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LncRNA GTL2 regulates myoblast proliferation and differentiation via the PKA-CREB pathway in Duolang sheep

Zoological Research 2024年第6期45卷 1261-1275页

作者： Qian Chen Jing-Jing Bao He-Chun Zhang Chang Huang Qian Zhao Ya-Bin Pu Lin Jiang adel Hosseiny Muhammad Ibrahim Tanveer Hussain Xiao-Hong He Yue-Hui Ma Qian-Jun Zhao Institute of Animal Science Chinese Academy of Agricultural Sciences(CAAS)Beijing 100193China Chaoyang Chaomu Breeding Farm Co. Ltd.ChaoyangLiaoning 122629China Department of Animal Breeding Desert Research CenterCairo 11435Egypt Department of Biological Sciences Virtual University of PakistanLahore 54000Pakistan

Long non-coding RNAs(lncRNAs),which are RNA molecules longer than 200 nucleotides that do not encode proteins,are implicated in a variety of biological processes,including growth and *** research into the role of lnc RNAs in skeletal muscle development,the regulatory mechanisms governing ovine skeletal muscle development remain *** this study,we analyzed the expression profiles of lnc RNAs in skeletal muscle from 90-day-old embryos(F90),1-month-old lambs(L30),and 3-year-old adult sheep(A3Y) using RNA *** total,4738 lnc RNAs were identified,including 997 that were differentially ***-time series expression miner analysis identified eight significant expression profiles and a subset of lnc RNAs potentially involved in muscle *** Encyclopedia of Genes and Genomes enrichment analysis revealed that the predicted target genes of these lnc RNAs were primarily enriched in pathways associated with muscle development,such as the c AMP and Wnt signaling ***,the expression of lnc RNA GTL2 was found to decrease during muscle ***,GTL2 was highly expressed during the differentiation of skeletal muscle satellite cells(SCs) and was shown to modulate ovine myogenesis by affecting the phosphorylation levels of PKA and ***,GTL2 was found to regulate both the proliferation and differentiation of SCs via the PKACREB signaling ***,this study provides a valuable resource and offers novel insights into the functional roles and regulatory mechanisms of lnc RNAs in ovine skeletal muscle growth and development.

关键词： Skeletal muscle LncRNA Skeletal muscle satellite cells Sheep PKA-CREB pathway

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The Use of M-Government and M-Health Applications during the COVID-19 Pandemic in Saudi Arabia

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Journal of Software Engineering and Applications 2022年第11期15卷 406-416页

作者： Ahad Abdulqader Allam Amer Nizar Abu Ali Wed H. Ghabban Alaaldin Alrowwad Najmah adel Fallatah Omair Ameerbakhsh Ibrahim M. Alfadli Fahad M. Ghabban Information System Department College of Computer Science and Engineering Taibah University Madina Saudi Arabia Applied College University of Tabuk Tabuk Saudi Arabia Department of Business School University of Jordan-Aqaba Branch Aqaba Jorden

The automated proficiencies of the Kingdom of Saudi Arabia, in vision 2030, influence a decade of continual expenditure in contemporary automation and unified government platforms. It affords a reliable base for the COVID-19 response’s significant facets, encompassing continued connection to many e-government systems. The worldwide COVID-19 epidemic has reinvigorated the role of e-government. The health crisis has altered SADAIA to lunch Tawakkalna m-government application to execute business continuity strategies, offer important services to people, and assure their fulfilment. The study intends to assess the impact of the COVID-19 pandemic on users’ satisfaction with m-government services and Health Care apps in the Al-Madinah region. It analyses the elements that enable people’s use of online government services, and m-government services are a solution to handle the crisis. The finding shows that trust in e-government, trust in the internet, ease of use and usefulness are the important factors in using the application during the pandemic.

关键词： M-Government M-Health Application COVID-19 Pandemic Citizens’ Satisfaction

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12 Years Analysis of Bacterial Isolates and Their Antibiotics Sensitivity in a Tertiary Care Burns Unit

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Modern Plastic Surgery 2016年第3期6卷 11-19页

作者： Said Saud Al-Busaidi Zainab Said Al-Hashimy adel Mohamed Hashish Sheikh Mohammad Ashik Iqbal Faruquee Hassan Ahmed Hamouda Ahmed Osama Abdulhamed Fawzi Mohamed Abdul-Aleem Department of Plastic Reconstructive and Craniofacial Surgery Khoula Hospital Muscat Sultanate of Oman Directorate of Pharmacy and Medical Stores Khoula Hospital Muscat Sultanate of Oman

The aim of this study was to review the changes in distribution of bacterial populations and their antibiotic sensitivity over 12 years in a tertiary care burn unit. Understanding the periodic variation of isolated microorganisms and their antibiotic sensitivity helps in selecting the appropriate antimicrobial therapy before culture and sensitivity are reported. It also aids the design of antibiotics protocols. The study was retrospective. The data were obtained from the computerised hospital medical record system and the burn unit records. Overall, Pseudomonas aeruginosa was the most commonly isolated microorganism followed by Staphylococcus aureus, Meticillin-resistant Staphylococcus aureus (MRSA), and the genus Acinetobacter. Acinetobacter isolation rose rapidly and became more prevalent than P. aeruginosa over the last three years. Other organisms became isolated more frequently, such as Klebsiella pneumoniae, but their overall prevalence was low. Pseudomonas species frequency of isolation declined. P. aeruginosa, MRSA, and other microorganisms showed increasing sensitivity to a number of antibiotics. MRSA remained highly sensitive to vancomycin, and Acinetobacter showed high resistance to all antibiotics tested except colistin. K. pneumoniae was highly resistant to most of the antibiotics tested except the carbapenems, but the resistance to carbapenems increased over time.

关键词： Burn Microorganism Antibiotic Resistance Sensitivity

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Different Analytical Methods of Para-Phenylenediamine Based Hair Dye

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Journal of Cosmetics, Dermatological Sciences and Applications 2013年第3期3卷 17-25页

作者： Hatem Abdel Moniem Ahmed Ragaa Mohamed Abdel Maaboud Fathy Fahim Abdul Latif adel Mohamed Kamal El-Dean Kamal Mohamed El-Shaieb Eugenio Vilanova Carmen Estevan Chemistry De- partment Faculty of Science Minia University Minia Egypt Chemistry Department Faculty of Science Assiut University Assiut Egypt Department of Forensic Chemistry Faculty of Forensic Sciences Naif Arab University for Security Sciences Riyadh Saudi Arabia Department of Forensic Medicine & Clinical Toxicology Faculty of Medicine Assiut University Assiut Egypt Institute of Bioengineering Unit of Toxicology and Chemical Safety University Miguel Hernández of Elche Elche Spain Institute of Bioengineering Unit of Toxicology and Chemical Safety University Miguel Hernández of Elche Elche Spain.

Many cases of toxicity and mortality either due to accidental or deliberate ingestion of hair dyes were reported in Egypt, Sudan, Israel, Morocco, Saudi Arabia, India and Tunisia. In the field of forensic analytical toxicology, the identification and quantification of chemicals are essential in deaths related to intoxication. The aim of the present study is to conduct chemico-analytical characterization of para-phenylenediamine (PPD) based hair dye of (Black stone hair dye, SHD) currently used for dying hear in Egypt, to confirm the identification of its components, that may be potentially toxic on oral or dermal exposure, this study uses comparison between different analytical methods. The applied analytical methods were inductively coupled plasma/MS (ICP/MS), witch used to determine the metal components of the dye, high performance liquid chromatography/MS (HPLC/MS) and gas chromatography/mass spectroscopy (GC/MS) were used for qualitative and quantitative analysis of PPD in the dye. A derivatization method was applied by transforming PPD (aromatic amines) into corresponding imine derivatives. This compound was prepared by condensation of 4-methylbenzeneamine with benzaldehyed to give N-benzylidene-4-methylbenzene-amine, which is a very stable internal standard. ICP/MS analysis revealed that most metal components of hair dye are Be, Na, Al, K, Ca, Sc, Ti, V, Cr, Mn, Fe, Cu, and Zr, where HPLC/MS analysis revealed that PPD is the main ingredient of SHD. Derivatization is necessary for accurate determination of PPD in hair dye by GC/MS method and this results could not be obtained by direct injection of dye (without derivatization).

关键词： PPD PPD1 Stone Hair Dye ICP HPLC/MS and GC/MS

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High Resolution Medium Energy ion Scattering Analysis for Investigating UltraShallow Junction of Antimony Implanted in Conventional Silicon

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材料科学与工程（中英文A版） 2016年第1期6卷 17-22页

作者： Talal H. Alzanki Kandil M. Kandil Chris Jeynes Brian J. Sealy Mohammad R. Alenezi AbdullahAlmeshal Naziha M. Aldukhanand adel Ghoneim Department of Electronic Engineering Collage of Technological Studies Public Authority for Applied Education &Training(PAAET) P.O. BOX 42325 Safat Kuwait Department of Applied Sciences Collage of Technological Studies Public Authority for Applied Education &Training (PAAET) P.O. BOX 42325 Safat Kuwait Advanced Technology Institute School of Electronics and Physical Sciences University of Surrey Guildford GU2 7XH UK

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Validation of a Method for Characterization of Ethanol in Water by HS-GC-FID to Serve the Traceability of Halal Measurements

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Green and Sustainable Chemistry 2024年第2期14卷 17-28页

作者： adel B. Shehata Abdulrahman R. Al Askar Mohammed A. Al Rasheed Abdulrahman M. Al Zahrany Fahd A. Al Kharraa Sowailem A. Al Sowailem Chemistry Department/National Measurement and Calibration Center (NMCC) Saudi Standards Metrology and Quality Organization (SASO) Riyadh Kingdom of Saudi Arabia

The determination of the ethanol content in food products is of fundamental importance for HALAL certification. In this work, an analytical method for the determination of ethanol in water by headspace gas chromatography with flame ionization detector (HS-GC-FID) has been developed and validated for the use in characterization of ethanol reference materials. The validation study was carried out in the linear calibration range 100 - 1500 mg/kg using the NIST SRM 2900, nominal 95.6%. The studied performance characteristics of the method were the limit of detection, LOD, the limit of quantification LOQ, selectivity, linearity, precision, recovery and bias. The validation results showed that the method is selective, precise, accurate and free from any significant bias. The LOD and LOQ were 1.27 and 3.86 mg/kg respectively and the estimated expanded uncertainty was 2% indicating that the method is fit for the purpose of certification of ethanol in water reference materials.

关键词： Ethanol HS-GC-FID Validation Linearity Precision Bias

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外资水务企业在华FDI对我国水务产业的影响及启示

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科技创业月刊 2016年第4期29卷 51-53页

作者：周伟 adel Ben Youssef(法) Grazia Cecere(法) Boulanger Mathieu(法) 武汉大学经济与管理学院武汉大学中国产学研合作问题研究中心湖北武汉430072 尼斯大学法国尼斯060000 巴黎电信管理学院法国巴黎91000

在回顾国内外有关水务产业引入竞争机制文献的基础上,探讨了外资水务在华FDI对我国水务产业的影响。最后,得出了对我国水务产业市场化改革的建议：对自然垄断环节和非自然垄断环节采用差异化战略;混合所有制改革与国际化是提升我国水务... 详细信息

在回顾国内外有关水务产业引入竞争机制文献的基础上,探讨了外资水务在华FDI对我国水务产业的影响。最后,得出了对我国水务产业市场化改革的建议：对自然垄断环节和非自然垄断环节采用差异化战略;混合所有制改革与国际化是提升我国水务企业竞争力的良方;关注“高溢价收购”背后的成本转移,加强政府管制力度。

关键词：外资水务企业对外直接投资(FDI) 水务产业

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The Effectiveness of Intraoperative Frozen Section Analysis of Safety Margins in Breast Conserving Surgery and the Role of Surgeon in Decreasing the Rate of Positive Margins

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Surgical Science 2017年第12期8卷 499-509页

作者： Omar Farouk Ahmed Senbel Mosab Shetiwy Essam Attia Ahmed Abdallah Osama El-Damshety Ashraf Khater Sameh Roshdy Amr Abouzid Amr Hossam Islam H. Metwally Omar Hamdy Amir M. Zaid Mahmoud Abdelaziz Mohamed Elmetwally adel Fathi Emad-Eldeen Hamed Khaled Abdel Wahab Wagdi El-Kashef Mohamed Hafez Khaled Zalata Mohamed Hegazy adel Denewer Surgical Oncology Department Oncology Center Faculty of Medicine Mansoura University Mansoura Egypt Pathology Department Faculty of Medicine Mansoura University Mansoura Egypt

Introduction: Nowadays the more accepted surgical option for treating early breast cancer is breast conserving surgery. The main challenge in this type of surgery is to get free safety margins without need of second surgical operation, so many breast surgeons have started to depend on intraoperative frozen sections to ensure free safety margins. Aim of work: To assess our policy that we prefer to depend on intraoperative frozen section analysis to get free safety margin in breast conserving surgery from the 1st surgery, and its oncologic outcome. Patients and Methods: This is a retrospective study conducted in Oncology Center—Mansoura University (OCMU), where the data of 219 patients with breast cancer, who were managed by breast conserving surgery with intraoperative frozen section analysis of the safety margins, was analyzed. Results: The intraoperative frozen section analysis of safety margin was negative from the start in 183 (83.6%) patients, while it was positive in 36 patients (16.4%). Intraoperative decision of margin re-excision was applied for 29 patients (13.2%) in order to reach negative margin, modified radical mastectomy was offered for 4 patients (1.8%), while nipple sparing mastectomy with immediate breast reconstruction using latissimus dorsi flap was offered for 3 patients (1.4%). The postoperative paraffin results were typical with intraoperative frozen section analysis results in 216 patients (98.6%) and different results were obtained in only 3 patients (1.4%) who were managed by modified radical mastectomy in a second operation. Only 4 patients had local recurrence (1.8%) during the period of follow-up duration which was ranged from 1 to 86 months with mean ± SD (22.3 ± 14.1). Conclusion: The intraoperative frozen section analysis of safety margins in breast conserving surgery has very high-rate typical results with the paraffin section analysis and it is very helpful in decreasing the rate of second surgical operation in cases of infiltrated m

关键词： Breast Conserving Surgery Intraoperative Frozen Section Analysis Safety Margins Breast

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选矿过程仿真程序包设计

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国外金属矿选矿 1984年第1期 1-8页

作者： G.T.adel K.V.S.Sastry 周贤渭加利福尼亚大学材料科学和矿物工程系加利福尼亚大学材料科学和矿物工程系

本文介绍由伯克利市加利福尼亚大学(University of California Berkeley)研制的选矿厂通用仿真器的要点。这种非实验性质的(state-of-the-art)结构化设计方法以“自顶而下”设计方法为基础用于构成一个完全结构化的模块化仿真器。它不... 详细信息

本文介绍由伯克利市加利福尼亚大学(University of California Berkeley)研制的选矿厂通用仿真器的要点。这种非实验性质的(state-of-the-art)结构化设计方法以“自顶而下”设计方法为基础用于构成一个完全结构化的模块化仿真器。它不受单项作业模型和程序的限制。这种仿真器提供了两种操作水平。即能够按预定的流程或者按用户编制的流程进行仿真,操作水平的选择取决于用户对计算机知识了解的程度。这种仿真器的设计原理在流程仿真领域内可认为是独具一格的。本文还列举了一个简单的实例解说明仿真器的用法。

关键词：仿真器程序库执行程序编译程序仿真程序包工厂设计程序块用户接口结构化自顶而下选矿厂加工厂

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Reaction of Nitrilimines with 2-Aminopicoline, 3-Amino-1,2,4-Triazole, 5-Aminotetrazole and 2-Aminopyrimidine

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International Journal of Organic Chemistry 2014年第3期4卷 201-207页

作者： Rami Y. Morjan Basam S. Qeshta Hussein T. Al-Shayyah John M. Gardiner Basam A. Abu-Thaher adel M. Awadallah Department of Chemistry Islamic University of Gaza Gaza Palestine Manchester Institute of Biotechnology School of Chemistry and EPS The University of Manchester Manchester UK

The reaction of picoline derivatives 3-6 with hydrazonoylhalide 1a produced imidazo[1,2-a]pyridines 7-10, while the reaction of the same picoline derivatives with hydrazonoylhalide 1b afforded imidazo[1,2-a]pyridine-2-ones 11-13. The reaction of 1b, c with 3-amino-1,2,4-triazole 14 produced the acyclic adducts 18 and 19, respectively. Reaction of 1b, 1c with 5-aminotetrazole 20 produced the acyclic products 23 and 24, respectively. Finally, the reaction of 1b with 4, 6-dimethyl-2-aminopyrimidine 27 afforded compound 29 rather than its isomeric structure 28. The structure of the products was confirmed by the different spectroscopic analytical methods including IR, MS, 1HNMR and 13CNMR.

关键词： Nitrilimines Picolines Imidazo[1 2-a]Pyridine Triazoles Tetrazoles Pyrimidines

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