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Current Zoology 2011年第1期57卷 8-17页

作者： Cedric SUEUR Paul SALZE Christiane WEBER odile petit Department of Ecology and Evolutionary Biology Princeton University 08544 Princeton USA Ethologie des Primates Departement d'Ecologie Physiologie et Ethologie UMR 7178 CNRS-UdS 23 rue Becquerel 67087 Strasbourg France Laboratoire Image et Ville ERL 7230 CNRS-UdS 3 rue de l'Argonne 67000 Strasbourg France

Wild animals use their habitat according to ecological pressures such as predation, resource availability or tempera- ture, yet little is known about how individuals use their environment in semi free-ranging conditions. We assessed whether a semi-free ranging group of Tonkean macaques Macaca tonkeana used its wooded parkland in a heterogeneous way. GIS and GPS were used to determine whether individuals adjusted their behaviors according to variation in environmental constraints over time of day and the course of a year. We demonstrated that social and resting activities occurred in high altitude areas and areas with a high density of bushes, whereas the group foraged in areas where the density of bushes and grass was low. In general, the animals used areas exposed to the sun that were not on a slope. Semi-free ranging Tonkean macaques seemed to behave like their wild counterparts in terms of activity budget, land use per activity and thermoregulation

关键词： GPS GIS Temperature Topography Activity budget Spatial autocorrelation Primates

Hepatitis B and human immunodeficiency virus co-infection

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World Journal of Gastroenterology 2014年第46期20卷 17360-17367页

作者： Bao-Chau Phung Philippe Sogni odile Launay Université Paris Descartes Sorbonne Paris Cité75006 ParisFrance Assistance Publique-H?pitaux de Paris H?pital CochinCIC Cochin Pasteur75014 ParisFrance Inserm CIC141775014 ParisFrance APHP H?pital CochinService d’hépatologie75014 ParisFrance

Hepatitis B and human immunodeficiency virus(HBV and HIV)infection share transmission patterns and risk factors,which explains high prevalence of chronic HBV infection in HIV infected *** natural course of HBV disease is altered by the HIV infection with less chance to clear acute HBV infection,faster progression to cirrhosis and higher risk of liver-related death in HIVHBV co-infected patients than in HBV mono-infected *** infected patients with chronic hepatitis B should be counseled for liver damage and surveillance of chronic hepatitis B should be performed to screen early hepatocellular *** tools are now available to evaluate liver *** hepatitis B core antibodies(anti-HBc)are a good predictive marker of occult HBV *** the prevalence and significance of occult HBV infection is controversial,but its screening may be important in the management of antiretroviral *** against HBV infection is recommended in non-immune HIV *** optimal treatment for almost all HIV-HBV co-infectedpatients should contain tenofovir plus lamivudine or emtricitabine and treatment should not be stopped to avoid HBV *** term tenofovir therapy may lead to significant decline in hepatitis B surface *** emergence of resistant HBV strains may compromise the HBV therapy and vaccine therapy.

关键词： Chronic hepatitis B Human immunodeficiency virus Management Occult hepatitis Treatment

Overlap syndrome consisting of PSC-AIH with concomitant presence of a membranous glomerulonephritis and ulcerative colitis

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World Journal of Gastroenterology 2014年第16期20卷 4811-4816页

作者： odile Warling Christophe Bovy Carla Combra Timothée Noterdaeme Jean Delwaide Edouard Louis Department of Internal Medicine CHU de LiègeUniversity of Liège4000 LiegeBelgium Department of Internal Medicine NephrologyCHU de LiègeUniversity of Liège4000 LiegeBelgium Department of Abdominal Surgery and Transplantation CHU de LiègeUniversity of Liège4000 LiegeBelgium Department of Cardiovascular Surgery German Heart Center80636 MunichGermany Department of Internal Medicine GastroenterologyCHU de LiègeUniversity of Liège4000 LiegeBelgium

The association of primary sclerosing cholangitis(PSC)and autoimmune hepatitis(AIH)is known as an overlap syndrome(OS).OS can also be described in the setting of concomitant presence of AIH and *** diseases can in some cases be associated with ulcerative *** this case report we describe,to our knowledge,the first case in the literature of a young Caucasian male suffering from ulcerative colitis and an overlap syndrome consisting of an association betweenPSC-AIH,with the concomitant presence of a membranous glomerulonephritis.

关键词： Primary sclerosing cholangitis Autoimmune hepatitis Overlap syndrome Ulcerative colitis Membranous glomerulonephritis

Hallmarks in colorectal cancer:Angiogenesis and cancer stem-like cells

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World Journal of Gastroenterology 2014年第15期20卷 4189-4196页

作者： Muriel Mathonnet Aurelie Perraud Niki Christou Hussein Akil Carole Melin Serge Battu Marie-odile Jauberteau Yves Denizot Department of Digestive Surgery Limoges University Hospital87042 LimogesFrance Homéostasie Cellulaire at Pathologies Faculty of MedicineUniversity of Limoges87025 LimogesFrance Institut 145 GEIST UMR CNRS 7276Faculty of MedicineUniversity of Limoges87025 LimogesFrance

Carcinogenesis is a multistep process that requires the accumulation of various genetic and epigenetic aberrations to drive the progressive malignant transformation of normal human *** major hallmarks of carcinogenesis that have been described are angiogenesis and the stem cell characteristic of limitless replicative *** properties have been targeted over the past decade in the development of therapeutic treatments for colorectal cancer(CRC),one of the most commonly diagnosed and lethal cancers *** treatment of solid tumor cancers such as CRC has been challenging due to the heterogeneity of the tumor itself and the chemoresistance of the malignant ***,the same microenvironment that maintains the pool of intestinal stem cells that contribute to the continuous renewal of the intestinal epithelia also provides the necessary conditions for proliferative growth of cancer stem-like *** cancer stem-like cells are responsible for the resistance to therapy and cancer recurrence,though they represent less than 2.5%of the tumor *** stromal environment surrounding the tumor cells,referred to as the tumor niche,also supports angiogenesis,which supplies the oxygen and nutrients needed for tumor ***-angiogenic therapy,such as with bevacizumab,a monoclonal antibody against vascular-endothelial growth factor,significantly prolongs the survival of metastatic CRC ***,such treatments are not completely curative,and a large proportion of patient tumors retain chemoresistance or show *** article reviews the current knowledge regarding the molecular phenotype of CRC cancer cells,as well as discusses the mechanisms contributing to their *** personalized therapeutic approaches that are based on the interaction of the carcinogenic hallmarks,namely angiogenic and proliferative attributes,could improve survival and decrease adverse effects induced by unnecessary chemotherapy.

关键词： Colon cancer Stem cell Cancer stem-like cell Tumor-initiating cell Microenvironment

Experimental demonstration of robust nanophotonic devices optimized by topological inverse design with energy constraint

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Photonics Research 2022年第7期10卷 1787-1802页

作者： GUOWU ZHANG DAN-XIA XU YURI GRINBERG odile LIBOIRON-LADOUCEUR Department of Electrical and Computer Engineering McGill UniversityMontréalQuebec H3A 0E9Canada National Research Council Canada OttawaOntario K1A 0R6Canada

In this paper,we present the experimental results for integrated photonic devices optimized with an energyconstrained inverse design *** this constraint is applied,optimizations are directed to solutions that contain the optical field inside the waveguide core medium,leading to more robust designs with relatively larger minimum feature *** optimize three components:a mode converter(MC),a 1310 nm/1550 nm wavelength duplexer,and a three-channel C-band wavelength demultiplexer for coarse wavelength division multiplexing(CWDM)application with 50 nm channel *** energy constraint leads to nearly binarized structures without applying independent binarization *** also reduces the appearance of small *** the MC,well-binarized design,improved insertion loss,and cross talk are obtained as a ***,the proposed constraint improves the robustness to fabrication imperfections as shown in the duplexer *** energy constraint optimization,the corresponding spectrum shifts for the duplexer under±10 nm dimensional variations are reduced from 105 nm to 55 nm and from 72 nm to 60 nm for the 1310 nm and 1550 nm channel,*** the CWDM demultiplexer,robustness toward±10 nm fabrication error is improved by a factor of *** introduction of the energy constraint into topological optimization demonstrates computational gain with better-performing designs.

关键词： waveguide constraint inverse

Opposing regulatory functions of the TIM3 (HAVCR2) signalosome in primary effector T cells as revealed by quantitative interactomics

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Cellular & Molecular Immunology 2021年第6期18卷 1581-1583页

作者： Yunhao Zhai Javier Celis-Gutierrez Guillaume Voisinne Daiki Mori Laura Girard odile Burlet-Schiltz Anne Gonzalez de Peredo Romain Roncagalli Bernard Malissen Centre d’Immunologie de Marseille-Luminy Aix Marseille UniversitéINSERMCNRS13288MarseilleFrance Centre d’Immunophénomique Aix Marseille UniversitéINSERMCNRSMarseilleFrance Institut de Pharmacologie et de Biologie Structurale Département Biologie Structurale BiophysiqueProtéomique Génopole Toulouse Midi Pyrénées CNRS UMR 5089ToulouseFrance

Deciphering how T-cell antigen receptor signals are modulated by coinhibitors is a fundamental goal in immunology and of considerable clinical interest because blocking coinhibitory signals via therapeutic antibodies have become a standard cancer immunotherapeutic *** of the attention devoted to T-cell immunoglobulin and mucin domain-3(TIM3;also known as HAVCR2 or CD366)molecules stems from their expression on exhausted T cells in settings of chronic viral infection and ***,T cells expressing high levels of both PD-1 and TIM3 coinhibitors appear more dysfunctional than those expressing PD-1 *** therapies intending to block both PD-1 and TIM3 are thus actively being explored in the cancer treatment *** interaction with Galectin-9(GAL-9)and carcinoembryonic antigen-related cell adhesion molecule 1(CEACAM-1),the tyrosines found in the TIM3 cytoplasmic tail are phosphorylated.1 Because these conserved tyrosines do not form a recognizable inhibitory signaling motif,the mechanism by which TIM3 transmits inhibitory signals has not been ***,TIM3 also has costimulatory activity in T cells.2,3 Published biochemical studies attempting to unveil the mode of action of TIM3 have relied on approaches addressing one candidate effector at a time with limited quantitative insight,and most used transformed *** mice expressing an affinity Twin-Strep-tag(OST)at the TIM3-protein C-terminus(TIM3OST mice)(Figs.1a and S1a)and affinity purification coupled with mass spectrometry(AP-MS),we herein defined the composition and dynamics of the signaling protein complex(signalosome)used by TIM3 in primary effector T *** results provide a more complete model of TIM3 signaling and explain its paradoxical coinhibitory and costimulatory functions.

关键词： TIM3 expressing devoted

Transient and etiology-related transcription regulation in cirrhosis prior to hepatocellular carcinoma occurrence

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World Journal of Gastroenterology 2009年第3期15卷 300-309页

作者： Frédérique Caillot Céline Derambure Paulette Bioulac-Sage Arnaud Franois Michel Scotte odile Goria Martine Hiron Maryvonne Daveau Jean-Philippe Salier Inserm Unité 905 and Institut Fédératif de Recherches Multidisciplinaires sur les Peptides Faculté de Médecine-Pharmacie76183 RouenFrance Service d'Anatomie Pathologique Centre Hospitalier Universitaireand Inserm U88933000 BordeauxFrance Département Pathologie Centre Hospitalier Universitaire76183 RouenFrance Service de Chirurgie Générale et Digestive Centre Hospitalier Universitaire76183 RouenFrance Service d'Hépato-gastro-entérologie Centre Hospitalier Universitaire76183 RouenFrance

AIM： To search for transcription dysregulation that could （1） differentiate hepatocellular carcinoma （HCC）-free from HCC-related cirrhosis （2） differentiate HCC-free cirrhosis related to HCV from that related to alcohol intake. METHODS： Using microarray analysis, we compared transcript levels in HCC-free cirrhosis （alcoholism： 7; hepatitis C： 7）, HCC-associated cirrhosis （alcoholism： 10; hepatitis C： 10） and eight control livers. The identified transcripts were validated by qRT-PCR in an independent cohort of 45 samples （20 HCC-free cirrhosis; 15 HCC-associated cirrhosis and 10 control livers）. We also confirmed our results by ***： In HCC-free livers, we identified 70transcripts which differentiated between alcoholicrelated-cirrhosis, HCV-related cirrhosis and control livers. They mainly corresponded to down-regulation. Dysregulation of Signal Transduction and Activator of Transcription-3 （STAT-3） was found along with related changes in STAT-3 targets which occurred in an etiology-dependent fashion in HCC-free cirrhosis. In contrast, in HCC, such transcription dysregulations were not observed. CONCLUSION： We report that transcriptional dysregulations exist in HCC-free cirrhosis, are transiently observed prior to detectable HCC onset and may be appear like markers from cirrhosis to HCC transition.

关键词： Liver Pathology Alcoholism Hepatitis Cvirus Gene expression Carcinogenesis

法律图书馆和经济科学学院,厄拉德校园,南特,法国

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世界建筑 2003年第9期 36-43页

作者： Sarl odile DECQ BenoIt Cornette 萨尔.奥递尔.DECQ.贝努瓦.考尔耐特公司

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World Journal of Gastroenterology 2016年第2期22卷 490-500页

作者： Hussein Akil Aurélie Perraud Marie-odile Jauberteau Muriel Mathonnet Laboratoire Homéostasie Cellulaire et Pathologies(LHCP-EA3842) Facultéde Médecine et de PharmacieFédération de Recherche GEIST87025 LimogesFrance Service de Chirurgie Digestive Générale et EndocrinienneCHU de Limoges87042 LimogesFrance Service d’Immunologie CHU de Limoges87042 LimogesFrance

Colorectal cancer(CRC) is the second most common cause of cancer-related death in western countries. Approximately one-quarter of newly diagnosed patients for CRC have metastases, and a further 40%-50% experience disease recurrence or develop metastases after all standard therapies. Therefore, understanding the molecular mechanisms involved in the progression of CRC and subsequently developing novel therapeutic targets is crucial to improve management of CRC and patients' long-term survival. Several tyrosine kinase receptors have been implicated in CRC development, progression and metastasis, including epidermal growth factor receptor(EGFR) and vascular EGFR. Recently, tropomyosin-related kinase B(Trk B), a tyrosine kinase receptor, has been reported in CRC and found to clearly exert several biological and clinical features, such as tumor cell growth and survival in vitro and in vivo, metastasis formation and poor prognosis. Here we review the significance of Trk B and its ligand brain derived-neurotrophic factor in CRC. We focus on their expression in CRC tumor samples, and their functional roles in CRC cell lines and in in vivo models. Finally we discuss therapeutic approaches that can lead to the development of novel therapeutic agents for treating Trk B-expressing CRC tumors.

关键词： Colorectal cancer Tyrosine kinase receptor B Brain-derived neurotrophic factor Therapeutic targets Cell survival

Inhibition of glucuronidation in pancreatic cancer improves gemcitabine anticancer activity

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Cancer Communications 2022年第11期42卷 1212-1216页

作者： Nicolas Alejandro Fraunhoffer Analía Meilerman Abuelafia Brice Chanez Martin Bigonnet odile Gayet Julie Roques Eduardo Chuluyan Nelson Dusetti Juan Iovanna Cancer Research Center of Marseille InsermPaoli-Calmettes InstitutAix-Marseille UniversityScientific and Technological Park of LuminyMarseille 13288France Buenos Aires University Center for Pharmacological and Botanical StudiesFaculty of MedicineNational Council for Scientific and Technical ResearchBuenos AiresC1121ABGArgentina Buenos Aires University Faculty of MedicineDepartment of MicrobiologyParasitology and ImmunologyBuenos Aires C1121ABGArgentina Predicting Med Scientific and Technological Park of LuminyMarseille 13288France

Dear Editor,Pancreatic ductal adenocarcinoma(PDAC)treatment is focused on two *** polychemotherapy,FOLFIRINOX(folinic acid,fluorouracil,irinotecan,oxali-platin),is used in patients with good health conditions[1],while gemcitabine,as monotherapy,in patients with poor health conditions[2–4].Gemcitabine resistance-associated pathways have been targeted to sensitize cancer cells,but the results were *** a transcrip-tomic bioinformatics analysis combined with biological validation,we showed that glucuronidation was associ-ated with the gemcitabine resistance in PDAC,and its inhibition could switch tumors from resistant to sensitive.

关键词： gemcitabine cancer chemotherapy