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血压水平对急性卒中后病死率的影响

世界核心医学期刊文摘（心脏病学分册） 2005年第11期1卷 59-60页

作者： Okumura K. ohya y. Maehara A. 代喆 Department of Cardiovascular Medicine Nephrology and NeurologyUniversity of the Ryukyus School of Medicine 207 Uehara Nishihara-cho Okinawa 903-0215 Japan

Objective: We evaluated the relationship between admission blood pressure(BP) and early prognosis in patients with acute stroke in a single cohort. Design: The subjects comprised 1004 cases of brain infarction and 1097 cases of brain hemorrhage, who were admitted to hospitals on the day of stroke onset. Death within 30 days after onset was evaluated in relation to admission BP levels. Results: In brain infarction, a U-shaped relationship was found between BP levels and mortality rate, with a nadir at systolic blood pressure(SBP) of 150-169mmHg and at diastolic blood pressure(DBP) of 100-110mmHg. After adjustments for age and sex, the highest relative risks(RR) was observed in the lowest BP levels compared with nadir groups, and were 2.69 95%confidence interval(CI), 1.43-5.07 in SBP and 3.49(95%CI, 1.58-7.74) in DBP. In subjects with previous hypertension, the relationship between prognosis and SBP level shifted significantly toward higher pressure by about 10 mmHg compared with those without previous hypertension. In subjects with brain hemorrhage, the relationship between BP levels and mortality rate showed a J-shape in SBP and a U-shape in DBP. Highest BP levels had the poorest prognoses(≥230 mmHg in SBP, RR=4.13, 95%CI=2.45-6.94; ≥120 mmHg in DBP, RR=1.83, 95%CI=1.11-3.04). Conclusion: Lower and higher BP after brain infarction and higher BP after brain hemorrhage were predictors for poor early prognosis. In subjects with brain infarction, patients with previous hypertension had better outcomes at higher admission BP level than did normotensive patients.

关键词：急性卒中脑出血病脑梗死病相对风险

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喂食中长期缺乏亚硝酸盐和硝酸盐可导致小鼠代谢综合征、内皮功能障碍及心血管病死亡

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中华高血压杂志 2017年第6期25卷 507-507页

作者：刘莉叶鹏 Kina-Tanada M Sakanashi M Tanimoto A Kaname T Matsuzaki T Noguchi K Uchida T Nakasone J Kozuka C Ishida M Kubota H Taira y Totsuka y Kina SI Sunakawa H Omura J Satoh K Shimokawa H yanagihara N Maeda S ohya y Matsushita M Masuzaki H Arasaki A Tsutsui M

一氧化氮不仅通过一氧化氮合成酶（nitric oxide synthases,NOS）由L-精氨酸合成,还可由其惰性代谢物,亚硝酸盐和硝酸盐合成。绿叶蔬菜中含有丰富的硝酸盐。但是膳食中亚硝酸盐/硝酸盐的缺乏是否导致疾病的发生还有待澄清。该研究人员假... 详细信息

一氧化氮不仅通过一氧化氮合成酶（nitric oxide synthases,NOS）由L-精氨酸合成,还可由其惰性代谢物,亚硝酸盐和硝酸盐合成。绿叶蔬菜中含有丰富的硝酸盐。但是膳食中亚硝酸盐/硝酸盐的缺乏是否导致疾病的发生还有待澄清。该研究人员假设,喂食中长期缺乏亚硝酸盐/硝酸盐会诱导小鼠发生代谢综合征。

关键词：亚硝酸盐和硝酸盐代谢综合征内皮功能障碍心血管病一氧化氮合成酶小鼠喂食死亡

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Two types of K+ channels regulate proliferation and death of bovine brain en-dothelial cells

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Two types of K+ channels regulate proliferation and death of...

用双酶标记法观察AB型人唾液腺中A和B抗原分布的研究

第十五届国际药理学大会

作者： Daiju yamazaki Susumu ohya Katsuhiko Muraki Kivofumi Asai yuji Imaizumi Molecular and Cellular Pharmacology Graduate School of Pharmaceutical SciencesNagoya City University. Molecular and Cellular Pharmacology Graduate School of Pharmaceutical SciencesNagoya City University. Cellular Pharmacology School of PharmacyAichi gakuin University. Molecular Neurobiology Graduate School of Medical SciencesNagoya City University. Molecular and Cellular Pharmacology Graduate School of Pharmaceutical SciencesNagoya City University.

＜正＞ Brain capillary endothelial cells （ BCECs） contribute to brain homeostasis by forming blood brain barrier. Here we report functional analyses of ion channels and receptors in the regulation of cell proliferation and cell death in t-BBEC 117, an immortalized cell line derived from bovine brain endothelial cells. In t-BBEC 117, metabotropic P2y receptors （P2yRs）, Ca2+- activated K+ channel （SK2）, transient receptor potential （TRP） channel and inwardly rectifier K+ channel （ Kir2. x） were functionally expressed. We found a positive feedback mechanism for the regulation of [ Ca2+ ] i following the stimulation of P2 yRs. The initial rise of [Ca2+]i enhanced SK2 current, which hyperpolarized the cells and further increased Ca2+ entry through TRP channels. This mechanism enhanced cell proliferation. Furthermore, in approximately 20% of cells, where Kir2. x channels were highly expressed, the excess hyperpolarization was induced by the activation of Kir2. x following the SK2 activation. This resulted in cell death. Thus, P2y stimulation in BCECs enhances cell proliferation via SK2 activation, and, in a portion of cells, induces cell death by switching Kir2. x channels on.

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中国法医学杂志 1988年第3期 162-163页

作者： y.Bunai H.Komoriya I.ohya 孙云青歧阜大学医学院法医学教室

通过双酶标记法对6例尸体(5例为分泌型,1例为非分泌型)颌下腺和舌下腺中的A、B抗原的分布进行了研究。

关键词：粘液细胞抗原非分泌型导管细胞酶标记法 AB

志愿者模拟屏气不足或无法屏气的肝脏成像中K空间加权成像对比重建(KWIC)的放射状容积屏气检查(VIBE)具有超过Cartesian VIBE的优势

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国际医学放射学杂志 2016年第5期 596-597页

作者： y.Fujinaga y.Kitou A.ohya y.Adachi N.Tamaru A.Shiobara 王克亚 Department of Radiology Shinshu University School of Medicine

摘要目的探讨应用K空间加权成像对比重建(KIWC)的放射状容积屏气检查(r-VIBE)较Cartesian VIBE(c-VIBE)减少运动伪影方面的优势。方法采集10例健康志愿者的rVIBE-KIWC和c-VIBE影像。每次采集时间24 s。在扫描信

关键词： Cartesian VIBE KWIC 加权成像屏气放射状容积

定量图象分析系统在肺脂肪栓塞分级方面的应用

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中国法医学杂志 1988年第3期 148-148页

作者： y.Bunai I.ohya 王坚岐阜大学医学部法医学教室

用定量图象分析方法,对5例严重的肺脂肪栓塞尸解病例进行测定。每例均从经福尔马林固定的肺脏切取5个组织标本。全部组织浸入0.5％锇酸液中过夜,然后用冰冻切片机切至8μm厚,用装有连接装置的快速图象感受器系统进行图象分析。这个系统... 详细信息

用定量图象分析方法,对5例严重的肺脂肪栓塞尸解病例进行测定。每例均从经福尔马林固定的肺脏切取5个组织标本。全部组织浸入0.5％锇酸液中过夜,然后用冰冻切片机切至8μm厚,用装有连接装置的快速图象感受器系统进行图象分析。这个系统能从周围组织中区别脂肪栓塞。因为高密度的栓塞在锇酸中染黑,它的大小通过连接的计算机能计算出来。在每

关键词：图象分析脂肪病例景物分析栓子肺脂肪栓塞平均尺寸

Study on chemical behavior of energetic hydrogen isotopes implanted into impurities-contained boron films

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Study on chemical behavior of energetic hydrogen isotopes im...