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妇女毛滴虫病的治疗

生殖与避孕 2007年第3期27卷 224-225,228页

作者： Foma F Gülmezoglu am 单位不详

硝基咪唑类药物的短期治疗方案与长期治疗方案同样有效。在现有各种治疗毛滴虫的硝基咪唑类药物中，替哒唑的疗效优于甲硝唑。确诊毛滴虫感染妇女常常比治疗更难。

关键词：长期治疗方案毛滴虫病感染妇女硝基咪唑类药物甲硝唑

The Potency of Sargassum dupficatum Bory Extract on Inflammatory Bowel Disease Therapy in Rattus norvegicus

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Journal of Life Sciences 2012年第2期6卷 144-154页

作者： Aulanni,am Anna Roosdiana Nur Lailatul Rahmah Laboratory of Biochemistry Department of Chemistry Faculty of Sciences Brawijaya University Malang 65145 Indonesia Medical Veterinary School Brawijaya University Malang 65145 Indonesia Department of Agroindustrial Technology Faculty of Agriculture Technology Brawijaya University Malang 65145 Indonesia

Inflammatory Bowel Disease （IBD） was a chronic inflammatory disease of the digestive tract especially in small and large intestines that induced by indomethacin. Potency of ethanol and ethyl acetate extract from brown seaweed （Sargassum duplicatum Bory） against indomethacin induced jejunum damage was evaluated in Rattus norvegicus. Control rats induced by corn oil orally. IBD rats induced by indomethacin of 15 mg/kg body weight （bw） orally and incubated for 7 days. Therapy rats were treated orally by brown seaweed extract of 100 mg/kg bw respectively for seven days. Based on phytochemistry test, Sargassum duplicatum Bory extract contains flavonoids, phlorotanin, and alkaloid. The result of preparative Thin Layer Chromatography （TLC） and Infra Red （IR） spectrum of extract spots showed the same result （function group similarity） with gallic acid standard as polyphenol. Sargassum duplicatum Bory extract decreased Malondialdehid （MDA） level （54.20%） significantly using Thiobarbituric Acid （TBA） assay, repaired ZO-1 and occludin protein expressions by immunohistochemistry and repaired jejunum damage by histological observation.

关键词： Indomethacin IBD Sargassum duplicatum bory extract MDA ZO-I occludin histology of jejunum.

Associated factors for a hyperechogenic pancreas on endoscopic ultrasound

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World Journal of Gastroenterology 2010年第34期16卷 4329-4334页

作者： Cheol Woong Choi Gwang Ha Kim Dae Hwan Kang Hyung Wook Kim Dong Uk Kim Jeong Heo Geun am Song Do Youn Park Suk Kim Department of Internal Medicine Pusan National University School of Medicine and the Medical Research Institute Pusan National University Hospital Department of Internal Medicine Pusan National University School of Medicine and the Medical Research Institute Department of Pathology Pusan National University School of Medicine and the Medical Research Institute Department of Radiology Pusan National University School of Medicine and the Medical Research Institute

AIM: To identify the associated risk factors for hyperechogenic pancreas (HP) which may be observed on endoscopic ultrasound (EUS) and to assess the relationship between HP and obesity. METHODS: From January 2007 to December 2007, we prospectively enrolled 524 consecutive adults who were scheduled to undergo EUS. Patients with a history of pancreatic disease or with hepatobiliary or advanced gastrointestinal cancer were excluded. Finally,284 patients were included in the analyses. We further analyzed the risk of HP according to the categories of visceral adipose tissue (VAT) and subcutaneous adipose tissue in 132 patients who underwent abdominal computed tomography scans. RESULTS: On univariate analysis, age older than 60 years, obesity (body mass index > 25 kg/m 2 ), fatty liver, diabetes mellitus, hypertension and hypercholesterolemia were identified as risk factors associated with HP (P < 0.05). On multivariate analysis, fatty liver [P = 0.008, odds ratio (OR) = 2.219], male gender (P = 0.013, OR = 2.636), age older than 60 years (P = 0.001, OR = 2.874) and hypertension (P = 0.044, OR = 2.037) were significantly associated with HP. In the subgroup analysis, VAT was a statistically significant risk factor for HP (P = 0.010, OR = 5.665, lowest quartile vs highest quartile). CONCLUSION: HP observed on EUS was associated with fatty liver, male gender, age older than 60 years, hypertension and VAT.

关键词： Endoscopic Ultrasound Hyperechogenic pancreas Obesity

Current status and prospects of clinical proteomics studies on detection of colorectal cancer:Hopes and fears

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World Journal of Gastroenterology 2006年第41期12卷 6594-6601页

作者： ME de Noo RAEM Tollenaar am Deelder LH Bouwman Department of Surgery Leiden University Medical CenterLeidenThe Netherlands Biomolecular Mass Spectrometry Unit Department of ParasitologyLeiden University Medical CenterLeidenThe Netherlands

Colorectal adenocarcinoma （CRC） is the third most common type of cancer and the fourth most frequent cause of death due to cancer worldwide. Given the natural history of CRC, early diagnosis appears to be the most appropriate tool to reduce disease-related mortality. A field of recent interest is clinical proteomics, which was reported to lead to high sensitivity and specificities for early detection of several solid tumors. This emerging field uses mass spectrometry-based protein profiles/patterns of easy accessible body fluids to distinguish cancer from non-cancer patients. These discrepancies may be a result of：（i） proteins being abnormally produced or shed and added to the serum proteome, （2） proteins clipped or modified as a consequence of the disease process, or （3） proteins subtracted from the proteome owing to disease-related proteolytic degradation pathways. Therefore, protein pattern diagnostics would provide easy and reliable tools for detection of cancer. This paper focuses on the current status of clinical proteomics research in oncology and in colorectal cancer especially, and will reflect on pitfalls and fears in this relatively new area of clinical medicine, which are reproducibility issues and pre-analytical factors, statistical issues, and identification and nature of discriminating proteins/peptides.

关键词： Proteomics Colorectal cancer Protein profiling Diagnosis Biomarkers Statistical issues

Prednisolone inhibits SaOS2 osteosarcoma cell proliferation by activating inducible nitric oxide synthase

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World Journal of Translational Medicine 2016年第1期5卷 53-58页

作者： Alessandra Cazzaniga Jeanette am Maier Sara Castiglioni Dipartimento di Scienze Biomediche e Cliniche Luigi Sacco Università di Milano

AIM:To investigate the effect of prednisolone,a synthetic glucocorticoid used in inflammatory diseases,on the growth of cultured osteosarcoma ***:Two osteosarcoma cell lines with different degree of differentiation were ***2 show a rather mature phenotype,while U2 OS are negative for almost all osteoblastic *** cells were exposed to different concentrations of prednisolone(1-9 μmol/L) with or without antioxidants or the inhibitor of inducible nitric oxide synthase(i NOS) l-N6-(iminoethyl)-lysine-HCl(L-NIL).Cell growth was assessed by counting viable *** production of nitric oxide(NO) was measured in the conditioned media by the Griess *** production of reactive oxygen species was quantified using 2'-7'-dichlorofluorescein *** blot with specific antibodies against NOSs was performed on cell ***:Prednisolone inhibited SaOS2 cell growth in a dose dependent *** significant effects were observed in *** inhibition of SaOS2 growth is not due to oxidative stress,because antioxidants do not rescue cell *** high concentrations of NO inhibit bone formation,we also measured NO and found it induced in SaOS2,but not in U2 OS,exposed to prednisolone,because of the upregulation of i NOS as detected by western ***,we treated SaOS2 with prednisolone in the presence or in the absence of L-NIL.L-NIL prevented NO release induced by prednisolone at all the concentrations apart from 9 μmol/*** the same concentrations,we found that L-NIL rescued SaOS2 growth after exposure to *** U2 OS cells,prednisolone did not induce NO production nor affected cell *** together,these data indicate that a link exists between increased amounts of NO and growth inhibition in response to prednisolone in ***:Prednisolone inhibited SaOS2 proliferation by increasing the release of NO through the upregulation of i NOS,while no effect was exerted on U2OS.

关键词： Osteosarcoma cells Prednisolone Nitric oxide Inducible nitric oxide synthase Endothelial nitric oxide synthase Reactive oxygen species

Modified Triple P Approach by Gynecologic Oncologist-Led Team for Placenta Accreta Spectrum Improves the Outcome: Non-Randomized Controlled Trial

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Open Journal of Obstetrics and Gynecology 2019年第7期9卷 1039-1049页

作者： Mohammad am Ahmed Mostafa M. Khodry Gynecologic Oncology Unit South Valley University Qena Egypt Obstetrics and Gynecology Department South Valley University Qena Egypt

Introduction: Placenta Accreta Spectrum (PAS) is associated with significant maternal and fetal morbidity and mortality. The ideal conservative management still does not exist. We aimed to compare the outcome of cesarean section for PAS by a gynecologic oncologist-led team using the modified triple P approach and by a non-gynecologic oncologist-led team. Material and Methods: This is non-randomized controlled trial. Group A had Cesarean Section by gynecologic oncologist. Gynecologic oncologist-led team did all Cesarean Section following a modified triple P approach. The first P is for “Plan” the uterine incision. The second P for “Pelvic” devascularization by internal iliac artery ligation. The third P is for Placenta non-separation with resection of the myometrium. Group B had Cesarean Section by non-gynecologic oncologist-led team. The main outcome measures were the need for hysterectomy, amount of blood loss, and the management-related complications. Results: Group A had significantly less estimated blood loss, and received less number of backed RBCs units, and less operative time than group B. The uterus is preserved in all cases of group A and in 50% of cases of group B. The overall maternal morbidity rate was 17.5% in group A and 72.2% in group B. Conclusion: This study provides evidence that the modified triple P approach for PAS by gynecologic oncologist-led team presents lower maternal morbidity in comparison to surgery by non-gynecologic oncologist-led team.

关键词： Placenta Accreta Gynecologic Oncologist Surgery Outcome

Intrahepatic cholestasis without jaundice

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Hepatobiliary & Pancreatic Diseases International 2009年第1期8卷 103-105页

作者： Thomas Namdar Andreas Raffel Stefan Andreas Topp Jan Schulte am Esch Günther Fürst Wolfram Trudo Knoefel Claus Ferdinand Eisenberger Department of General Visceral and Pediatric Surgery Heinrich-Heine University Institute of Diagnostic Radiology Heinrich-Heine University

BACKGROUND:Cholangiocarcinoma(CC),the most common biliary tract malignancy,is frequently seen in advanced unresectable stages and is typically localized *** diagnosis is unusual because of nonspecific *** jaundice is usually the first sign of tumor. METHOD:We present a patient with a CC(Klatskin tumor) with a complete biliary drainage by an aberrant bile duct without jaundice. RESULTS:A 67-year-old woman presented with persisting elevation of liver *** tests showed a Klatskin tumor typeⅡ.A curative right hepatic trisegmentectomy was performed after liver volume augmentation by preoperative vein embolization. CONCLUSIONS:A direct drainage of the right posterior bile duct into the common bile duct as an aberrant hepatic duct is a rare variation and is present in less than 5%of the *** case of persistently perturbed liver function tests,an aberrant bile duct can cover up severe intrahepatic cholestasis and even obscure the diagnosis of a Klatskin *** to now it has not been described in the literature.

关键词： Klatskin tumor hyperbilirubinemia cholangiocarcinoma

A Generalized Non-Linear Flow Law Based on Modified Zerilli-Armstrong Model and Its Implementation into Abaqus/Explicit FEM Code

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World Journal of Engineering and Technology 2022年第2期10卷 334-362页

作者： Pierre Tize Mha amèvi Tongne Olivier Pantalé Production Engineering Laboratory INPT/ENIT Toulouse University Tarbes France

Non-linear numerical modeling, widely used in research and development to understand many complex processes such as forming or machining, does not guarantee the success of a study to be performed. Indeed, the numerical simulation uses finite element codes where the models already integrated are not based on shapes adjustable to any type of study. In this study, a new form of non-linear constitutive flow law based on the Modified Zerilli-Armstrong model, which can answer the above problem, has been developed to apply it to the numerical simulation of two different tests (a quasi-static compression test, the necking of a circular bar). This flow law is based on the modified Zerilli-Armstrong model, which, together with the new modified Johnson-Cook model, has been compared to appreciate the relevance of the proposal. For that, an implementation of this new law via the VUHARD subroutine into the Abaqus/Explicit finite element code was made to model the two tests. The comparison of the results obtained (from identification) by our proposed law with those obtained using the NMJC shows that this new law better approaches the experiments than the other one. This is also shown through the numerical results using the Abaqus software. It can be said that this way of formulating a flow law allows highlighting the great performance of the proposed approach. Although this law has been only used for quasi-static tests, we can say that it can also be used in dynamic tests.

关键词： Zerilli-Armstrong Flow Law Constitutive Behavior Finite Element Method Numerical Implementation Johnson-Cook Flow Law

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头孢呋新酯

国外医药（抗生素分册） 1989年第5期10卷 348-349页

作者： Emmerson am 陈汉源

头孢呋新(ce furoxi me)为注射用第二代头孢菌素。它体外抗菌活性很强,对肠道细菌产的β内酰胺酶稳定性高,且药代动力学特征良好。因为它在生理pH时高度离解,脂溶性差,基本上口服不吸收。头孢呋新酯(Cefuroxime axe(?)l)为头孢呋新前体... 详细信息

头孢呋新(ce furoxi me)为注射用第二代头孢菌素。它体外抗菌活性很强,对肠道细菌产的β内酰胺酶稳定性高,且药代动力学特征良好。因为它在生理pH时高度离解,脂溶性差,基本上口服不吸收。头孢呋新酯(Cefuroxime axe(?)l)为头孢呋新前体药,在头孢呋新C4位羧基上发生酯化,从而提高了亲脂性,增加口服后吸收率。头孢呋新酯吸收后仅3～4分钟内在肠粘膜和门循环中迅速水解,去酯分解为头孢呋新、乙醛和乙酸。血循环中测不到头孢呋新酯原药。制剂由于曾存在一些与药物本身理化特性有关的问题,发展头孢呋新酯花了相当长的时间。

关键词：头孢呋新头孢菌素头孢呋新酯