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基于常压质谱技术的化学反应中间体监测研究进展

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质谱学报 2024年第1期45卷 31-43,I0002页

作者：葛喜洋尹伊颜欧阳津那娜北京师范大学化学学院放射性药物化学教育部重点实验室北京100875 北京师范大学(珠海校区)文理学院化学系广东珠海519087

随着科技的发展,化学反应研究逐渐在合成、化工、能源、环境、生物、医学等领域展现出重要的推动作用。然而,反应基质复杂,中间体种类、分子质量、寿命及动态变化多样,反应条件各异,使反应中间体的捕获与检测难度增大,同时给检测提出了... 详细信息

随着科技的发展,化学反应研究逐渐在合成、化工、能源、环境、生物、医学等领域展现出重要的推动作用。然而,反应基质复杂,中间体种类、分子质量、寿命及动态变化多样,反应条件各异,使反应中间体的捕获与检测难度增大,同时给检测提出了更高要求。常压质谱技术因具有高灵敏度、高选择性、分析速度快、原位监测等特点,近年来在化学反应中间体的监测及机理探究方面展示出独特优势。基于此,本文综述了常压质谱技术在电化学、光化学、等离子体化学、微滴化学等反应过程中,反应中间体捕获、检测、监测及相关机理研究等方面的进展。针对不同反应类型,详细介绍常压质谱检测方法的建立,阐明其在瞬时反应中间体的捕获和机理探究方面的应用,并进行总结和展望。

关键词：常压质谱反应中间体在线监测机理研究

二苯基甲烷二异氰酸酯(MDI)改性沥青及其混合料高温性能研究

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中国高新科技 2024年第17期 83-85页

作者：欧阳进徐磊湖南路桥建设集团有限公司湖南长沙410007

制备3%MDI、5%MDI和7%MDI改性沥青及其混合料,通过动态剪切流变试验和车辙试验研究不同掺量MDI改性沥青及其混合料的高温性能。结果表明,MDI改性剂的加入增大了基质沥青的黏弹性,提高了基质沥青的软化点,降低了针入度指标;不同掺量MDI... 详细信息

制备3%MDI、5%MDI和7%MDI改性沥青及其混合料,通过动态剪切流变试验和车辙试验研究不同掺量MDI改性沥青及其混合料的高温性能。结果表明,MDI改性剂的加入增大了基质沥青的黏弹性,提高了基质沥青的软化点,降低了针入度指标;不同掺量MDI改性剂的加入均增大了基质沥青的车辙因子指标G~*/sinδ和沥青混合料的动稳定度值。其中,7%MDI改性沥青在车辙因子G~*/sinδ=2.2kPa水平对应的临界温度最高,其对沥青混合料动稳定度的提升程度亦最大,7%MDI改性沥青及其混合料可适用于相对更高温度环境中的沥青路面设计与应用。

关键词：道路工程聚合物改性沥青高温性能二苯基甲烷二异氰酸酯(MDI)

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扫描电镜实验课程教学模式探索

科教导刊 2024年第11期 122-124页

作者：张毅欧阳静杨阳中南大学资源加工与生物工程学院湖南长沙410083

文章提出了“导学、自学、助学”模式,通过展示高校学科专业背景,建立依托大型精密仪器和科研项目的课程内容遴选机制,充分发挥扫描电镜在本科实验教学中的作用,将理论教学与实践教学融合,拓宽了学生的职业前景并培养其创造性思维和意识... 详细信息

文章提出了“导学、自学、助学”模式,通过展示高校学科专业背景,建立依托大型精密仪器和科研项目的课程内容遴选机制,充分发挥扫描电镜在本科实验教学中的作用,将理论教学与实践教学融合,拓宽了学生的职业前景并培养其创造性思维和意识,深化了学生对基础知识的理解,培养了学生解决仪器科学与工程技术领域复杂问题的能力,为交叉学科的高质量发展和培养满足国家高新技术需求的拔尖人才奠定了基础。

关键词：学生扫描电镜实验课程教学模式

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Fluorescence resonance energy transfer-based nanomaterials for the sensing in biological systems

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Chinese Chemical Letters 2022年第10期33卷 4505-4516页

作者： Xiaotong Shen Wei Xu jin ouyang Na Na School of Life Science Beijing Institute of TechnologyBeijing 100081China Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China

The applications of fluorescence resonance energy transfer(FRET)are coming to be one of the simplest and most accessible strategy with super-resolved optical ***,nanomaterials have become ideal for constructing FRET-based system,due to their unique advantages of tunable emission,broad absorption,and long fluorescence(FL)*** limitations of traditional FRET-based detections,such as the intrinsic FL,auto-FL,as well as the short FL lifetime,could be overcome with ***,numbers of FRET-based nanomaterials have been constructed for precise,sensitive and selective detections in biological *** could act as both energy donors and/or acceptors in the optical energy transfer process for biological *** other nanomaterials would not participate in the energy transfer process,but act as the excellent matrix for *** review will be roughly classified into nanomaterial-involved and uninvolved *** detection targets,such as nucleic acids,pathogenic microorganisms,proteins,heavy metal ions,and other applications will be ***,the other biological applications,including environmental evaluation and mechanism studies would also be summarized.

关键词： Nanomaterials Fluorescence resonance energy transfer Nano-sensors Detection Biochemical processes

Peptide-assembled siRNA nanomicelles confine MnOx-loaded silicages for synergistic chemical and gene-regulated cancer therapy

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Chinese Chemical Letters 2023年第4期34卷 453-458页

作者： jingjing Li Juanjuan Wei Yixuan Gao Qi Zhao Jianghui Sun jin ouyang Na Na Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100085China

Chemodynamic therapy(CDT) is a promising therapeutic approach for in situ cancer treatment, but it is still hindered by inefficient single-modality treatment and the weak targeted delivery of reagents into mitochondria(the main site of intracellular ROS production). Herein, to obtain a multimodal strategy,peptide-assembled si RNA nanomicelles were prepared to confine ultrasmall MnOxin small silica cages(silicages), which is convenient for synergistic chemical and gene-regulated cancer therapy. Given the free energy and versatility of small silicages, as well as the excellent Fenton-like activity of ultrasmall MnOx,MnOx-inside-loaded silicages(10 nm) were prepared for CDT delivery to mitochondria. Subsequently, to obtain a synergistic CDT and gene silencing treatment, the peptide-mediated assembly of si RNA and MnOx-loaded silicages were employed to obtain silicage@MnOx-si RNA nanomicelles(SMS NMs). After multiple modifications, sequential cancer cell-targeted delivery, GSH-controlled reagent release of si RNA and mitochondria-targeted delivery of MnOx-loaded silicages were successfully achieved. Finally, by both in vitro and in vivo experiments, SMS NMs were confirmed to be effective for synergistic chemical and gene-regulated cancer therapy. Our findings expand the applications of silicages and initiate the development of multimodal CDT.

关键词： Peptide-assembled siRNA nanomicelles MnOx-loaded silicages GSH-stimulated release Mitochondria-targeted delivery Cancer therap

Transplantation of Human Bone Marrow Mesenchymal Stem Cell Ameliorates the Autoimmune Pathogenesis in MRL/lpr Mice

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Cellular & Molecular Immunology 2008年第6期5卷 417-424页

作者： Kangxing Zhou Huayong Zhang ouyang jin Xuebing Feng Genhong Yao Yayi Hou Lingyun Sun Department of Rheumatology and Immunology The Affiliated DrumTower Hospital of Nanjing University Medical School 321 ZhongshanRoad Nanjing Jiangsu 210008 China Immunology Laboratory Nanjing University Medical School 22 HankouRoad Nanj ing Jiangsu 2 10093 China These authors contributed equally to this work

Recent evidence indicates that mesenchymal stem cells （MSC） possess immunosuppressive properties both in vitro and in vivo. We previously demonstrated the functional abnormality of bone marrow derived MSC in patients with systemic lupus erythematosus （SLE）. In this study, we aimed to investigate whether transplantation of human bone marrow derived MSC affects the autoimmune pathogenesis in MRL/Ipr mice. We found that human MSC from healthy donors reduced the proliferation of T lymphocytes from MRL/Ipr mice in a dose-dependent fashion. Two weeks after in vivo transfer of MSC, we detected significantly reduced serum levels of anti ds-DNA antibodies and 24 hour proteinuria in MRL/Ipr mice as compared with control groups without MSC transplantation. Moreover, flow cytometric analysis revealed markedly reduced number of CD4＋ T cells while increased Thl subpopulation in MSC group and MSC ＋ CTX group when compared with controls. Histopathological examination showed significantly reduced renal pathology in MSC-treated mice. Immunohistochemical studies further revealed reduced expression of TGF-~, FN, VEGF and the deposition of complement C3 in renal tissue after MSC and MSC ＋ CTX treatment. Taken together, we have demonstrated that transplantation of human MSC can significantly inhibit the autoimmune progression in MRL/Ipr mice. Cellular ＆ Molecular Immunology. 2008;5（6）：417-424.

关键词： systemic lupus erythematosus mesenchymal stem cell transplantation

慢性牙周炎患牙拔除后即刻与早期拔牙位点保存术的疗效对比分析

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深圳中西医结合杂志 2024年第15期34卷 23-26页

作者：欧阳瑾周虹宇陈露李洁婷中山市中医院广东中山528400

目的:分析慢性牙周炎患者患牙拔除后,即刻与早期拔牙位点保存术对拔牙位点骨量保存的疗效差异。方法:选取2023年1月至2024年1月中山市中医院口腔科门诊收治的因慢性牙周炎导致无保留价值的后牙患者45例,将患者随机分为A、B、C三组,每组1... 详细信息

目的:分析慢性牙周炎患者患牙拔除后,即刻与早期拔牙位点保存术对拔牙位点骨量保存的疗效差异。方法:选取2023年1月至2024年1月中山市中医院口腔科门诊收治的因慢性牙周炎导致无保留价值的后牙患者45例,将患者随机分为A、B、C三组,每组15例。A组为对照组,拔牙后清除感染组织,不进行位点保存,自然愈合;B组行即刻拔牙位点保存术;C组行早期拔牙位点保存术。三组患者均于术前及术后4个月进行锥形束计算机断层扫描(CBCT)检查,通过影像软件重叠同一位点影像,测量并比较牙槽骨的各维度空间骨量以及水平、垂直方向的骨量变化。结果:术后4个月,C组患者各维度空间骨量均高于A组、B组,差异具有统计学意义(P<0.05)。C组患者水平方向和垂直方向骨量变化均明显低于A组、B组,且B组垂直方向骨量变化低于A组,差异均具有统计学意义(P<0.05)。结论:早期拔牙位点保存术与即刻拔牙位点保存术均能一定程度上维持骨量,但早期拔牙位点保存术操作难度较低,手术时间短,术后反应小,因此慢性牙周炎患者患牙拔除后,可优先选择早期拔牙位点保存术作为拔牙后位点保存的方法。

关键词：慢性牙周炎即刻拔牙位点保存术早期拔牙位点保存术

Accelerated plasma degradation of organic pollutants in milliseconds and examinations by mass spectrometry

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Chinese Chemical Letters 2021年第11期32卷 3457-3462页

作者： Hua Lu Yiyan Yin Jianghui Sun Weixiang Li Xiaotong Shen Xiujuan Feng jin ouyang Na Na Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100085China School of Life Science Beijing Institute of TechnologyBeijing 100081China School of Mines China University of Mining&TechnologyBeijing 100085China

The rapid degradation of organic pollutants,process monitoring and online controlling to obtain advanced products and decreased by-products are great and challenging tasks in environmental ***,an accelerated plasma degradation in milliseconds was achieved by combining electrospray-based acceleration and plasma-based *** the degradation of chloroaniline as an example,97%of the degradation can be achieved in *** velocity distribution of droplets was determined to be 40-50 m/s after being degraded for 0.30 ms,which exhibited different degradation behaviors in different ***,by virtue of the real-time and on-line detection ability of ambient mass spectrometry,intermediates,by-products and advanced products were ***,degradation mechanisms for different degradation times were proposed,which would provide theoretical guidance on obtaining efficient and green *** fabrication,examining and understanding of accelerated plasma degradation not only enlarged application of accelerated reactions,but also promoted green and efficient degradation for environmental treatments.

关键词： Accelerated plasma degradation Organic pollutants Milliseconds Intermediates Ambient mass spectrometry Degradation Mechanisms

Carotid endarterectomy for ameliorating the symptoms of transient ischemic attack A six-month postoperative follow-up

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Neural Regeneration Research 2007年第12期2卷 764-768页

作者： Chenxi ouyang Bi jin Yiqing Li Jianyong Liu Weici Wang Department of Vascular Surgery Union Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Hubei Province China

BACKGROUND： Carotid endarterectomy has certain risks, but it has obvious effects on preventing the occurrence of stroke. OBJECTIVE： To identify the effects of carotid endarterectomy on ameliorating the clinical symptoms and physical signs of patients with cerebral ischemia. DESIGN： A follow-up study. SETTING： Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology. PARTICIPANTS： Sixteen patients with carotid atherosclerotic stenosis accompanied by ischemic symptoms were selected from the Department of Vascular Surgery, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology from March 2005 to May 2007. There were 11 males and 5 females, aged from 40 to 81 years old with a mean age of 60 years old, and they were all clearly diagnosed by carotid color Doppler ultrasound. Informed consent was obtained from all the patients. The study was approved by the hospital ethical committee. METHODS：（1） All the 16 patients were performed with unilateral stripping of arteriosclerotic plaque and Carotid endarterectomy, and 6 of them with bilateral stenosis was operated on the side with more serious stenosis. （2） The clinical symptoms, physical signs before and after operation, and the operative complications were observed. （3） The patients were followed up for 6 months postoperatively. The smoothness of carotid arteries was detected with color Doppler ultrasound. The degrees of satisfaction to the quality of living were evaluated. MAIN OUTCOME MEASURES：（1） Amelioration of clinical symptoms postoperatively; （2） Smoothness of carotid arteries postoperatively; （3） Degrees of satisfaction to the quality of living; （4） Postoperative complications. RESULTS： All the 16 patients were involved in the final analysis of results. （1） Amelioration of clinical symptoms and physical signs： The postoperative muscle strengths of 3 patients with stroke history were significantly ameliorated; For the

关键词： carotid endarterectomy cerebral ischemia stroke