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Chinese Science Bulletin 1997年第12期42卷 1030-1033页

作者： Liu, YX Hu, ZY Zou, RJ ockleford, cd State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing China Primate Research Center Kunming Institute of Zdogy Chinese Academy of Sciences Kunming China Department of Pre-clinical Sciences University of Leicester Leicester UK

INCREASING evidence has demonstrated that the locally controlled proteolytic activity generatedby coordinated expression of tPA and PAI-1 in different tissues may play an important role inmany reproductive events. These are largely related to fibrinolytic activity. They include folli-cle rupture, luteolysis, spermatogenesis and trophoblast implantation. Parturition, whichis a complex process, may also be associated with tissue destruction. Detachment of placentaldecidua and partial breakdown of fetal membranes are possible examples. It has been

关键词： tissue plasminogen activator (tPA) plasminogen activator inhibitor type-1 (PAI-1) placental basal plate im-munofluorescence parturition.

Localization and the possible role of plasminogen activators and inhibitors in early stages of placentation

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Chinese Science Bulletin 2000年第22期45卷 2056-2062页

作者： ockleford Colin D Department of Pre-Clinical Sciences University of LeicesterLeicester LEI 9HNUK

The distribution of mRNAs of tissue type (t) and urokinase type (u) plasminogen activator (PA) plus their corresponding inhibitors, type-1 (PAI-1) and type-2 (PAI-2) have been studied in the tissues of human first and second trimester placentae by in situ hybridization. The results show that: (i) All the molecules, tPA, uPA, PAI-1 and PAI-2, were identified in the blood vessels, the majority of extravillous trophoblastic cells of the decidual layer between Rohr’s and Nitabuch’s stria and in the trophoblast cells lining the chorionic plate, basal plate, intercotyledonary septae and cytotrophoblast cells of the chorionic villous tree. (ii) No expression of such probes was observed in the basal and chorionic plate, glandular cells of the decidua, the septal tissues or the villous core mesenchyme. The co-distribution of the molecules observed suggests that the co-ordinated expression of the activators and inhibitors in various cells of the placental tissue may play a role in angiogenesis related to

关键词： plasminogen activator plasminogen activator inhibitor placentation angiogenesis in situ hybridization.

Localization and possible role of membrane type metallo-proteinase and tissue inhibitors of metalloproteinase-1 in early stages of placentation

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Chinese Science Bulletin 2000年第16期45卷 1484-1489页

作者： ockleford Colin D. Department of Pre-Clinical Sciences University of LeicesterLeicester LEI 7RHUK

Human placental tissues from the first and second trimesters of gestation have been investigated using riboprobe in situ hybridisation of mRNA sequences coding for membrane type metalloproteinase (MT-1-MMP) and tissue inhibitors of metalloproteinase-1 (TIMP-1). Results show that (i) both mRNAs express at a relatively high level in the chorion laeve trophoblast cells and the adjacent decidual cells of fetal membrane; (ii) the most abundant expression of the two mRNAs was found in the extravillous trophoblast between Rohrs and Nitabuch striae of basal plate, trophoblast shell and gland cells of the decidua; (iii) isolated or small groups of cytotrophoblast cells in the chorionic villi and in the cells lining arterioles in decidua and stem villi also expressed both MT-1-MMP and TIMP-1 at defferent extents. The data suggest that the coordinated expression of the MT-MMP and its inhibitor TIMP in defferent cells of the placental tissue may play an essential role in trophoblast invasion and angiogenesis

关键词： placenta trophoblast basal plate fetal membrane MT-l-MMP TIMP-1 in situ hybridization.

Microstructure Evolution of Cu-Pb Monotectic Alloys Processed in Drop Tube

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Journal of Materials Science & Technology 2002年第1期18卷 73-76页

作者： Cao, cd Wei, BB Northwestern Polytech Univ Dept Appl Phys Xian 710072 Peoples R China

Rapid solidification of Cu-Pb monotectic alloys has been accomplished during free fall in a 3 m drop tube. Both macrosegregated and uniformly dispersed structures are observed in Cu-40 wt pct Pb alloy droplets, whereas droplets of composition Cu-64 wt pct Pb exhibit only macrosegregation morphologies. The microstructures are strongly dependent on droplet size. The higher undercooling tends to facilitate liquid phase separation and results in more extensive macrosegregation in smaller droplets. There exists a pronounced tendency for the Pb-rich liquid to occupy the surface of the droplets of both compositions, resulting from the quite lower surface tension of the Pb-rich phase and causing a Pb-rich layer at the surface of the solidified droplet. The nucleation of monotectic cells in the Cu-40 wt pct Pb droplets with dispersed structures preferentially occurs at the droplet surface. A single nucleation event takes place more frequently as droplet size is reduced.

关键词： Rapid solidification Undercooling Immiscibility Containerless processing Low-gravity Monotectic

MICROWAVE IRRADIATED DRY WITTIG REACTION

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Chinese Chemical Letters 1995年第6期6卷 467-468页

作者： Xu, cd Chen, GY Huang, X Hangzhou Univ Dept Chem Hangzhou 310028 Peoples R China

The dry Wittig reaction of stable ylides with aldehydes were performed within several minutes under microwave irradiation. Remarkable rate enhancements and dramatic reductions of reaction times have been observed.

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Pharmacognostic standardization of stems of Thespesia lampas(Cav.)Dalz & Gibs

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Asian Pacific Journal of Tropical Biomedicine 2012年第5期2卷 357-363页

作者： Chumbhale DS Upasani cd Department of Pharmacognosy Amrutvahini College of Pharmacy SNJB'S Shriman Sureshdada Jain College of Pharmacy

Objective:To establish the standardization parameters for complete pharmacoguoslic evaluation of stems of Tlespesia lampas(***)(Cav.) Dalz & Gibs(Malvaceae),an important planl in the Indian system of ***:Morphological,microscopical,physico-chemical evaluations,florescence analysis of *** stems were investigated and preliminary phytochemical analysis,GO-MS analysis and HPTLC fingerprinting were carried out for qualitative phytochemical evaluation of various extracts of stems of ***:Chemomieroscopy revealed the presence of *** grains and calcium oxalate *** evaluation used to detennine numerical slandards showed a result with total ash(9.03± 0.05)%w/w,acid insoluble ash(1.50±0.01)%w/w,water soluble ash(2.51±0.02)%w/w,sulphated ash(7.50+0.01)%w/w,ethanol soluble extractive(0.24±0.02)%w/w,water soluble extractive(0.08 ±0.01)<7,w/w,moisture content(6.03±0.05)%w/w and total crude fibre content of stem powder(47.36±0.32)%w/*** characteristics of the stem powder showed presence of steroids, starch,alkaloid,flavonoids and *** phytochemical analysis revealed presence of glycosides,phenolic compounds,tannins,steroids,saponins,flavonoids,carbohydrates and ***-MS analysis showed the presence of fatty acids such as dodecanoic acid, lelraclecanoic acid,n-hexadecanoic acid,9-lelradecenal and HPTLC fingerprinting revealed the presence of β-sitosterol and quercetin in stems of ***:The pharmacognostic standardization of *** is useful towards establishing standards for quality, purity and sample identification.

关键词： Thespesia lampas Stems Pharmacognosy Malvaceae Physicochemical analysis Preliminary phytochemical testing GC-MS analysis Phelloderm Periderm Xylem

Seroepidemiology of Helicobacter pylori infection among asymptomatic Chinese children

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World Journal of Gastroenterology 2000年第5期6卷 759-761页

作者： Xu cd Chen SN Jiang SH Xu JY Shanghai Second Mil Med Univ Ruijin Hosp Dept Pediat Shanghai 200025 Peoples R China

INTRODUCTIONIncreasing data has demonstrated that Helicobacterpylori(***),a spiral gram negativebacterium,colonized in human stomach,can causetype B gastritis,is strongly associated withgastric and duodenal ulceration,and has beenimplicated in the causation of gastric carcinomaand mucosa-associated lymphoid tissue(MALT)*** has been reported that there

关键词： Helicobacter infection/infancy children Helicobacter pylori seroepidemiology gastritis stomach neoplasms gastric mucosa family

人和恒河猴胎盘基盘分泌tPA和PAI-1部位的鉴定

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科学通报 1997年第12期42卷 1324-1326页

作者：刘以训胡召元邹如金 C.D.ockleford 中国科学院动物研究所生殖生物学国家重点实验室北京100080 中国科学院昆明动物研究所灵长类研究中心昆明650107 DepartmentofPre-clinicalSciences SchoolofMedicineLeicesterUniversityUK.

tPA和PAI-1通过定向有限的蛋白水解对某些生殖过程,如卵泡破裂、黄体萎缩、精子发生和胚泡着床发挥重要作用.分娩涉及胎膜的有限破裂和母体子宫与蜕膜的分离.有报道指出,分娩前血中PAI-1和tPA水平达到高峰.胎膜的羊膜上皮细胞和绒毛膜... 详细信息

tPA和PAI-1通过定向有限的蛋白水解对某些生殖过程,如卵泡破裂、黄体萎缩、精子发生和胚泡着床发挥重要作用.分娩涉及胎膜的有限破裂和母体子宫与蜕膜的分离.有报道指出,分娩前血中PAI-1和tPA水平达到高峰.胎膜的羊膜上皮细胞和绒毛膜细胞能分泌tPA,而蜕膜层能表达PAI-1(另文报道).为进一步证实tPA和PAI-1协同表达是否在分娩机制中也起重要作用,本文以人分娩胎盘和妊娠150d临产前恒河猴的胎盘基盘为材料,用免疫荧光和激光共聚焦扫描显微镜比较研究了tPA和PAI-1在这些组织中的细胞定位.实验结果表明,tPA和PAI-1集中于恒河猴子宫肌蜕膜层与分离蜕膜交界层中.在子宫肌蜕膜组织以及肌层细胞中皆为阴性反应.在蜕膜组织血管周围有明显PAI-1的分布,证实了tPA和PAI-1在母体与胎儿分离机制中起重要作用.

关键词： tPA PAI-1 胎盘基盘分娩机制恒河猴人

纤溶酶原激活因子和抑制因子在早期胎盘中的表达及其功能

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科学通报 2000年第12期45卷 1297-1302页

作者：胡召元冯强高洪娟 C.D.ockleford 刘以训中国科学院动物研究所生殖生物学国家重点实验室北京100080 Department of Pre-Clinical Sciences.University of Leicester LeicesterLE19HNUK

用原位杂交方法研究了人早期胎盘中组织型（ｔ）和尿激酶型（ｕ）纤溶酶原激活因子（ＰＡ）与其相应的抑制因子１型（ＰＡＩ－１）和２型（ＰＡＩ－２）ｍＲＮＡ的分布。结果表明：（１）在绒毛和蜕膜的血管壁，Ｒｏｈｒｓ和Ｎｉｔｓｂ... 详细信息

用原位杂交方法研究了人早期胎盘中组织型（ｔ）和尿激酶型（ｕ）纤溶酶原激活因子（ＰＡ）与其相应的抑制因子１型（ＰＡＩ－１）和２型（ＰＡＩ－２）ｍＲＮＡ的分布。结果表明：（１）在绒毛和蜕膜的血管壁，Ｒｏｈｒｓ和Ｎｉｔｓｂｕｃｈｈ纹间的蜕膜中的大部分外细胞滋养层细胞沿绒毛盘、基底盘、绒毛叶间隔和绒毛膜的细胞滋养层细胞以及蜕膜的腺体细胞中都检测到ｔＰＡ，ｕＰＡ，ＰＡＩ－１和ＰＡＩ－２ｍＲＮＡ；（２）在基底绒毛盘和隔组织或绒毛核间充质中都没有这些分子的表达．纤溶酶原激活因子和抑制因子在胎盘组织不同细胞中的协同表达可能在胎盘早期阶段从螺旋动脉转化为子官胎盘动脉中的血管发生和绒毛－蜕膜血流系统的建立以及胎盘的形成过程中起重要作用．

关键词：纤溶酶原激活因子抑制因子早期胎盘表达

膜基质金属蛋白酶和金属蛋白酶抑制因子-1在早期胎盘中的表达及其功能的研究

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科学通报 2000年第6期45卷 607-611页

作者：刘以训胡召元冯强高洪娟刘奎 C. D. ockleford 中国科学院动物研究所生殖生物学国家重点实验室北京100080 Department of Pre-Clinical Sciences University of Leicester

用原位杂交方法研究了人早期胎盘中膜型金属蛋白酶（ＭＴ－ＭＭＰ－１）和金属蛋白酶抑制因子－１的分布．结果表明：（１）在绒毛滋养层细胞和与其邻近的蜕膜细胞中ＭＴ－ＭＭＰ－１和ＴＩＭＰ－１的表达量相对较高；（２）在基底盘，... 详细信息

用原位杂交方法研究了人早期胎盘中膜型金属蛋白酶（ＭＴ－ＭＭＰ－１）和金属蛋白酶抑制因子－１的分布．结果表明：（１）在绒毛滋养层细胞和与其邻近的蜕膜细胞中ＭＴ－ＭＭＰ－１和ＴＩＭＰ－１的表达量相对较高；（２）在基底盘，Ｒｏｈｒｓ和Ｎｉｔａｂｕｃｈ纹间的外绒毛膜滋养层细胞，滋养层和蜕膜的腺体细胞表达最高；（３）胎膜分离层和绒毛干的少量细胞滋养层细胞以及蜕膜和绒毛干的血管壁上有明显的ＭＴ－ＭＭＰ－１和ＴＩＭＰ－１的表达．结果提示，胎盘不同细胞ＭＴ－ＭＭＰ与其抑制因子ＴＩＭＰ－１的协同表达在早期胎盘滋养层浸入和血管发生中发挥重要作用；同时，两者可能对在临产时在母体与胎儿的分离机制中也起某种作用．

关键词：胎盘滋养层金属蛋白酶抑制因子-1 TIMP-1