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a.ma.ine a.eliora.es dia.etes type 2-induced nephropa.hy in ra.s

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a.ia. Pa.ific Journa. of Tropica. Biomedicine 2024年第1期14卷 8-16页

作者： Fa.ema. O.Ka.el ohoud Sha.roud Ma. a.lim a.Sa.ta. a.ma. Ga.a. S a.d El-a.iz a.dulha.i S.Burza.gi Dua. Ba.hshwin Ma.a.Ja.a. Sha.id Ka.im Depa.tment of Clinica. Pha.ma.ology Faculty of MedicineKing Abdulaziz UniversityJeddah 21589Saudi Arabia Depa.tment of a.a.omy Faculty of MedicineKing Abdulaziz UniversityJeddah 21589Saudi Arabia

Objective:To a.sess the nephroprotective potentia. of a.ma.ine in a.ra. model of streptozotocin-induced dia.etic ***:a.single dose of streptozotocin(40 mg/kg)coupled with a.fructose diet induced dia.etes in Wista. ***(40 a.d 80 mg/kg)wa. a.ministered to ra.s for 12 *** body weight a.d fa.ting blood glucose were mea.ured *** level,urine output,tota. protein,a.bumin,blood urea.nitrogen,crea.inine,a.d cysta.in-C were a.so determined a. the end of the ***,superoxide dismuta.e,gluta.hione,interleukin-1β,interleukin-6,a.d tumor necrosis fa.tor-a.pha.were eva.ua.ed in kidney *** study wa. a.so performed using hema.oxylin a.d eosin ***:a.ma.ine a. both doses significa.tly increa.ed fina. body weight,a.d lowered fa.ting blood glucose,urine output,insulin,tota. protein,a.bumin,blood urea.nitrogen,crea.inine,a.d cysta.in-C levels compa.ed with the dia.etic group(Pa.ma.ory ma.kers a.d a.tioxida.t effect were significa.tly improved in a.ma.ine-trea.ed ***,the histopa.hologica. cha.ges in rena. structure were a.eliora.ed by a.ma.ine ***:a.ma.ine a.levia.es dia.etic nephropa.hy by improving rena. functions a.d reducing infla.ma.ion a.d oxida.ive *** molecula. mecha.isms of its nephroprotective a.tions need to be investiga.ed in future study.

关键词： a.ma.ine Type 2 dia.etes Nephropa.hy Oxida.ive stress Nephroprotection

a.Ca.e of Ectopic Growth Hormone Relea.ing Hormone (GHRH) from Pa.crea.ic Neuroendocrine Tumor Resista.t to Thera.y

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Open Journa. of Endocrine a.d Meta.olic Disea.es 2013年第7期3卷 271-275页

作者： ohoud a.moha.eb Jua. Rivera Division of Endocrinology McGill University Health Centre Montreal Canada Specia.ized Dia.etes a.d Endocrine Center King Fahad Medical City Riyadh KSA

Introduction: Ectopic secretion of GHRH is a.ra.e ca.se of a.romega.y. However, its recognition is clinica.ly importa.t beca.se different thera.eutic a.proa.hes a.e required. Ca.e Presenta.ion: We present a.cha.lenging ca.e of a.romega.y seconda.y to ectopic GHRH secretion from pa.crea.ic neuroendocrine tumor in a.52-yea.-old fema.e. The pa.ient is trea.ed with different moda.ities which include pegvisoma.t in a. a.tempt to control the stimula.ed GH-a.is considering the limited da.a.a.out its use in trea.ment of ectopic a.romega.y. Conclusion: GHRH-secreting tumor is a.ra.e ca.se of a.romega.y. Surgica. resection of the tumor is the thera.y of choice whenever possible. However, further studies a.e wa.ra.ted for unresecta.le tumor or resista.t ca.es.

关键词： Ectopic GHRH a.romega.y Pa.crea.ic Neuroendocrine Tumor

Nucleosides 10: Synthesis of New Deriva.ives of Pyrimidine a.d Fused Pyrimidine Nucleosides of Expected Biologica. a.tivity

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Interna.iona. Journa. of Orga.ic Chemistry 2019年第3期9卷 107-120页

作者： La.la.M. Brea. Mosselhi a. M. Moha.ed ohoud a. a. a.-Thuba.ti Fa.ma.E. M. Eiba.h Depa.tment of Chemistry Faculty of Science Taif University Al-Haweiah Taif KSA Depa.tment of Chemistry Faculty of Science Cairo University Giza Egypt Depa.tment of Chemistry Faculty of Science King Saud University Riyadh KSA

Pyrimidines, such a. 6-a.ino-2-thio a.d 2-methylthioura.ils a.d fused pyrimidines, such a. thienopyrimidines rea.ted with 1-O-a.etyl-2,3,5-tri-O- benzoyl-β-D-ribofura.ose to get new deriva.ives of the corresponding nucleosides. The obta.ned protected nucleosides were deprotected by metha.olic sodium methoxide to get the corresponding free ura.il a.d thienopyrimidine nucleosides. The new nucleosides formed were tested for biologica. a.tivity a.a.nst some of microorga.ism (some fungi a.d ba.teria.species). Some of the tested products showed modera.e a.tivity a.d the results were reported.

关键词： Synthesis Nucleosides Pyrimidines Fused Pyrimidines Heterocycles Biologica. a.tivity

Cyclocondensa.ion Rea.tions of Hydra.onoyl Chlorides with Some a.ines: Synthesis of New Fused Heterocycles of Expected Microbiologica. a.tivity

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Interna.iona. Journa. of Orga.ic Chemistry 2017年第1期7卷 12-24页

作者： Mosselhi a. M. Moha.ed Lia.a.M. B. a.u-a.ola.ohoud N. a. a.-Za.di Hosa. a. H. Sa.d Depa.tment of Chemistry Faculty of Science Taif University Taif Saudi Arabia Depa.tment of Chemistry Faculty of Science Cairo University Giza Egypt Depa.tment of Chemistry College of Education & Science Taif University Taif Saudi Arabia Depa.tment of Chemistry Faculty of Science Zagazig University Zagazig Egypt

New functiona.ized fused heterocycles, such a., 1,3,6,9,11-penta.ubstituted-pyrido[3,2-f:6,5-f']bis([1,2,4]tria.olo[4,3-a.-pyrimidin-5(1H)-ones (6) a.d 1,3-disubstituted-7-[(E)-2-(thiophen-2-yl)ethenyl]-1,4,9,9a.tetra.ydro-6H-[1,2,4]tria.ino[4,3-b][1,2,4,5]-tetra.in-6-ones (16) were synthesized via.rea.tion of the hydra.onoyl chlorides (1) with 1,3,6-triphenyl-9-thioxo-9,10-dihydro-pyrimido [4,5-b]pyrido[4,5-d][1,2,4]tria.olo[4,3-a.pyrimidin-5,7(1H,8H)-di-one (5) a.d 4-a.ino-6-[(2-thiophen-2-yl)ethenyl]-3-thioxo-3,4-dihydro-[1,2,4]tria.in-5(2H)-one (11), respectively. The mecha.ism a.d the regioselectivity of the studied rea.tions ha.e been discussed. The biologica. a.tivity of the products ha. been eva.ua.ed a.a.nst some fungi a.d ba.teria.species. The tested compounds exhibited modera.e a.tivity a.a.nst the ba.teria.species.

关键词： Hydra.onoyl Chlorides a.ines Fused Heterocycles Biologica. a.tivity

Endometria. Sa.pling Performed by Gynecologica. Residents in Tra.ning

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Open Journa. of Obstetrics a.d Gynecology 2014年第4期4卷 182-185页

作者： Osa.a.Sa.kea. Ba.ouh ohoud a.-Sha.ra.y a.ma. H. a.dulja.ba. Ha.sa. S. O. a.dulja.ba. Depa.tment of Obstetrics & Gynecology Baterji Medical College Jeddah KSA Depa.tment of Obstetrics & Gynecology Medical College King Abdulaziz University Jeddah KSA

Objectives: Endometria. sa.pling beca.e the first choice in screening endometria. pa.hology. The technique is a.cura.e a.d simple. The a.m is to eva.ua.e the use of endometria. sa.ple in outpa.ients’ clinic a. a.routine by LEVEL of gynecologica. resident in tra.ning. Methods: a.retrospective study of 463 pa.ients seen by the residents a. Ka.H. a.deta.led history wa. obta.ned from medica. records file. Rea.ons for endometria. sa.pling were divided into 6 ca.egories, including screening, PMB, Menorrha.ia.or a.B, bulky uterus a.d cervica. lesion. Endometria. sa.ple wa. obta.ned using Pipelle. Results: Out of 463 pa.ients, 128 ha. en-dometria. sa.pling a. screening (27.6%), 84 ha. PMB (18.1%), 91 Menorrha.ia.(19.7%), 108 a.B (23.3%), 20 bulky uterus (4.3%) a.d 32 cervica. lesion (6.9%). In 30% of ca.es the sa.ple insufficient, dia.nosis in 54.2% benign, endometria. hyperpla.ia.(6.0%) 19 dia.nosed (endometria. ca.cer) (4.1%) in (5.6%) ha. endometritis. 70% of pa.ients sa.ed ha. a.D&C. Conclusion: Endometria. biopsy is found to be a.cura.e, ea.y, a.d sa.e a.d ca. be done by LEVEL of gynecologica. residents, a.cura.y of 70% of ca.es, a.ditiona. endometria. a.sessment underta.en if dia.nosis is not ma.e.

关键词： Endometria. Endometria. Biopsy Outpa.ient