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Diagnostic delay in oral squamous cell carcinoma: the role of cognitive and psychological variables

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International Journal of Oral Science 2014年第1期6卷 39-45页

作者： vera Panzarella Giuseppe Pizzo Francesco Calvino Domenico Compilato Giuseppe Colella Giuseppina Campisi Department of Surgical Oncological and Oral Sciences University of Palermo Department of Head/Neck Surgery Oral Cavity and Audio/Verbal Communication Second University of Naples

This retrospective study investigated, in two cohorts of subjects living in Southern Italy and awaiting treatment for oral squamous cell carcinoma （OSCC）, the variables related to diagnostic delay ascribable to the patient, with particular reference to the cognitive and psychological ones. A total of 156 patients with OSCC （mean age： 62 years, M/F： 2.39 ： 1） were recruited at the Universities of Palermo and Naples. Risk factors related to patient delay included： sociodemographic, health-related, cognitive and psychological variables. The analysis was conducted by considering two different delay ranges： dichotomous （≤1 month vs. 〉 1 month） and polytomous （〈1 month, 1-3 months, 〉3 months） delay. Data were investigated by univariate and multivariate analyses and a Pvalue≤0.05 was considered statistically significant. For both delay measurements, the most relevant variables were：＇Personal experience of cancer＇（dichotomous delay： P=0.05, odds ratio （0R）=0.33, 95% confidence interval （CI）=0. 11-0.99; polytomous delay： P=0.006, Chi-square= 10.224） and ＇Unawareness＇（dichotomous delay： P〈0.01, 0R=4.96, 95% CI--2.16-11.37; polytomous delay： P=0.087, Chi-square=4.77）. Also ＇Denial＇（P〈0.01, 0R=6.84, 95% CI=2.31-20.24） and ＇Knowledge of cancer＇（P=0.079, Chi-square=8.359） were found to be statistically significant both for dichotomous and for polytomous categorization of delay, respectively. The findings of this study indicated that, in the investigated cohorts, the knowledge about cancer issues is strongly linked to the patient delay. Educational interventions on the Mediterranean population are necessary in order to increase the patient awareness and to emphasize his/her key role in early diagnosis of OSCC.

关键词： cognitive/psychological factors diagnosis oral squamous cell carcinoma patient delay

Visible-light-induced synthesis of phosphorylated N-heterocycles through proton-coupled electron transfer

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Science China Chemistry 2021年第5期64卷 681-683页

作者： vera A.Vil’ Igor B.Krylov Alexander O.Terent’ev N.D.Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences Moscow 119991Russia

Phosphorus-containing organic compounds are important feedstock for the synthesis of value-added bioactive ***,the development of highly efficient synthetic methods for the construction of phosphorus-element bonds has drawn huge attention in the past decades[1].Particularly,the formation of P–C bonds from phosphoruscentered radicals has been demonstrated to be one of the most efficient and convenient strategies,which has been widely applied for the synthesis of organic phosphorus compounds in recent years.

关键词： synthesis bonds phosphorus

A Damage Scenario for the 2012 Northern Italy Earthquakes and Estimation of the Economic Losses to Residential Buildings

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International Journal of Disaster Risk Science 2017年第3期8卷 326-341页

作者： Fabrizio Meroni Thea Squarcina vera Pessina Mario Locati Marco Modica Roberto Zoboli Istituto Nazionale di Geofisica e Vulcanologia(INGV) Sezione di MilanoVia Bassini 15MilanItaly Istituto di Ricerca sulla Crescita Economica Sostenibile(IRCrES) Via Corti1220131 MilanItaly

In May 2012 a seismic sequence occurred in Northern Italy that was characterized by two main shocks with a magnitude range between 5.5 and 6. These shocks represent a good case study by which to quantify the monetary losses caused by a moderate earthquake in a densely populated and economically well-developed *** loss estimation accounts for damage to residential buildings, and considers the full effect of all the seismic aftershock events that lasted for nearly a month. The building damage estimation is based on the European Macroseismic Scale(EMS-98) definitions, which depict the effects of an earthquake on built-up areas in terms of observed intensities. Input data sources are the residential building census provided by Istituto Nazionale di Statistica—the Italian National Institute of Statistics(ISTAT)—and the official market value of real estate assets, obtained from the Osservatorio del Mercato Immobiliare—the Real Estate Market Observatory(OMI). These data make it possible to quantify the economic losses due to earthquakes, an economic indicator updated yearly. The proposed multidisciplinary method takes advantage of seismic,engineering, and economic data sets, and is able to provide a reasonable after the event losses scenario. Data are not gathered for each single building and the intensity values are not a simple hazard indicator, but, notwithstanding its coarseness, this method ensures both robust and reproducible results. As the local property value is availablethroughout the Italian territory, the present loss assessment can be effortlessly repeated for any area, and may be quickly reproduced in case of future events, or used for predictive economic estimations.

关键词： Earthquake damage Economic losses EMS-98 intensity Northern Italy 20 May 2012 earthquake

An Inactivated Vaccine from a Field Strain of Bovine Herpesvirus-1(BoHV-1) has High Antigenic Mass and Induces Strong Efficacy in a Rabbit Model

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Virologica Sinica 2013年第1期28卷 36-42页

作者： Julian Ruiz-Sáenz Jairo Jaime Victor vera Microbiology and Epidemiology Group Faculty of Veterinary Medicine and Animal Science National University of Colombia Grupo de Investigación CENTAURO Agrarian Sciences Faculty Universidad de Antioquia A.A. 1226

Bovine Herpesvirus-1 （BoHV-1） is a DNA virus belonging to the family Herpesviridae, subfamily Alfaherpesvirinae; it is a worldwide pathogen, causing serious economic losses in livestock. In Colombia there have been multiple isolates of BoHV-1 that have been subjected to molecular characterization, classifying most of the country isolates as BoHV-I.1. In the present study we developed and evaluated an ethyleneimine binary inactivated isolate from the native BoHV-1 strain （C6rdoba-2） in a rabbit model of vaccination and infection. The vaccine was evaluated in two phases, one of immunogenicity with vaccination and a booster after 21 days, and an evaluation phase of protection against challenge with a highly virulent reference strain. The results demonstrate optimum serum-conversion, with protective neutralizing antibody titers 28 days post vaccination and optimal protection against challenge with the reference strain with decreased clinical signs of infection, protection against the onset of fever and decrease of virus excretion post challenge. In conclusion, our results show the enormous potential that an immunogenic inactivated vaccine has produced from the native BoHV-I.1 strain, which produces a high antigen mass to the vaccine to induce optimal immunity and protection, and it is a strong candidate for evaluation and possible future use in different cattle populations.

关键词： Antigenic Mass Adjuvant Binary Ethyleneimine Bovine Herpesvirus-1 Vaccine

An ETD Method for American Options under the Heston Model

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Computer Modeling in Engineering & Sciences 2020年第8期124卷 493-508页

作者： Rafael Company vera N.Egorova Lucas Jódar Ferran Fuster Valls Instituto de Matemática Multidisciplinar Universitat Politècnica de ValènciaValencia46022Spain Depto.de Matemática Aplicada y Ciencias de la Computación Universidad de CantabriaSantander39005Spain Nfoque Advisory Services Madrid28001Spain

A numerical method for American options pricing on assets under the Heston stochastic volatility model is developed.A preliminary transformation is applied to remove the mixed derivative term avoiding known numerical drawbacks and reducing computational *** boundary is treated by the penalty *** nonlinear partial differential equation is solved numerically by using the method of *** full discretization the exponential time differencing method is *** analysis establishes the stability and positivity of the proposed *** numerical convergence behaviour and effectiveness are investigated in extensive numerical experiments.

关键词： Heston model American option pricing exponential time differencing semi-discretization

Methods for the use of the best Russian innovations in forest fire detection and suppression

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Journal of Forestry Research 2021年第6期32卷 2255-2263页

作者： Alexander A.Martynyuk vera A.Savchenkova Nikolay A.Korshunov Roman V.Kotelnikov All-Russian Research Institute of Silviculture and Mechanization of Forestry(ARRISMF) Institutskaya str.15PushkinoMoscow regionRussia141202

This paper addresses the final stage of the study concerning the practical use of the best Russian methods,technologies and means for detecting and extinguishing forest fires in *** general,the work is aimed at increasing the effectiveness of the forest fire protection system by improving the methodological and technical support for the use of the best new *** the course of the study,analytical methods have been applied,tested and used in silviculture,while developing and improving the regulatory legal and methodological *** on the selection of research directions in the preliminary stages of work,analysis of the current state,use,and the development forecast of the most effective and promising technologies was carried *** addition,for detecting,controlling and extinguishing forest fires,including a comparative analysis of their economic efficiency,methods for practical use of the best Russian innovations was developed.A significant number of new developments have accumulated which,for a number of reasons,have not been *** into account the current state and dynamics of these promising methods,technologies,means of detecting and extinguishing forest fires,this study substantiates the development forecast of these promising innovations and their *** structure includes general provisions,concepts and terminology,regulatory support,the procedure for assessing the feasibility and effectiveness of the innovations,as well as a list of recommended documents for studying the use of technology for detecting,controlling and extinguishing forest *** methods will help meet modern requirements for the protection of forests from wildfires,and present an algorithm for their implementation in practice.

关键词： Forest protection Fire suppression Wildfire Efficacy

Liquid biopsy approach to pancreatic cancer

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World Journal of Gastrointestinal Oncology 2021年第10期13卷 1263-1287页

作者： Sonia Perales Carolina Torres Cristina Jimenez-Luna Jose Prados Joaquina Martinez-Galan Jose Manuel Sanchez-Manas octavio Caba Department of Biochemistry and Molecular Biology I Faculty of SciencesUniversity of GranadaGranada 18071Spain Department of Biochemistry and Molecular Biology III and Immunology Faculty of SciencesUniversity of GranadaGranada 18071Spain Institute of Biopathology and Regenerative Medicine(IBIMER) Center of Biomedical Research(CIBM)University of GranadaGranada 18100Spain Department of Medical Oncology Hospital Universitario Virgen de las NievesGranada 18011Spain School for International Postgraduate Studies University of GranadaGranada 18071Spain

Pancreatic cancer(PC)continues to pose a major clinical *** has been little improvement in patient survival over the past few decades,and it is projected to become the second leading cause of cancer mortality by *** dismal 5-year survival rate of less than 10%after the diagnosis is attributable to the lack of early symptoms,the absence of specific biomarkers for an early diagnosis,and the inadequacy of available *** patients are diagnosed when the disease has already metastasized and cannot be *** interception is vital,actively intervening in the malignization process before the development of a full-blown advanced *** early diagnosis of PC has a dramatic impact on the survival of patients,and improved techniques are urgently needed to detect and evaluate this disease at an early *** is difficult to obtain tissue biopsies from the pancreas due to its anatomical position;however,liquid biopsies are readily available and can provide useful information for the diagnosis,prognosis,stratification,and follow-up of patients with PC and for the design of individually tailored *** aim of this review was to provide an update of the latest advances in knowledge on the application of carbohydrates,proteins,cell-free nucleic acids,circulating tumor cells,metabo-lome compounds,exosomes,and platelets in blood as potential biomarkers for PC,focusing on their clinical relevance and potential for improving patient outcomes.

关键词： Pancreatic cancer Biomarkers Liquid biopsy Clinical management Cancer interception Cancer monitoring

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Elements of surprise

Elements of surprise

Molecular and in vitro Characterization of Field Isolates of Bovine Herpesvirus-1

作者： vera Tobin.

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Virologica Sinica 2012年第1期27卷 26-37页

作者： Julian Ruiz-Saenz Jairo Jaime Gloria Ramirez Victor vera Faculty of Veterinary Medicine and Animal Science National University of Colombia

Bovine Herpesvirus-1 (BoHV-1) is distributed worldwide and is a major pathogen in cattle, being the causal agent of a variety of clinical syndromes. The aim of this study was to isolate and to characterize (molecular and biological characterization) BoHV-1 from 29 immunosuppressed animals. It was possible to obtain 18 isolates, each from a different animal, such as from the respiratory and reproductive tracts. In some cases the cytopathic effect was visible 12 hours post-inoculation, and became characteristic after 36-48 hours. Biological characteristics were evaluated and compared with Iowa and Colorado-1 reference strains, and differences were found in plaque size, virus titer measured by TCID50 and PFU/mL, and one step virus curves. These results showed that some isolates had a highly virulent-like behavior in vitro, compared to the reference strains, with shorter eclipse periods, faster release of virus into the supernatants, and higher burst size and viral titer. There were no differences in glycoprotein expression of BoHV-1 isolates, measured by Western blot on monolayers. Moreover, using restriction endonucleases analysis, most of the viruses were confirmed as BoHV-1.1 and just one of them was confirmed as BoHV-1.2a subtype. These findings suggest that some wild-type BoHV-1 isolates could be useful as seeds to develop new monovalent vaccines.

关键词： Bovine herpesvirus 1 Genital infection Respiratory infection Latent infection