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Stroke & Vascular Neurology 2021年第4期6卷 658-667页

作者： Waleed Brinjikji oana madalina mereuta Daying Dai David F Kallmes Luis Savastano Yang Liu Shahid M Nimjee Raul G Nogueira Mehdi Abbasi Ramanathan Kadirvel Radiology Mayo ClinicRochesterMinnesotaUSA Neurosurgery Mayo ClinicRochesterMinnesotaUSA Neurosurgery Ohio State University Medical CenterColumbusOhioUSA Neurology Emory University School of MedicineAtlantaGeorgiaUSA

There has been growing interest and insight into the histological composition of retrieved stroke *** of the main focuses of the stroke clot analysis literature has been the implications of clot composition on mechanical thrombectomy ***,the holy grail of clot analysis may not be in the field of clot-device interaction,but rather,in understanding mechanisms of fibrinolysis *** mechanisms underlying the low response to fibrinolytic therapy,even with the newer,more powerful agents,remain poorly *** factors such as embolus size,location and collateral status influence alteplase delivery and recanalisation rates;compositional analyses focused on histological and ultrastructural characteristics offer unique insights into mechanisms of alteplase *** this review,we strive to provide comprehensive review of current knowledge on clot composition and ultrastructural analyses that help explain resistance to fibrinolysis.

关键词： fibrin histological resistance

Abdominal imaging in COVID-19

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World Journal of Radiology 2021年第7期13卷 227-232页

作者： Daniel Vasile Balaban oana madalina Baston Mariana Jinga Department of Internal Medicine and Gastroenterology Carol Davila University of Medicine and Pharmacy Dr.Carol Davila Central Military Emergency University Hospital Bucharest 020021Romania Department of Radiology Medical Imaging and Interventional RadiologyCarol Davila University of Medicine and PharmacyDr.Carol Davila Central Military Emergency University HospitalBucharest 020021Romania

Initially thought of as a respiratory infection,coronavirus disease-2019(COVID-19)is now recognized as a complex disease with a wide clinical spectrum,including digestive *** several studies have evaluated chest imaging findings in COVID-19,few papers have looked at the abdominal imaging features of these ***,biliary,pancreas and bowel involvement have been reported in COVID-19 infected *** this review,we aim to summarize currently available data related to abdominal imaging techniques in COVID-19,in accordance with relevant clinical and laboratory workup of these *** mechanisms,indications and imaging findings related to COVID-19 are discussed based on published ***,practice points for clinicians are highlighted in order to adequately recognize digestive-related injuries of severe acute respiratory syndrome coronavirus 2 *** there’s been a steady accumulation of data with respect to abdominal imaging findings in COVID-19,currently available recommendations are based on limited *** is a wide spectrum of abdominal imaging findings in COVID-19,which includes hepato-biliary,pancreatic and luminal pathology.

关键词： COVID-19 Gastrointestinal Digestive Features Imaging Ultrasound Computed tomography

Possibilities of Experimental Modulation of Senescence by Stimulation of Antiradical Defense

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Journal of Biomedical Science and Engineering 2015年第4期8卷 237-245页

作者： Manuela Ciocoiu Magda Badescu oana Badulescu madalina Mocanu Codruta Badescu Department of Pathophysiology Faculty of Medicine University of Medicine and Pharmacy “Grigore T. Popa” Iasi Romania Internal Medicine Clinic St. Spiridon Hospital University of Medicine and Pharmacy “Grigore T. Popa” Iasi Romania

Various epidemiological studies have shown an inverse association between the consumption of polyphenols or polyphenol-rich foods and the risk of neurodegenerative, hepatic diseases. The research aimed to fight oxidative stress and lipid metabolism changes in the context of?administration?of antioxidants, such as polyphenolic extract of Aronia melanocarpa and zinc aspartate, known for its neurotrophic effects in intrinsic aging processes. Zinc aspartate and poly-phenolic extract from Aronia melanocarpa reduce oxidative stress values both in serum, liver homogenate, and in brain homogenate. Oxidative stress assessed by malondialdehyde (MDA), glutathione peroxidase (GPx) and total antioxidant capacity (TAC) markers was reduced in animals receiving additional zinc salts and polyphenolic extract of Aronia melanocarpa, which underlines their role in antioxidant defense. This combination produces more superior hypolipidemic and antioxidant effects than in the case of separate administration within experimental senescence induced in the murine model. Further studies will investigate the effect of different dose combinations of zinc aspartate and polyphenolic extract of Aronia melanocarpa at different periods of treatments on age-associated liver/cerebral dysfunction.

关键词： Senescence Zinc Aspartate Aronia melanocarpa Oxidative Stress

Involvement of Autoimmune Diseases in the Pathogenesis of Chronic Immune Thrombocytopenic Purpura

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Journal of Biomedical Science and Engineering 2015年第3期8卷 142-148页

作者： madalina Mocanu Magda Badescu Manuela Ciocoiu Codruta Badescu Cristina Elena Iancu oana Badulescu Department of Pathophysiology “Grigore T.Popa”University of Medicine and PharmacyIasiRomania Department of Internal Medicine “Grigore T.Popa”University of Medicine and PharmacyIasiRomania Deparment of Pharmaceutical Science Ⅱ “Grigore T.Popa”University of Medicine and PharmacyIasiRomania

Chronic immune thrombocytopenic purpura (ITP) is a condition based on an immune-mediated mechanism that determines the premature hyperdestruction of the thrombocytes in peripheral blood, as well as their deficient synthesis at the level of the bone marrow. The chronic immune purpura could be of primary, idiopathic cause, as well as of secondary cause, occurring in the context of other pathologies. The characteristic of the primary form of the disease is the presence of isolated thrombocytopenia, defined by a platelet count under 100,000/mm3 in peripheral blood, in the absence of supporting causes for thrombocytopenia. In the secondary form of the disease, the decreased platelet count is due to associated pathologies involving an immune mechanism, responsible for the occurrence of thrombocytopenia. This study aims to emphasize the involvement of autoimmune diseases, such as systemic lupus erythematosus (SLE), dermatomyositis, rheumatoid polyarthritis or antiphospholipid syndrome in the pathogenesis of secondary thrombocytopenia. Furthermore, the study was conducted on a sample of 40 patients, divided into two groups: The first group comprising asymptomatic patients diagnosed with thrombocytopenia following routine tests, and the second group comprising patients with hemorrhagiparous symptomatology (petechiae, ecchymoses, epistaxis, gingivorrhagia), who went to the doctor in order to determine the etiology of the hemorrhagiparous syndrome. The average value of the thrombocytopenia of the patients included in the study was of 60.20 ± 19.75 × 103/μL. Laboratory investigations performed in order to establish the etiology of thrombocytopenia showed that 80% of patients presented positive antiplatelet antibodies. Moreover, 20% of the patients in the study showed positive anti-double-stranded DNA, 20% were identified with IgG anticardiolipin antibodies, while antinuclear antibodies were present in 10% of the patients.

关键词： Thrombocytopenic Purpura Antiplatelet Antibodies Systemic Lupus Erythematosus Antiphospholipid Syndrome