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Repeat laparoscopic anatomical liver resection in a hepatocellular carcinoma patient:a case report

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Hepatoma Research 2022年第1期8卷 248-253页

作者： Kazuharu Igarashi Kohei Mishima Takahiro ozaki Go Wakabayashi Department of Surgery Ageo Central General HospitalAgeoSaitama 362-8588Japan Department of General-Pediatric Hepatobiliary Pancreatic Surgery Kitasato University School of MedicineSagamiharaKanagawa 252-0374Japan

Anatomical resection(AR)has been reported to achieve better long-term outcomes than non-anatomical resection for the treatment of hepatocellular carcinoma(HCC).The surgical feasibility and oncological significance of laparoscopic AR(LAR),especially“subsegment resection”,“cone unit resection”,and repeat LAR for HCC,remain *** present a 67-year-old patient with alcoholic liver cirrhosis and HCC who underwent full LAR three times,focusing on the technical aspects of the Glissonean *** LAR for recurrent HCC could be a safe and feasible ***,HCC recurred in the neighboring segment twice,even though pathological vascular invasion and marginal remnants were not *** should investigate the oncological significance and advancements in subsegmentectomy and cone unit resection,in the future.

关键词： Repeat laparoscopic anatomical liver resection HCC Glissonean approach subsegmentectomy cone unit resection

Soluble ST2 protein inhibits LPS stimulation on monocyte-derived dendritic cells

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Cellular & Molecular Immunology 2012年第5期9卷 399-409页

作者： Akihisa Nagata Naoki Takezako Hiroyuki Tamemoto Hiromi Ohto-ozaki SatoshiOhta Shin-ichi Tominaga Ken Yanagisawa Department of Biochemistry School of Medicine Jichi Medical University Shimotsuke-shi Tochigi Japan Hematology Division National Hospital Organization Disaster Medical Center of Japan Tachikawa-shi Tokyo Japan

ST2 protein is a soluble splicing variant of ST2L protein, which is the receptor for interleukin-33 （IL-33）. Previously, we reported that soluble ST2 suppressed the signal transduction of lipopolysaccharide （LPS） and cytokine production in monocytic cells. To investigate whether or not this inhibitory effect occurs in dendritic cells, which are the key players in innate and adaptive immunity, human monocyte-derived dendritic cells were pre-treated with soluble ST2 protein before LPS stimulation. Although soluble ST2 did not attenuate the LPS-induced maturation of dendritic cells, pre-treatment with soluble ST2 suppressed cytokine production and inhibited LPS signaling. Moreover, the proliferation of naive T cells was inhibited significantly by soluble ST2 pre-treatment. IL-33 had little effect on the cytokine production of immature monocyte-derived dendritic cells. Furthermore, soluble ST2 protein was internalized into dendritic cells, suggesting that soluble ST2 protein acts by a noncanonical mechanism other than the sequestration of IL-33.

关键词： dendritic cells LPS signal transduction ST2 TLR4

Possible key residues that determine left gastric artery blood flow response to PACAP in dogs

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World Journal of Gastroenterology 2010年第38期16卷 4865-4870页

作者： Mu-Xin Wei Ping Hu Ping Wang Satoru Naruse Kiyoshi Nokihara Victor Wray Tsuyoshi ozaki Department of Traditional Chinese Medicine First Af��liated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Internal Medicine Nagoya University Graduate School of Medicine Hipep Laboratories Nakatsukasacho Department of Structural Biology Helmholtz Centre for Infection Research Institute of Physiological Sciences Okazaki 444-8787Japan

AIM:To determine the effect of pituitary adenylate cy-clase-activating polypeptide (PACAP) on left gastric artery (LGA) flow and to unveil the structural or functional important sites that may be critical for discrimination of different receptor subtypes. METHODS: Peptides, including PACAP-27, PACAP-38, amino acid substituted PACAP-27 and C-terminus truncated analogues PACAP (27-38), were synthesized by a simultaneous multiple solid-phase peptide synthesizer. Flow probes of an ultrasound transit-time blood flowmeter were placed around the LGA of beagle dogs. Whenpeptides were infused intravenously, the blood flow was ***: [Ala4, Val5]-PACAP-27 caused a concentration-dependent vasodepressor action which was similar to that caused by PACAP-27. The LGA blood flow response to [Ala4, Val5]-PACAP-27 was significantly higher than that to PACAP-27, which was similar to that to vasoactive intestinal polypeptide (VIP) at the same dose. [Ala6]-PACAP-27 did not increase the peak LGA ? ow. [Gly8]-PACAP-27 showed a similar activity to VIP. [Asn24, Ser25, Ile26]-PACAP-27 did not change the activity of peptides at all doses. CONCLUSION: NH2 terminus is more important to biological activity of peptides and specifi c receptor recognition than COOH-terminus.

关键词： Pituitary adenylate cyclase-activating poly-peptide Pituitary adenylate cyclase-activating polypeptide 27 Pituitary adenylate cyclase-activating polypeptide P38 Left gastric artery Blood fl ow

Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver

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World Journal of Gastroenterology 2009年第45期15卷 5712-5715页

作者： Takayuki Takeichi Shinji Uemoto Sachiko Minamiguchi Izumi Takeyoshi yukihiro Inomata Koichi Tanaka Eiji Kobayashi Department of Transplantation and Immunology Kyoto University Hospital 54 Kawara-cho ShogoinSakyo-ku Kyoto 606-8507 Japan Second Department of Surgery Gunma University School of Medicine 3-39-15 Showa-machi Maebashi Gunma 371-8511 Japan Department of Trans-plantation and Pediatric Surgery Postgraduate School of Medical Science Kumamoto University Kumamoto 1-1-1 Honjyo Ku-mamoto 860-8556 Japan Laboratory of Anatomic Pathology Kyoto University Hospital 54 Kawara-cho Shogoin Sakyo-ku Kyoto 606-8507 Japan Division of Organ Replacement Research Center for Molecular Medicine Jichi Medical School Minami-kawachi-machi Kawachi-gun Tochigi 329-0498 Japan

AIM: To investigate the effects of a novel Leukotriene B4 receptor antagonist and/or tacrolimus on ischemia-reperfusion in a rat liver model. METHODS: Male Lewis rats were pretreated with ONO-4057 (100 mg/kg) and/or tacrolimus (1 mg/kg) orally, and divided into four experimental groups; group 1 (control), group 2 (ONO-4057), group 3 (tacrolimus), group 4 (ONO-4057 + tacrolimus). RESULTS: There was a tendency for long survival in the groups treated with tacrolimus alone and ONO-4057 plus tacrolimus. Post-reperfusion serum aspartate aminotransferase levels decreased more signif icantly in ONO-4057 plus tacrolimus group (P < 0.01), than in the tacrolimus alone group (P < 0.05), compared to controls. CONCLUSION: This study demonstrated that pretreat-ment with ONO-4057 in combination with tacrolimus produced additive effects in a rat model of liver isch-emia-reperfusion injury.

关键词： Ischemia-reperfusion injury Leukotriene B4 Uver Tacrolimus

Administration frequency as well as dosage of PTH are associated with development of cortical porosity in ovariectomized rats

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Bone Research 2017年第2期5卷 109-122页

作者： Aya Takakura Ji-Won Lee Kyoko Hirano yukihiro Isogai Toshinori Ishizuya Ryoko Takao-Kawabata Tadahiro Iimura Pharmaceuticals Research Center Asahi Kasei Pharma Corporation Shizuoka Japan Graduate School of Medicine Division of Analytical BioMedicine Ehime University Ehime Japan Division of Bio-Imaging Proteo-Science Center (PROS) Ehime University Ehime Japan Division of Analytical Bio-Medicine Advanced Research Support Center (ADRES) Ehime University Ehime Japan and Artificial Joint Integrated Center Ehime University Hospital Ehime Japan

To investigate whether the administration frequency of parathyroid hormone(PTH) is associated with the development of cortical porosity, this study established 15 dosage regimens of teriparatide [human PTH(1–34), TPTD] with four distinct concentrations and four distinct administration frequencies of TPTD to 16-week-old ovariectomized rats. Our analyses demonstrated that the bone mineral density, mechanical properties, and bone turnover were associated with the total amount of TPTD administered. Our observations further revealed that the cortical porosity was markedly developed as a result of an increased administration frequency with a lower concentration of total TPTD administration in our setting, although the highest concentration also induced cortical porosity. Deconvolution fluorescence tiling imaging on calcein-labeled undecalcified bone sections also demonstrated the development of cortical porosity to be closely associated with the bone site where periosteal bone formation took place. This site-specific cortical porosity involved intracortical bone resorption and an increased number and proximity of osteocytic lacunae,occasionally causing fused lacunae. Taken together, these findings suggested the involvement of local distinctions in the rate of bone growth that may be related to the site-specific mechanical properties in the development of cortical porosity induced by frequent and/or high doses of TPTD.

关键词： frequency Administration PTH

α-fetoprotein,vascular endothelial growth factor receptor-1 and early recurrence of hepatoma

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World Journal of Gastroenterology 2012年第4期18卷 340-348页

作者： Toshiya Kamiyama Masato Takahashi Kazuaki Nakanishi Hideki Yokoo Hirofumi Kamachi Nozomi Kobayashi Michitaka ozaki Satoru Todo Department of General Surgery Graduate School of MedicineHokkaido University Department of Transplantation Surgery Graduate School of MedicineHokkaido University Department of Molecular Surgery Graduate School of MedicineHokkaido University

AIM:To investigate whether α-fetoprotein (AFP) and vascular endothelial growth factor receptor (VEGFR)-1 correlate with early recurrence of hepatoma/hepatocel-lular carcinoma (HCC).METHODS:From 2000 to 2005,114 consecutive pa-tients with HCC underwent primary curative *** mean age was 60.7 (8.7) years and 94 patients were *** median follow-up period was 71.2 mo (range:43-100 mo).Immediately prior to commencing laparotomy,5 mL bone marrow was aspirated from thesternum and collected in citrate-coated test *** initial 2 mL of bone marrow aspirate was discarded in each *** mRNA and VEGFR-1 mRNA in the bone marrow and peripheral blood (BM-and PH-AFP mRNA and BM-and PH-VEGFR-1 mRNA,respectively) were measured by real-time quantitative reverse transcription polymerase chain *** normal controls,VEGFR-1 mRNA in the bone marrow and peripheral blood was also measured in 11 living liver *** data were evaluated for any correlation with early recurrence,comparing clinical and pathological ***:The cut-off value of the BM-AFP mRNA and PH-AFP mRNA level in patients with HCC was set at 1.92 × 10-7 and zero,respectively,based on data from the controls.A total of 34 (29.8%) and six (5.4%) patients were positive for BM-AFP mRNA and PH-AFP mRNA,*** BM-VEGFR-1 mRNA levels in all HCC patients were higher than those in the normal con-trols,and this was the case also for *** 25-percentile values for the BM-and PH-VEGFR-1 mRNA in HCC patients were used as the cut-off values for assigning the patients into two groups based on these transcript *** High group for BM-VEG-FR-1 mRNA contained 81 (71.1%) HCC cases and the Low group was assigned 33 (28.9%) *** numbers for PH-VEGFR-1mRNA were 78 (75.0%) and 26 (25.0%),*** recurred in 80 patients;in the remnant liver in 48 cases,in the remnant liver and remote tissue in 20,and in the remote tissue alone in ***-AFP mRNA-positive cases

关键词： α-fetoprotein Vascular endothelial growth factor receptor-i mRNA Early recurrence Hepatocellular carcinoma

Body mass index is associated with age-at-onset of HCV-infected hepatocellular carcinoma patients

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World Journal of Gastroenterology 2011年第7期17卷 914-921页

作者： Takumi Akiyama Toshihiko Mizuta Seiji Kawazoe Yuichiro Eguchi Yasunori Kawaguchi Hirokazu Takahashi Iwata ozaki Kazuma Fujimoto Department of Internal Medicine Saga Medical School Department of Hepatology Saga Prefectural Hospital Department of Hepatology Saga Prefectural Hospital Saga 8408571 Japan

AIM: To identify factors associated with the age at onset of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). METHODS: Five hundred and fifty-six consecutive patients positive for HCV antibody and treatment-nafive HCC diagnosed between 1995 and 2004 were analyzed. Patients were classified into three groups according to age at HCC onset: 60 years old were lower and mean BMI values of female patients 25 kg/m2 [hazard ratio (HR), 1.8, P = 0.045], excessive alcohol consumption (HR, 2.5, P = 0.024), male sex (HR, 3.6, P = 0.002), and GGT levels > 50 IU/L (HR, 2.4, P = 0.014) were independently associated with HCC onset in patients < 60 years. Low ALT level was the only factor associated with HCC onset in patients aged ≥ 80 years. CONCLUSION: Increased BMI is associated with increased risk for early HCC development in HCV-infected patients. Achieving recommended BMI and reducing alcohol intake could help prevent hepatic carcinogenesis.

关键词： Age-at-onset Hepatocellular carcinoma Hepatitis C virus Body mass index Alcohol consumption Sex difference

Preparation of hemicellulolic oligosaccharides from Chamaecyparis obtuse （Hinoki） slurry using commercial enzymes

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Frontiers of Chemical Science and Engineering 2012年第2期6卷 224-231页

作者： Yuya KUMAGAI Hirokazu USUKI yukihiro YAMAMOTO Akihiro YAMASATO Takafumi MUKAIHARA Tadashi HATANAKA Okayama Prefectural Technology Center for Agriculture Forestry and FisheriesResearch Institute for Biological Sciences(RIBS)Okayama 716-1241Japan Research Fellow of the Japan Society for the Promotion of Science(JSPS) Japan Nagoya University Nagoya 464-8601Japan

Wood biomass is anticipated to serve as a substitute for carbon source, which has no feedstock competition with foods. Biomass is commonly used for the production of bio-ethanol by a series of processes such as pretreatment, enzymatic degradation, and fermentation. Hemicellulose, constituting 20 wt-% - 40 wt-% ofbiomass materials, contains various kinds of saccharides known to be bioactive substrates. Practical usage of hemicellulose is generally limited to its conversion to bio-ethanol. Here, we aimed to prepare hemicellulolic oligosaccharides, more valuable products other than ethanol. Therefore, the Hinoki slurry was treated with lime at room temperature for 3 h, and then neutralized with HCI. The resulting sample was treated with 13 types of commercial enzymes, and the saccharides produced in the supernatant were evaluated. The result showed that the commercial enzyme Cellulase SS （Nagase ＆ Co., LTD.） effectively degraded the slurry to produce disaccharides and trisaccharides. Analysis of sugar components by liquid chromatography/mass spectrography （LC/MS） after the derivation with ethyl 4- aminobenzoate （ABEE） showed that mannobiose, manno- Nose, and cellobiose were the major oligosaccharides. These results indicate valuable oligosaccharides can be successfully produced from Hinoki softwood slurry.

关键词： hemicellulolic oligosaccharides Chamaecyparis obtuse (Hinoki) commercial enzyme manno-oligosaccharide cello-oligosaccharide

Aggregation-enhanced direct S_(0)-T_(n) transitions and room-temperature phosphorescence in gold(I)-complex single crystals

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Aggregate 2022年第1期3卷 159-167页

作者： Akihiro Ando Kazuhisa ozaki Urara Shiina Eikichi Nagao Kyohei Hisano Kenji Kamada Osamu Tsutsumi Department of Applied Chemistry Ritsumeikan UniversityKusatsuJapan Nanomaterials Research Institute(NMRI) National Institute of Advanced Industrial Science and Technology(AIST)IkedaJapan

The design of efficient aggregation-induced emission materials requires an improved understanding of photophysical processes in aggregated ***,the photophysical behavior of an Au(I)complex(R6)that exhibits intense roomtemperature phosphorescence(RTP)in crystals is *** addition,the photophysical processes related to RTP are discussed based on the structure of the molecular aggregates and the primary structure of the *** extremely efficient S_(0)-T_(n) direct transition is found to occur in the R6 ***,intermolecular Au-Au interactions and the internal/external heavy-atom effects of Au atoms are demonstrated to enhance the electronic transitions involving intersystem crossing,namely,direct S_(0)-T_(n) excitation,radiative T_(1)-S_(0) transition(phosphorescence),and S_(1)-T_(n) intersystem *** of the dense molecular packing,both Au-Au interactions and heavy-atom effects play important roles in the *** a result,R6 shows more efficient RTP in crystals than in *** insights into the mechanism of highly efficient RTP in Au(I)-complex crystals are expected to advance the development of new luminogens for a variety of sensing and imaging applications.

关键词： aggregation-induced emission aurophilic interaction gold(I)complex phosphorescence spin-forbidden transition