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Endometrial Sampling Performed by Gynecological Residents in Training

Open Journal of Obstetrics and Gynecology 2014年第4期4卷 182-185页

作者： Osama Sadkeak Bajouh ohoud al-shamrany Ahmad H. Abduljabbar Hassan S. O. Abduljabbar Department of Obstetrics & Gynecology Baterji Medical College Jeddah KSA Department of Obstetrics & Gynecology Medical College King Abdulaziz University Jeddah KSA

Objectives: Endometrial sampling became the first choice in screening endometrial pathology. The technique is accurate and simple. The aim is to evaluate the use of endometrial sample in outpatients’ clinic as a routine by LEVEL of gynecological resident in training. Methods: A retrospective study of 463 patients seen by the residents at KAUH. A detailed history was obtained from medical records file. Reasons for endometrial sampling were divided into 6 categories, including screening, PMB, Menorrhagia or AUB, bulky uterus and cervical lesion. Endometrial sample was obtained using Pipelle. Results: Out of 463 patients, 128 had en-dometrial sampling as screening (27.6%), 84 had PMB (18.1%), 91 Menorrhagia (19.7%), 108 AUB (23.3%), 20 bulky uterus (4.3%) and 32 cervical lesion (6.9%). In 30% of cases the sample insufficient, diagnosis in 54.2% benign, endometrial hyperplasia (6.0%) 19 diagnosed (endometrial cancer) (4.1%) in (5.6%) had endometritis. 70% of patients saved had a D&C. Conclusion: Endometrial biopsy is found to be accurate, easy, and safe and can be done by LEVEL of gynecological residents, accuracy of 70% of cases, additional endometrial assessment undertaken if diagnosis is not made.

关键词： Endometrial Endometrial Biopsy Outpatient

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Nucleosides 10: Synthesis of New Derivatives of Pyrimidine and Fused Pyrimidine Nucleosides of Expected Biological Activity

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International Journal of Organic Chemistry 2019年第3期9卷 107-120页

作者： Laila M. Break Mosselhi A. M. Mohamed ohoud A. A. al-Thubaiti Fatma E. M. Eibaih Department of Chemistry Faculty of Science Taif University Al-Haweiah Taif KSA Department of Chemistry Faculty of Science Cairo University Giza Egypt Department of Chemistry Faculty of Science King Saud University Riyadh KSA

Pyrimidines, such as 6-amino-2-thio and 2-methylthiouracils and fused pyrimidines, such as thienopyrimidines reacted with 1-O-acetyl-2,3,5-tri-O- benzoyl-β-D-ribofuranose to get new derivatives of the corresponding nucleosides. The obtained protected nucleosides were deprotected by methanolic sodium methoxide to get the corresponding free uracil and thienopyrimidine nucleosides. The new nucleosides formed were tested for biological activity against some of microorganism (some fungi and bacteria species). Some of the tested products showed moderate activity and the results were reported.

关键词： Synthesis Nucleosides Pyrimidines Fused Pyrimidines Heterocycles Biological Activity

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Cyclocondensation Reactions of Hydrazonoyl Chlorides with Some Azines: Synthesis of New Fused Heterocycles of Expected Microbiological Activity

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International Journal of Organic Chemistry 2017年第1期7卷 12-24页

作者： Mosselhi A. M. Mohamed Liala M. B. Abu-alola ohoud N. A. al-Zaidi Hosam A. H. Saad Department of Chemistry Faculty of Science Taif University Taif Saudi Arabia Department of Chemistry Faculty of Science Cairo University Giza Egypt Department of Chemistry College of Education & Science Taif University Taif Saudi Arabia Department of Chemistry Faculty of Science Zagazig University Zagazig Egypt

New functionalized fused heterocycles, such as, 1,3,6,9,11-pentasubstituted-pyrido[3,2-f:6,5-f']bis([1,2,4]triazolo[4,3-a]-pyrimidin-5(1H)-ones (6) and 1,3-disubstituted-7-[(E)-2-(thiophen-2-yl)ethenyl]-1,4,9,9a-tetrahydro-6H-[1,2,4]triazino[4,3-b][1,2,4,5]-tetrazin-6-ones (16) were synthesized via reaction of the hydrazonoyl chlorides (1) with 1,3,6-triphenyl-9-thioxo-9,10-dihydro-pyrimido [4,5-b]pyrido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidin-5,7(1H,8H)-di-one (5) and 4-amino-6-[(2-thiophen-2-yl)ethenyl]-3-thioxo-3,4-dihydro-[1,2,4]triazin-5(2H)-one (11), respectively. The mechanism and the regioselectivity of the studied reactions have been discussed. The biological activity of the products has been evaluated against some fungi and bacteria species. The tested compounds exhibited moderate activity against the bacteria species.

关键词： Hydrazonoyl Chlorides Azines Fused Heterocycles Biological Activity

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