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LDHA Desuccinylase Sirtuin 5 as A Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer

Genomics, Proteomics & Bioinformatics 2023年第1期21卷 177-189页

作者： oh kwang kwon In Hyuk Bang So Young Choi Ju Mi Jeon Ann-Yae Na Yan Gao Sam Seok Cho Sung Hwan Ki Youngshik Choe Jun Nyung Lee Yun-Sok Ha Eun Ju Bae Tae Gyun kwon Byung-Hyun Park Sangkyu Lee BK21 Plus KNU Multi-Omics Based Creative Drug Research Team College of PharmacyResearch Institute of Pharmaceutical SciencesKyungpook National UniversityDaegu 41566Republic of Korea Department of Biochemistry and Molecular Biology Chonbuk National University Medical SchoolJeonjuJeonbuk 54896Republic of Korea College of Pharmacy Chosun UniversityGwangju 61452Republic of Korea Korea Brain Research Institute Daegu 41068Republic of Korea Department of Urology School of MedicineKyungpook National UniversityDaegu 41566Republic of Korea Department of Urology Kyungpook National University HospitalDaegu 41566Republic of Korea College of Pharmacy Chonbuk UniversityJeonjuJeonbuk 54896Republic of Korea School of Pharmacy Sungkyunkwan UniversitySuwon 16419Republic of Korea

Prostate cancer(PCa)is the most commonly diagnosed genital cancer in men *** 80%of the patients who developed advanced PCa suffered from bone metastasis,with a sharp drop in the survival *** great efforts,the detailed mechanisms underlying castration-resistant PCa(CRPC)remain *** 5(SIRT5),an NAD+-dependent desuccinylase,is hypothesized to be a key regulator of various ***,compared to other SIRTs,the role of SIRT5 in cancer has not been extensively ***,we revealed significantly decreased SIRT5 levels in aggressive PCa cells relative to the PCa *** correlation between the decrease in the SIRT5 level and the patient’s reduced survival rate was also *** quantitative global succinylome analysis,we characterized a significant increase in the succinylation at lysine 118(K118su)of lactate dehydrogenase A(LDHA),which plays a role in increasing LDH *** a substrate of SIRT5,LDHA-K118su significantly increased the migration and invasion of PCa cells and LDH activity in PCa *** study reveals the reduction of SIRT5 protein expression and LDHA-K118su as a novel mechanism involved in PCa progression,which could serve as a new target to prevent CPRC progression for PCa treatment.

关键词： Sirtuin 5 Lactate dehydrogenase A Lysine succinylation PCa progression

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Utilization of biomarkers for the prognostic prediction of cardiac arrest survivors using a multi-modal approach

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World Journal of Emergency Medicine 2024年第2期15卷 131-134页

作者： Changshin Kang Yeonho You Jung Soo Park Byeong kwon Park Jae kwang Lee Byung Kook Lee Department of Emergency Medicine College of MedicineChungnam National UniversityDaejeon 35015Republic of Korea Department of Emergency Medicine Chungnam National University HospitalDaejoen 35015Republic of Korea Department of Emergency Medicine Konyang University HospitalCollege of MedicineDaejeon 35015Republic of Korea Department of Emergency Medicine Chonnam National University Medical SchoolChonnam National University HospitalGwangju 61469Republic of Korea

International guidelines for post-cardiac arrest care recommend using multi-modal strategies to avoid the withdrawal of life-sustaining therapy(WLST)in patients with the potential for neurological recovery.[1]However,a clear methodology for multi-modal approaches has yet to be ***-specific enolase(NSE)is currently the only recommended biomarker,and the European Resuscitation Council(ERC)and the European SocietyofIntensiveCareMedicine(ESICM)have proposed a cutoff value of 60μg/L at 48 and/or 72 h after the return of spontaneous circulation(ROSC)as a multimodal prognostic tool for predicting poor neurological outcomes.

关键词： cardiac modal return

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Pressure-induced hydrogen-dominant high-temperature superconductors

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National Science Review 2024年第7期11卷 14-16页

作者： Ho-kwang Mao Shanghai Advanced Research in Physical Sciences Center for High Pressure Science and Technology Advanced Research

Recent studies of hydrogen-dominant（superhydride） materials have led to putative discoveries of near-room temperature superconductivity at high pressures. The idea started more than half-a-century ago as a by-product of the quest for metallic hydrogen for which a natural consequence of its very high Debye temperature and phonon frequency due to the very low mass of the hydrogen atoms would lead to a high superconducting critical temperature （Tc） in weak coupling Bardeen-Cooper-Schrieffer（BCS） expression.

关键词： HYDRIDE LANTHANUM

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Optimizing multi-parameter distributed fiber sensors:a hybrid Rayleigh-Brillouin-Raman System approach

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Light(Science & Applications) 2024年第3期13卷 393-395页

作者： kwang Yong Song Dept.of Physics Chung-Ang University84 Heukseok-roDongjak-guSeoul 06974Korea

An optimized single-end hybrid Rayleigh,Brillouin,and Raman distributed fiber sensing system has been developed for simultaneous measurement of multiple *** system integrates 3-bit pulse coding for the Raman signal and the Brillouin amplification of the Rayleigh-backscattered signal,discriminating strain,temperature,and vibration using a single sensing fiber.

关键词： fiber Rayleigh signal

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Liquid Metal Grid Patterned Thin Film Devices Toward Absorption‑Dominant and Strain‑Tunable Electromagnetic Interference Shielding

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Nano-Micro Letters 2024年第11期16卷 541-553页

作者： Yuwen Wei Priyanuj Bhuyan Suk Jin kwon Sihyun Kim Yejin Bae Mukesh Singh Duy Thanh Tran Minjeong Ha kwang‑Un Jeong Xing Ma Byeongjin Park Sungjune Park Department of Polymer‑Nano Science and Technology Department of Nano Convergence EngineeringJeonbuk National UniversityJeonju 54896Republic of Korea School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Composites Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea School of Materials Science and Engineering Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea School of Materials Science and Engineering and Sauvage Laboratory for Smart MaterialsHarbin Institute of Technology(Shenzhen)ShenzhenGuangdong 518055People’s Republic of China

The demand of high-performance thin-film-shaped deformable electromagnetic interference(EMI)shielding devices is increasing for the next generation of wearable and miniaturized soft *** highly reflective conductive materials can effectively shield EMI,they prevent deformation of the devices owing to rigidity and generate secondary electromagnetic pollution ***,soft and stretchable EMI shielding thin film devices with absorption-dominant EMI shielding behavior is *** devices consist of liquid metal(LM)layer and LM grid-patterned layer separated by a thin elastomeric film,fabricated by leveraging superior adhesion of aerosol-deposited LM on *** devices demonstrate high electromagnetic shielding effectiveness(SE)(SE_(T) of up to 75 dB)with low reflectance(SER of 1.5 dB at the resonant frequency)owing to EMI absorption induced by multiple internal reflection generated in the LM grid ***,the excellent stretchability of the LM-based devices facilitates tunable EMI shielding abilities through grid space adjustment upon strain(resonant frequency shift from 81.3 to 71.3 GHz@33%strain)and is also capable of retaining shielding effectiveness even after multiple strain *** newly explored device presents an advanced paradigm for powerful EMI shielding performance for next-generation smart electronics.

关键词： Absorption-dominant electromagnetic interference shielding Liquid metals Soft and stretchable electronics Thin film devices Tunable electromagnetic interference shielding

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Magnetic methods in studies of new superconducting hydrides in a diamond anvil cell

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National Science Review 2024年第7期11卷 16-18页

作者： Viktor V.Struzhkin Ho-kwang Mao Center for High Pressure Science&Technology Advanced Research

In recent years, we have witnessed great success in discoveries of high-transition-temperature（Tc） hydrides using high-pressure experiments. This has been achieved by creating metallic hydrogen‘alloys’ with other ...

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Editorial for Machine learning and AI for underground metaverse

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Underground Space 2024年第6期19卷 1-3页

作者： Kok-kwang Phoon Qiujing Pan Chong Tang Information Systems Technology and Design/Architecture and Sustainable Design Singapore University of Technology and DesignSingapore 487372 School of Civil Engineering Central South UniversityChangsha 410075China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

It is widely recognized that civil engineering practice,including underground construction,is lagging the fast pace digital transformation taking place in many *** key reason for this revolution is the emergence and convergence of digital technologies that include machine learning,artificial intelligence(AI),blockchain,cloud/edge computing,Internet of Things,5G communication,automation,digital twin,and *** parallel,Industry 4.0 is now complemented by Industry 5.0 that advocates a shift from economic value to societal value(sustainability,well-being,etc.).This means a shift from enterprises benefiting shareholders(profits)to stakeholders(people).

关键词： learning artificial underground

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Pyrometallurgical recycling of end-of-life lithium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1554-1571页

作者： Juheon Lee kwang Won Park Il Sohn Sanghoon Lee Department of Materials Science and Engineering Seoul 03722Korea Yonsei Industry Cooperation Center Yonsei UniversitySeoul 03722Korea RD Solution Wanju gunJeollabuk do 55365Korea

The global importance of lithium-ion batteries(LIBs)has been increasingly underscored with the advancement of high-performance energy storage ***,the end-of-life of these batteries poses significant challenges from environmental,economic,and resource management *** review paper focuses on the pyrometallurgy-based recycling process of lithium-ion batteries,exploring the fundamental understanding of this process and the importance of its *** on the high energy consumption and emission gas issues of the pyrometallurgical recycling process,we systematically analyzed the capital-intensive nature of this process and the resulting technological ***,we conducted an in-depth discussion on the future research directions to overcome the existing technological barriers and *** review will provide valuable insights for researchers and industry stakeholders in the battery recycling field.

关键词： spent lithium-ion batteries recycling sustainability lithium valuable metal

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Research on Cavitation Characteristics and Influencing Factors of Herringbone Gear Pump

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2917-2946页

作者： Jinlong Yang kwang-Hee Lee Chul-Hee Lee Department of Mechanical Engineering of Inha University Incheon22212South Korea

Cavitation is a common issue in pumps,causing a decrease in pump head,a fall in volumetric efficiency,and an intensification of outlet flow *** is one of the main hazards that affect the regular operation of the *** on pump cavitation mainly focuses on mixed flow pumps,jet pumps,external spur gear pumps,***,there are few cavitation studies on external herringbone gear *** addition,pumps with different working principles significantly differ in the flow and complexity of the internal flow ***,it is urgent to study the cavitation characteristics of external herringbone gear *** with experimentalmethods,visual research and cavitation area identification are achieved through computation fluid dynamic(CFD),and changing the boundary conditions and shape of the gear rotor is *** simulation yields a head error of only 0.003%under different grid numbers,and the deviation between experimental and simulation results is less than 5%.The study revealed that cavitation causes flow pulsation at the outlet,and the cavitation serious area is mainly distributed in the meshing gap and meshing *** can be inhibited by reducing the speed,increasing the inlet pressure,and changing the helix angle can be *** example,when the inlet pressure is 5 bar,the maximumgas volume fraction in themeshing area is less than 50%.These results provide a reference for optimizing the design and finding the optimal design parameters to reduce or eliminate cavitation.

关键词： Herringbone gear pump cavitation rotating speed inlet pressure helix angle TwinMesh

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Changes in microorganisms and metabolites during long-term fermentation of commercially manufactured anchovy sauce

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Food Science and Human Wellness 2024年

作者： Daehyeon Kim Seong-Eun Park Eun-Ju Kim Seung-Ho Seo kwang-Moon Cho Sun Jae kwon Hong-Seok Son Department of Biotechnology， College of Life Sciences and Biotechnology， Korea University Sonlab Inc. 3. AccuGene Inc.

This study was performed to investigate the changes in microbial communities and metabolites during the long-term fermentation of commercially manufactured anchovy sauce. Samples of commercial anchovy sauce were collected from large-scale fermentation tanks with fermentation periods of up to 7.87 years. The complex bacterial community was simplified to two genera， Tetragenococcus and Halanaerobium， after approximately 0.55 years of fermentation. Although genera， such as Saccharomyces， Cladosporium， Candida， and Aspergillus， were relatively dominant， no clear pattern was identified in fungal community analysis. The longitudinal metabolite profile demonstrated that approximately half (55.8%) of the metabolites present in anchovy sauce were produced within a year of fermentation due to rapid fermentation. Despite the static microbial community， the contents of several metabolites including amino acids and biogenic amines changed continuously during the long-term fermentation of anchovy sauce. This study provides novel insights into the changes in microbiota and metabolites in fish sauce produced without any starter inoculation.

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