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Validation of the PAGE-B score to predict hepatocellular carcinoma risk in caucasian chronic hepatitis B patients on treatment

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World Journal of Gastroenterology 2022年第6期28卷 665-674页

作者： Pinar Gokcen Fatih Guzelbulut Gupse Adali Ayca Gokce Degirmenci Salturk oguzhan Ozturk Ozgur Bahadir Emine Kanatsiz Mevlut Kiyak Kamil Ozdil Hamdi Levent Doganay Department of Gastroenterology Health Sciences UniversityUmraniye Teaching and Research HospitalIstanbul 34764Turkey Department of Gastroenterology Health Sciences UniversityHaydarpasa Numune Teaching and Research HospitalIstanbul 34668Turkey

BACKGROUND Several risk scores have been developed to predict hepatocellular carcinoma(HCC)risk in chronic hepatitis B(CHB)*** majority of risk scores are based on pretreatment variables that are no longer considered risk factors for HCC development due to the suppression of hepatitis B virus replication early in the course of potent antiviral treatment in most *** PAGE-B score,which is based on platelet levels,age and sex,has been shown to accurately predict HCC risk in CHB patients on antiviral treatment in various *** We aimed to evaluate the PAGE-B score in predicting HCC risk in Turkish CHB patients on antiviral *** In this study,we recruited 742 CHB patients who had been treated with tenofovir disoproxil fumarate or entecavir for≥1 *** groups were determined according to the PAGE-B scores as follows:≤9,low;10-17,moderate and≥18,*** cumulative HCC incidences in each risk group were computed using Kaplan-Meier analysis and were compared using the log-rank *** accuracy of the PAGE-B score in predicting HCC risk was evaluated using a timedependent area under the receiver operating characteristic(AUROC)curve at all study time *** and multivariate logistic regression analyses were used to assess the risk factors for HCC *** The mean follow-up time was 54.7±1.2 *** was diagnosed in 26 patients(3.5%).The cumulative HCC incidences at 1,3,5 and 10 years were 0%,0%,0%and 0.4%in the PAGE-B low-risk group;0%,1.2%,1.5%and 2.1%in the PAGE-B moderate-risk group;and 5%,11.7%,12.5%,and 15%in the PAGE-B high-risk group,respectively(log-rank P<0.001).The AUROCs of the PAGE-B score in the prediction of HCC development at 1,3,5 and 10 years were 0.977,0.903,0.903 and 0.865,*** the multivariable analysis,older age,male sex,lower platelet levels,presence of cirrhosis,and absence of alanine aminotransferase normalization at month 6 were associated with HCC development(all P<0.05).C

关键词： Chronic hepatitis B Hepatocellular carcinoma PAGE-B score Surveillance

The compartmented alginate fibres optimisation for bitumen rejuvenator encapsulation

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Journal of Traffic and Transportation Engineering(English Edition) 2017年第4期4卷 347-359页

作者： Amir Tabakouic Dirk Braak Mark van Gerwen oguzhan Copuroglu Wouter Post Santiago J. Oarcia Erik Schlangen Materials & Environment Faculty of Civil Engineering and Geosciences Delft University of Technology DelftThe Netherlands Novel Aerospace Materials Group Faculty of Aerospace Engineering Delft University of Technology DelftThe Netherlands

This article presents development of a novel self-healing technology for asphalt pave- ments, where asphalt binder rejuvenator is encapsulated within the compartmented alginate fibres. The key objective of the study was to optimise the compartmented alginate fibre design, i.e., maximising amount of rejuvenator encapsulated within the fibre. The results demonstrate that optimum rejuvenator content in the alginate fibre is of 70：B0 rejuvenator/alginate ratio. The fibres are of sufficient thermal and mechanical strength to survive harsh asphalt mixing and compaction processes. Furthermore, results illustrate that zeer open asfalt beton （ZOAB） asphalt mix containing 5% of 70：30 rejuvenator/alginate ratio compartmented alginate fibres has higher strength, stiffness and better healing properties in comparison to the control asphalt mix, i.e., mix without fibres, and mix containing fibres with lower rejuvenator content. These results show that compartmented alginate fibres encapsulating bitumen rejuvenator present a promising new approach for the development of self-healing asphalt pavement systems.

关键词： Self-healing Asphalt pavements Compartmented fibres Calcium alginate Rejuvenation

Fasciola hepatica infestation as a very rare cause of extrahepatic cholestasis

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World Journal of Gastroenterology 2004年第20期10卷 3076-3077页

作者： Ahmet Dobrucali Rafet Yigitbasi Yusuf Erzin oguzhan Sunamak Erdal Polat Hakan Yakar Division of Gastroenterology Cerrahpasa Medical FacultyIstanbul UniversityTurkey Division of Microbiology and Parasitology Cerrahpasa Medical FacultyIstanbul UniversityTurkey

Fasciola hepatica,an endemic parasite in Turkey,is still a very rare cause of cholestasis *** ingestion of contaminated water plants like watercress,humans can become the definitive host of this *** symptoms may be sudden but in some cases they may be preceeded by a long period of fever,eosinophilia and vague gastrointestinal *** report a woman with cholangitis symptoms of sudden onset which was proved to be due to Fasciola hepatica infestation by an endoscopic retrograde cholangiography.

关键词： Adult Animals Antiplatyhelmintic Agents Bithionol Cholangiopancreatography, Endoscopic Retrograde Cholestasis, Extrahepatic Fasciola hepatica purification Fascioliasis Female Humans

Values of high-resolution computed tomography and pulmonary function tests in managements of patients with chronic hepatitis C virus infection

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World Journal of Gastroenterology 2004年第3期10卷 381-384页

作者： oguzhan Okutan Zafer Kartaloglu Ahmet Ilvan Ali Kutlu Erkan Bozkanat Emir Silit GATA Haydarpasa Training Hospital Department of Pulmonary DiseasesIstanbulTurkey Gumussuyu Military Hospital Department of Pulmonary DiseasesIstanbulTurkey GATA Haydarpasa Training Hospital Department of RadiologyIstanbulTurkey

AIM:To investigate pulmonary involvement via pulmonary function tests (PFT) and high-resolution computed tomocjraphy (HRCT) in patients with chronic hepatitis C virus (HCV) infection. METHODS:Thirty-four patients with chronic HCV infection without diagnosis of any pulmonary diseases and 10 healthy cases were enrolled in the study,PFT and HRCT were performed in all cases. RESULTS:A decrease lower than 80% of the predicted value was detected in vital capacity in 9/34 patients,in forced expiratory volume in one second in 8/34 patients,and in forced expiratory flow 25-75 in 15/34 patients,*** monoxide diffusing capacity (DLCO) was decreased in 26/34 *** of interstitial pulmonary involvement were detected in the HRCT of 16/34 *** difference was found between controls and patients with HCV infection in findings of HRCT (X^2=4.7,P=0.003).Knodell histological activity index (KHAI) of 28/34 patients in whom liver biopsy was applied was 9.0±*** findings,PFT values and DLCO were not affected by KHAI in patients with HCV *** these patients,all the parameters were related with age. CONCLUSION:We suggest that chronic hepatitis C virus infection may cause pulmonary interstitial involvement without evident respiratory symptoms.

关键词： Respiratory Function Tests Tomography, X-Ray Computed Adult Aged Female Hepatitis C, Chronic Humans Lung Diseases Male Middle Aged

Meckel's diverticulum manifested by a subcutaneous abscess

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World Journal of Gastroenterology 2009年第48期15卷 6123-6125页

作者： oguzhan Karatepe Gokhan Adas Merih Altiok Deniz Ozcan Sedat Kamali Servet Karahan Department of General Surgery Okmeydam Training and Research Hospital Department of Pathology Okmeydam Training and Research Hospital

This case report describes an extremely rare complication of a Meckel's diverticulum:enterocutaneous fistula of the *** presence of Meckel's diverticulum is a well known entity,but subcutaneous perforation of the diverticulum is very *** we report the case of a patient with the complaint of a right lower quadrant abscess,preoperatively diagnosed as enterocutaneous fistula,which was determined intraoperatively to be a fistula resulting from Meckel's diverticulum.

关键词： Meckel's diverticulum Enterocutaneous fistula Abscess

Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study)

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World Journal of Gastroenterology 2009年第1期15卷 112-116页

作者： Gokhan Adas Soykan Arikan Ozgur Kemik Ali Oner Nilgun Sahip oguzhan Karatepe Okmeydani Training Hospital Okmeydani/SisliIstanbul 34715 Turkey

AIM： TO establish which scolicidal agents are superior and more suitable for regular use. METHODS： Echinococcus granu/osus protoscoleces were obtained from 25 patients with liver hydatid cysts. Various concentrations of albendazole sulfone, albendazole sulfoxide, and albendazole sulfone and albendazole sulfoxide mixed together in concentrations of 50 μg/mL, and H202 in a concentration of 4%, NaCI 20%, and 1.5% cetrimide-0.15% chlorhexidine （10% Savlon-Turkey） were used to determine the scolicidal effects. Albendazole （ABZ） derivatives and other scolicidal agents were applied to a minimum of 100 scoleces for 5 and 10 min. The degree of viability was calculated according to the number of living scolices per field from a total of 100 scolices observed under the microscope. RESULTS： After 5 min, ABZ sulfone was 97.3% effective, ABZ sulfoxide was 98.4% effective, and the combined solution was 98.6% effective. When sulfone, sulfoxide and the combined solutions were compared, the combined solution seemed more effective than sulfone. However, there was no difference when the combined solution was compared with sulfoxide. After 10 min, hypertonic salt water, sulfone, sulfoxide, and the combined solution compared to other solutions looked more effective and this was statistically significant on an advanced level. When sulfone, sulfoxide, and the combined solutions were compared with each other, the combined solution appeared more effective than sulfone. When the combined solution was compared with sulfoxide, there was no difference. CONCLUSION： Despite being active, ABZ metabolites did not provide a marked advantage over 20% hypertonic saline. According to these results, we think creating a newly improved and more active preparation is necessary for hydatid cyst treatment.

关键词： Hydatid disease AIbendazole In vitrostudy Combined solution Scolicidal agents

Combined Single Step Definitive Treatment in Acute Pilonidal Sinus Abscess Running Head: Single Step Treatment of Pilonidal Abscess

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Surgical Science 2010年第1期1卷 24-26页

作者： Dogan Yildirim oguzhan Sunamak Ahmet Pergel Mourad Mounla 不详

Backgrounds: The treatment of choice has been drainage and definitive surgical treatment after an interval for acute pilonidal sinus abscess till now. Because of the high incidence of chronic pilonidal sinus disease following drainage and aiming the cure in one step, synchronous treatment choices to drainage have been attempted recently. We analyzed retrospectively 20 patients with pilonidal sinus abscess on whom we carried out drainage+ marsupialization as singlestep treatment. Methods: Drainage+ synchronous marsupialization results of 20 patients (17 male, 3 female) between 20 to 37 years of age (mean 28) were analyzed retrospectively on the parameters of operation time, recovery period, time to workreturn and recurrence ratios. Results Operation times were between 15 to 25 minutes. Mean recovery period was 45 days (3050 days), the mean period from operation to workreturn was 24 (2230) days. There were full recovery in 18 patients (90%) and recurrence in 2 patients (10%). Silver nitrate ablation treatment achieved cure in recurrences. Conclusion: Drainage+ Marsupialization is an applicable and successful combined choice in the treatment of Pilonidal sinus abscess.

关键词： Pilonidal Sinus Abscess Drainage Marsupialization Definitive Treatment Combined Treatment

Intrathyroidal ectopic thymus:Ultrasonographic features and differential diagnosis

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Artificial Intelligence in Medical Imaging 2021年第2期2卷 32-36页

作者： Erdal Karavas oguzhan Tokur Sonay Aydin Dilek Gokharman Cigdem Uner Department of Radiology Erzincan Binali Yildirim UniversityErzincan 24100Turkey Department of Radiology Ankara Training and Research HospitalAnkara 06230Turkey Department of Child Radiology Ankara Sami Ulus Training and Research HospitalAnkara 06560Turkey

Intrathyroidal ectopic thymus(IET)is defined as an ectopic thymus tissue that is generally found incidentally and rarely in the thyroid gland in the pediatric *** occurs as a result of disruption of the embryological migration path and the settling of the thymus tissue into the thyroid *** the differential diagnosis,it is mostly confused with thyroid *** thyroid nodules are less common in children than adults,the rate of malignancy is much ***,knowing the general ultrasound findings of IET better may prevent unnecessary invasive attempts and surgical *** this article,we tried to compile the key imaging findings of IET.

关键词： Thymus Intrathyroidal thymus Ultrasonography Diagnosis

Predicting the Mechanical Properties of BHA-Li2O Composites Using Artificial Neural Networks

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Journal of Biomaterials and Nanobiotechnology 2011年第1期2卷 98-101页

作者： Hasan Huseyin Celik oguzhan Gunduz Nazmi Ekren Zeeshan Ahmad Faik Nuzhet Oktar 不详

In this study the mechanical properties of bovine hydroxyapatite (BHA)-Li2O composites are predicted using artificial neural networks (ANN) and then compared with obtained experimental values. BHA was mixed with lithium carbonate (Li2CO3) and sintered at various temperatures between 900-1300°C. Selected experimental values obtained for the compression strength, microhardness and density were used to define and train the ANN system. Intermediate data values not used to train the ANN model were then used to compare and determine the reliability of the ANN system. The results demonstrate the viable potential in using the ANN approach in predicting mechanical properties even with limited data sets.

关键词： Artificial Neural Network Hydroxyapatite Li2O Composites Bioceramic