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Association between serum cystatin C level and hemodynamically significant aortic stenosis: a prospective cohort study

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Journal of Geriatric Cardiology 2021年第12期18卷 986-995页

作者： odong christopher Xing-Feng XU Yi-Fen LIN Shao-Zhao ZHANG Yi-Quan HUANG Xiang-Bin ZHONG Zhen-Yu XIONG Tara Scarlett Rosalyn CHEN Chao-Guang XU Xiao-Dong ZHUANG Xin-Xue LIAO Department of Cardiology the First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChina NHC Key Lab-oratory of Assisted Circulation Sun Yat-Sen UniversityGuangzhouChina Department of Rehabilitation Medicine the Seventh Affiliated Hospital of Sun Yat-Sen UniversityShenzhenChina

BACKGROUND Cystatin C(CysC)is a cysteine protease inhibitor involved in proteins catabolism and plays an essential role in human vascular *** may also increase the risk of aortic stenosis(AS),but limited studies have reported on this *** study aimed to investigate if elevated serum CysC levels are associated with hemodynamically significant *** Serum CysC levels were estimated in 4,791 participants,samples were collected in 1990−*** study popula-tion was divided into quintile ***-up continued in 2011-2013 when participants returned for echocardiography *** of aortic valve disease(AVD)was ascertained by Doppler echocardiography through the end of *** defined in hemodynamic progression was assessed and classified as aortic sclerosis,mild stenosis,and moderate-to-severe *** Overall,a total of 4,791 participants(mean age:54.8±5.0 years,females:57.6%,blacks:8.2%)were included in this *** a follow-up of 21 years,we identified 736 cases(15.4%)of aortic sclerosis,194 cases(4.0%)of mild stenosis,and 42 cases(0.7%)of moderate-to-severe *** with serum CysC levels within individual quintile groups,the odds ratio(OR)was per standard deviation associated with an increased incidence of AVD(OR=1.15,95%CI:1.05−1.26,P=0.002).CONCLUSIONS In this large population-based study,an increased serum CysC levels is independently associated with the incidence of hemodynamically significant ***,this association appears not to extend to patients with extremely high serum CysC levels and necessitate further investigation.

关键词： stenosis aortic hemodynamic

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