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Agmatine ameliorates diabetes type 2-induced nephropathy in rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第1期14卷 8-16页

作者： Fatemah O.Kamel ohoud Shagroud Mai AAlim A.Sattar Ahmad Gamal S Abd El-Aziz Abdulhadi S.Burzangi Duaa Bakhshwin Maha Jamal Shahid Karim Department of Clinical Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Anatomy Faculty of MedicineKing Abdulaziz UniversityJeddah 21589Saudi Arabia

Objective:To assess the nephroprotective potential of agmatine in a rat model of streptozotocin-induced diabetic ***:A single dose of streptozotocin(40 mg/kg)coupled with a fructose diet induced diabetes in Wistar ***(40 and 80 mg/kg)was administered to rats for 12 *** body weight and fasting blood glucose were measured *** level,urine output,total protein,albumin,blood urea nitrogen,creatinine,and cystatin-C were also determined at the end of the ***,superoxide dismutase,glutathione,interleukin-1β,interleukin-6,and tumor necrosis factor-alpha were evaluated in kidney *** study was also performed using hematoxylin and eosin ***:Agmatine at both doses significantly increased final body weight,and lowered fasting blood glucose,urine output,insulin,total protein,albumin,blood urea nitrogen,creatinine,and cystatin-C levels compared with the diabetic group(P<0.05).Inflammatory markers and antioxidant effect were significantly improved in agmatine-treated ***,the histopathological changes in renal structure were ameliorated by agmatine ***:Agmatine alleviates diabetic nephropathy by improving renal functions and reducing inflammation and oxidative *** molecular mechanisms of its nephroprotective actions need to be investigated in future study.

关键词： Agmatine Type 2 diabetes Nephropathy Oxidative stress Nephroprotection

Elemental Compositions of Some Eye Shadow Products Marketed in Saudi Arabia

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Journal of Cosmetics, Dermatological Sciences and Applications 2018年第4期8卷 236-243页

作者： Faten M. Ali Zainy Fatima Bannani ohoud A. Alotaibi Department of Chemistry Faculty of Science King Abdulaziz University Jeddah KSA Department of Chemistry Faculty of Science Jeddah University Jeddah KSA

This study focuses on the determination, as well as, the composition of some heavy metals contained in 12 eye shadow cosmetic samples. An elemental analysis of heavy metals (Ti, Cr, Fe, Ni, Cu, Co, Mn, Pb, and Zn) was performed by X-ray Fluorescence. The constitution of some samples was studied by Powder X-Ray Diffraction. Heavy metals exist as zinc oxide, Titanium dioxide, Iron oxide, Bismuth oxychloride, and lead sulfide. The quantification of selected toxic heavy metals lead, copper and nickel were achieved by Inductively Coupled Plasma-Optical Emission Spectrometry after digestion with concentrated acids. In all analyzed samples lead had a concentration less than 20 ppm, which indicated good manufacturing practice. Copper and nickel levels were within acceptable concentrations, but overpasses the safe limit appeared in China samples. The prolonged use of cosmetics case an allergic problem for consumers. Therefore, quality controls are highly controlled for imported products with different regulations.

关键词： Cosmetic Eye Shadow Heavy Metals ICP XRD XRF

Endometrial Sampling Performed by Gynecological Residents in Training

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Open Journal of Obstetrics and Gynecology 2014年第4期4卷 182-185页

作者： Osama Sadkeak Bajouh ohoud Al-Shamrany Ahmad H. Abduljabbar Hassan S. O. Abduljabbar Department of Obstetrics & Gynecology Baterji Medical College Jeddah KSA Department of Obstetrics & Gynecology Medical College King Abdulaziz University Jeddah KSA

Objectives: Endometrial sampling became the first choice in screening endometrial pathology. The technique is accurate and simple. The aim is to evaluate the use of endometrial sample in outpatients’ clinic as a routine by LEVEL of gynecological resident in training. Methods: A retrospective study of 463 patients seen by the residents at KAUH. A detailed history was obtained from medical records file. Reasons for endometrial sampling were divided into 6 categories, including screening, PMB, Menorrhagia or AUB, bulky uterus and cervical lesion. Endometrial sample was obtained using Pipelle. Results: Out of 463 patients, 128 had en-dometrial sampling as screening (27.6%), 84 had PMB (18.1%), 91 Menorrhagia (19.7%), 108 AUB (23.3%), 20 bulky uterus (4.3%) and 32 cervical lesion (6.9%). In 30% of cases the sample insufficient, diagnosis in 54.2% benign, endometrial hyperplasia (6.0%) 19 diagnosed (endometrial cancer) (4.1%) in (5.6%) had endometritis. 70% of patients saved had a D&C. Conclusion: Endometrial biopsy is found to be accurate, easy, and safe and can be done by LEVEL of gynecological residents, accuracy of 70% of cases, additional endometrial assessment undertaken if diagnosis is not made.

关键词： Endometrial Endometrial Biopsy Outpatient

Nucleosides 10: Synthesis of New Derivatives of Pyrimidine and Fused Pyrimidine Nucleosides of Expected Biological Activity

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International Journal of Organic Chemistry 2019年第3期9卷 107-120页

作者： Laila M. Break Mosselhi A. M. Mohamed ohoud A. A. Al-Thubaiti Fatma E. M. Eibaih Department of Chemistry Faculty of Science Taif University Al-Haweiah Taif KSA Department of Chemistry Faculty of Science Cairo University Giza Egypt Department of Chemistry Faculty of Science King Saud University Riyadh KSA

Pyrimidines, such as 6-amino-2-thio and 2-methylthiouracils and fused pyrimidines, such as thienopyrimidines reacted with 1-O-acetyl-2,3,5-tri-O- benzoyl-β-D-ribofuranose to get new derivatives of the corresponding nucleosides. The obtained protected nucleosides were deprotected by methanolic sodium methoxide to get the corresponding free uracil and thienopyrimidine nucleosides. The new nucleosides formed were tested for biological activity against some of microorganism (some fungi and bacteria species). Some of the tested products showed moderate activity and the results were reported.

关键词： Synthesis Nucleosides Pyrimidines Fused Pyrimidines Heterocycles Biological Activity

Cyclocondensation Reactions of Hydrazonoyl Chlorides with Some Azines: Synthesis of New Fused Heterocycles of Expected Microbiological Activity

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International Journal of Organic Chemistry 2017年第1期7卷 12-24页

作者： Mosselhi A. M. Mohamed Liala M. B. Abu-Alola ohoud N. A. Al-Zaidi Hosam A. H. Saad Department of Chemistry Faculty of Science Taif University Taif Saudi Arabia Department of Chemistry Faculty of Science Cairo University Giza Egypt Department of Chemistry College of Education & Science Taif University Taif Saudi Arabia Department of Chemistry Faculty of Science Zagazig University Zagazig Egypt

New functionalized fused heterocycles, such as, 1,3,6,9,11-pentasubstituted-pyrido[3,2-f:6,5-f']bis([1,2,4]triazolo[4,3-a]-pyrimidin-5(1H)-ones (6) and 1,3-disubstituted-7-[(E)-2-(thiophen-2-yl)ethenyl]-1,4,9,9a-tetrahydro-6H-[1,2,4]triazino[4,3-b][1,2,4,5]-tetrazin-6-ones (16) were synthesized via reaction of the hydrazonoyl chlorides (1) with 1,3,6-triphenyl-9-thioxo-9,10-dihydro-pyrimido [4,5-b]pyrido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidin-5,7(1H,8H)-di-one (5) and 4-amino-6-[(2-thiophen-2-yl)ethenyl]-3-thioxo-3,4-dihydro-[1,2,4]triazin-5(2H)-one (11), respectively. The mechanism and the regioselectivity of the studied reactions have been discussed. The biological activity of the products has been evaluated against some fungi and bacteria species. The tested compounds exhibited moderate activity against the bacteria species.

关键词： Hydrazonoyl Chlorides Azines Fused Heterocycles Biological Activity