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Degradable and Tunable Keratin-fibrinogen Hydrogel as Controlled Release System for Skin Tissue Regeneration

Journal of Bionic Engineering 2023年第3期20卷 1049-1059页

作者： Sung Jun Min Jae Seo Lee Haram Nah Ho-Jin Moon sang Jin Lee Hyeon Jeong Kang Yu-Shik Hwang Il Keun kwon Dong Nyoung Heo Department of Dentistry Graduate SchoolKyung Hee University26 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea Biofriends Inc 26 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea Department of Dental Materials School of DentistryKyung Hee University26 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology School of DentistryKyung Hee UniversitySeoul02447Korea Kyung Hee University Medical Science Research Institute Kyung Hee University23 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea

Biodegradable hydrogels are promising biomaterials for use in controlled-release systems for skin tissue regeneration. Controlled delivery systems constitute an important aspect of tissue engineering because they can modulate various physiological responses, including early immune response, tissue remodeling, and cell proliferation and maturation in the wound-healing process. Hydrogels composed of various biomaterials have been developed to overcome the limitations of conventional drug- or protein-delivery systems, such as limited targeting ability, low stability, and the induction of drug resistance. Hydrogels based on keratin, a natural polymer extracted from human hair, can provide adequate cell support and control homeostasis. Consequently, they can be applied for skin tissue engineering. In this study, we prepared degradable, tunable, and biocompatible hydrogels for controllable protein delivery. We synthesized keratin-fibrinogen (KER-FBG) by the chemical coupling reaction and prepared hydrogels through polymerization with thrombin. The structures and morphologies of the KER-FBG hydrogels were confirmed. Furthermore, the mechanical properties, swelling ratio, degradation, release behavior, and biocompatibility were investigated. The KER-FBG hydrogels presented promising biological performance, indicating that the material is suitable as a controlled protein delivery carrier.

关键词： Keratin Fibrinogen Hydrogel Drug delivery Degradable

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Macular hole closure induced by intravitreal injection in diabetic macular edema

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International Journal of Ophthalmology(English edition) 2022年第10期15卷 1720-1722页

作者： sang Yoon Kim Han Jo kwon Sung Who Park Ik Soo Byon Seung Min Lee Department of Ophthalmology Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsan 50612Republic of Korea Department of Ophthalmology Biomedical Research InstitutePusan National University HospitalBusan 49241Republic of Korea Pusan National University School of Medicine Yangsan 50612Republic of Korea

Dear Editor,Macular hole(MH)formation is uncommon in patients with diabetic macular edema(DME).Few cases of MH associated with DME treatment have been described,including a report of four out of eight eyes with MH and diabetic retinopathy(DR)having DME[1].However,no case of resolution of MH after DME treatment has been *** report three consecutive cases of MH closure achieved by intravitreal injection for DME treatment.

关键词： injection diabetic edema

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低危宫颈癌妇女单纯子宫切除术与根治性子宫切除术的比较

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中国临床药理学杂志 2024年第8期40卷 1159-1159页

作者： PLANTE M kwon J S FERGUSON S 王超群

回顾性资料显示,早期低危宫颈癌患者参数浸润发生率较低,这就提出了这些患者是否需要根治性子宫切除术的问题。然而,比较根治性和单纯性子宫切除术结果的大型随机试验数据缺乏。本研究进行了一项多中心、随机、非劣效性试验,比较了低危... 详细信息

回顾性资料显示,早期低危宫颈癌患者参数浸润发生率较低,这就提出了这些患者是否需要根治性子宫切除术的问题。然而,比较根治性和单纯性子宫切除术结果的大型随机试验数据缺乏。本研究进行了一项多中心、随机、非劣效性试验,比较了低危宫颈癌(病变≤2cm,间质浸润有限)患者的根治性子宫切除术和单纯性子宫切除术,包括淋巴结评估。主要结局是3年盆腔肿瘤复发(盆腔复发)。预先规定的3年盆腔复发组间差异的非劣效性界限为4个百分点。

关键词：根治性子宫切除术盆腔肿瘤回顾性资料间质浸润宫颈癌患者盆腔复发预先规定低危

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Clinical applications of fractional flow reserve in bifurcation lesions

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Journal of Geriatric Cardiology 2012年第3期9卷 278-284页

作者： sang Hyun Park Bon-kwon Koo Seoul National University College of Medicine I O1 Daehang-ro Chongno-gu Seoul 110-744 South Korea

为冠的分叉损害的经皮的冠的干预(一种总线标准) 为简单冠的损害与一种总线标准相比与更低的程序的成功率和更坏的临床的结果被联系了。Angiographic 评估独自有时是不精密的并且不反映分叉损害的功能的意义。部分流动储备(FFR ) 是一... 详细信息

为冠的分叉损害的经皮的冠的干预(一种总线标准) 为简单冠的损害与一种总线标准相比与更低的程序的成功率和更坏的临床的结果被联系了。Angiographic 评估独自有时是不精密的并且不反映分叉损害的功能的意义。部分流动储备(FFR ) 是一个容易可获得、可靠、可再现的生理的参数。这个参数是特定的 epicardial 损害并且两个都反映狭窄和特定的动脉供应的心肌的领土的度。最近的研究证明了为分叉损害的那指导 FFR 的临时的方面分支干预策略可行、有效并且能减少不必要的复杂干预和相关复杂并发症。然而，冠的生理学和 FFR 的陷井的足够的理解是必要的适当地为复杂分叉损害的一种总线标准使用 FFR。

关键词：病变分叉临床应用分数储备血流冠状动脉生理参数

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Microenvironmental regulation of stem cells injected in the area at risk of neurodegenerative diseases

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BIOCELL 2022年第10期46卷 2231-2234页

作者： JU HYUNG LEE IL-kwon KIM sang WOO KIM SOYEON LIM SEAHYOUNG LEE KI-CHUL HWANG BYEONG-WOOK SONG Graduate Program of Biomedical Engineering Yonsei UniversitySeoul03722Korea Institute for Bio-Medical Convergence College of MedicineCatholic Kwandong UniversityGangwon-do25601Korea Department for Medical Science College of MedicineCatholic Kwandong UniversityGangwon-do25601Korea

The complex mechanism of degenerative diseases and the non-specific modulation of regenerative targets aretopics that need to be elucidated in order to advance the use of stem cells in improvement of neurodegenerative *** pre-transplantation through post-transplantation, there are many changes in the conditions, both inside andoutside of the stem cells that have not been carefully considered. This has hindered development in the field of celltherapy and regeneration. This viewpoint highlights the potential implications of intracellular and extracellularalterations of stem cells in transplanted areas at risk of neurodegenerative disease.

关键词： Cell therapy Microenvironment Neurodegenerative disease Stem cells

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Nearly-complete labial adhesions diagnosed with repetitive cystitis in postmenopausal women:A case report

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World Journal of Clinical Cases 2022年第35期10卷 12990-12995页

作者： Hyejin kwon Department of Obstetrics and Gynecology Won Kwang University Sanbon HospitalWon Kwang University School of MedicineGunpo-si15865Gyeonggi-doSouth Korea

BACKGROUND Nearly-complete labial adhesions diagnosed with repetitive cystitis in postmenopausal women:A case report CASE SUMMARY The case of an 83-year-old woman who presented with dysuria,urination disorders,recurrent cystitis,and bacteriuria and was admitted to a private hospital after 1 mo of antibiotic treatment without improvement of her *** examination,labial adhesions were observed with nearly-complete labial fusion with a pinpoint *** was detected in urine analysis,and the urine culture test was positive for Escherichia ***,a parenteral antibiotic(Fosfomycin)and topical estrogen cream were ***,since the adhesion did not separate after 2 wk of treatment,surgical correction was ***,adhesiolysis was conducted with a blunt ***,hysteroscopy and cystoscopy were *** findings showed no abnormalities of the endometrium and endocervix,and the cystoscopic results were also ***,labiaplasty was completed to prevent adhesion *** month after the surgery,the discomfort while urinating was eliminated and the adhesion did not *** Labial adhesions in postmenopausal women cannot be successfully treated with estrogen creams,and surgical treatment should be considered.

关键词： Post menopause Genitalia,female Cystitis Gynecologic Surgical Procedures Atrophy Urinary Retention Case report

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Safety of acupotomy in a real-world setting:A prospective pilot and feasibility study

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Journal of Integrative Medicine 2022年第6期20卷 514-523页

作者： sang-Hoon Yoon Chan-Young kwon Hee-Geun Jo Jae-Uk Sul Hyangsook Lee Jiyoon Won Su Jin Jeong Jun-Hwan Lee Jungtae Leem Chung-Yeon Korean Medicine Clinic Gangnam-guSeoul 06224Republic of Korea Department of Oriental Neuropsychiatry Dong-eui University College of Korean MedicineBusanjin-guBusan 47340Republic of Korea Department of Herbal Pharmacology College of Korean MedicineGachon University1342 Seongnamdae-roSujeong-guSeongnam 13120Republic of Korea Department of Korean Rehabilitation Medicine Dongshin University Korean Medicine HospitalGwangju 61619Republic of Korea Acupuncture and Meridian Science Research Center Kyung Hee UniversityDongdaemun-guSeoul 02447Republic of Korea Department of Science in Korean Medicine Graduate SchoolKyung Hee UniversityDongdaemun-guSeoul 02447Republic of Korea KM Science Research Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea Department of Statistics Support Medical Science Research InstituteKyung Hee University Medical CenterDongdaemun-guSeoul 02447Republic of Korea Clinical Medicine Division Korea Institute of Oriental MedicineYuseong-guDaejeon 34054Republic of Korea Korean Medicine Life Science University of Science&Technology(UST)Campus of Korea Institute of Oriental MedicineYuseong-guDaejeon 34054Republic of Korea College of Korean Medicine Wonkwang UniversityIksanJeollabuk-do54538Republic of Korea

Objective:Acupotomy is a modern acupuncture method that includes modern surgical *** acupotomy is relatively more invasive than filiform acupuncture treatment,it is important to establish the safety profile of this *** justify further large-scale prospective observational studies,this preliminary study was performed to assess the feasibility of the approach and investigate the safety profile and factors potentially associated with adverse events(AEs).Methods:This was a prospective pilot study that assessed the feasibility of a large-scale forthcoming safety study on acupotomy treatment in a real-world *** feasibility(call response rate,dropout rate,response rate for each variable and recruitment per month)and safety profile(incidence,type,severity and causality of AEs,and factors potentially associated with AEs)were ***:A total of 28 participants joined the study from January to May 2018.A follow-up assessment was achieved in 258(1185 treatment points)out of 261 sessions(1214 treatment points).The response rate via telephone on the day after treatment was 87.3%.There were 8 systemic AEs in all the sessions(8/258;3.11%)and 27 local AEs on the total points treated(27/1185;2.28%).Severe AEs did not *** AE and local AE occurrence were associated with blade width and the number of needle stimulations per treatment ***:The findings suggest that it could be feasible to analyze the safety of acupotomy in a realworld ***,the primary data on some relevant AEs could be *** are planning large-scale prospective studies based on these *** registration:Clinical Research Information Service(CRIS)KCT0002849(https://***/cris/search/***/11487).

关键词： Acupotomy Acupuncture Safety Adverse effects Observational study Traditional Chinese medicine

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A metabolite of the gut microbiota:a facilitator of chemotherapy efficacy in cancer

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3189-3191页

作者： Byungsuk kwon School of Biological Sciences University of UlsanUlsanRepublic of Korea

A recent study has identified a surprising metabolic connection between the gut microbiota and intratumoral neutrophils that impairs the oxidative stress adaptation response to chemotherapy in pancreatic cancer.1 This finding suggests that a microbiota metabolite might be used as an additive in improving chemotherapeutic efficacy for cancer patients.

关键词： chemotherapy cancer additive

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Analysis of the effectiveness of cognitive rehabilitation for patients with chronic mental illness:A meta-analysis

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World Journal of Clinical Cases 2023年第32期11卷 7822-7832页

作者： Jong-Sik Jang Seri oh Geonwoo Kim Narae Lee Hyesu Song Jihye Park Yushin Lee Minji Kim Mihwa kwon Department of Occupational Therapy Kangwon National UniversitySamcheok 25949South Korea Department of Occupatioanl Therapy Kangwon National University Graduate SchoolSamcheok 25949South Korea Department of Occupational Therapy U1 UniversityChung-Cheong Bukdo 25949South Korea Department of Occupation Therapy Dongnam Health UniversityGyeonggi-do 16328South Korea

BACKGROUND People suffering from chronic mental illness are sensitive to stressful stimuli,lack coping skills,and have low self-esteem due to problems such as social *** also experience depression,isolation,fear,and *** to cognitive dysfunction,people suffering from chronic mental illness have inadequate cognitive processes that lead to distorted *** To confirm the effectiveness of cognitive rehabilitation therapy in improving cognitive function and alleviating behavioral and psychological symptoms in patients with chronic mental illness,and to identify the cognitive function that had the main *** The quality of the studies was evaluated using the Assessment of Multiple Systematic Reviews criteria,and data published from 2011 to December 2022 were searched using PubMed,Cochrane,RISS,KISS,and *** keywords used in the search were“mental illness,”“cognitive rehabilitation,”“cognition,”and“mental.”A meta-analysis was conducted on the 12 selected *** The level of evidence for the 12 documents was that of a randomized experimental *** types in cognitive rehabilitation can be divided into cognitive behavior,cognitive training,cognitive rehabilitation,and computerized cognitive *** of the studies were on schizophrenia,and the measurement areas were cognitive functions(e.g.,concentration,memory,and executive function)as well as depression,sociability,and quality of *** a result of the meta-analysis of each variable,the effect size for cognitive rehabilitation treatment was in the following order:Sociability,memory,concentration,executive function,quality of life,and ***,sociability and memory exhibited significant *** Cognitive rehabilitation aids cognitive function and sociability in patients with chronic mental illness and can be used as evidence for cognitive rehabilitation in mental health and occupational therapy.

关键词： Cognitive function Mental illness Cognitive rehabilitation Cognitive training Cognitive therapy Schizophrenia Occupational therapy

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All-hydrocarbon,all-conjugated cycloparaphenylene-polycyclic aromatic hydrocarbon host–guest complexes stabilized by CH–πinteractions

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Nano Research 2022年第6期15卷 5545-5555页

作者： Hyejin kwon Carson.J.Bruns Paul M.Rady Department of Mechanical Engineering University of ColoradoBoulder427 UCB1111 Engineering DriveBoulderCO 80309USA ATLAS Institute 112518th St.320 UCBBoulderCO 80309USA

Polycyclic aromatic hydrocarbons(PAHs)are promising nanocarbon materials with diverse optoelectronic properties,yet they also pose concerning environmental and health *** the ubiquity of PAHs in the environment(crude oil,emissions,and biomass),most supermolecules rely on heteroatoms for *** discovered and characterized a family of all-hydrocarbon,all-π-conjugated[n]cycloparaphenylene-PAH host–guest *** built a theoretical framework to rapidly select these complexes and predict their stabilities,driven exclusively by CH–π*** than a dozen complexes were confirmed experimentally and assembled directly from commercially available *** motif offers a versatile way to combine the advantageous properties of organic semiconductors with the rich dynamic,stereochemical,stimulus-responsive,and stressdissipative behavior of host–guest complexes,while creating new opportunities for bespoke PAH separation or remediation materials.

关键词： cycloparaphenylenes density functional calculations host−guest systems hydrocarbons polycycles self-assembly supramolecular chemistry

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