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Possibilities of Experimental Modulation of Senescence by Stimulation of Antiradical Defense

Journal of Biomedical Science and Engineering 2015年第4期8卷 237-245页

作者： Manuela Ciocoiu Magda Badescu oana badulescu Madalina Mocanu Codruta Badescu Department of Pathophysiology Faculty of Medicine University of Medicine and Pharmacy “Grigore T. Popa” Iasi Romania Internal Medicine Clinic St. Spiridon Hospital University of Medicine and Pharmacy “Grigore T. Popa” Iasi Romania

Various epidemiological studies have shown an inverse association between the consumption of polyphenols or polyphenol-rich foods and the risk of neurodegenerative, hepatic diseases. The research aimed to fight oxidative stress and lipid metabolism changes in the context of?administration?of antioxidants, such as polyphenolic extract of Aronia melanocarpa and zinc aspartate, known for its neurotrophic effects in intrinsic aging processes. Zinc aspartate and poly-phenolic extract from Aronia melanocarpa reduce oxidative stress values both in serum, liver homogenate, and in brain homogenate. Oxidative stress assessed by malondialdehyde (MDA), glutathione peroxidase (GPx) and total antioxidant capacity (TAC) markers was reduced in animals receiving additional zinc salts and polyphenolic extract of Aronia melanocarpa, which underlines their role in antioxidant defense. This combination produces more superior hypolipidemic and antioxidant effects than in the case of separate administration within experimental senescence induced in the murine model. Further studies will investigate the effect of different dose combinations of zinc aspartate and polyphenolic extract of Aronia melanocarpa at different periods of treatments on age-associated liver/cerebral dysfunction.

关键词： Senescence Zinc Aspartate Aronia melanocarpa Oxidative Stress

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Polyphenolic extract association with renin inhibitors in experimental arterial hypertension

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Journal of Biomedical Science and Engineering 2013年第4期6卷 493-497页

作者： Manuela Ciocoiu Magda Badescu oana badulescu Dana Tutunaru Laurentiu Badescu Department of Biochemistry University “Dunarea de Jos” Galati Romania Department of Cellular and Molecular Biology University of Medicine and Pharmacy “Gr. T. Popa” Iasi Romania Department of Pathophysiology Faculty of Medicine University of Medicine and Pharmacy “Gr. T. Popa” Iasi Romania

Various epidemiological studies have shown an inverse association between the consumption of polyphenols or polyphenol-rich foods and the risk of cardiovascular diseases. The purpose of the study was to emphasize the effects of the association between the renin inhibitor and the polyphenolic extract on biochemical parameters and systolic and diastolic blood pressure. The polyphenols are extracted from isolated and purified vegetable material represented by the mature fruit of the Aronia melanocarpa. The experiment was performed on the arterial hypertension model. In the arterial hypertensive model the cardioprotective effects of the polyphenolic extract from Aronia melanocarpa are represented by the antioxidant, hypocolesterolemiant intervention. Polyphenolic extract from Aronia melanocarpa reduce systolic and diastolic arterial tension values in rats with drug-induced hypertension, a phenomenon more pronounced when polyphenols are associated with Aliskiren (renin inhibitor). The combination between the Aliskiren and polyphenolic extract produce superior hypolipidemic and antioxidant effects than in the case of separate administration within experimental arterial hypertension induced in the murine model.

关键词： Arterial Hypertension Aliskiren Aronia melanocarpa Oxidative Stress

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Involvement of Autoimmune Diseases in the Pathogenesis of Chronic Immune Thrombocytopenic Purpura

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Journal of Biomedical Science and Engineering 2015年第3期8卷 142-148页

作者： Madalina Mocanu Magda Badescu Manuela Ciocoiu Codruta Badescu Cristina Elena Iancu oana badulescu Department of Pathophysiology “Grigore T.Popa”University of Medicine and PharmacyIasiRomania Department of Internal Medicine “Grigore T.Popa”University of Medicine and PharmacyIasiRomania Deparment of Pharmaceutical Science Ⅱ “Grigore T.Popa”University of Medicine and PharmacyIasiRomania

Chronic immune thrombocytopenic purpura (ITP) is a condition based on an immune-mediated mechanism that determines the premature hyperdestruction of the thrombocytes in peripheral blood, as well as their deficient synthesis at the level of the bone marrow. The chronic immune purpura could be of primary, idiopathic cause, as well as of secondary cause, occurring in the context of other pathologies. The characteristic of the primary form of the disease is the presence of isolated thrombocytopenia, defined by a platelet count under 100,000/mm3 in peripheral blood, in the absence of supporting causes for thrombocytopenia. In the secondary form of the disease, the decreased platelet count is due to associated pathologies involving an immune mechanism, responsible for the occurrence of thrombocytopenia. This study aims to emphasize the involvement of autoimmune diseases, such as systemic lupus erythematosus (SLE), dermatomyositis, rheumatoid polyarthritis or antiphospholipid syndrome in the pathogenesis of secondary thrombocytopenia. Furthermore, the study was conducted on a sample of 40 patients, divided into two groups: The first group comprising asymptomatic patients diagnosed with thrombocytopenia following routine tests, and the second group comprising patients with hemorrhagiparous symptomatology (petechiae, ecchymoses, epistaxis, gingivorrhagia), who went to the doctor in order to determine the etiology of the hemorrhagiparous syndrome. The average value of the thrombocytopenia of the patients included in the study was of 60.20 ± 19.75 × 103/μL. Laboratory investigations performed in order to establish the etiology of thrombocytopenia showed that 80% of patients presented positive antiplatelet antibodies. Moreover, 20% of the patients in the study showed positive anti-double-stranded DNA, 20% were identified with IgG anticardiolipin antibodies, while antinuclear antibodies were present in 10% of the patients.

关键词： Thrombocytopenic Purpura Antiplatelet Antibodies Systemic Lupus Erythematosus Antiphospholipid Syndrome

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