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Management of Complex Wounds with Dermal Substitute Assisted by a Negative Pressure System

Modern Plastic Surgery 2023年第4期13卷 95-105页

作者： Cuahutémoc Márquez Espriella Ruiz Garza Jorge Gerardo Barbosa Villarreal fernando Dávila Díaz Rodrigo Cuervo Vergara Marco Antonio Campollo López Ana Priscila Gutierrez Alvarez Mauricio Chama Naranjo Alfredo García Corral Jesús Ricardo Pérez Benítez Omar Alberto Pulido López Ricardo Alberto Jaimes Duran Edwing Michel Garibaldi Bernot Mauro Cortes Aguilar Carlos Manuel García Córdova Carlos Emiliano Camacho Rodriguez Hayah Camacho Rodriguez Hayah Martinez Villalobos Claudia Nallely Ochoa Contreras Erick Cesar Randall Cruz Soto Herrera Lozano Luis Arturo Department of Plastic and Reconstructive Surgery Hospital Central Sur Petróleos Mexicanos Mexico City Mexico

Introduction: The standard treatment for complex wound care is autografting. The advent of dermal substitutes has provided a novel tool for the preparation of the bed to be grafted. However, most types of dermal matrices require the application of a skin graft a second time. Currently, other strategies have been developed to improve the vascularization process, such as negative pressure wound therapy (NPWT), which has been reported to reduce the time required for vascular growth and dermal matrix integration and thus achieve a shorter waiting period for autologous graft application. The present study aims to evaluate the effectiveness and safety of dermal matrix management associated with NPWT in the treatment of complex wounds. Methods: Seven patients with a diagnosis of complex wounds were enrolled in this study between July 1, 2015, and June 31, 2016. After debridement and having an adequate wound bed, patients who met the criteria for the application of combined therapy were treated with dermal substitutes and a negative pressure system. The percentage of graft integration into the wound bed, complications, length of hospital stay, and duration of therapy were analyzed. Results: The mean age was 42.5 ± 16 (39 - 54) years old;three women and four men were included in the study. The approximate size of skin loss was 120.7 ± 75 cm2 (25 - 250 cm2). The combined therapy of dermal matrix plus NPWT was instituted in all cases for a period of 14 days. There were no complications, with 100% graft integration in 6 of 7 cases. Patients were discharged after a mean hospital stay of 5.4 days. Conclusions: This study demonstrates that the utilization of combined dermal matrix plus NPWT therapy can be performed safely and effectively in patients with complex wounds with low complication rates and a short hospital stay.

关键词： Negative Pressure Wound Therapy Complex Wound Dermal Matrix Wound Therapy

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Pedigree analysis of 220 almond genotypes reveals two world mainstream breeding lines based on only three different cultivars

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Horticulture Research 2021年第1期8卷 72-82页

作者： Felipe Perez de los Cobos Pedro J.Martinez-Garcia Agusti Romero Xavier Miarnau Iban Eduardo Werner Howad Mourad Mnejja Federico Dicenta Rafel Socias i Company Maria J.Rubio-Cabetas Thomas M.Gradziel Michelle Wirthensohn Henri Duval Doron Holland Pere Arus Francisco J.Vargas Ignasi Batlle Institut de Recerca i Tecnologia Agroalimentaries(IRTA) Mas BoveCtra.Reus-El Morell Km 3843120 ConstantiTarragonaSpain Institut de Recerca i Tecnologia Agroalimentaries(IRTA) Centre de Recerca en Agrigenomica(CRAG)CSIC-IRTA-UAB-UB.Cerdanyola del Valles(Bellaterra)08193 BarcelonaSpain Centro de Edafologia y Biologia Aplicada del Segura Consejo Superior de Investigaciones Cientificas(CEBAS-CSIC)P.O.Box 16430100 EspinardoMurciaSpain Institut de Recerca i Tecnologia Agroalimentaries(IRTA) FruitcentrePCiTALGardeny ParkFruitcentre Building25003 LleidaSpain Centro de Investigacion y Tecnologia Agroalimentaria de Aragon(CITA) Avda.Montanana 93050059ZaragozaInstituto Agroalimentario de Aragon IA2(CITA-Universidad de Zaragoza)ZaragozaSpain University of California 1 Shields AvenueDavisCA 95616USA University of Adelaide Waite ResearchSchool of AgricultureFood and WinePMB 1Glen OsmondAdelaideSA 5064Australia Institut National de la Recherche Agronomique(INRA) Domain St.Maurice CS 6009484143 Montfavet CedexFrance Agricultural Research Organization Newe-Ya’ar Research CenterP.O.Box 1021Ramat Yishad 30095Israel

Loss of genetic variability is an increasing challenge in tree breeding programs due to the repeated use of a reduced number of founder ***,in almond,little is known about the genetic variability in current breeding stocks,although several cases of inbreeding depression have been *** gain insights into the genetic structure in modern breeding programs worldwide,marker-verified pedigree data of 220 almond cultivars and breeding selections were *** coefficients,pairwise relatedness,and genetic contribution were calculated for these *** results reveal two mainstream breeding lines based on three cultivars:“Tuono”,“Cristomorto”,and“Nonpareil”.Descendants from“Tuono”or“Cristomorto”number 76(sharing 34 descendants),while“Nonpareil”has 71 *** mean inbreeding coefficient of the analyzed genotypes was 0.041,with 14 genotypes presenting a high inbreeding coefficient,over *** programs from France,the USA,and Spain showed inbreeding coefficients of 0.075,0.070,and 0.037,*** to their genetic contribution,modern cultivars from Israel,France,the USA,Spain,and Australia trace back to a maximum of six main founding *** the group of 65 genotypes carrying the S f allele for self-compatibility,the mean relatedness coefficient was 0.125,with“Tuono”as the main founding genotype(24.7%of total genetic contribution).The results broaden our understanding about the tendencies followed in almond breeding over the last 50 years and will have a large impact into breeding decision-making process *** current genetic variability is required in almond breeding programs to assure genetic gain and continuing breeding progress.

关键词： breeding cultivar founding

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Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy

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Chronic Diseases and Translational Medicine 2019年第4期5卷 258-266页

作者： Amin Zargar Samantha Chang Ankita Kothari Antoine M.Snijders Jian-Hua Mao Jessica Wang Amanda C.Hernandez Jay D.Keasling Trever G.Bivona Joint BioEnergy Institute Lawrence Berkeley National LaboratoryEmeryvilleCA 94608USA QB3 Institute University of California-Berkeley174 Stanley HallBerkeleyCA 94720USA Biological Systems and Engineering Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Chemical&Biomolecular Engineering Department of BioengineeringUniversity of CaliforniaBerkeleyCA 94720USA Helen Diller Family Comprehensive Cancer Center University of CaliforniaSan FranciscoCA 94143USA Department of Cellular and Molecular Pharmacology University o f CaliforniaSan FranciscoCA 94143USA

Despite tremendous efforts to fight cancer,it remains a major public health problem and a leading cause of death *** increased knowledge of cancer pathways and improved technological platforms,precision therapeutics that specifically target aberrant cancer pathways have improved patient ***,a primary cause of unsuccessful cancer therapy remains cancer drug *** this review,we summarize the broad classes of resistance to cancer therapy,particularly pharmacokinetics,the tumor microenvironment,and drug resistance ***,we describe how bacterial-mediated cancer therapy,a bygone mode of treatment,has been revitalized by synthetic biology and is uniquely suited to address the primary resistance mechanisms that confound traditional *** genetic engineering,we discuss how bacteria can be potent anticancer agents given their tumor targeting potential,anti-tumor activity,safety,and coordinated delivery of anti-cancer drugs.

关键词： Cancer therapy Synthetic biology Drug resistance Bacterial-mediated therapy

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Prognostic factors and predictive model for in-hospital mortality following hip fractures in the elderly

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Chinese Journal of Traumatology 2018年第3期21卷 163-169页

作者： J. Sanz-Reig J. Salvador Marin J. Ferrandez Martinez D. Orozco Beltran J.F. Martinez Lopez J.A. Quesada Rico Department of Orthopedic Surgery Sant Joan d' Alacant University Hospital Alicante Spain Department of Medicine Miguel Hernandez University Elche Spain

Purpose： The incidence of hip fractures is increasing within the aging population. Our objective was to identify and quantify the risk factors and develop a predictive model for the in-hospital mortality among hip fracture patients older than 65 years. Methods： This is a prospective study conducted on 331 hip fracture patients older than 65 years admitted to our hospital from 2011 to 2014. Patients＇ demographics, prehospitalization residential status, pre- fracture comorbidity data, anti-aggregant and anticoagulant medication, preoperative hemoglobin value, type of fractures, type of treatments, time to surgery, and complications were recorded. Results： The average age was 83 years, 73% female, and 57% of them sustained a femoral neck fracture. In 62.8% of patients, the number of pre-fracture baseline comorbidities was 〉2. The in-hospital mortality rate was 11.4%. In multivariate analysis, age over 90 years, congestive heart failure, asthma, rheumatologic disease, lung cancer, and not taking antiaggregant medication were independently associated with in-hospital mortality. A formula and risk stratification scoring for predicting the risk for in-hospital mortality was developed, Risk-adjustment model based on these variables had acceptable accuracy for predicting in-hospital mortality （c-statistic 0.77）. Conclusion： Advanced age, and five prefracture comorbidities have a strong association with in-hospital mortality in a hip fracture patient older than 65 years old. Our predictive model was specifically designed for the old hip fracture population. It has an accuracy similar to other risk models. The specificity, positive predictive value, and negative predictive value are high. In addition, it could discriminate a high risk patient from a low risk patient for in-hospital mortality.

关键词： Hip fractures In-hospital mortality Prognostic factors Elder population

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儿童早期空气污染与呼吸道感染:ESCAPE项目中10个欧洲出生队列的分析

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环境与职业医学 2014年第3期31卷 202-202页

作者： Elaina A.MacIntyre Ulrike Gehring Anna Molter Elaine Fuertes Claudia Klümper Ursula Kramer Ulrich Quass Barbara Hoffmann Mireia Gascon Bert Brunekreef Gerard H.Koppelman Rob Beelen Gerard Hoek Matthias Birk Johan C.de Jongste H.A.Smit Josef Cyrys Olena Gruzieva Michal Korek Anna Bergstrom Raymond M.Agius Frank de Vocht Angela Simpson Daniela Porta Francesco Forastiere Chiara Badaloni Giulia Cesaroni Ana Esplugues Ana fernández-Somoano Aitana Lerxundi Jordi Sunyer Marta Cirach Mark J.Nieuwenhuijsen Goran Pershagen Joachim Heinrich

[背景]将交通源空气污染作为幼儿期呼吸道感染的危险因素的研究很少。[目的]在10个欧洲出生队列——BAMSE（瑞典）、GASPⅡ（意大利）、GINIplus和LISAplus（德国）、MAAS（英国）、PIAMA（荷兰）和4个INMA队列（西班牙）——中研究空... 详细信息

[背景]将交通源空气污染作为幼儿期呼吸道感染的危险因素的研究很少。[目的]在10个欧洲出生队列——BAMSE（瑞典）、GASPⅡ（意大利）、GINIplus和LISAplus（德国）、MAAS（英国）、PIAMA（荷兰）和4个INMA队列（西班牙）——中研究空气污染与肺炎、哮喘及中耳炎之间的相关性，并使用meta分析得出综合效应估值。[方法]评价家长报告的医师诊断的儿童早期肺炎、中耳炎以及哮喘与全年平均污染物水平[二氧化氮（NO2）、氮氧化物（NOx）、≤2．5gm的颗粒物（PM2.5）、PM2.5吸光度、PM10、PM2.5-10（粗PM）]间的关联，污染物浓度的估计采用土地利用回归模型并根据孩子的出生住址分配。作为ESCAPE项目的一部分，每个研究区域都采用相同的方案建立回归模型。用logistic回归来计算每个研究校正后的效应估值，用随机效应meta分析来计算合并的估计值。[结果]除了PM2.5外的所有污染物，肺炎的合并校正优势比（OR）均升高（例如，N02每增加10μg／m3，OR=1．30，95％CI：1．02～1．65；PM10每增加10μg／m3的OR=1．76，95％CI：1．00—3．09）。对于中耳炎和哮喘，除了NO2与中耳炎问的关联（每10μg／m3对应的OR=1．09，95％CI：1．02～1．16），所有分析的结果均无显著性。[结论]对ESCAPE项目中10个欧洲出生队列进行的meta分析为空气污染和儿童早期肺炎之间的相关性找到一致性的证据，也为与中耳炎间的相关性找到了一些证据。

关键词：早期肺炎呼吸道感染出生队列空气污染欧洲儿童 meta分析 logistic

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奥美拉唑引起的皮肤色素沉着类似灰色皮病

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世界核心医学期刊文摘（皮肤病学分册） 2006年第9期2卷 7-7页

作者： ramrez-Hernndez M Martnez-Escribano J.A Martnez-Barba E. 冯义国 Department of Dermatology Virgen de la Arrixaca University Hospital 30120 El Palmar Murcia Spain

Background: Omeprazole has been associated with multiple adverse effects including skin reactions but, to date, cutaneous hyperpigmentation has not been described as an adverse effect of this drug. Observations: We describe a case of a 52-year-old Caucasian woman who developed skin hyperpigmentation in the upper trunk, mimicking ashy dermatosis, 2 months after initiating omeprazole treatment. Histopathologic examination of a skin biopsy taken from a pigmentedmacule showed dermal macropha-ges containing golden-brown granules, which also displayed a sulphur peak on energy-dispersive X-ray microanalysis. High-performance liquid chromatography (HPLC) and mass spectrometry were also performed on the drug and on a biopsy specimen revealing the same chromatograms as well as the same mass spectra. Conclusions: According to our results, omeprazole itself may induce cutaneous pigmentation and, to our knowledge, this is the first report of this finding.

关键词：皮肤色素沉着奥美拉唑皮病灰色组织病理检查高效液相色谱活检标本不良反应

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生长兔日粮中棕榈仁粕的营养价值

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饲料博览 2012年第2期22卷 21-21页

作者： Carrión S De Blas J C Méndez J Caídas A García-Rebollar P 不详

为确定饲料中的棕榈仁粕(PKM)对生长兔的营养价值,在试验1中,选用新西兰×加州50日龄生长兔20只来确定PKM的能量、粗蛋白、纤维和脂肪消化率。通过不同方法对其营养价值进行评估,试验分为对照组(基础日粮)和试验组(在基础日粮中添加***... 详细信息

为确定饲料中的棕榈仁粕(PKM)对生长兔的营养价值,在试验1中,选用新西兰×加州50日龄生长兔20只来确定PKM的能量、粗蛋白、纤维和脂肪消化率。通过不同方法对其营养价值进行评估,试验分为对照组(基础日粮)和试验组(在基础日粮中添加***-1)。PKM的能量、粗蛋白、乙醚提取物和中性洗涤纤维的消化率分别为0.549(±0.056,SE)、0.541(±0.069)、0.850(±0.048)和0.430(±0.101),可消化的能量为10.9±***-1DM;试验2中,412只生长兔被随机分配在2个试验日粮组来衡量其增长性能。试验结果表明,与对照组相比,PKM日粮组对饲料及可消化能量的摄入无显著差异,但平均日增重(P=0.003)和饲料效率(P<0.001)略有下降(约5%),死亡率和软粪便中产气荚膜梭菌数量都不受日粮类型的影响。说明棕榈仁粕可以作为生长兔的纤维、蛋白质和脂肪来源,其可以替代其他日粮中大量的纤维成分,并且对生产性能没有不利影响。

关键词：棕榈仁粕能量养分消化率育肥性能生长兔

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Dense matter with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 28-44页

作者： Anna L.Watts WenFei Yu Juri Poutanen Shu Zhang Sudip Bhattacharyya Slavko Bogdanov Long Ji Alessandro Patruno Thomas E.Riley Pavel Bakala Altan Baykal Federico Bernardini Ignazio Bombaci Edward Brown Yuri Cavecchi Deepto Chakrabarty Jér?me Chenevez Nathalie Degenaar Melania Del Santo Tiziana Di Salvo Victor Doroshenko Maurizio Falanga Robert D.Ferdman Marco Feroci Angelo F.Gambino MingYu Ge Svenja K.Greif Sebastien Guillot Can Gungor Dieter H.Hartmann Kai Hebeler Alexander Heger Jeroen Homan Rosario Iaria Jean in 't Zand Oleg Kargaltsev Aleksi KurkelaTheoretical Physics Department CERN XiaoYu Lai Ang Li XiangDong Li ZhaoSheng Li Manuel Linares FangJun Lu Simin Mahmoodifar Mariano Méndez M.Coleman Miller Sharon Morsink Joonas N?ttil? Andrea Possenti Chanda Prescod-Weinstein JinLu Qu Alessandro Riggio Tuomo Salmi Andrea Sanna Andrea Santangelo Hendrik Schatz Achim Schwenk LiMing Song Eva?rámková Benjamin Stappers Holger Stiele Tod Strohmayer Ingo Tews Laura Tolos Gabriel T?r?k David Tsang Martin Urbanec Andrea Vacchi RenXin Xu YuPeng Xu Silvia Zane GuoBao Zhang ShuangNan Zhang WenDa Zhang ShiJie Zheng Xia Zhou Anton Pannekoek Institute for Astronomy University of Amsterdam Shanghai Astronomical Observatory Tuorla Observatory Department of Physics and Astronomy University of Turku Nordita KTH Royal Institute of Technology and Stockholm University Institute of High Energy Physics Chinese Academy Sciences Tata Institute of Fundamental Research Columbia Astrophysics Laboratory Columbia University Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen Leiden Observatory Leiden University Research Center for Computational Physics and Data Processing Silesian University in Opava Physics Department Middle East Technical University INAF Osservatorio Astronomico di Roma New York University Abu Dhabi Dipartimento di Fisica Enrico Fermi University of Pisa INFN Italian National Institute for Nuclear Physics Department of Physics and Astronomy Michigan State University Department of Astrophysical Sciences Princeton University Mathematical Sciences and STAG Research Centre University of Southampton MIT Kavli Institute for Astrophysics and Space Research DTU Space Technical University of Denmark INAF/IASF Palermo via Ugo La Malfa 153 Universita degli Studi di Palermo Dipartimento di Fisica e Chimica International Space Science Institute (ISSI) Faculty of Science University of East Anglia INAF Istituto di Astrofisica e Planetologie Spaziali Institut für Kernphysik Technische Universit?t Darmstadt ExtreMe Matter Institute EMMI GSI Helmholtzzentrum für Schwerionenforschung GmbH Instituto de Astrof'?sica Pontificia Universidad Católica de Chile Department of Physics & Astronomy Kinard Lab of Physics Clemson University School of Physics and Astronomy Monash University SRON Netherlands Institute for Space Research Department of Physics The George Washington University Faculty of Science and Technology University of Stavanger School of Physics and Mechanical & Electrical Engineering Hubei University of Education Department of Astronomy Xiamen University (Haiyun Campus) School of Astronomy and Space

In this White Paper we present the potential of the Enhanced X-ray Timing and Polarimetry(eXTP) mission for determining the nature of dense matter; neutron star cores host an extreme density regime which cannot be replicated in a terrestrial laboratory. The tightest statistical constraints on the dense matter equation of state will come from pulse profile modelling of accretion-powered pulsars, burst oscillation sources, and rotation-powered pulsars. Additional constraints will derive from spin measurements, burst spectra, and properties of the accretion flows in the vicinity of the neutron star. Under development by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020 s.

关键词： neutron X-rays dense matter equation of state

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阴茎特发性皮肤钙质沉着症

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世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 38-38页

作者： S'anchez-Merino J.M. Bouso-MonteroM. fern'andez-Flores A. Garca-Alonso J. 刘超

Calcification of the skin occurs in three main forms: dystrophic; metastatic; and *** calcinosis cutis of the penis is a rare event and only 4 cases have been *** we present another case in a 19-year-old man and discu... 详细信息

关键词：皮肤钙质沉着症营养障碍文章报道

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局限性脉络膜血管瘤光动力治疗后持续性脉络膜肥厚

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世界核心医学期刊文摘（眼科学分册） 2006年第6期2卷 40-40页

作者： Hussain N. Das T. Mohan ram L. S. Sumasri K. 王大江(译) 不详 Smt. Kanuri Sa Itkamma Retina-Vitreous Services L. V. Prasad Eye Institute L. V. Prasad Marg Banjara Hills Hyderabad 500 034 India

A 19-year-old man presented with blurred vision in the right eye,which was diagnosed as a circumscribed choroidal hemangioma. The choroidal thickening on B-scan ultrasonography persisted after receiving repeat photody... 详细信息

关键词：局限性脉络膜血管瘤光动力疗法持续性治疗后肥厚男性患者视物模糊维替泊芬肿瘤消退 B超检查

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