Enugu Nigeria Institute of Child Health University of Nigeria Teaching Hospital Enugu Nigeria National Primary Health Care Development Agency Federal Ministry of Health Abuja Nigeria Department of Paediatric Surgery Enugu State University Teaching Hospital Enugu Nigeria

The original online version of this article (Tagbo, B. N., et al. 2014 “Retrospective Evaluation of Intussusception in Under-Five Children in Nigeria”, 2014, 4, 123-132, http://***/10.4236/wjv.2014.43015) was publis... 详细信息

关键词： Intussusception Children Rotavirus Surgery Bloody Stool Nigeria