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世界核心医学期刊文摘（神经病学分册） 2005年第1期1卷 55-56页

作者： k.wabara S. ogawara k. Misawa S. 高方 Department of Neurology Chiba University School of Medicine 1- 8- 1 InohanaChuo-kuChiba 260- 8670 Japan Dr.

Back.round: Campylobacter jejuni enteritis is the most common antecedent infection in Guillain Barré syndrome (GBS). C. jejuni related GBS is usually acute motor axonal neuropathy (AMAN), but previous reports described many cases of the demyelinating subtype of GBS (acute inflammatory demyelinating polyneuropathy ) after C. jejuni infection. Objective: To investigate whether C. jejuni infection elicits AIDP. Methods: In 159 consecutive patients with GBS, antibodies against C. jejuni were measured using ELISA. Antecedent C. jejuni infection was determined by the strict criteria of positive C. jejuni serology and a history of a diarrheal illness within the previous 3 week.. Electrodiagnostic studies were performed week.y for the first 4 week., and sequential findings were analyzed. Results: There was evidence of recent C. jejuni infection in 22 (14% ) patients. By electrodiagnostic criteria, these patients were classified with AMAN (n = 16; 73% ) or AIDP (n = 5; 23% ) or as unclassified (n = 1) in the first studies. The five C. jejuni positive patients with the AIDP pattern showed prolongedmotor distal latencies in two or more nerves and had their rapid normalization within 2 week., eventually all showing the AMAN pattern. In contrast, patients with cytomegalovirus or Epstein Barr virus related AIDP (n = 13) showed progressive increases in distal latencies in the 8 week. after onset. Conclusion: Patients with C. jejuni related Guillain Barré syndrome can show transient slowing of nerve conduction, mimick.ng demyelination, but C. jejuni infection does not appear to elicit acute inflammatory demyelinating polyneuropathy.

关键词：脱髓鞘作用多神经病空肠弯曲杆菌急性运动巨细胞病毒轴索血清学反应近期感染标准检测神经传导

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半侧面肌痉挛的异常肌反应:F波还是三叉神经反射?

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世界核心医学期刊文摘（神经病学分册） 2006年第6期2卷 34-35页

作者： Misawa S. k.wabara S. ogawara k. Hattori T. 高宗恩 Department of Neurology Chiba University School of Medicine 1-8-1 Inohana Chuo-ku Chiba 2608670 Japan Dr.

Objective: In patients with hemifacial spasm (HFS), abnormal muscle responses (AMR) are frequently present. The objective of this study was to investigate whether the afferent input of AMR is mediated by antidromic facial nerve stimulatio n or orthodromic trigeminal nerve stimulation. Methods: AMR in the orbicularis oris muscle were recorded in 28 patients with HFS. When AMR were present, they were recorded after subthreshold stimulation of the facial nerve and weak.stimulation delivered to the sk.n. Results: AMR were recordable in 24 (86%) of the patients, and usually consisted of the early constant component (mean onset latency, 10.0 ms) and late variable component (35.3 ms), similar to R1 and R2 of the bli nk.reflex. The early or late components of AMR, or both, were frequently elicite d after subthreshold stimulation of the facial nerve (43%)and sk.n stimulation (88%). Conclusions: AMR are lik.ly to be mediated by trigeminal afferent inputs , rather than antidromic activation of the facial nerve, and are a type of trige minal reflex.

关键词：半侧面肌痉挛异常肌反应神经反射面神经刺激三叉神经刺激 F波皮肤刺激阈下刺激口轮匝肌

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高血糖可改变人类糖尿病性神经病患者的不应期

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世界核心医学期刊文摘（神经病学分册） 2005年第2期1卷 20-20页

作者： Misawa S. k.wabara S. ogawara k. 陈云春 Department of Neurology Chiba University School of Medicine 1-8 -1 Inohana Chuo ku 260-8670 Chiba Japan

Objective: To investigate the effects of hyperglycemia on axonal excitability in human diabetics. Diabetic nerve dysfunction is partly associated with the alt ered polyol pathway and Na+ k.ATPase activity, probably resulting in a decrea se in the transaxonal Na+gradient and reduced nodal Na+currents. Methods:Thres hold track.ng was used to measure the relative refractory periods (RPs) of media n motor axons in 58 diabetic patients, 45 normal subjects, and 12 patients with non diabetic axonal neuropathy. In diabetic patients, the relationship of RPs w ith hemoglobin A1c (HbA1c) levels was analyzed. Results: The mean RP was similar for diabetics and normal controls as a group, but was longer in patients with n on diabetic neuropathy than in normal controls (P=0.02). Diabetic patients with good glycemic control (HbA1c levels < 7%) had longer RPs than patients with po orer glycemic control and normal controls (P=0.01). RP was longest at the HbA1c level of 6%, gradually decreasing and reaching a plateau at the HbA1c level of 8 9%. Conclusions: Hyperglycemia shortens RPs, possibly because metabolic abno rmalities lead to reduced nodal Na+currents, and thereby to a lower inactivatio n of Na+channels when generating an action potential. Significance: RP measurem ents could provide new insights into the ionic pathophysiology of human diabetic neuropathy.

关键词：糖尿病性神经病高血糖不应期非糖尿病性正中神经病理生理机制追踪法动作电位达一

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Telomeric 3'G-overhang extension in AZddG-induced telomere shortened HL60 cells

Telomeric 3'G-overhang extension in AZddG-induced telomere s...

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第二届全国“跨学科蛋白质研究”学术讨论会

作者：刘晓红 Tsuk.sa ogawara Mineo Saneyoshi Toyofumi Yamaguchi Biotechnology Research Center Teik.o University of Science and Technology Uenohara Institute of Biophysics Chinese Academy of Sciences15 Datun RoadChaoyang District Department of Biosciences Teikyo University of Science and TechnologyUenohara Biotechnology Research Center Department of Biosciences Teikyo University of Science and TechnologyUenohara

Telomere maintenance is important for all dividing cells,including cancer *** telomeres are essential for genomic stability,and without mechanisms maintaining telomeres,cells activate pathways leading to cell-cycle arrest or apoptosis.(1).Activation of telomerase is thought crucial in telomere maintenance plays an important role in the mechanism of tumor cell immortalization (2).TERT (telomerase reverse transcriptase) is the catalytic subunit of human *** is responsible for the addition of 5’-TTAGGG-3’ repeats to telomeric *** normal cells,telomerase activity appears to be tightly controlled,but is reactivated in about 90% of malignant tumor cells (3). 3’-azido-2’,3’-dideoxyguanosine (AZddG) 5’-triphosphate (AZddGTP) is a potent and selective inhibitor against HeLa cell *** hybridization analysis of genomic DNA prepared from the cells that had been cultured in the presence of AZddG revealed reproducible telomere shortening (4).Telomere 3’ single-stranded G-overhangs,the terminus of each telomeric DNA,are essential for proper telomere ***1 (protection of telomere) is one of the protection proteins of telomere that binds specifically to the 3’G-overhang and has been described as a regulator of telomere length.

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Regulatory T cells percentage in peripheral blood before and after eradication of <i>Helicobacter pylori</i>

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Health 2014年第4期6卷 236-242页

作者： Yuk. Satoh Hatsue ogawara Osamu k.wamura Yasuyuk. Shimoyama Motoyasu k.sano Ak.hik. Yok.hama Tak.yuk. Saitoh Hiroshi Handa Norifumi Tsuk.moto Hirok.zu Murak.mi Department of Blood Transfusion Service Gunma University Hospital Maebashi Japan Department of Endoscopy and Endoscopic Surgery Gunma University Hospital Maebashi Japan Department of Laboratory Sciences Course of Health Sciences Gunma Graduate School of Health Sciences Maebashi Japan Department of Medicine and Clinical Science Gunma Graduate School of Medicine Maebashi Japan Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Maebashi Japan Faculty of Health Sciences Gunma Paz College Takasaki Japan Oncology Center Gunma University Hospital Maebashi Japan

Helicobacter pylori (H. pylori) induces gastroduodenal diseases and vigorous humural and cellular immune abnormalities. In order to clarify the immunological changes before and after eradication of H. pylori, the percentages and ratios of the following cells in the peripheral blood of 32 H. pylori-infected patients and 25 control subjects were analyzed: CD4+ T cells, CD8+ T cells, T helper 1 cells (Th1), T helper 2 cells (Th2), CD4+CD25+ T cells, Foxp3+ regulatory T cells (Treg), CD4/CD8 ratio, and Th1/Th2 ratio. CD4/CD8 ratio was significantly higher in H. pylori-infected patients before (mean ± SD, 2.9 ± 1.9) and after (mean ± SD, 2.8 ± 1.6) eradication of H. pylori than in control subjects (mean ± SD, 2.1 ± 0.9). The percentage of Th2 cells was significantly higher in H. pylori-infected patients (mean ± SD, 2.6 ± 1.1) than in control subjects (mean ± SD, 1.9 ± 1.1;p < 0.02). The percentage of Th2 cells after eradication of H. pylori (mean ± SD, 2.3 ± 1.4) was lower than that before eradication. There was no significant difference between control subjects (mean ± SD, 4.1% ± 1.5%) and patients before H. pylori eradication (mean ± SD, 4.5% ± 2.4%) in the percentage of Tregs, but the percentage was significantly higher in patients after H. pylori eradication (mean ± SD, 5.2% ±2.6%) than in control subjects. The function of peripheral induced Tregs was reported to suppress the excessive immune reaction in chronic inflammation. These data suggest that Tregs may proliferate and be activated to suppress the activation of humoral immunity in H. pylori-infected patients, and these changes continue after 3 months or later of successful eradication of H. pylori.

关键词： Helicobacter pylori Regulatory T Cell Th1 Cell Th2 Cell

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