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发挥图书馆教育功能铸牢中华民族共同体意识

民族教育研究 2023年第5期 12-18页

作者：谢欧张学敏西南大学西南民族教育与心理研究中心教师教育学院重庆400715 西南大学西南民族教育与心理研究中心重庆400715

图书馆作为公共文化服务机构,在铸牢中华民族共同体意识过程中发挥着不可替代的作用。作为文化存在的图书馆内蕴文化认同教育价值,作为教育存在的图书馆亦是激活公众集体记忆的重要载体。因此,图书馆教育与铸牢中华民族共同体意识存在... 详细信息

图书馆作为公共文化服务机构,在铸牢中华民族共同体意识过程中发挥着不可替代的作用。作为文化存在的图书馆内蕴文化认同教育价值,作为教育存在的图书馆亦是激活公众集体记忆的重要载体。因此,图书馆教育与铸牢中华民族共同体意识存在三重耦合连接,其宣传功能塑造中华民族主体的共同体意识认知、文化功能提供中华民族共同体意识教育的文化养料、对话功能建构中华民族共同体意识教育的个人空间与社交空间。基于此三重耦合连接,图书馆需把握保持历时性和长时性影响的时间维浸润要义、保持空间传播面覆盖性的空间维集成要义,以及确保中华民族共同体意识引领的建设要义,最终通过其教育价值的有效发挥更好地实现铸牢中华民族共同体意识。

关键词：图书馆铸牢中华民族共同体意识公共教育文化认同空间涵养

Green Vertical‑Cavity Surface‑Emitting Lasers Based on InGaN Quantum Dots and Short Cavity

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Nano-Micro Letters 2023年第12期15卷 115-125页

作者： Tao Yang Yan‑Hui Chen Ya‑Chao Wang Wei ou Lei‑Ying Ying Yang mei Ai‑Qin Tian Jian‑Ping Liu Hao‑Chung Guo Bao‑Ping Zhang Laboratory of Micro/Nano‑Optoelectronics School of Electronic Science and EngineeringXiamen UniversityXiamen 361005FujianPeople’s Republic of China Suzhou Institute of Nano‑Tech and Nano‑Bionics Chinese Academy of SciencesSuzhou 215123JiangsuPeople’s Republic of China Department of Photonics National Yang Ming Chiao Tung UniversityHsinchu 30010TaiwanPeople’s Republic of China Semiconductor Research Center Honhai Research InstituteNew Taipei 220236TaiwanPeople’s Republic of China

Room temperature low threshold lasing of green GaNbased vertical cavity surface emitting laser(VCSEL)was demonstrated under continuous wave(CW)operation.By using self-formed InGaN quantum dots(QDs)as the active region,the VCSEL emitting at 524.0 nm has a threshold current density of 51.97 A cm^(-2),the lowest ever reported.The QD epitaxial wafer featured with a high IQE of 69.94%and theδ-function-like density of states plays an important role in achieving low threshold current.Besides,a short cavity of the device(~4.0λ)is vital to enhance the spontaneous emission coupling factor to 0.094,increase the gain coefficient factor,and decrease the optical loss.To improve heat dissipation,AlN layer was used as the current confinement layer and electroplated copper plate was used to replace metal bonding.The results provide important guidance to achieving high performance GaN-based VCSELs.

关键词： Green vertical cavity surface emitting laser GaN Low threshold InGaN quantum dots

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粗纺绒线双面机绣产品的开发

毛纺科技 2015年第4期43卷 6-10页

作者：龚雪鸥清华大学美术学院北京100084

研究了运用新型水溶性纤维对粗纺羊绒纱线进行处理的多种方法,以及如何改进绒线强度、捻度、纱支等以满足机绣用纱的要求。使用60 Nm羊绒和水溶性纤维按45∶55质量比混纺的纱线,同时解决了机绣设备硬件配置和打版设计等技术难题,在田岛... 详细信息

研究了运用新型水溶性纤维对粗纺羊绒纱线进行处理的多种方法,以及如何改进绒线强度、捻度、纱支等以满足机绣用纱的要求。使用60 Nm羊绒和水溶性纤维按45∶55质量比混纺的纱线,同时解决了机绣设备硬件配置和打版设计等技术难题,在田岛多功能刺绣机TMLHⅡ-902型设备上开发出具有独特质感和外观效果的粗纺绒线双面机绣产品,开辟了粗纺绒线在纺织行业中的新应用,为绒线机绣产品创新提供了新的技术支撑点,为羊绒产品生产企业提供了借鉴。

关键词：粗纺羊绒纱线水溶性纤维双面机绣产品开发

Role of exosomal long non-coding RNAs in colorectal cancer

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World Journal of Gastrointestinal Oncology 2021年第8期13卷 867-878页

作者： Ru Sun Xiao-Yun He Cheng mei Chun-Lin ou Department of Blood Transfusion Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Blood Transfusion Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

Exosomes are a class of small extracellular vesicles,30-150 nm in diameter,that transfer biological information(e.g.,DNA,RNA,and protein)via cell-to-cell communication.Exosomes play critical roles in the occurrence and development of human cancers,including colorectal cancer(CRC).Recent studies have shown that long non-coding RNAs(lncRNAs)can be encapsulated in exosomes,which transfer lncRNAs from secretory cells into recipient cells.This process affects the progression of CRC,since exosomal lncRNAs display special and extensive functions in CRC tumorigenesis,including malignant proliferation,metastasis,chemoresistance,and inflammatory response.Moreover,due to their specificity and sensitivity,exosomal lncRNAs are released into body fluids(e.g.,urine,sputum,and plasma),which have the potential to be biomarkers of CRC tumorigenesis within screening efforts and medical and epidemiologic research.In this review,we aim to clarify the function and mechanism of exosomal lncRNAs in CRC tumorigenesis and provide a strategy for early diagnosis and medical treatment of this malignancy.

关键词： Exosomes Long non-coding RNAs Colorectal cancer Chemoresistance Inflammatory response Therapy

Relation Between Cellular Senescence and Liver Diseases

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Chinese Medical Sciences Journal 2016年第2期31卷 121-126页

作者： Guo-wen Li xue-feng Yang Nian Fu Yan ou-yang Kai Qing Department of Gastroenterology the Affiliated Nanhua Hospital of University of South China

Cellular senescence refers to a process that cellular proliferation and differentiation modulated by the multiple stimulating factors gradually decline. Aging cells present the irreversible stop of proliferation and differentiation and change in secretory function because the cell cycle of aging cells is steadily blocked at some point. It has have been shown that cellular senescence plays an important role in the occurrence and development of liver diseases. In this paper, we review the advances in relations between cellular senescence and liver diseases.

关键词： cellular senescence mechanism liver diseases liver fibrosis liver cancer

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超声弹性成像定量分析脂肪肝的初步探讨

中国医科大学学报 2009年第8期38卷 632-634页

作者：李银燕王学梅张义侠欧国成中国医科大学附属第一医院超声诊断科沈阳110001

目的探讨超声弹性成像定量诊断脂肪肝的应用价值。方法选择轻度、中度、重度脂肪肝患者77例,设正常对照组30例,使用超声弹性成像技术测量感兴趣区域内蓝色区域面积并计算比值。结果各组间超声弹性成像图像表现有不同特点。感兴趣区域内... 详细信息

目的探讨超声弹性成像定量诊断脂肪肝的应用价值。方法选择轻度、中度、重度脂肪肝患者77例,设正常对照组30例,使用超声弹性成像技术测量感兴趣区域内蓝色区域面积并计算比值。结果各组间超声弹性成像图像表现有不同特点。感兴趣区域内蓝色区域面积比值在各组脂肪肝之间比较有显著差异。结论超声弹性成像感兴趣区域内蓝色区域面积比值可作为定量分析脂肪肝的参考指标。

关键词：超声弹性成像脂肪肝定量分析

In situ deformation behavior of TC21 titanium alloy with different α morphologies(equiaxed/lamellar)

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Rare Metals 2021年第5期40卷 1173-1181页

作者： Wei Long mei-Gui ou Xi-Qin Mao Yi-Long Liang College of Materials and Metallurgy Guizhou UniversityGuiyang 550025China Key Laboratory for Materials Structure and Strength of Guizhou Province Guizhou UniversityGuiyang 550025China National Local Joint Engineering Laboratory for High Performance Metal Structure Materials and Manufacturing Technology Guizhou UniversityGuiyang 550025China

To study the effect ofαphase morphology(equiaxedα(αE)/lamellarα(αL))on the in situ tensile behavior of TC21 alloy,the slip band,dislocation,crack initiation,and propagation were analyzed by scanning electron microscopy(SEM)with in situ tensile stage and transmission electron microscopy(TEM).The results show that the slip bands first concentrate in theαE phases and easily truncate at theα/βphase boundaries,whereas the slip bands move across theαlamellae in theαL phase.Microcracks are easily generated inαE orα/βphase boundaries with large plastic deformation.When the quantity ofαL is more thanαE,the crack tip is more easily deflected atαphases orαclusters with different orientations,making the main crack propagation path more zigzag.When the volume fraction ratio ofαE toαL is~3:4,i.e.,the volume fraction ofαE is close to that ofαL,TC21 alloy exhibits better strength and slower crack propagation rate.

关键词： In situ tensile TC21 alloy Equiaxed Lamellar αPhase

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肿瘤新生血管靶向超声造影剂的实验研究

实用药物与临床 2011年第6期14卷 457-459,F0003页

作者：李银燕王学梅欧国成中国医科大学附属第一医院超声科沈阳110001

目的制备分别携带VEGF和CD34抗体以及同时携带2种抗体的靶向超声造影剂,并对其体外寻靶能力及免疫活性进行鉴定。方法采用吸附法制造3种靶向超声造影剂,每种靶向超声造影剂又根据微泡与抗体的配比比例及pH值具体各分为6组,共18组(实验组... 详细信息

目的制备分别携带VEGF和CD34抗体以及同时携带2种抗体的靶向超声造影剂,并对其体外寻靶能力及免疫活性进行鉴定。方法采用吸附法制造3种靶向超声造影剂,每种靶向超声造影剂又根据微泡与抗体的配比比例及pH值具体各分为6组,共18组(实验组)。使用荧光免疫法,在体外鉴定每个实验组的寻靶能力及免疫活性。同时,设普通造影剂对照组、二抗代替一抗对照组。在电镜下计算靶向超声造影剂的结合率,并进行比较。结果电镜及光镜下观察,靶向超声造影剂为圆形,大小及分布较均匀,无任何聚集现象。荧光显微镜下观察,MBV实验组、MBC实验组、MBB实验组与靶向超声微泡结合的内皮细胞胞浆表达为绿色,而未与靶向超声微泡结合的内皮细胞及其他实验组、普通造影剂对照组与二抗代替一抗对照组均未表达。电镜下观察,靶向超声微泡组部分内皮细胞与靶向微泡结合,MBV实验组的结合率为3.475 5%±0.139 2%,MBC实验组的结合率为3.544 4%±0.214 5%,MBB实验组的结合率为3.682%±0.124 6%,各组比较差异无统计学意义(P>0.05),而其他实验组及对照组未见与微泡结合的内皮细胞。结论自制的3种靶向超声造影剂在体外有寻靶能力及免疫活性,可用于动物肿瘤模型新生血管的体内特异性靶向显影的实验研究。

关键词：靶向超声造影剂肿瘤新生血管 VEGF CD34

Anti-inflammatory mechanism of rhein in treating asthma based on network pharmacology

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Journal of Traditional Chinese Medicine 2022年第2期42卷 296-303页

作者： FENG Junfang CHEN ou WANG Yibiao Department of Pediatrics the Second HospitalCheeloo College of MedicineShandong UniversityJinan 250033China School of Nursing Cheeloo College of MedicineShandong UniversityJinan 250012China

OBJECTIVE:To predict the anti-inflammatory targets and related pathways of rhein in the treatment of asthma by using network pharmacology,and to further explore its potential mechanism in asthma.METHODS:The corresponding targets of rhein were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),and the rhein-target network was constructed with Cytoscape 3.7.1 software.The Genbank and Drugbank databases were used to collect and screen asthma targets,and the rhein-target-disease interaction network was constructed.A target protein-protein interaction(PPI)network was constructed using the STRING database to screen key targets.Finally,Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis was used to identify biological processes and signaling pathways.The anti-asthmatic effects of rhein were tested in vitro,and the expression levels of proteins in the mitogen-activated protein kinase/nuclear factor kappa-B(MAPK/NF-κB)signaling pathway were assessed by western blot analysis.RESULTS:Altogether,83 targets of rhein were screened in the relevant databases,989 targets of asthma were obtained in the National Center for Biotechnology Information(NCBI)GENE Database.PPI network analysis and KEGG pathway enrichment analysis predicted that rhein could regulate the epidermal active growth factor receptor(EGFR),mitogen-activated protein kinase 14(MAPK14),tumour necrosis factor receptor superfamily member 1A(TNFRSF1A),receptor tyrosineprotein kinase erb B-2(ERBB2),and other signaling pathways.Furthermore,we selected the MAPK signaling pathway to determine the anti-inflammatory effects of rhein.Consistently,further in vitro experiments demonstrated that rhein was shown to inhibit HBE cells inflammation.CONCLUSION:The anti-inflammatory mechanism of rhein in the treatment of asthma may be related to EGFR,MAPK14,TNFRSF1A and ERBB2 as well as their signaling pathways.To prevent the exacerbation of asthma,instead of targeting a single pathway or a single target,all these tar

关键词： asthma rhein anti-inflammatory agents pharmacology drug development