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Risk prediction platform for pancreatic fistula after pancreatoduodenectomy using artificial intelligence

World Journal of Gastroenterology 2020年第30期26卷 4453-4464页

作者： In Woong Han Kyeongwon Cho Youngju Ryu Sang Hyun Shin Jin Seok Heo Dong Wook Choi Myung Jin Chung oh chul kwon Baek Hwan Cho Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Medical Artificial Intelligence Research Center Department of Medical Device Management and ResearchSAIHSTSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Department of Radiology Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Artificial Intelligence Research Center Medical DataBase IncorporatedSeoul 06048South Korea

BACKGROUND Despite advancements in operative technique and improvements in postoperative managements,postoperative pancreatic fistula(POPF)is a life-threatening complication following pancreatoduodenectomy(PD).There are some reports to predict POPF preoperatively or intraoperatively,but the accuracy of those is *** intelligence(AI)technology is being actively used in the medical field,but few studies have reported applying it to outcomes after *** To develop a risk prediction platform for POPF using an AI *** Medical records were reviewed from 1769 patients at Samsung Medical Center who underwent PD from 2007 to 2016.A total of 38 variables were inserted into AI-driven *** algorithms tested to make the risk prediction platform were random forest(RF)and a neural network(NN)with or without recursive feature elimination(RFE).The median imputation method was used for missing *** area under the curve(AUC)was calculated to examine the discriminative power of algorithm for POPF *** The number of POPFs was 221(12.5%)according to the International Study Group of Pancreatic Fistula definition *** median imputation,AUCs using 38 variables were 0.68±0.02 with RF and 0.71±0.02 with *** maximal AUC using NN with RFE was *** risk factors for POPF were identified by AI algorithm:Pancreatic duct diameter,body mass index,preoperative serum albumin,lipase level,amount of intraoperative fluid infusion,age,platelet count,extrapancreatic location of tumor,combined venous resection,co-existing pancreatitis,neoadjuvant radiotherapy,American Society of Anesthesiologists’score,sex,soft texture of the pancreas,underlying heart disease,and preoperative endoscopic biliary *** developed a web-based POPF prediction platform,and this application is freely available at http://*** This study is the first to predict POPF with multiple risk factors using *** platform is reli

关键词： Postoperative pancreatic fistula Pancreatoduodenectomy Neural networks Recursive feature elimination

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Suppression of gold nanoparticle agglomeration and its separation via nylon membranes

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Chinese Journal of Chemical Engineering 2017年第7期25卷 931-937页

作者： Ayyavoo Jayalakshmi In-chul Kim Young-Nam kwon School of Urban and Environmental Engineering Ulsan National Institute of Sdence and TechnologyUlsan 689-798Korea KIST-UNIST UIsan Center for Convergent Materials UNIST(Ulsan National Institute of Science and Technology)Korea Environment and Resources Research Center Korea Research Institute Chemical TechnologyDaejeon 305-606Korea

Use of ultraporous nylon membrane is one of the most widely employed techniques for removal of hard and soft nanoparticles in the semiconductor industry, and the accurate determination of membrane pore size is necessary in order to avoid manufacturing defects caused by contamination. The gold nanoparticle has several benefits for the evaluation of polymeric membranes; however, the nanoparticles agglomerate easily on the nylon membrane and make it difficult to evaluate the membrane precisely. The properties of 2-amino-2-hydroxymethyl-1,3-propanediol(ADP) ligand in gold nanoparticle solution were systematically investigated, and ADP was utilized for improved evaluation of the nylon membranes. Nylon membrane used in this study was prepared by phase inversion techniques. Ultrathin dense layer on top of the membrane surface and Darcy structures in the microporous membrane support were observed. The gold particle rejection was carried out at various p H values from 4 to14 and higher rejection was observed at p H 4 and 8. The suppression of gold colloid agglomeration using ADP and monodispersity of gold colloids was also analyzed by confocal laser scanning microscopy(CLSM), transmission electron microscopy(TEM), and scanning electron microscopy(SEM). van der Waals interaction energy of the particles was reduced in the addition of ADP. The presence of ADP ligand in the gold solutions prevented the agglomeration of gold nanoparticles and reduced the adsorption of the particles on the nylon membrane surface,leading to precise evaluation of membrane pore sizes.

关键词： Particle size Electron microscopy Gold colloid flock Semiconductor

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Free ubiquitin: a novel therapeutic target for neurodegenerative diseases

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Neural Regeneration Research 2021年第9期16卷 1781-1782页

作者： chul-Woo Park kwon-Yul Ryu Department of Life Science University of SeoulSeoulRepublic of Korea

Neurodegenerative diseases are widespread and the increasing number of patients with these diseases can no longer be ignored. Dementia is a symptom of many neurodegenerative diseases, and Alzheimer's disease(AD), which is associated with memory and learning disabilities, accounts for approximately 60 to 80% of all dementia cases(Wyss-Coray, 2016).

关键词： diseases degenerative Alzheimer

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Influence of the preparation method on the catalytic activity of Mg-Al hydrotalcites as solid base catalysts

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Green Energy & Environment 2019年第3期4卷 287-292页

作者： Sungjae Park Dahye kwon Ji Yeon Kang Ji chul Jung Department of Chemical Engineering Myongji University

Mg-Al hydrotalcites were synthesized using different preparation methods(a co-precipitation method, a urea method, and a simple one) to analyze their effect on the catalytic activity of these solid base catalysts. The method strongly affected the structure of their layers(e.g., the growth and stacking of the layers, and the type of intercalated anions) and, accordingly, their catalytic activity. The Mg-Al hydrotalcite prepared by co-precipitation showed the best catalytic performance in the isomerization of glucose into fructose, due to the small crystallite size and sand rose morphology enhancing the exposure of surface active sites to reactants.

关键词： Mg-Al hydrotalcite Preparation method Base catalyst Glucose isomerization Fructose

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Tuning the base properties of Mg–Al hydrotalcite catalysts using their memory effect

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Journal of Energy Chemistry 2020年第7期29卷 229-236,I0008页

作者： Dahye kwon Ji Yeon Kang Suna An Inchan Yang Ji chul Jung Department of Chemical Engineering Myongji UniversityYongin 17058Republic of Korea

Herein,the relationship between the structure and base properties of Mg–Al hydrotalcite catalysts was comprehensively investigated in relation to heat treatment and rehydration processes,which are well known as memory effects of *** structure of Mg–Al hydrotalcites changed from layered double hydroxide(LDH)to mixed metal oxide and subsequently to a spinel structure during heat treatment,and it was returned from mixed metal oxide to a LDH structure by *** on various characterizations,we successfully proposed a detailed mechanism of memory *** also confirmed that the Mg–Al hydrotalcites had weak or strong base sites and that their base properties could be systematically tuned by heat treatment and *** prepared Mg–Al hydrotalcites were applied to a model reaction,isomerization of glucose to fructose,as base *** the catalysts tested,the rehydrated Mg–Al hydrotalcite efficiently produced fructose due to its appropriate base and structure *** finally concluded that the base sites of Mg–Al hydrotalcites can be designed as desired by heat treatment and ***,through systematic design of the base sites of Mg–Al hydrotalcites,these can be promising catalysts for various heterogeneous reactions over base catalysts,giving excellent catalytic performances.

关键词： Mg–Al hydrotalcite Structure Base properties Heat treatment Rehydration

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Favorable surgical treatment outcomes for chronic constipation with features of colonic pseudo-obstruction

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World Journal of Gastroenterology 2012年第32期18卷 4441-4446页

作者： Eon chul Han Heung-kwon oh Heon-Kyun Ha Eun Kyung Choe Sang Hui Moon Seung-Bum Ryoo Kyu Joo Park Department of Surgery Seoul National University College of MedicineSeoul 110-744South Korea Seoul National University Hospital Gangnam Center Seoul 110-744South Korea

AIM:To determine long-term outcomes of surgical treatments for patients with constipation and features of colonic ***:Consecutive 42 patients who underwent surgery for chronic constipation within the last 13 years were prospectively *** identified a subgroup with colonic pseudo-obstruction(CPO) features,with dilatation of the colon proximal to the narrowed transitional zone,in contrast to typical slowtransit constipation(STC),without any dilated colonic *** outcomes of surgical treatments for chronic constipation with features of CPO were analyzed and compared with outcomes for ***:Of the 42 patients who underwent surgery for constipation,33 patients had CPO with dilatation of the colon proximal to the narrowed transitional *** were 16 males and 17 females with a mean age of 51.2 ± 16.1 *** had symptoms of chronic intestinal obstruction,including abdominal distension,pain,nausea,or vomiting,and the mean duration of symptoms was 67 mo(range:6-252 mo).Preoperative defecation frequency was 1.5 ± 0.6 times/wk(range:1-2 times/wk).Thirty-two patients underwent total colectomy,and one patient underwent diverting transverse *** was no surgery-related *** histologic examination showed hypoganglionosis or agangliosis in 23 patients and hypoganglionosis combined with visceral neuropathy or myopathy in 10 *** contrast,histology of STC group revealed intestinal neuronal dysplasia type B(n = 6) and visceral myopathy(n = 3).Early postoperative complications developed in six patients with CPO;wound infection(n = 3),paralytic ileus(n = 2),and intraabdominal abscess(n = 1).Defecation frequencies 3 mo after surgery improved to 4.2 ± 3.2 times/d(range:1-15 times/d).Long-term follow-up(median:39.7 mo) was available in 32 patients;all patients had improvements in constipation symptoms,but two patients needed intermittent medication for management of *** 32 patients had distinct

关键词： Constipation Total colectomy Pseudoobstruction Surgical outcome Hypoganglionosis

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Role of computed tomographic colonoscopy of postoperative surveillance in patient with gastric cancer

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World Journal of Gastroenterology 2007年第11期13卷 1646-1651页

作者： Dae Won Jun oh Young Lee Hyun chul Lim Sung Joon kwon Hang Lak Lee Byung chul Yoon Ho Soon Choi Joon Soo Hahm Min Ho Lee Dong Hoo Lee Department of Internal Medicine Hanyang University College of Medicine Seoul Korea Department of Radiology Hanyang University College of Medicine Seoul Korea Department of General Surgery Hanyang University College of Medicine Seoul Korea

AIM： TO examine the diagnostic yield of colorectal neoplasia at computed tomographic colonoscopy （CTC） as well as the feasibility of contrast enhanced CTC in patients with gastric cancer. METHODS： To examine the incidence of colon polyp we selected postoperative 188 gastric cancer patients, which we refer to as the ‘colon polyp survey group’. To examine the feasibility of CTC for early detection of colon cancer or advanced colon adenoma, we selected 47 gastric cancer patients （M：F 29：18, mean age 53.8 years）, which we call the ‘CT colonoscopy group’. All the 47 patients underwent successive CTC and colonoscopy on the same day. RESULTS： Totally 109 colon polyps were observed from 59 out of 188 gastric cancer patients, the inddence rate of colon polyps in gastric cancer patients being 31.4%. The sensitivity of CTC in detecting individuals with at least 1 lesion of any size was 57.1%, the specificity was 72.7%, the positive predictive value was 47.1%, and the negative predictive value was 71.9%. When the cutoff size was decreased to 6 mm, the sensitivity and specificity were 80.0% and 92.9%, respectively, with positive and negative predictive values of 57.1% and 97.5%, respectively. Only one patient was classified as false negative by virtual colonoscopy. CONCLUSION： The diagnostic yield of colorectal polyp was 31.4% in patients with gastric cancer, and contrast enhanced CTC is an acceptable tool for the detection of synchronous colorectal advanced adenoma and postoperative surveillance of gastric cancer patients.

关键词： Stomach cancer Colon cancer Computed tomocjraphic colonoscopy

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Trends in the incidence of cryptorchidism and hypospadias of registry-based data in Korea： a comparison between industrialized areas of petrochemical estates and a non-industrialized area

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Asian Journal of Andrology 2011年第5期13卷 715-718页

作者： Sae chul Kim Su Kyoung kwon Yeon Pyo Hong Department of Urology Chung-Ang University College of Medicine Seoul 156-756 Korea Department of Preventive Medicine Chung-Ang University College of Medicine Seoul 156-756 Korea

This study aimed to represent the recent trends in the nationwide incidence of cryptorchidism and hypospadias in Korea, and to determine whether there is evidence of spatial heterogeneity in the incidence. The incidence was calculated as the number of newly diagnosed patients （males） during the first 4 years after a live birth in a population, nationally and regionally （a non-industrialized area （Chuncheon） and petrochemical estates （Yeocheon and Ulsan））, between 2000 and 2005. The data （numerator） for new patients were acquired from the National Health Insurance Review Agency, and the data （denominator） for the resident registration population were from the National Statistical Office. Between 2000 and 2005, the national incidence of cryptorchidism and hypospadias had an increased tendency from 5.01 to 17.43 per 10 000 persons and from 1.40 to 3.28 per 10 000 persons, respectively. The incidence of cryptorchidism was significantly higher in Yeocheon （throughout the study period） and in Ulsan （2001, 2002, 2004 and 2005） than the national incidence, whereas the incidence in Chuncheon was significantly lower in 2001 and 2002. It was difficult to compare the rates of hypospadias yearly and regionally because of the small number of cases. In conclusion, the incidence of cryptorchidism has recently increased in Korea. The petrochemical estates, Yeocheon and Ulsan, had a significantly higher incidence of cyptorchidism than the national incidence, which suggests that further study is needed to obtain a more precise estimation of the trends in the incidence of the anomalies and to confirm the association between petrochemicals and the anomalies.

关键词： cryptorchidism hypospadias incidence petrochemical estate

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Coupled CUBIC Congestion Control for MPTCP in Broadband Networks

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Computer Systems Science & Engineering 2023年第4期45卷 99-115页

作者： Jae Yong Lee Byung chul Kim Youngmi kwon Kimoon Han Department of Information and Communications Engineering Chungnam National UniversityDaejeon34134Korea Agency for Defense Development Daejeon34186Korea

Recently,multipath transmission control protocol(MPTCP)was standardized so that data can be transmitted through multiple paths to utilize all available path ***,when high-speed long-distance networks are included in MPTCP paths,the traffic transmission performance of MPTCP is severely deteriorated,especially in case the multiple paths’characteristics are heavily *** order to alleviate this problem,we propose a“Coupled CUBIC congestion control”that adopts TCP CUBIC on a large bandwidth-delay product(BDP)path in a linked increase manner for maintaining fairness with an ordinary TCP traversing the same bottleneck *** verify the performance excellence of the proposed algorithm,we implemented the Coupled CUBIC Congestion Control into Linux kernels by modifying the legacy MPTCP linked-increases algorithm(LIA)congestion control source *** constructed asymmetric heterogeneous network testbeds mixed with large and small BDP paths and compared the performances of LIA and Coupled CUBIC by *** results show that the proposed Coupled CUBIC utilizes almost over 80%of the bandwidth resource in the high BDP path,while the LIA utilizes only less than 20%of the bandwidth for the same *** was confirmed that the resource utilization and traffic transmission performance have been greatly improved by using the proposed Coupled CUBIC in high-speed multipath networks,as well as maintaining MPTCP fairness with competing single-path CUBIC or Reno TCP flows.

关键词： MPTCP congestion control Coupled CUBIC high BDP network

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Is thalamocortical tract injury responsible for memory impairment in a patient with putaminal hemorrhage?

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Neural Regeneration Research 2015年第2期10卷 321-322页

作者： Hyeok Gyu kwon chul Hoon Chang Sung Ho Jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Department of Neurosurgery College of Medicine Yeungnam University

Prior to development of diffusion tensor imaging （DTI）, there were many difficulties in visualization and estimation of the Papez circuit in the live human brain （Papez, 1995）. Diffusion tensor tractography （DTT）, derived from DTI, allows for identification and visualization of neural tracts in the Papez circuit （Concha et al., 2005; kwon et al., 2010; Granziera et al., 2011; Jang and Yeo, 2013; Jang et al., 2014a）. In the current study, using DTT, we report on a patient who showed injured thalamocortical tract between the anterior thalamic nuclei and the cingulate gyrus following a putaminal hemorrhage.

关键词： Is thalamocortical tract injury responsible for memory impairment in a patient with putaminal hemorrhage ROI DTT

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