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The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis

Cellular & Molecular Immunology 2017年第3期14卷 276-284页

作者： Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick sc Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin Division of Rheumatology Allergy and Clinical Immunology University of California at Davis Davis CA 95616 USA Third Department of Internal Medicine Division of Gastroenterology and Hepatology Kansai Medical University Osaka 573-1191 Japan Hunan Key Laboratory of Medical Epigenomics Department of Dermatology The Second Xiangya Hospital Central South University Changsha Hunan 410011 People's Republic of China Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences Nagoya 467-8601 Japan Department of Microbiology Monash University Melbourne Australia Division of Gastroenterology and Hepatology University of California at Davis School of Medicine. Sacramento. CA 95817. USA

Exosomes are nanoparticles of endocytic origin, secreted by a myriad of cell populations that are attracting increased attention by virtue of their ability to modulate cell-to-cell communications. They are also attracting attention in a variety of immunological issues, including autoimmunity and, in particular, their ability to regulate cytokine and chemokine activation. Primary biliary cirrhosis （PBC） is considered a model autoimmune disease, which has a highly focused cytotoxic response against biliary epithelial cells. We have isolated exosomes from plasma from 29 patients with PBC and 30 healthy controls （HCs）, and studied the effect of these exosomes on co-stimulatory molecule expression and cytokine production in mononuclear cell populations using an ex vivo system. We also identified the microRNA （miRNA） populations in PBC compared to HC exosomes. We report herein that although exosomes do not change cytokine production, they do significantly alter co-stimulatory molecule expression on antigen-presenting populations. Further, we demonstrated that CD86 up-regulated expression on CD14＋ monocytes, whereas CD40 up-regulated on CD11c＋ dendritic cells by exosomes from patients with PBC. In addition, there were differences of miRNA expression of circulating exosomes in patients with PBC. These data have significant importance based on observations that co-stimulatory molecules play a differential role in the regulation of T-cell activation. Our observation indicated that aberrant exosomes from PBC selectively induce expression of co-stimulatory molecules in different subset of antigen-presenting cells. These alterations may involve in pathogenesis of autoimmune liver disease.

关键词： autoimmunity exosome microRNA primary biliary cirrhosis

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Analytical Approach for Forecasting of Measurement Value from Dam Monitoring

Analytical Approach for Forecasting of Measurement Value fro...

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第一届堆石坝国际研讨会

作者： Slavko Milevski M.sc.Civ.Eng Macedonian Power Plant Department for technical monitoring and maintenance at dams and other civil objectsPlostad na revolucija b.b.6330 Struga R.Macedonia

＜正＞Analysis of Data’s from Dam Monitoring is very important factor for dam behavior. Monitoring of various quantities is performed within the technical monitoring system of dam,with aim to provide an assessment of dam behavior. Monitored values should be within in certain range depending on dam type,quantity type,as well as on the changing range of external physical causing quantities. Last years are increased acknowledgements in direction of discovery analytical methods which uses data’s from dam monitoring to get better result in forecast of dam’s behavior. In Employment for technical monitoring at dams was developed model for forecasting of measurement value from dam monitoring. Model uses method of multiple statistical correlations for forecasting of measurement value on measurement place（instrument）.Calculated theoretical value can be compare with measured *** when measurement values outdo expected theoretical value,control would be initializing. Model is base at assumption that measurement value can be function from time,hydrostatical effect and influence of season. With calculation of equation for each measurement data are gain system of equation and solving of this system of equation is gain prognoses value. For practical use of model is made an application in Visual *** use measurement data’s stored in databases. In this paper will be described implementation of that model for monitoring data’s assessment from dam in frame of Company Macedonian power plants. This model uses existing monitoring database’s,across the user-friendly interface.

关键词： dam monitoring data measurement model

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A Comparative Study of the Cytotoxicity of Silver-based Dressings in Monolayer Cell,Tissue Explant,and Animal Models

A Comparative Study of the Cytotoxicity of Silver-based Dres...

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第八届全国烧伤外科学年会

作者： Burd A Kwok CH Hung sc Lam WK Division of Plastic and Reconstructive Surgery Department of SurgeryThe Chinese University of Hong KongPrince of Wales HospitalHong Kong

＜正＞Over the past decade,a variety of advanced silver-based dressings have been *** are considerable variations in the structure,composition,and silver content of these new *** the present study,we examined five commercially available silver-based dressings （Acticoat,Aquacel Ag, Contreet Foam,PolyMem Silver,Urgotul SSD）.We assessed their cytotoxicity in a monolayer cell culture, a tissue explant culture model,and a mouse excisional wound *** results showed that Acticoat, Aquacel Ag,and Contreet Foam,when pretreated with specific solutes,were likely to produce the most significant cytotoxic effects on both cultured keratinocytes and fibroblasts,while PolyMem Silver and Urgotul SSD demonstrated the least *** cytotoxicity correlated with the silver released from the dressings as measured by silver concentration in the culture *** the tissue explant culture model,in which the epidermal cell proliferation was evaluated,all silver dressings resulted in a significant delay of *** the mouse excisional wound model,Acticoat and Contreet Foam indicated a strong inhibition of wound reepithelialization on the postwounding-day *** findings may,in part, explain the clinical observations of delayed wound healing or inhibition of wound epithelialization after the use of certain topical silver *** should be exercised in using silver-based dressings in clean superficial wounds such as donor sites and superficial burns and also when cultured cells are being applied to wounds.

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蠕虫对宿主体内最适寄生部位的选择

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国外医学（寄生虫病分册） 1995年第4期22卷 149-152页

作者： Sukhdeo MVK Sukhdeo sc 潘劲草

脊椎动物的寄生蠕虫通常在宿主体内选择非常特异的寄生部位,且此前往往需经过宿主多个器官的移行过程。然而,其机制至今未明。本文提出一种研究蠕虫此种行为的思路,即从寄生虫自身的角度及其对环境察识的观点出发来考虑,寄生虫的环境特... 详细信息

脊椎动物的寄生蠕虫通常在宿主体内选择非常特异的寄生部位,且此前往往需经过宿主多个器官的移行过程。然而,其机制至今未明。本文提出一种研究蠕虫此种行为的思路,即从寄生虫自身的角度及其对环境察识的观点出发来考虑,寄生虫的环境特征及其对环境的应答活动构成了行为的基本因素。结果提示,蠕虫对宿主体内固定环境的应答通常是以定型的方式进行,假设宿主体内生理与生化的平衡给寄生虫提供了一可预测的环境,寄生虫只需感知环境信息中的少量信息即可诱发合宜的应答。然而对寄生虫的感觉及神经系统的研究存在技术困难,因此,须考虑应用多学科方法(寄生虫学、生态学、进化生物学和神经行为学等)来研究寄生虫的行为策略,预期未来的研究方向应是寄生虫感觉生理学和行为生态学的综合。

关键词：蠕虫宿主体内寄生部位

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Dynamic Analysis for Structures Isolated with Dampers

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China Ocean Engineering 1996年第3期11卷 269-280页

作者： Gu Peiying and Gao Ming M. sc, Engineer, Material and Structure Department, Nanjing Hydraulic Research Institute, Nanjing 210024 Professor, Material and Structure Department, Nanjing Hydraulic Research Institute, Nanjing 210024 Material and Structure Department Nanjing Hydraulic Research Institute Nanjing 210024

In this paper, mathematical models and dynamic analyses for both SDOF and MDOF structures isolated with dampers are established and performed, and a comprehensive computation method is provided. The shock absorbing effect is illustrated through an example of a two DOF damper-isolated system excited by sinusoidal waves and actual ground acceleration input recorded in earthquakes. It is shown that most of the responses of the structure with dampers reduce greatly near the resonant zone, but acceleration is enlarged in the lower or higher frequency zone; among various parameters, the influence of frictional coefficient n is the most significant, that of damping ratio of the dampers , is the second, and that of stiffness coefficient of the dampers k, is the slightest.

关键词： shock absorbing structure isolated with dampers shock absorbing effect dynamic analysis parametric analysis

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根治术后病理T3期或切缘阳性前列腺癌的辅助放疗的系统综述和荟萃分析

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中国癌症杂志 2009年第2期19卷 83-84页

作者： Morgan sc Waldron TS Eapen L 秦晓健单位不详

研究背景：前列腺癌是西方国家男性最常见的非皮肤来源恶性肿瘤,病死率排第二位。根治性前列腺切除（RP）是临床局限性前列腺癌标准的外科治疗手段。然而,术后病理诊断发现肿瘤侵出前列腺包膜（pT3）或者切缘阳性（R1）的患者预后不佳,... 详细信息

研究背景：前列腺癌是西方国家男性最常见的非皮肤来源恶性肿瘤,病死率排第二位。根治性前列腺切除（RP）是临床局限性前列腺癌标准的外科治疗手段。然而,术后病理诊断发现肿瘤侵出前列腺包膜（pT3）或者切缘阳性（R1）的患者预后不佳,5年生化疾病进展率高达67%。目前接受RP手术的患者中约有50％会碰到以上至少一种情况。

关键词：局限性前列腺癌术后病理诊断切缘阳性根治性荟萃分析系统综述辅助放疗 T3期

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Aspirin and clopidogrel after ischemic stroke or transient ischemiic attack

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中华物理医学与康复杂志 2018年第10期40卷 732-732页

作者： Johnston sc Easton JD Farrant M

BACKGROUND AND OBJECTIVE In 2013,the CHANCE trial found a 32%lower risk of stroke recurrence at 90 days by using a combination of clopidogrel and aspirin, as compared to aspirin alone, in a Chinese sample. This study, the Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) trial was designed to generalize these results to the international *** This randomized, double-blind, placebo-controlled trial enrolled 4,881 patients from 10 countries. Patients with NIHSS stroke scores of less than three were randomized within 12 hours after an acute ischemic stroke. The treatment group received a loading dose

关键词：阿司匹林攻击 TIA 血小板试用学习

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倍受关注的国际工业以太网系列标准起草工作组(IEC/sc65C/WGs)第三次会议(北京)纪要

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仪器仪表标准化与计量 2004年第3期 1-3页

作者：中国IEC/sc65C/WGs代表团

2004年5月12日～14日，IEC sc65C/JWG10、WG11、WG13联合工作组会议在北京中国职工之家饭店召开，来自13个国家的39名自动化技术专家参加了本次会议。本次会议由机械工业仪器仪表综合技术经济研究所和全国工业过程测量和控制标准化技术... 详细信息

2004年5月12日～14日，IEC sc65C/JWG10、WG11、WG13联合工作组会议在北京中国职工之家饭店召开，来自13个国家的39名自动化技术专家参加了本次会议。本次会议由机械工业仪器仪表综合技术经济研究所和全国工业过程测量和控制标准化技术委员会承担，中国代表团由机械工业仪器仪表综合技术经济研究所的冯晓升、梅恪、郑旭，浙大中控的冯冬芹，中科院沈阳自动化所的徐皑冬，重庆邮电学院自动化所的王平、王浩7人组成。会议主要讨论了实时以太网提案、网络保密性提案和工业线缆提案。下面分别介绍这三个提案的讨论情况。

关键词：工作组 IEC/sc65C/WGs JWG 会议 sc 北京

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EATING ON THE ROAD: WHERE ARE THE CARBOHYDRATES?

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中国运动医学杂志 1999年第2期18卷 187-192页

作者： Suzanne Nelson Steen D. sc. R. D. (The University of Washington,Department of Interocollegiate Athletics, Husky Sports Nutrition Services,Seattle,Washington) The University of Washington Department of Intercollegiate AthleticsHusky Sports Nutrition Services 美国

INTRODUCTIONObtaining a nutritious high-carbohydrate meal while traveling can be a challenge for *** many teams,meal stops are often made at fast-food restaurants because they are convenient,relatively inexpensive,and appealing to *** the athletes hunger may be satisfied,what about their nutritional status-Did they eat enough carbohydrates to replenish their glycogen stores-Did they consume too much fat-What about vitamins and minerals-Did they drink enough to restore normal hydration-No matter where athletes are traveling to compete,it is important that they choose the proper fuel for optimal *** this *** meals that provide ample amounts of carbohydrates is the primary challenge.

关键词： Office ARE EATING ON THE ROAD WHERE ARE THE CARBOHYDRATES

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天籁之音容不得一点损伤 APE、TTA、FLAC转换为“无损”MP3

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电脑爱好者 2007年第6期 88-89页

作者： sc

现在最流行的音频格式就要属MP3、WMA了,不过网上也经常出现一些APE、TTA或FLAC等常见的无损压缩音频文件,这些音频文件的音质虽好,但体积过大,而且大部分的MP3随身听都不能识别这些格式,今天我们的目标就是在尽量保留它们原有音质的条... 详细信息

现在最流行的音频格式就要属MP3、WMA了,不过网上也经常出现一些APE、TTA或FLAC等常见的无损压缩音频文件,这些音频文件的音质虽好,但体积过大,而且大部分的MP3随身听都不能识别这些格式,今天我们的目标就是在尽量保留它们原有音质的条件下,将这些文件转换为MP3格式。

关键词： TTA 音频文件 FLAC 文件名无损压缩文本编辑器文本编辑程序压缩包 APE

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