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Efficacy and safety of LY01005 versus goserelin implant in Chinese patients with prostate cancer: A multicenter, randomized, open-label, phase III, non-inferiority trial

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Chinese Medical Journal 2023年第10期136卷 1207-1215页

作者： Chengyuan Gu Zengjun wang Tianxin Lin Zhiyu Liu Weiqing Han Xuhui zhang Chao Liang Hao Liu Yang Yu Zhenzhou Xu Shuang Liu Jingen wang Linghua Jia xin Yao Wenfeng Liao Cheng Fu Zhaohui Tan Guohua He Guoxi Zhu Rui Fan Wenzeng Yang xin Chen Zhizhong Liu Liqiang Zhong Benkang Shi Degang Ding Shubo Chen Junli Wei Xudong Yao Ming Chen Zhanpeng Lu Qun xie Zhiquan Hu Yinhuai wang Hongqian Guo Tiwu Fan Zhaozhao Liang Peng Chen Wei wang Tao Xu Chunsheng Li Jinchun xing Hong Liao Dalin He Zhibin wu Jiandi Yu Zhongwen Feng Mengxiang Yang Qifeng Dou Quan Zeng Yuanwei Li xin Gou Guangchen Zhou xiaofeng wang Rujian Zhu Zhonghua zhang bo zhang Wanlong Tan Xueling Qu Hongliang Sun Tianyi Gan Dingwei Ye Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Urology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong 510120China Department of Urology The Second Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116023China Department of Urology The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityHunan Cancer CenterChangshaHunan 410013China Department of Urology First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030000China Department of Urology Jiangxi Provincial People’s HospitalSchool of MedicineNanchang UniversityNanchangJiangxi 330006China Department of Urology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Urology Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyangLiaoning 110043China Department of Urology Inner Mongolia People’s HospitalHohhotInner Mongolia 010010China Department of Urinary Surgery Taizhou Hospital of Traditional Chinese MedicineTaizhouJiangsu 225300China Department of Urology Linfen People’s HospitalLinfenShanxi 041000China Department of Urology Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhouHenan 450006China Department of Urology The Affiliated Hospital of Hebei UniversityBaodingHebei 071000China Department of Urology Chifeng Municipal HospitalChifeng Clinical Medical College of Inner Mongolia Medical UniversityChifengInner Mongolia 024000China Department of Urology Baogang HospitalBaotouInner Mongolia 014010China Department of Oncology The Second People’s Hospital of YibinYibinSichuan 644000China Department of Urology Qilu Hospital of Shandong UniversityJinanShandong 250014China Department of Urology Henan Provincial People’s Hos

Background:LY01005(Goserelin acetate sustained-release microsphere injection)is a modified gonadotropin-releasing hormone(GnRH)agonist injected *** phase III trial study aimed to evaluated the efficacy and safety of LY01005 in Chinese patients with prostate ***:We conducted a randomized controlled,open-label,non-inferiority trial across 49 sites in *** study included 290 patients with prostate cancer who received either LY01005 or goserelin implants every 28 days for three *** primary efficacy endpoints were the percentage of patients with testosterone suppression≤50 ng/dL at day 29 and the cumulative probability of testosterone≤50 ng/dL from day 29 to ***-inferiority was prespecified at a margin of-10%.Secondary endpoints included significant castration(≤20 ng/dL),testosterone surge within 72 h following repeated dosing,and changes in luteinizing hormone,follicle-stimulating hormone,and prostate specific antigen ***:On day 29,in the LY01005 and goserelin implant groups,testosterone concentrations fell below medical-castration levels in 99.3%(142/143)and 100%(140/140)of patients,respectively,with a difference of-0.7%(95%confidence interval[CI],-3.9%to 2.0%)between the two *** cumulative probabilities of maintaining castration from days 29 to 85 were 99.3%and 97.8%,respectively,with a between-group difference of 1.5%(95%CI,-1.3%to 4.4%).both results met the criterion for *** endpoints were similar between *** treatments were ***01005 was associated with fewer injection-site reactions than the goserelin implant(0%vs.1.4%[2/145]).Conclusion:LY01005 is as effective as goserelin implants in reducing testosterone to castration levels,with a similar safety *** registration:***,NCT04563936.

关键词： Prostatic neoplasms LY01005 Gonadotropin-releasing hormone agonist Efficacy Safety

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多段进水A/O生物接触氧化工艺模拟

地球科学与环境学报 2021年第5期43卷 908-916页

作者：吴沛朱继涛顾鑫张凯冷峻彤王子捷胡博长安大学建筑工程学院陕西西安710061 长安大学住房和城乡建设部给水排水重点实验室陕西西安710061

基于活性污泥1号数学模型(ASM1),结合Fick扩散定律建立了多段进水A/O生物膜工艺数学模型,并采用处理高浓度生活污水的三段进水A/O生物接触氧化工艺的试验结果对模型进行了验证和校验。最后,采用建立的模型研究了工艺的最佳进水流量分配... 详细信息

基于活性污泥1号数学模型(ASM1),结合Fick扩散定律建立了多段进水A/O生物膜工艺数学模型,并采用处理高浓度生活污水的三段进水A/O生物接触氧化工艺的试验结果对模型进行了验证和校验。最后,采用建立的模型研究了工艺的最佳进水流量分配系数。结果表明:(1)多段进水A/O生物接触氧化工艺对高浓度生活污水有较好的处理效果,当工艺的内回流比控制在0.75~1.00时,可以达到较高的总氮去除效率(>85%);(2)建立的模型可以很好地模拟三段进水A/O生物接触氧化工艺的运行;(3)当进水碳氮比为10时,模拟得到的工艺最佳流量分配系数分别为0.5、0.3和0.2。该模型能够用于多段进水A/O生物接触氧化工艺各处理单元内发生的生化反应过程的模拟,对多段进水A/O生物接触氧化工艺的运行和设计有指导意义。

关键词：多段进水缺氧/好氧生物接触氧化工艺活性污泥1号数学模型流量分配系数回流比去除效率模拟

Study protocol:A cross-sectional study on psychology and behavior investigation of Chinese residents,PBICR

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Psychosomatic Medicine Research 2022年第3期4卷 30-41页

作者： Yu-Jia wang Ayidana Kaierdebieke Si-Yuan Fan Rui-Feng zhang Meng-Jie Huang Han Li xiao-Nan Sun Qi-Yu Li Wen-Jia Meng Wen-Yu wu Zhi Lin Jing-Yao Liu xin-Pei wang Yun-Chou wu Jing-Qi Tang Yi-Ke Sun Ke Chen Pu Ge Wai-Kit Ming Casper zhang Zheng Feei Ma Lei Feng xin-Yue zhang Yu-Yao Niu Yu-Pei Yan Yi-Le Jin Guang-Ze Gao Shuang Dai Yu-Liu Li Yue Tan Yi-Wei wu Qi zhang Gui Gui xian-Li Pan Yan-Ming Liao xian-Qi Zhao Ya-Ting zhang Hui-Yi Chen Yue-Wei Qiu xiao-Min Fu Jiang-Ling Zhou Dan Li Ke-Han Li Meng-Wei Xu Zhe wang Yue-Qi wang Yong Ma xin-Ying Sun Yi-bo wu College of Humanities and Social Science Harbin Medical UniversityHarbin150081China School of Public Health Xi'an Jiaotong UniversityXi'an710061China Department of Preventive Medicine Yanjing Medical CollegeCapital Medical UniversityBeijing101300China Preschool Education Guangzhou Huangpu District Phoenix Lake KindergartenGuangzhou510000China School of Public Health Shandong UniversityJinan250012China National Drug Clinical Trial Institute The Second Affiliated HospitalXi'an Jiaotong UniversityXi'an741004China School of Humanities and Health Management Jinzhou Medical UniversityJinzhou121000China School of Arts and Media The University of New South WalesSydneyNSW 2052Australia School of Health Management Harbin Medical UniversityHarbin150081China College of Communication and Art Design University of Shanghai for Science and TechnologyShanghai200093China Medical Equipment Department Peking University First HospitalBeijing100034China School of Philosophy Anhui UniversityHefei230039China College of Integrated Traditional Chinese and Westem Medicine Jining Medical UniversityJining272000China Faculty of Health Sciences University of MacaoMacao999078China Jockey Club College of Veterinary Medicine and Life Sciences City University of Hong KongHong KongChina School of Public Health The University of Hong KongHong Kong000000China Centre for Public Health and Wellbeing School of Health and Social WellbeingCollege of HealthScience and SocietyUniversity of the West of EnglandBristol BS161QYUK Centre For Life Science National University of Singapore117456Singapore School of Stomatology Zhejiang University School of MedicineHangzhou 310006China Faculty of Arts and Humanities University of MacaoMacao999078China Department of Humanities Arts and MediaChangzhi Medical CollegeChangzhi046013China Baotou Clinical College Inner Mongolia Medical UniversityBaotou010110China Tongliao Clinical College Inner Mongolia Medical UniversityTongliao010110China School of Ima

Objective:This study protocol identifies the basic research route and framework of psychological and behavioral surveys among Chinese residents,aims establishing a database through a multicenter,large-sample cross-sectional survey in China to provide strong data support for research development in various fields and a more comprehensive and systematic understanding of the physical and mental health status of the ***:The study was conducted from June 20,2022 to August 31,2022,using stratified sampling and quota sampling methods,a total of 148 cities,202 districts and counties,390 townships/towns/sub-districts,and 780 communities/villages(excluding Hong Kong,Macao,and Taiwan)from 23 provinces,5 autonomous regions,and 4 municipalities directly under the central government in China were *** questionnaire was distributed one-on-one and face-to-face to the public by trained investigators,and the questionnaire included eight aspects:personal basic information,personal health status,family basic information,social environment in which they were located,psychological level scale,behavioral level scale,other scales,and attitude towards social hot *** analysis will be performed after questionnaire ***:Data collection is *** findings will support physical and mental health research and strategy development in China and even globally,guiding policy-makers and health care organizations to reform their programs to ensure the best interests of residents and their families.

关键词： Chinese residents Psychology Behavior Cross-sectional survey

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赛艇训练多参数遥测系统的研制

西安体育学院学报 2005年第4期22卷 78-81页

作者：欧阳波王培勇沈杜张鑫时永乐清华大学人文学院北京100084 清华大学生物医学工程系北京100084

根据教练员的要求选择桨频和心率作为测量参数,利用干簧管传感器和导电橡胶心电传感器分别检测桨频和心率信号;使用单片机对数据进行计算并将结果通过段式液晶显示器件进行显示,同时将数据存储在E2PROM里无线传输模块采用成熟产品数据... 详细信息

根据教练员的要求选择桨频和心率作为测量参数,利用干簧管传感器和导电橡胶心电传感器分别检测桨频和心率信号;使用单片机对数据进行计算并将结果通过段式液晶显示器件进行显示,同时将数据存储在E2PROM里无线传输模块采用成熟产品数据可通过串行接口传送到PC计算机,实现了数据的保存、回放、分析和打印等功能经过初步实验,系统解决了国家赛艇队教练不能实时得到运动员训练数据的难题。

关键词：遥测系统赛艇多参数研制液晶显示器件 PC计算机运动员训练导电橡胶成熟产品无线传输数据存储传感器教练员单片机实用性心率

Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-Bin Ling Qiao-Nan Shan Xu-Yong Wei Rui wang Chang-Ku Jia Li Zhuang Tian Shen Li-Min Ding Zhi-Dan Xu Lai-Bang Luo Li-bo Sun Guang-Ming Li Tai-Shi Fang Nan Jiang Kun zhang Zhao-Jie Su Zhi-Hai Peng Ren Lang Tao Jiang Qiang He Lin-Sen Ye Yang Yang Yu-Ting He Wen-Zhi Guo Liu-Gen Lan Xu-Yong Sun Dong Chen Zhi-Shui Chen Da-Wei Zhou Shao-Jun Ye Qi-Fa Ye Min Tian Jian-Hua Shi bo wang Jiang Liu Qian Lu Wei Rao Jin-Zhen Cai Tao Lv Jia-Yin Yang Pu-Sen wang Lin Zhong Jing-Sheng Ma Qi-Gen Li Sheng-Dong wu Chang-Jiang Lu Cai-De Lu Dong-Hua zhang Xuan wang Zi-Qiang Li Mu-Jian Teng Jun-Jie Li Wen-Tao Jiang Jian-Hua Li Quan-Bao zhang Ning-Qi Zhu Zheng-xin wang Kang He Qiang xia Shao-Hua Song Zhi-Ren Fu Wei Qiu Guo-Yue Lv Rui-Peng Song Ji-Zhou wang Zheng wang Jian Zhou Gang Chen Ying-Peng Zhao Li Li Ze-Min Hu Qi-Jie Luo Zhong-Zhou Si Bin xie xiao-Shun He Zhi-Yong Guo Shu-Sen Zheng xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China Liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and Liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma Liver transplantation Conversion

VB12负载纳米零价镍固定地下水中U(Ⅵ)/Se(Ⅳ)的效能研究

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环境化学 2023年第11期42卷 4032-4042页

作者：吴兴农李小燕温馨王澜付晓辉刘小亮黄希张益硕刘波东华理工大学核辐射探测及应用工程研究中心南昌330013 江西省辐射环境监督站南昌330013

本研究用液相还原法制备了VB12负载纳米零价镍(VB12@nZVNi)复合材料,通过动态试验探讨了复合材料原位固定地下水中U(Ⅵ)/Se(Ⅳ)的固定效果.运用Thomas、Yoon-Nelson模型对所得试验数据进行拟合,讨论VB_(12)@nZVNi固定U(Ⅵ)/Se(Ⅳ)的性能... 详细信息

本研究用液相还原法制备了VB12负载纳米零价镍(VB12@nZVNi)复合材料,通过动态试验探讨了复合材料原位固定地下水中U(Ⅵ)/Se(Ⅳ)的固定效果.运用Thomas、Yoon-Nelson模型对所得试验数据进行拟合,讨论VB_(12)@nZVNi固定U(Ⅵ)/Se(Ⅳ)的性能.结果表明,VB_(12)@nZVNi材料对模拟U(Ⅵ)/Se(Ⅳ)污染地下水有着较好的固定效果,对U(Ⅵ)/Se(Ⅳ)的最大吸附量分别为106.96 mg·g^(-1)、103.92 mg·g^(-1).Yoon-Nelson、Thomas模型符合其动态吸附过程,且理论吸附量和半穿透率与实际值比较接近.因此,VB_(12)@nZVNi可以作为一种有前景的固定材料,用于含U(Ⅵ)/Se(Ⅳ)地下水的固定和净化处理.

关键词：维生素B12 纳米零价镍负载铀(Ⅵ) 硒(Ⅳ) 地下水

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红河断裂带北、中段近期重力变化及深部变形

地震地质 2021年第6期43卷 1537-1562页

作者：汪健申重阳孙文科谈洪波胡敏章梁伟锋韩宇飞张新林吴桂桔王青华中国地震局地震研究所地震大地测量重点实验室武汉430071 中国科学院大学地球与行星科学学院北京100049 中国地震局第二监测中心西安710054 中国地震台网中心北京100045 云南省地震局昆明650041

地表地质调查与深部地球物理探测结果表明,红河断裂带北、中段地壳结构与变形具有显著的横向差异性。为检测其地壳现今深部物质迁移和变形特征,文中利用红河断裂带北、中段2013—2019年3条流动重力剖面的观测资料,经分析和去除地表垂直... 详细信息

地表地质调查与深部地球物理探测结果表明,红河断裂带北、中段地壳结构与变形具有显著的横向差异性。为检测其地壳现今深部物质迁移和变形特征,文中利用红河断裂带北、中段2013—2019年3条流动重力剖面的观测资料,经分析和去除地表垂直运动、地表水循环、剥蚀和冰川均衡调整引起的重力效应,获取了地壳深部物质迁移引起的趋势性重力变化信息。结果表明,红河断裂带近期的重力动态变化具有分段性特征:北段、中段和中南段剖面的平均变化率为(-0.39±1.30)μGal/a、(0.16±1.57)μGal/a和(0.29±1.25)μGal/a,北段剖面以红河断裂为界,NE侧呈负变化、SW侧呈正变化,SW侧相对NE侧以(3.1±0.55)μGal/a·100km的重力变化率增加,反映出青藏高原物质东流背景下深部物质跨越红河断裂带后受澜沧江刚性块体阻挡、质量不断累积的特征;中段剖面断裂带区域的重力变化率比两侧低,体现了红河断裂的深部控制作用;中南段剖面的重力整体呈正变化,反映了印支、华南块体与川滇菱形地块间相互侧向挤压、深部物质累积的性质。基于重力变化反演的莫霍面变形结果表明:近期红河断裂带的莫霍面平均以0.54cm/a的速率持续隆升,北段、中段和中南段的平均变形速率为-0.06cm/a、1.36cm/a、0.32cm/a,在一定程度上反映出区域非均衡构造运动作用;北段莫霍面自东向西由下沉逐渐转为隆升;中段东侧隆升、西侧下沉;中南段变形速率低且两侧差异小;红河断裂带区域的变形速率明显低于两侧地块,体现了其对地壳深部变形较强的边界控制作用。文中的研究结果可为青藏高原东南缘断裂活动性研究提供新的约束。

关键词：红河断裂带重力变化重力反演质量迁移深部变形

P53表达对双表达淋巴瘤患者预后影响的研究

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中国实验血液学杂志 2019年第5期27卷 1504-1514页

作者：丁欣侯淑玲李雅琴李喜李丽连科王刚刚武晓博张振华刘虎王艳强张巧花山西医科大学山西医科大学附属大医院山西太原030000 山西医科大学淋巴肿瘤科山西太原030000 山西医科大学病理科山西太原030000

目的:研究P53表达对双表达淋巴瘤(double expressor lymphoma,DEL)患者预后的影响,以及MYC、BCL2和P53表达三者间的相互作用。方法:选择山西医科大学附属大医院2012年9月1日至2018年5月31日经明确病理诊断的初诊DLBCL患者88例,采用免疫... 详细信息

目的:研究P53表达对双表达淋巴瘤(double expressor lymphoma,DEL)患者预后的影响,以及MYC、BCL2和P53表达三者间的相互作用。方法:选择山西医科大学附属大医院2012年9月1日至2018年5月31日经明确病理诊断的初诊DLBCL患者88例,采用免疫组织化学(IHC)技术检测淋巴组织标本MYC、BCL2、P53、CD10、BCL6、MUM1和Ki-67的表达。用Kaplan-Meier法和Log-rank检验进行生存分析和比较,利用单因素和多因素分析MYC、BCL2和P53表达对预后的影响。结果:对比P53^-组患者,P53^+组患者LDH水平和NCCN-IPI评分更高,治疗总有效率(ORR)更低,总生存时间更短,死亡率更高(P值均小于0.05)。在MYC^+、BCL2^+或MYC^+/BCL2^+的DLBCL患者中,P53^+患者的OS显著更短(P0.05);在伴有MYC^+/P53^+、MYC^+/BCL2^+和BCL2^+/P53^+的DLBCL患者中,MYC^+/P53^+过表达组OS最短(3年OS率为31.6%),其次是MYC^-/BCL2^+/P53^+组(3年OS率为46.2%),MYC^+/BCL2^+/P53^-组OS较长(3年OS率为63.6%)(P值均小于0.05)。COX比例风险回归模型分析显示,本队列中P53表达和NCCN-IPI是独立预后因子。结论:P53与MYC表达对DLBCL患者预后有负协同作用;P53表达加强了MYC^+/BCL2^+双表达淋巴瘤患者的不利预后;MYC^+/P53^+共表达比MYC^+/BCL2^+双表达患者预后更差。

关键词：弥漫大B细胞淋巴瘤 P53 MYC BCL2 预后

光纤光栅传感技术在水下挤密砂桩挤密扩径研究中的应用

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中国港湾建设 2015年第8期35卷 14-16,84页

作者：吴心怡王海燕胡小波张曦中交上海三航科学研究院有限公司上海200032

将光纤光栅传感测试技术应用于水下挤密砂桩沉桩过程桩身应力、桩端阻力以及加速度测试,基于测试数据分析得到挤密扩径过程中动端阻力与理论计算单桩极限承载力的关系、挤密扩径后期动端阻力随时间的变化以及动端阻力与沉降速率的关系,... 详细信息

将光纤光栅传感测试技术应用于水下挤密砂桩沉桩过程桩身应力、桩端阻力以及加速度测试,基于测试数据分析得到挤密扩径过程中动端阻力与理论计算单桩极限承载力的关系、挤密扩径后期动端阻力随时间的变化以及动端阻力与沉降速率的关系,提出水下挤密砂桩挤密扩径过程终桩控制标准的建议,对于提高挤密砂桩质量控制有积极意义。

关键词：光纤光栅(FBG) 挤密砂桩扩径动端阻力