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Glycine supplementation reduces the severity of chemotherapy-induced oral mucositis in hamsters

Natural science 2013年第9期5卷 972-978页

作者： odara maria de sousa sá Nilza Nelly Fontana Lopes maria Teresa seixas Alves Rajesh V.Lalla maria Luiza Vilela Oliva Eliana maria Monteiro Caran department of Pediatrics Federal University of Sao PauloSao PauloBrazil Former Head Division of dentistry Pediatric Oncology InstituteSao PauloBrazil department of Pathology Federal University of Sao PauloSao PauloBrazil section of Oral Medicine University of Connecticut Health CenterFarmingtonUSA department of Biochemistry Federal University of Sao PauloSao PauloBrazil department of Pediatrics IOP/GRAACC Medical School of Federal University of Sao PauloSao PauloBrazil

Objective: Oral mucositis (OM) is a devastating toxicity associated with cytotoxic cancer therapy. The OM pathogenesis and the complex interactions occur in response to tissue insult. Application of this evolving model has aided in the development of mechanistically based therapies for the prevention and treatment of mucositis. The present study was to assess the effects of glycine supplementation on chemotherapy-induced oral mucositis. Methods: In a hamster cheek pouch model of chemotherapy-induced oral mucositis, one group of 20 animals received systemic glycine supplementation for 7 days, while another similar control group did not. Clinical mucositis severity and neutrophil infiltrate (on histology) were assessed by blinded examiners. Free radical production was measured as malondialdehyde (MDA) levels. Results: As compared to control animals, glycine-treated animals demonstrated a highly significant reduction in clinical severity of oral mucositis, neutrophil infiltrate, and MDA levels (p sions: Glycine supplementation reduces the severity of chemotherapy-induced oral mucositis in an animal model. This effect is at least partly mediated through inhibition of the inflammatory response and reduced production of damaging free radicals.

关键词： Glycine Chemotherapy Oral Mucositis Neutrophils Malondialdehyde Inflammatory

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