检索结果-南通市图书馆

Opposing regulatory functions of the TIM3 (HAVCR2) signalosome in primary effector T cells as revealed by quantitative interactomics

引用

Cellular & Molecular Immunology 2021年第6期18卷 1581-1583页

作者： Yunhao Zhai Javier Celis-Gutierrez Guillaume Voisinne Daiki Mori Laura Girard odile burlet-schiltz Anne Gonzalez de Peredo Romain Roncagalli Bernard Malissen Centre d’Immunologie de Marseille-Luminy Aix Marseille UniversitéINSERMCNRS13288MarseilleFrance Centre d’Immunophénomique Aix Marseille UniversitéINSERMCNRSMarseilleFrance Institut de Pharmacologie et de Biologie Structurale Département Biologie Structurale BiophysiqueProtéomique Génopole Toulouse Midi Pyrénées CNRS UMR 5089ToulouseFrance

Deciphering how T-cell antigen receptor signals are modulated by coinhibitors is a fundamental goal in immunology and of considerable clinical interest because blocking coinhibitory signals via therapeutic antibodies have become a standard cancer immunotherapeutic *** of the attention devoted to T-cell immunoglobulin and mucin domain-3(TIM3;also known as HAVCR2 or CD366)molecules stems from their expression on exhausted T cells in settings of chronic viral infection and ***,T cells expressing high levels of both PD-1 and TIM3 coinhibitors appear more dysfunctional than those expressing PD-1 *** therapies intending to block both PD-1 and TIM3 are thus actively being explored in the cancer treatment *** interaction with Galectin-9(GAL-9)and carcinoembryonic antigen-related cell adhesion molecule 1(CEACAM-1),the tyrosines found in the TIM3 cytoplasmic tail are phosphorylated.1 Because these conserved tyrosines do not form a recognizable inhibitory signaling motif,the mechanism by which TIM3 transmits inhibitory signals has not been ***,TIM3 also has costimulatory activity in T cells.2,3 Published biochemical studies attempting to unveil the mode of action of TIM3 have relied on approaches addressing one candidate effector at a time with limited quantitative insight,and most used transformed *** mice expressing an affinity Twin-Strep-tag(OST)at the TIM3-protein C-terminus(TIM3OST mice)(Figs.1a and S1a)and affinity purification coupled with mass spectrometry(AP-MS),we herein defined the composition and dynamics of the signaling protein complex(signalosome)used by TIM3 in primary effector T *** results provide a more complete model of TIM3 signaling and explain its paradoxical coinhibitory and costimulatory functions.

关键词： TIM3 expressing devoted

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quantitative interactomic of CD40 in primary B cells

引用

hLife 2024年第2期2卷 88-93页

作者： Jeremy Argenty Emilie Maturin Mylene Camus Valentin Mellado Jeanne Perroteau Benoit Pasquier Guillaume Voisinne odile burlet-schiltz Lih-Ling Lin Anne Gonzalez de Peredo Romain Roncagalli Bernard Malissen Centre d’Immunologie de Marseille-Luminy Aix Marseille UniversitéINSERMCNRSMarseilleFrance Centre d’Immunophénomique Aix Marseille UniversitéINSERMCNRS UMRMarseilleFrance Institut de Pharmacologie et de Biologie Structurale Département Biologie Structurale BiophysiqueProtéomique Génopole Toulouse Midi Pyrénées CNRS UMR 5089205 Route de NarbonneToulouse CedexFrance Checkpoint Immunology Immunology and Inflammation Therapeutic AreaSanofiVitryFrance Checkpoint Immunology Immunology and Inflammation Therapeutic AreaSanofiCambridgeUSA

INTRODUCTION Over the past few decades,antibody-based therapies have emerged as an additional tool to treat patients developing cancer and auto-immune *** natural properties of the developed antibodies may lead to agonist or blocking functions for the targeted ***,antibodies developed for clinical trials are extensively analyzed in vitro and in vivo for safety and efficacy,yet they are not routinely evaluated for their potential signaling effectiveness.

关键词： routine antibodies clinical

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Land use in semi-free ranging Tonkean macaques Macaca tonkeana depends on environmental conditions： A geographical information system approach

引用

Current Zoology 2011年第1期57卷 8-17页

作者： Cedric SUEUR Paul SALZE Christiane WEBER odile PETIT Department of Ecology and Evolutionary Biology Princeton University 08544 Princeton USA Ethologie des Primates Departement d'Ecologie Physiologie et Ethologie UMR 7178 CNRS-UdS 23 rue Becquerel 67087 Strasbourg France Laboratoire Image et Ville ERL 7230 CNRS-UdS 3 rue de l'Argonne 67000 Strasbourg France

Wild animals use their habitat according to ecological pressures such as predation, resource availability or tempera- ture, yet little is known about how individuals use their environment in semi free-ranging conditions. We assessed whether a semi-free ranging group of Tonkean macaques Macaca tonkeana used its wooded parkland in a heterogeneous way. GIS and GPS were used to determine whether individuals adjusted their behaviors according to variation in environmental constraints over time of day and the course of a year. We demonstrated that social and resting activities occurred in high altitude areas and areas with a high density of bushes, whereas the group foraged in areas where the density of bushes and grass was low. In general, the animals used areas exposed to the sun that were not on a slope. Semi-free ranging Tonkean macaques seemed to behave like their wild counterparts in terms of activity budget, land use per activity and thermoregulation

关键词： GPS GIS Temperature Topography Activity budget Spatial autocorrelation Primates

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatitis B and human immunodeficiency virus co-infection

引用

World Journal of Gastroenterology 2014年第46期20卷 17360-17367页

作者： Bao-Chau Phung Philippe Sogni odile Launay Université Paris Descartes Sorbonne Paris Cité75006 ParisFrance Assistance Publique-H?pitaux de Paris H?pital CochinCIC Cochin Pasteur75014 ParisFrance Inserm CIC141775014 ParisFrance APHP H?pital CochinService d’hépatologie75014 ParisFrance

Hepatitis B and human immunodeficiency virus(HBV and HIV)infection share transmission patterns and risk factors,which explains high prevalence of chronic HBV infection in HIV infected *** natural course of HBV disease is altered by the HIV infection with less chance to clear acute HBV infection,faster progression to cirrhosis and higher risk of liver-related death in HIVHBV co-infected patients than in HBV mono-infected *** infected patients with chronic hepatitis B should be counseled for liver damage and surveillance of chronic hepatitis B should be performed to screen early hepatocellular *** tools are now available to evaluate liver *** hepatitis B core antibodies(anti-HBc)are a good predictive marker of occult HBV *** the prevalence and significance of occult HBV infection is controversial,but its screening may be important in the management of antiretroviral *** against HBV infection is recommended in non-immune HIV *** optimal treatment for almost all HIV-HBV co-infectedpatients should contain tenofovir plus lamivudine or emtricitabine and treatment should not be stopped to avoid HBV *** term tenofovir therapy may lead to significant decline in hepatitis B surface *** emergence of resistant HBV strains may compromise the HBV therapy and vaccine therapy.

关键词： Chronic hepatitis B Human immunodeficiency virus Management Occult hepatitis Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

引用

World Journal of Gastroenterology 2016年第2期22卷 490-500页

作者： Hussein Akil Aurélie Perraud Marie-odile Jauberteau Muriel Mathonnet Laboratoire Homéostasie Cellulaire et Pathologies(LHCP-EA3842) Facultéde Médecine et de PharmacieFédération de Recherche GEIST87025 LimogesFrance Service de Chirurgie Digestive Générale et EndocrinienneCHU de Limoges87042 LimogesFrance Service d’Immunologie CHU de Limoges87042 LimogesFrance

Colorectal cancer(CRC) is the second most common cause of cancer-related death in western countries. Approximately one-quarter of newly diagnosed patients for CRC have metastases, and a further 40%-50% experience disease recurrence or develop metastases after all standard therapies. Therefore, understanding the molecular mechanisms involved in the progression of CRC and subsequently developing novel therapeutic targets is crucial to improve management of CRC and patients' long-term survival. Several tyrosine kinase receptors have been implicated in CRC development, progression and metastasis, including epidermal growth factor receptor(EGFR) and vascular EGFR. Recently, tropomyosin-related kinase B(Trk B), a tyrosine kinase receptor, has been reported in CRC and found to clearly exert several biological and clinical features, such as tumor cell growth and survival in vitro and in vivo, metastasis formation and poor prognosis. Here we review the significance of Trk B and its ligand brain derived-neurotrophic factor in CRC. We focus on their expression in CRC tumor samples, and their functional roles in CRC cell lines and in in vivo models. Finally we discuss therapeutic approaches that can lead to the development of novel therapeutic agents for treating Trk B-expressing CRC tumors.

关键词： Colorectal cancer Tyrosine kinase receptor B Brain-derived neurotrophic factor Therapeutic targets Cell survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Use of a new retrograde filling material(Biodentine) for endodontic surgery: two case reports

引用

International Journal of Oral Science 2014年第4期6卷 250-253页

作者： Grégory Caron Jean Azérad Marie-odile Faure Pierre Machtou Yves Boucher Private practice Dental School Paris Diderot University Dental Service Pitié Salpêtrière Hospital Septodont Saint-Maur-des-Fosses

Mineral trioxide aggregate（MTA） is considered at the present time as the gold standard for root-end filling in endodontic ***, this biocompatible material presents several drawbacks such as a long setting time and handling difficulties. The aim of this article is to present a new commercialized calcium silicate-based material named Biodentine with physical improved properties compared to MTA in a clinical application. Two endodontic microsurgeries were performed by using specific armamentarium（microsurgical instrumentation, ultrasonic tips） under high-power magnification with an operatory microscope. Biodentine was used as a root-end filling in order to seal the root canal system. The two cases were considered completely healed at 1 year and were followed for one more year. The 2-year follow-up consolidated the previous observation with absence of clinical symptoms and radiographic evidence of regeneration of the periapical tissues.

关键词： Biodentin endodontics healing periapical surgery retrograde filling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Combinations of chronic conditions,functional limitations and geriatric syndromes associated with periodontal disease

引用

Family Medicine and Community Health 2022年第3期10卷 20-26页

作者： Hussam M Alqahtani Siran M Koroukian Kurt Stange Nabil F Bissada Nicholas K schiltz Department of Population and Quantitative Health Sciences Case Western Reserve University School of MedicineClevelandOhioUSA Department of Preventive Dental Science King Saud bin Abdulaziz University for Health SciencesRiyadhSaudi Arabia Center for Community Health Integration Case Comprehensive Cancer CenterClevelandOhioUSA Department of Periodontics Case Western Reserve University School of Dental MedicineClevelandOhioUSA

Objective To identify complex multimorbid conditions,including chronic conditions,functional limitations and geriatric syndromes,associated with the presence and severity of periodontal disease(PD),after accounting for a series of demographic and behavioural *** This cross-sectional study used secondary data from a nationally representative sample,classification and regression tree analysis and random forest identified combinations of specific conditions constituting complex multimorbidity associated with the presence and severity of *** US National Health and Nutritional Examination Survey(2013-2014).Participants Individuals 60 years of age or older who completed a periodontal *** Among 937 participants aged 60 and over,the prevalence of PD was 72.6%.PD was associated with sociodemographic factors and limitations in instrumental activities of daily *** sex and non-white race were the two most critical predictors of stage III/IV *** important factors included age,education level and the federal poverty *** Rather than chronic conditions or geriatric syndromes,PD was associated with sociodemographic factors and functional *** for the co-occurrence of sociodemographic and functional limitations will help recognise older adults who are at an increased vulnerability to the severity of PD.

关键词： periodontal limitations functional

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Overlap syndrome consisting of PSC-AIH with concomitant presence of a membranous glomerulonephritis and ulcerative colitis

引用

World Journal of Gastroenterology 2014年第16期20卷 4811-4816页

作者： odile Warling Christophe Bovy Carla Combra Timothée Noterdaeme Jean Delwaide Edouard Louis Department of Internal Medicine CHU de LiègeUniversity of Liège4000 LiegeBelgium Department of Internal Medicine NephrologyCHU de LiègeUniversity of Liège4000 LiegeBelgium Department of Abdominal Surgery and Transplantation CHU de LiègeUniversity of Liège4000 LiegeBelgium Department of Cardiovascular Surgery German Heart Center80636 MunichGermany Department of Internal Medicine GastroenterologyCHU de LiègeUniversity of Liège4000 LiegeBelgium

The association of primary sclerosing cholangitis(PSC)and autoimmune hepatitis(AIH)is known as an overlap syndrome(OS).OS can also be described in the setting of concomitant presence of AIH and *** diseases can in some cases be associated with ulcerative *** this case report we describe,to our knowledge,the first case in the literature of a young Caucasian male suffering from ulcerative colitis and an overlap syndrome consisting of an association betweenPSC-AIH,with the concomitant presence of a membranous glomerulonephritis.

关键词： Primary sclerosing cholangitis Autoimmune hepatitis Overlap syndrome Ulcerative colitis Membranous glomerulonephritis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biological mesh reconstruction of the pelvic floor following abdominoperineal excision for cancer:A review

引用

World Journal of Clinical Oncology 2017年第3期8卷 249-254页

作者： Boris schiltz Nicolas Christian Buchs Marta Penna Cosimo Riccardo Scarpa Emilie Liot Philippe Morel Frederic Ris Division of Visceral Surgery Department of SurgeryUniversity Hospitals of Geneva Department of Colorectal Surgery Churchill HospitalOxford University Hospitals

Extralevator abdominoperineal excision and pelvic exenteration are mutilating operations that leave wide perineal *** large wounds are prone to infection and perineal herniation,and their closure is a major concern to most *** approaches to the perineal repair exist,varying from primary or mesh closure to myocutaneous *** technique has its own associated advantages and potential complications and the ideal approach is still *** the present study,we reviewed the current literature and our own local data regarding the use of biological mesh for perineal wound *** evidence suggests that the use of biological mesh carries an acceptable risk of wound complications compared to primary closure and is similar to flap *** addition,the rate of perineal hernia is lower in early follow-up,while long-term hernia occurrence appears to be similar between the different ***,it is an easy and quick reconstruction *** more expensive than primary closure,the cost associated with the use of a biological mesh is at least equal,if not less,than flap reconstruction.

关键词： Biological mesh Rectal cancer Pelvic exenteration Abdominoperineal resection Primary perineal wound closure Perineal wound infection Perineal hernia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hallmarks in colorectal cancer:Angiogenesis and cancer stem-like cells

引用

World Journal of Gastroenterology 2014年第15期20卷 4189-4196页

作者： Muriel Mathonnet Aurelie Perraud Niki Christou Hussein Akil Carole Melin Serge Battu Marie-odile Jauberteau Yves Denizot Department of Digestive Surgery Limoges University Hospital87042 LimogesFrance Homéostasie Cellulaire at Pathologies Faculty of MedicineUniversity of Limoges87025 LimogesFrance Institut 145 GEIST UMR CNRS 7276Faculty of MedicineUniversity of Limoges87025 LimogesFrance

Carcinogenesis is a multistep process that requires the accumulation of various genetic and epigenetic aberrations to drive the progressive malignant transformation of normal human *** major hallmarks of carcinogenesis that have been described are angiogenesis and the stem cell characteristic of limitless replicative *** properties have been targeted over the past decade in the development of therapeutic treatments for colorectal cancer(CRC),one of the most commonly diagnosed and lethal cancers *** treatment of solid tumor cancers such as CRC has been challenging due to the heterogeneity of the tumor itself and the chemoresistance of the malignant ***,the same microenvironment that maintains the pool of intestinal stem cells that contribute to the continuous renewal of the intestinal epithelia also provides the necessary conditions for proliferative growth of cancer stem-like *** cancer stem-like cells are responsible for the resistance to therapy and cancer recurrence,though they represent less than 2.5%of the tumor *** stromal environment surrounding the tumor cells,referred to as the tumor niche,also supports angiogenesis,which supplies the oxygen and nutrients needed for tumor ***-angiogenic therapy,such as with bevacizumab,a monoclonal antibody against vascular-endothelial growth factor,significantly prolongs the survival of metastatic CRC ***,such treatments are not completely curative,and a large proportion of patient tumors retain chemoresistance or show *** article reviews the current knowledge regarding the molecular phenotype of CRC cancer cells,as well as discusses the mechanisms contributing to their *** personalized therapeutic approaches that are based on the interaction of the carcinogenic hallmarks,namely angiogenic and proliferative attributes,could improve survival and decrease adverse effects induced by unnecessary chemotherapy.

关键词： Colon cancer Stem cell Cancer stem-like cell Tumor-initiating cell Microenvironment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：