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An integrated spatial planning of the mountainous landscapes for ski sports in a case area at the eastern Türkiye

Journal of Mountain Science 2024年第3期21卷 754-767页

作者： SATIR Onur TOSUN Busra COSKUN OZYOL Funda ozdemir omer faruk BERBEROGLU Suha Dept.of Landscape Architecture Van Yuzuncu Yil UniversityVan 65090Türkiye School of Physical Education&Sports Van Yuzuncu Yil UniversityVan 65090Türkiye Van Yuzuncu Yil University Dept.of Architecture&Urban Planning Van 65090Türkiye Dept.of Remote Sensing&GIS Cukurova UniversityAdana 01330Türkiye

Mountainous regions have disadvantages in economic development because of harsh physical and climatic ***,winter tourism activities are one of the key components for supporting economic development in the *** a ski resort area supports direct and indirect employment in a region,and it stops immigration from mountainous regions to other *** research aimed to assess the potential ski areas using a multi criteria evaluation technique in the Van region which is located in the eastern part of Tü*** this context,snow cover duration,sun effect,slope,slope length,elevation,population density,distance from main roads and lake visibility were used as input factors in the decision making *** factor was standardized using a fuzzy technique based on existing well-known ski centers in Tü*** weight of inputs was defined by applying a survey to the professional *** most important factors were detected as transportation opportunities and snow covers whereas,the least important factors were elevation and population ***,lake visibility was very important to make a difference from other existing facilities in the ***,it was included as constraints and lake visible areas were extracted at the final stage of the *** ski areas were mapped in three levels as professional,intermediate and beginner *** of the suitable areas was selected as a sample projection and for the 3D simulation of the ski investment *** costs and benefits were *** was found that a ski tourism area investment can be amortized in 3 years in the region.

关键词： Winter sports and tourism Decision making 3D simulation and modelling Landscape planning GIS

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Cellulolytic characterization of the rumen-isolated Acinetobacter pittii ROBY and design of a potential controlled-release drug delivery system

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Engineering Microbiology 2024年第3期4卷 22-28页

作者： Ruken Sariboga omer faruk Sarioglu Istanbul Medeniyet University Department of Molecular Biology and GeneticsIstanbul 34730Turkey Istanbul Medeniyet University Science and Advanced Technologies Research Center(BILTAM)Istanbul 34730Turkey

A novel cellulolytic bacterial strain,ROBY,was isolated from a bovine rumen sample using the enrichment cul-ture *** isolate was found to be Acinetobacter pittii,with>99%similarity according to 16S rRNA gene sequence *** potential use of this strain in combination with doxorubicin(Dox)-integrated cellulose nanoparticles(Dox-CNPs)was evaluated as a proof-of-concept study for the further development of this approach as a novel controlled-release drug delivery *** isolate can utilize CNPs as the sole carbon source for growth and degrade both Dox-CNPs and empty CNPs with high *** cellulases isolated from bacteria may also be used to trigger Dox *** results also demonstrated that the release of Dox into the environment due to nanoparticle degradation in the samples incubated with Dox-CNPs significantly affected bac-terial cell viability(∼75%decrease),proving the release of Dox due to bacterial cellulase activity and suggesting the great potential of this approach for further development.

关键词： Acinetobacter pittii Microcrystalline cellulose Cellulose nanoparticle Controlled-release drug delivery system Doxorubicin

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Safety and efficiency of Wharton’s Jelly-derived mesenchymal stem cell administration in patients with traumatic brain injury:First results of a phase I study

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World Journal of Stem Cells 2024年第6期16卷 641-655页

作者： Serdar Kabatas ErdinçCivelek Osman Boyalı Gülseli Berivan Sezen omer ozdemir Yeliz Bahar-ozdemir Necati Kaplan Eyüp Can Savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Türkiye Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Türkiye Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Traumatic brain injury(TBI)is characterized by a disruption in the normal function of the brain due to an injury following a trauma,which can potentially cause severe physical,cognitive,and emotional *** cell transplantation has evolved as a novel treatment modality in the management of TBI,as it has the potential to arrest the degeneration and promote regeneration of new cells in the ***’s Jelly-derived mesenchymal stem cells(WJ-MSCs)have recently shown beneficial effects in the functional recovery of neurological *** To evaluate the safety and efficiency of MSC therapy in *** We present 6 patients,4 male and 2 female aged between 21 and 27 years who suffered a *** 6 patients underwent 6 doses of intrathecal,intramuscular(i.m.)and intravenous transplantation of WJ-MSCs at a target dose of 1×106/kg for each application *** was assessed using the Modified Ashworth scale(MAS),motor function according to the Medical Research Council Muscle Strength Scale,quality of life was assessed by the Functional Independence Measure(FIM)scale and Karnofsky Performance Status *** Our patients showed only early,transient complications,such as subfebrile fever,mild headache,and muscle pain due to ***,which resolved within 24 *** the one year follow-up,no other safety issues or adverse events were *** 6 patients showed improvements in their cognitive abilities,muscle spasticity,muscle strength,performance scores and fine motor skills when compared before and after the *** values,which we used to assess spasticity,were observed to statistically significantly decrease for both left and right sides(P<0.001).The FIM scale includes both motor scores(P<0.05)and cognitive scores(P<0.001)and showed a significant increase in pretest posttest *** difference observed in the participants’Karnofsky Performance Scale values pre and post the intervention was statistically si

关键词： Traumatic brain injury Wharton Jelly Stem cell therapy Transplantation Mesenchymal stem cell

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Allogeneic mesenchymal stem cells may be a viable treatment modality in cerebral palsy

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World Journal of Clinical Cases 2024年第9期12卷 1585-1596页

作者： Osman Boyalı Serdar Kabatas ErdinçCivelek omer ozdemir Yeliz Bahar-ozdemir Necati Kaplan Eyüp Can Savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Turkey Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34360Turkey Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Turkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Turkey Department of Histology and Embryology Istinye UniversityFaculty of Medicineİstanbul 34010Turkey Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Turkey

BACKGROUND Cerebral palsy(CP)describes a group of disorders affecting movement,balance,and *** in motor functions constitute the main body of CP *** symptoms surface in early childhood and patients are affected for the rest of their ***,treatment involves various pharmacotherapies for different types of CP,including antiepileptics for epilepsy and Botox A for focal ***,none of these methods can provide full symptom *** has prompted researchers to look for new treatment modalities,one of which is mesenchymal stem cell therapy(MSCT).Despite being a promising tool and offering a wide array of possibilities,mesenchymal stem cells(MSCs)still need to be investigated for their efficacy and *** To analyze the efficacy and safety of MSCT in CP *** Our sample consists of four CP patients who cannot stand or walk without external *** of these cases received allogeneic MSCT six times as 1×106/kg intrathecally,intravenously,and intramuscularly using umbilical cord-derived MSCs(UC-MSC).We monitored and assessed the patients pre-and post-treatment using the Wee Functional Independence Measure(WeeFIM),Gross Motor Function Classification System(GMFCS),and Manual Ability Classification Scale(MACS)*** utilized the Modified Ashworth Scale(MAS)to measure *** We found significant improvements in MAS scores after the intervention on both *** months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;four months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;12 months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=***,there was no significant difference in motor functions based on WeeFIM results(P>0.05).GMFCS and MACS scores differed significantly at 12 months after the intervention(P=0.046,P=0.046).Finally,there was no significant change in cognitive functions(P>0.05).CONCLUSION In light of our findings,we believe that UC-MSC therapy has a positive effect on spasticity

关键词： Cerebral palsy Mesenchymal stem cell Transplantation Wharton’s jelly Muscle spasticity

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Using Metaheuristic OFA Algorithm for Service Placement in Fog Computing

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Computers, Materials & Continua 2023年第12期77卷 2881-2897页

作者： Riza Altunay omer faruk Bay Department of Information Systems Gazi UniversityAnkara06680Turkey Department of Computer Technologies Ondokuz Mayis UniversitySamsun55100Turkey Department of Electrical-Electronics Engineering Gazi UniversityAnkara06560Turkey

The use of fog computing in the Internet of Things(IoT)has emerged as a crucial solution,bringing cloud services closer to end users to process large amounts of data generated within the *** its advantages,the increasing task demands from IoT objects often overload fog devices with limited resources,resulting in system delays,high network usage,and increased energy *** of the major challenges in fog computing for IoT applications is the efficient deployment of services between fog *** address this challenge,we propose a novel Optimal Foraging Algorithm(OFA)for task placement on appropriate fog devices,taking into account the limited resources of each fog *** OFA algorithm optimizes task sharing between fog devices by evaluating incoming task requests based on their types and allocating the services to the most suitable fog *** our study,we compare the performance of the OFA algorithm with two other popular algorithms:Genetic Algorithm(GA)and Randomized Search Algorithm(RA).Through extensive simulation experiments,our findings demonstrate significant improvements achieved by the OFA ***,it leads to up to 39.06%reduction in energy consumption for the Elektroensefalografi(EEG)application,up to 25.86%decrease in CPU utilization for the Intelligent surveillance through distributed camera networks(DCNS)application,up to 57.94%reduction in network utilization,and up to 23.83%improvement in runtime,outperforming other *** a result,the proposed OFA algorithm enhances the system’s efficiency by effectively allocating incoming task requests to the appropriate fog devices,mitigating the challenges posed by resource limitations and contributing to a more optimized IoT ecosystem.

关键词： Internet of Things cloud computing fog computing

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Optimization of drill bit replacement time in open-cast coal mines

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International Journal of Coal Science & Technology 2019年第3期6卷 399-407页

作者： omer faruk Ugurlu Mustafa Kumral Department of Mining and Materials Engineering McGill University 3450 University Street Montreal QC H3A 0E8 Canada

To gain a competitive edge within the international and compet让ive setting of coal markets, coal producers must find new ways of reducing costs. Increasing bench drilling efficiency and performance in open-cast coal mines has the potential to generate savings. Specifically, monitoring, analyzing, and optimizing the drilling operation can reduce drilling costs. For example, determining the optimal drill bit replacement time will help to achieve the desirable penetration rate. This paper presents a life data analysis of drill bits to fit a statistical distribution using failure records. These results are then used to formulate a cost minimization problem to estimate the drill bit replacement time using the evolutionary algorithm. The effect of cost on the uncertainty associated with replacement time is assessed through Monte-Carlo simulation. The relationship between the total expected replacement cost and replacement time is also presented. A case study shows that the proposed approach can be used to assist with designing a drill bit replacement schedule and minimize costs in open-cast coal mines.

关键词： Cost minimization Drilling operation Optimum replacement time Evolutionary algorithm Sensitivity analysis Monte Carlo simulation

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Performance investigation of LAMBDA and bootstrapping methods for PPP narrow-lane ambiguity resolution

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Geo-Spatial Information Science 2021年第4期24卷 604-614页

作者： omer faruk Atiz Sermet Ogutcu Salih Alcay Pan Li Ilkay Bugdayci Department of Geomatics Engineering Necmettin Erbakan UniversityKonyaTurkey Department of Geodesy and Remote Sensing German Research Centre for GeosciencesPotsdamGermany

Precise point positioning with ambiguity resolution(PPP-AR)is a powerful tool for geodetic and time-constrained applications that require high *** performance of PPP-AR highly depends on the reliability of the correct integer carrier-phase ambiguity *** this study,the performance of narrow-lane ambiguity resolution of PPP using the Least-squares AMBiguity Decorrelation(LAMBDA)and bootstrapping methods is extensively investigated using real data from 55 IGS stations over one-month in *** PPP with 24-,12-,8-,4-,2-,1-and½-h sessions using two different cutoff angles(7°and 30°)was conducted with three PPP modes:***-float and two kinds of ambiguity-fixed PPP using the LAMBDA and bootstrapping methods for narrow-lane AR,*** results show that the LAMBDA method can produce more reliable results for 2 hour and shorter observation sessions com-pared with the bootstrapping method using a 7°cutoff *** a 30°cutoff angle,the LAMBDA method outperforms the bootstrapping method for observation sessions of 4 h and *** long observation times,the bootstrapping method produced much more accurate coordinates compared with the LAMBDA method without considering the wrong fixes *** results also show that occurrences of fixing the wrong integer ambiguities using the bootstrapping method are higher than that of the LAMBDA method.

关键词： Ambiguity resolution narrow-lane Precise point positioning(PPP) LAMBDA bootstrapping

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Ensemble and optimized hybrid algorithms through Runge Kutta optimizer for sewer sediment transport modeling using a data pre-processing approach

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International Journal of Sediment Research 2023年第6期38卷 847-858页

作者： Enes Gul Mir Jafar Sadegh Safari omer faruk Dursun Gokmen Tayfur Department of Civil Engineering Inonu University Department of Civil Engineering Yasar University Department of Civil Engineering Izmir Institute of Technology

Uncontrolled sediment deposition in drainage and sewer systems raises unexpected maintenance *** this end,implementation of an accurate model relying on effective parameters involved is a reliable *** this study,three machine learning techniques,namely extreme learning machine(ELM),multilayer perceptron neural network(MLPNN),and M5P model tree(M5PMT);and three optimization approaches of Runge Kutta(RUN),genetic algorithm(GA),and particle swarm optimization(PSO) are applied for *** optimization and ensemble hybridization approaches are applied in the modeling *** the case of hybrid optimized models,the ELM and MLPNN models are hybridized with RUN,GA,and PSO algorithms to develop six hybrid models of ELM-RUN,ELM-GA,ELMPSO,MLPNN-RUN,MLPNN-GA,and *** hybrid models are developed through coupling the ELM and MLPNN models with the M5PMT *** data pre-processing approach is applied to find the best randomness characteristic of the utilized *** illustrate that the RUNbased hybrid models outperform the GA-and PSO-based *** the MLPNN-RUN and MLPNN-M5PMT hybrid models generate better results than their alternatives,MLPNN-M5PMT slightly outperforms MLPNN-RUN model with a coefficient of determination of 0.84 and a root mean square error of *** current study shows the superiority of the ensemble-based approach to the optimization *** investigation is needed by considering alternative optimization techniques to enhance sediment transport modeling.

关键词： Ensemble learning Hybrid model Machine learning Open channels Sediment transport Sewer pipes

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Predicting cash holdings using supervised machine learning algorithms

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Financial Innovation 2022年第1期8卷 1459-1477页

作者： ŞirinÖzlem omer faruk Tan Department of Industrial Engineering Faculty of EngineeringMEF UniversityIstanbulTurkey Department of Accounting and Finance Faculty of Business AdministrationMarmara UniversityIstanbulTurkey

This study predicts the cash holdings policy of Turkish firms,given the 20 selected features with machine learning algorithm methods.211 listed firms in the Borsa Istanbul are analyzed over the period between 2006 and *** linear regression(MLR),k-nearest neighbors(KNN),support vector regression(SVR),decision trees(DT),extreme gradient boosting algorithm(XGBoost)and multi-layer neural networks(MLNN)are used for *** reveal that MLR,KNN,and SVR provide high root mean square error(RMSE)and low R2 ***,more complex algorithms,such as DT and especially XGBoost,derive higher accuracy with a 0.73 R 2 ***,using advanced machine learning algorithms,we may predict cash holdings considerably.

关键词： boosting policy networks

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Effect of transcatheter aortic valve implantation on QT dispersion in patients with aortic stenosis

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Journal of Geriatric Cardiology 2014年第4期11卷 286-290页

作者： Hakan Erkan Engin Hatem Mustafa Tank Agac Levent Korkmaz Teyyar Gokdeniz Ahmet Cagrl Aykan Ezgi Kalaycloglu faruk Boyacl omer faruk Clrakoglu Sukru Celik Department of Cardiology Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital Camhk Street Trabzon 61040 Turkey Department of Cardiology Kafkas University Hospital Kars Turkey

Background QT dispersion （QTd） is a predictor of ventricular arrhythmia. Ventricular arrhythmia is an important factor influencing morbidity and mortality in patients with aortic stenosis. Surgical aortic valve replacement reduced the QTd in this patients group. However, the effect of transcatheter aortic valve implantation （TAVI） on QTd in patients with aortic stenosis is unknown. The aim of this study was to investigate the effect of TAVI on QTd in patients with aortic stenosis. Methods Patients with severe aortic stenosis, who were not candi-dates for surgical aortic valve replacement due to contraindications or high surgical risk, were included in the study. All patients underwent electrocardiographic and echocardiographic evaluation before, and at the 6th month after TAVI, computed QTd and left ventricular mass index （LVMI）. Results A total 30 patients were admitted to the study （mean age 83.2 ± 1.0 years, female 21 and male 9, mean valve area 0.7 ± 3 mm2）. Edwards SAPIEN heart valves, 23 mm （21 patients） and 26 mm （9 patients）, by the transfemoral approach were used in the TAVI procedures. All TAVI procedures were successful. Both QTd and LVMI at the 6th month after TAVI were significantly reduced com-pared with baseline values of QTd and LVMI before TAVI （73.8 ± 4 ms vs. 68 ± 2 ms, P=0.001 and 198 ± 51 g/m2 vs. 184 ± 40 g/m2, P=0.04, respectively）. There was a significant correlation between QTd and LVMI （r=0.646, P〈0.001）. Conclusions QTd, which malign ventricular arrhythmia marker, and LVMI were significantly reduced after TAVI procedure. TAVI may decrease the possibility of ventricu-lar arrhythmia in patients with aortic stenosis.

关键词： Aortic stenosis QT dispersion Transcatheter aortic valve implantation

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